Inhibition of host mitotic exit by virus

Several viruses have evolved strategies to inhibit the cell cycle during mitosis, sometimes leading to cell apoptosis. The host cell is able to enter mitosis but not exit properly. Among these viruses, the chicken anemia virus apoptin inhibits the host anaphase promoting complex/cyclosome (APC/C),an ubiquitin ligase with major roles in cell cycle regulation. Apoptin associates with APC/C subunit APC1 and prevents mitosis progression. Adenovirus E4orf4 instead associates with host PP2A phosphatase, leading to both mitotic arrest and apoptosis. The association between E4orf4 and PP2A supposedly affect APC/C phosphorylation state leading to its inactivation. The TAX protein from HTLV-1 activates APC/C ahead of schedule in the S-phase and later blocks mitosis progression by interacting with subunit APC3 and PAC/C associated protein CDC20. ICP0 from HSV1 induces degradation of CENP-A and CENP-C, host proteins important for mitotic progression and chromosome segregation. This degradation prevents chromosome segregation.

Matching UniProtKB/Swiss-Prot entries

17 entries grouped by strain (browse by keywords)

1 entry

Chicken anemia virus (isolate Germany Cuxhaven-1) (CAV) reference strain

VP3_CAVC1 Apoptin

1 entry

Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain

ICP0_EHV1B E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ICP0)

1 entry

Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) reference strain

TAX_HTL1C Protein Tax-1 (Protein X-LOR) (Protein PX) (Trans-activating transcriptional regulatory protein of ...

1 entry

Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) reference strain

TAX_HTL1A Protein Tax-1 (Protein X-LOR) (Protein PX) (Trans-activating transcriptional regulatory protein of ...

1 entry

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

ICP0_HHV11 E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Alpha-0 protein) (Immediate-early protein IE110) ...

1 entry

Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

ICP0_HHV2H E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (RING-type E3 ubiquitin transferaseICP0) (VMW118 ...

1 entry

Bovine herpesvirus 1.1 (strain Jura) (BoHV-1) (Infectious bovine rhinotracheitis virus)

ICP0_BHV1J E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (IER 2.9/ER2.6) (P135 protein) (RING-type E3 ...

1 entry

Bovine herpesvirus 1.2 (strain K22) (BoHV-1) (Infectious bovine rhinotracheitis virus)

ICP0_BHV1K E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (IER 2.9/ER2.6) (P135 protein) (RING-type E3 ...

1 entry

Chicken anemia virus (isolate Australia/CAU269-7/2000) (CAV)

VP3_CAVCA Apoptin

1 entry

Chicken anemia virus (isolate Japan 82-2) (CAV)

VP3_CAV82 Apoptin

1 entry

Chicken anemia virus (isolate USA 26p4) (CAV)

VP3_CAV26 Apoptin

1 entry

Chicken anemia virus (isolate USA CIA-1) (CAV)

VP3_CAVCI Apoptin

1 entry

Equine herpesvirus 1 (strain V592) (EHV-1) (Equine abortion virus)

ICP0_EHV1V E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Infected cell protein 0) (RING-type E3 ubiquitin ...

1 entry

Human T-cell leukemia virus 1 (isolate Melanesia mel5 subtype C) (HTLV-1)

TAX_HTL1L Protein Tax-1 (Protein X-LOR) (Trans-activating transcriptional regulatory protein of HTLV-1)

1 entry

Human T-cell leukemia virus 1 (isolate Zaire EL subtype B) (HTLV-1)

TAX_HTL1F Protein Tax-1 (Protein X-LOR) (Trans-activating transcriptional regulatory protein of HTLV-1)

1 entry

Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)

E413_ADE12 Probable early E4 13 kDa protein

1 entry

Suid herpesvirus 1 (strain Indiana-Funkhauser / Becker) (SuHV-1) (Pseudorabies virus (strain Indiana-Funkhauser / Becker))

ICP0_SUHVF E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Early protein 0) (EP0) (RING-type E3 ubiquitin ...