Inhibition of host mRNA nuclear export by virus

The nuclear export of cellular mRNAs is mediated by factors interacting with both the messenger ribonucleoprotein (mRNP) and the nucleoporins (Nup) to deliver the mRNAs through the nuclear pore complex to the cytoplasm.

Several viruses interfere with host mRNA nucleo-cytoplasmic trafficking, eventually leading to shutoff of host proteins expression. This gives viruses transcripts a competitive edge for access to the cellular translation machinery. Preventing the expression of host proteins is also a strategy to counteract the antiviral response.
For example, VSV matrix protein inhibits mRNA export by forming a complex with the mRNA export factor Rae1, whereas the 2A protease of picornaviruses promotes cleavage of host Nup98, Nup153, Nup62 .

Viruses inhibiting host mRNA nuclear export:

Family Virus Viral protein mRNA nuclear export inhibition strategy references
Picornaviridae Poliovirus (Enterovirus) 2A protease Breakdown of Nup62, Nup98, Nup153
HRV2, HRV14, HRV16 (Enterovirus) 2A protease Breakdown of Nup62, Nup98, Nup153
HRV (Enterovirus) 3A protease Breakdown of Nup153, Nup214, and Nup358
Theiler's virus (Cardiovirus) Leader protein Hyperphosphorylation of Nup98
Encephalomyocarditis virus (Cardiovirus) Leader protein Hyperphosphorylation of Nup62, Nup153, and Nup214
Rhabdoviridae Vesicular stomatitis virus (Vesiculovirus) M protein Disrupts Rae1-Nup98 interaction