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Orthorubulavirus (taxid:2560195)

VIRION

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Enveloped, spherical. Diameter from about 150nm nm.

GENOME

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Negative-stranded RNA linear genome, about 15 kb in size. Encodes for eight proteins.

Enzymes: RNA dependent RNA polymerase, RNA guanylyl transferase, mRNA methyltransferase

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. The V protein is produced through RNA editing of The P mRNA.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through HN glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.
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TAXONOMY Group V: Negative sense ssRNA viruses
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Subphylum: Haploviricotina
Class: Monjiviricetes
Order: Mononegavirales
Family: Paramyxoviridae
Genus: Orthorubulavirus
VIRUS
REFERENCE STRAIN Mumps virus
Sequence | Genome assembly | Proteome

Host

NATURAL HOST Humans, Apes, Pigs, Dogs
CELL TROPISM
INTERACTIONS Cell receptors:
Host-virus interaction

Ecology and disease


GEOGRAPHY Worldwide
ASSOCIATED DISEASES Mumps
TRANSMISSION Respiratory, saliva
VACCINE Mumps virus
ANTIVIRAL DRUGS

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of MDA-5 antiviral signaling

The V protein blocks also the type I and II interferon signaling pathways by interacting with and inhibiting host STAT1 and STAT2 .

NATURAL HOST Humans, Apes, Pigs, Dogs
TROPISM
ASSOCIATED DISEASES Mumps
TRANSMISSION Respiratory, saliva

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

97 entries grouped by strain

8 entries

Mumps virus genotype B (strain Miyahara vaccine) (MuV) reference strain

Select_allDeselect_all
L_MUMPM RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
HN_MUMPM Hemagglutinin-neuraminidase (EC 3.2.1.18)
FUS_MUMPM Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

pdb 2FYZ

V_MUMPM Non-structural protein V (Non-structural protein NS1)
NCAP_MUMPM Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
SH_MUMPM Small hydrophobic protein
PHOSP_MUMPM Phosphoprotein (Protein P)
MATRX_MUMPM Matrix protein

8 entries

Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain

Select_allDeselect_all
HN_PIV5 Hemagglutinin-neuraminidase (EC 3.2.1.18)

pdb 1Z4V; 1Z4W; 1Z4X; 1Z4Y; 1Z4Z; 1Z50; 3TSI; 4JF7

V_PIV5 Non-structural protein V

pdb 2B5L; 2HYE; 2K48; 4I1S

L_PIV5 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

pdb 6V85; 6V86

FUS_PIV5 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

pdb 1SVF; 2B9B; 4GIP; 4WSG

NCAP_PIV5 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

pdb 4XJN; 5WKN

SH_PIV5 Small hydrophobic protein
PHOSP_PIV5 Phosphoprotein (Protein P)

pdb 5WKN; 6V85; 6V86; 6VAG

MATRX_PIV5 Matrix protein (Membrane protein)

7 entries

Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain

Select_allDeselect_all
HN_PI2HT Hemagglutinin-neuraminidase (EC 3.2.1.18)
L_PI2HT RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_PI2HT Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_PI2HT Phosphoprotein (Protein P)
V_PI2HT Non-structural protein V
FUS_PI2HT Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
MATRX_PI2HT Matrix protein (Membrane protein)

6 entries

Simian virus 41 (SV41) reference strain

Select_allDeselect_all
HN_SV41 Hemagglutinin-neuraminidase (EC 3.2.1.18)
FUS_SV41 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
L_SV41 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_SV41 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
V_SV41 Non-structural protein V
MATRX_SV41 Matrix protein

8 entries

Mumps virus genotype A (strain Jeryl-Lynn) (MuV)

Select_allDeselect_all
L_MUMPJ RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

pdb 8IZL; 8IZM; 8X01; 8YXL; 8YXM; 8YXP

PHOSP_MUMPJ Phosphoprotein (Protein P)

pdb 3BBZ; 8IZL; 8IZM; 8X01; 8YXM; 8YXO; 8YXR

SH_MUMPJ Small hydrophobic protein
NCAP_MUMPJ Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

pdb 7EWQ; 7EXA

HN_MUMPJ Hemagglutinin-neuraminidase (EC 3.2.1.18)
V_MUMPJ Non-structural protein V
MATRX_MUMPJ Matrix protein

8 entries

Mumps virus genotype N (strain L-Zagreb vaccine) (MuV)

Select_allDeselect_all
L_MUMPZ RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
FUS_MUMPZ Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
V_MUMPZ Non-structural protein V (Non-structural protein NS1)
NCAP_MUMPZ Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
HN_MUMPZ Hemagglutinin-neuraminidase (EC 3.2.1.18)
PHOSP_MUMPZ Phosphoprotein (Protein P)
MATRX_MUMPZ Matrix protein

