Inhibition of host mitotic exit by virus

Several viruses have evolved strategies to inhibit the cell cycle during mitosis, sometimes leading to cell apoptosis. The host cell is able to enter mitosis but not exit properly. Among these viruses, the chicken anemia virus apoptin inhibits the host anaphase promoting complex/cyclosome (APC/C),an ubiquitin ligase with major roles in cell cycle regulation. Apoptin associates with APC/C subunit APC1 and prevents mitosis progression. Adenovirus E4orf4 instead associates with host PP2A phosphatase, leading to both mitotic arrest and apoptosis. The association between E4orf4 and PP2A supposedly affect APC/C phosphorylation state leading to its inactivation. The TAX protein from HTLV-1 activates APC/C ahead of schedule in the S-phase and later blocks mitosis progression by interacting with subunit APC3 and PAC/C associated protein CDC20. ICP0 from HSV1 induces degradation of CENP-A and CENP-C, host proteins important for mitotic progression and chromosome segregation. This degradation prevents chromosome segregation.

Matching UniProtKB/Swiss-Prot entries

17 entries grouped by protein (browse by keywords)

All proteins are shown (view only 12 complete proteome entries)

1 entry

Probable early E4 13 kDa protein

E413_ADE12
Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12) reference strain

7 entries

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (IER 2.9/ER2.6) (P135 protein) (RING-type E3 ubiquitin transferase ICP0)

Select_allDeselect_all
ICP0_EHV1B
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ICP0)

ICP0_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Alpha-0 protein) (Immediate-early protein IE110) (RING-type E3 ubiquitin transferase ICP0) (Trans-acting transcriptional protein ICP0) (VMW110)

ICP0_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (RING-type E3 ubiquitin transferaseICP0) (VMW118 protein)

ICP0_BHV1J
Bovine herpesvirus 1.1 (strain Jura) (BoHV-1) (Infectious bovine rhinotracheitis virus)
ICP0_BHV1K
Bovine herpesvirus 1.2 (strain K22) (BoHV-1) (Infectious bovine rhinotracheitis virus)
ICP0_EHV1V
Equine herpesvirus 1 (strain V592) (EHV-1) (Equine abortion virus)

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Infected cell protein 0) (RING-type E3 ubiquitin transferase ICP0)

ICP0_SUHVF
Suid herpesvirus 1 (strain Indiana-Funkhauser / Becker) (SuHV-1) (Pseudorabies virus (strain Indiana-Funkhauser / Becker))

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Early protein 0) (EP0) (RING-type E3 ubiquitin transferase ICP0)

4 entries

Protein Tax-1 (Protein X-LOR) (Protein PX) (Trans-activating transcriptional regulatory protein of HTLV-1)

Select_allDeselect_all
TAX_HTL1C
Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) reference strain
TAX_HTL1A
Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1)
TAX_HTL1F
Human T-cell leukemia virus 1 (isolate Zaire EL subtype B) (HTLV-1)

Protein Tax-1 (Protein X-LOR) (Trans-activating transcriptional regulatory protein of HTLV-1)

TAX_HTL1L
Human T-cell leukemia virus 1 (isolate Melanesia mel5 subtype C) (HTLV-1)

Protein Tax-1 (Protein X-LOR) (Trans-activating transcriptional regulatory protein of HTLV-1)

5 entries

Apoptin

Select_allDeselect_all
VP3_CAVC1
Chicken anemia virus (isolate Germany Cuxhaven-1) (CAV) reference strain
VP3_CAV26
Chicken anemia virus (isolate USA 26p4) (CAV)
VP3_CAV82
Chicken anemia virus (isolate Japan 82-2) (CAV)
VP3_CAVCA
Chicken anemia virus (isolate Australia/CAU269-7/2000) (CAV)
VP3_CAVCI
Chicken anemia virus (isolate USA CIA-1) (CAV)