7 entries

Mumps virus (strain SBL-1) (MuV)

Select_allDeselect_all
HN_MUMP1 Hemagglutinin-neuraminidase (EC 3.2.1.18)
FUS_MUMP1 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
NCAP_MUMP1 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
V_MUMP1 Non-structural protein V (Non-structural protein NS1)
PHOSP_MUMP1 Phosphoprotein (Protein P)
MATRX_MUMP1 Matrix protein
SH_MUMP1 Small hydrophobic protein

1 entry

Simian virus 41 (SV41)

PHOSP_SV41 Phosphoprotein (Protein P)

5 entries

Human parainfluenza 4a virus (strain Toshiba) (HPIV-4a)

Select_allDeselect_all
HN_PI4HA Hemagglutinin-neuraminidase (EC 3.2.1.18)
NCAP_PI4HA Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
V_PI4HA Non-structural protein V
PHOSP_PI4HA Phosphoprotein (Protein P)
MATRX_PI4HA Matrix protein

5 entries

Mumps virus (strain SBL) (MuV)

Select_allDeselect_all
FUS_MUMPS Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
V_MUMPS Non-structural protein V (Non-structural protein NS1)
MATRX_MUMPS Matrix protein
PHOSP_MUMPS Phosphoprotein (Protein P)
SH_MUMPS Small hydrophobic protein

4 entries

Human parainfluenza 2 virus (HPIV-2)

Select_allDeselect_all
V_PI2H Non-structural protein V
HN_PI2H Hemagglutinin-neuraminidase (EC 3.2.1.18)
PHOSP_PI2H Phosphoprotein (Protein P)
FUS_PI2H Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

4 entries

Human parainfluenza 4b virus (strain 68-333) (HPIV-4b)

Select_allDeselect_all
NCAP_PI4HB Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_PI4HB Phosphoprotein (Protein P)

pdb 4KYD; 4KYE

V_PI4HB Non-structural protein V
MATRX_PI4HB Matrix protein

4 entries

Mumps virus (strain Enders) (MuV)

Select_allDeselect_all
V_MUMPE Non-structural protein V (Non-structural protein NS1)
NCAP_MUMPE Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

pdb 7OZR

PHOSP_MUMPE Phosphoprotein (Protein P)
SH_MUMPE Small hydrophobic protein

3 entries

Mumps orthorubulavirus (MuV)

Select_allDeselect_all
HN_MUMPV Hemagglutinin-neuraminidase (EC 3.2.1.18)

pdb 5B2C; 5B2D; 6JJM; 6JJN

PHOSP_MUMPV Phosphoprotein
NCAP_MUMPV Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

3 entries

Mumps virus (strain RW) (MuV)

Select_allDeselect_all
FUS_MUMPR Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HN_MUMPR Hemagglutinin-neuraminidase (EC 3.2.1.18)
SH_MUMPR Small hydrophobic protein

2 entries

Mumps virus (strain Kilham) (MuV)

Select_allDeselect_all
FUS_MUMPK Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
SH_MUMPK Small hydrophobic protein

1 entry

Human parainfluenza 2 virus (strain Greer) (HPIV-2)

FUS_PI2HG Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

1 entry

La Piedad-Michoacan-Mexico virus (LPMV)

MATRX_LPMV Matrix protein

1 entry

Mumps virus (strain Belfast) (MuV)

SH_MUMPB Small hydrophobic protein

1 entry

Mumps virus (strain Bristol 1) (MuV)

SH_MUMPL Small hydrophobic protein

1 entry

Mumps virus (strain Edingburgh 2) (MuV)

SH_MUMP2 Small hydrophobic protein

1 entry

Mumps virus (strain Edingburgh 4) (MuV)

SH_MUMP4 Small hydrophobic protein

1 entry

Mumps virus (strain Edingburgh 6) (MuV)

SH_MUMP6 Small hydrophobic protein

1 entry

Mumps virus (strain Matsuyama) (MuV)

SH_MUMPA Small hydrophobic protein

1 entry

Mumps virus (strain Takahashi) (MuV)

SH_MUMPT Small hydrophobic protein

1 entry

Mumps virus genotype B (strain Urabe vaccine AM9) (MuV)

SH_MUMPU Small hydrophobic protein

1 entry

Parainfluenza virus 5 (isolate Canine/CPI+) (PIV5) (Simian virus 5)

HN_PIV5D Hemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Parainfluenza virus 5 (isolate Canine/CPI-) (PIV5) (Simian virus 5)

HN_PIV5C Hemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Parainfluenza virus 5 (isolate Human/LN) (PIV5) (Simian virus 5)

HN_PIV5L Hemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Parainfluenza virus 5 (strain 21004-WR) (PIV5) (Simian virus 5)

L_PIV5W RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...