Inhibition of host mRNA nuclear export by virus

The nuclear export of cellular mRNAs is mediated by factors interacting with both the messenger ribonucleoprotein (mRNP) and the nucleoporins (Nup) to deliver the mRNAs through the nuclear pore complex to the cytoplasm.

Several viruses interfere with host mRNA nucleo-cytoplasmic trafficking, eventually leading to shutoff of host proteins expression. This gives viruses transcripts a competitive edge for access to the cellular translation machinery. Preventing the expression of host proteins is also a strategy to counteract the antiviral response.
For example, VSV matrix protein inhibits mRNA export by forming a complex with the mRNA export factor Rae1, whereas the 2A protease of picornaviruses promotes cleavage of host Nup98, Nup153, Nup62 .

Viruses inhibiting host mRNA nuclear export:

Family Virus Viral protein mRNA nuclear export inhibition strategy references
Picornaviridae Poliovirus (Enterovirus) 2A protease Breakdown of Nup62, Nup98, Nup153
HRV2, HRV14, HRV16 (Enterovirus) 2A protease Breakdown of Nup62, Nup98, Nup153
HRV (Enterovirus) 3A protease Breakdown of Nup153, Nup214, and Nup358
Theiler's virus (Cardiovirus) Leader protein Hyperphosphorylation of Nup98
Encephalomyocarditis virus (Cardiovirus) Leader protein Hyperphosphorylation of Nup62, Nup153, and Nup214
Rhabdoviridae Vesicular stomatitis virus (Vesiculovirus) M protein Disrupts Rae1-Nup98 interaction

Matching UniProtKB/Swiss-Prot entries

58 entries grouped by strain (browse by keywords)

1 entry

Aichi virus (strain Human/A846/88/1989) (AiV) (Aichi virus (strain A846/88)) reference strain

POLG_AIVA8 Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0; Capsid protein VP3 (P1C) ...

1 entry

Encephalomyocarditis virus (strain Rueckert) (EMCV) reference strain

POLG_EMCVR Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0 (VP4-VP2); Capsid protein ...

1 entry

Human rhinovirus A serotype 89 (strain 41467-Gallo) (HRV-89) reference strain

POLG_HRV8A Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Poliovirus type 1 (strain Mahoney) reference strain

POLG_POL1M Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Salivirus A (isolate Human/Nigeria/NG-J1/2007) (SV-A) reference strain

POLG_SALVA Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0; Capsid protein VP3 (P1C) ...

1 entry

Vesicular stomatitis Indiana virus (strain San Juan) (VSIV) reference strain

MATRX_VSIVA Matrix protein

1 entry

Vesicular stomatitis New Jersey virus (strain Ogden subtype Concan) (VSNJV) reference strain

MATRX_VSNJO Matrix protein

1 entry

Bovine enterovirus (strain VG-5-27) (BEV)

POLG_BOVEV Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus A16 (strain G-10)

POLG_CX16G Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus A16 (strain Tainan/5079/98)

POLG_CX16T Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus A21 (strain Coe)

POLG_CXA21 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus A24 (strain EH24/70)

POLG_CXA24 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus A9 (strain Griggs)

POLG_CXA9 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus B1 (strain Japan)

POLG_CXB1J Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid ...

1 entry

Coxsackievirus B2 (strain Ohio-1)

POLG_CXB2O Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus B3 (strain Nancy)

POLG_CXB3N Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus B3 (strain Woodruff)

POLG_CXB3W Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus B4 (strain E2)

POLG_CXB4E Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus B4 (strain JVB / Benschoten / New York/51)

POLG_CXB4J Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus B5 (strain Peterborough / 1954/UK/85)

POLG_CXB5P Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus B6 (strain Schmitt)

POLG_CXB6S Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 1 (strain Human/Egypt/Farouk/1951) (E-1)

POLG_EC01F Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 11 (strain Gregory)

POLG_EC11G Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 12 (strain Travis)

POLG_EC12T Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 30 (strain Bastianni)

POLG_EC30B Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 5 (strain Noyce)

POLG_EC05N Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 6 (strain Charles)

POLG_EC06C Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 9 (strain Barty)

POLG_EC09B Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 9 (strain Hill)

POLG_EC09H Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Encephalomyocarditis virus

POLG_EMCV Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0 (VP4-VP2); Capsid protein ...

1 entry

Encephalomyocarditis virus (strain emc-b nondiabetogenic)

POLG_EMCVB Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0 (VP4-VP2); Capsid protein ...

1 entry

Encephalomyocarditis virus (strain emc-d diabetogenic)

POLG_EMCVD Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0 (VP4-VP2); Capsid protein ...

1 entry

Human enterovirus 70 (strain J670/71) (EV70) (EV-70)

POLG_HE701 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human enterovirus 71 (EV71) (EV-71)

POLG_HE71 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human enterovirus 71 (strain 7423/MS/87) (EV71) (EV-71)

POLG_HE71M Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human enterovirus 71 (strain USA/BrCr/1970) (EV71) (EV-71)

POLG_HE71B Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human enterovirus D68 (EV68) (EV-68)

POLG_HED68 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human klassevirus 1 (HKV-1)

POLG_HKV1 Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0; Capsid protein VP3 (P1C) ...

1 entry

Human rhinovirus 14 (HRV-14)

POLG_HRV14 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human rhinovirus 16 (HRV-16)

POLG_HRV16 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human rhinovirus 1A (HRV-1A)

POLG_HRV1A Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human rhinovirus 1B (HRV-1B)

POLG_HRV1B Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human rhinovirus 2 (HRV-2)

POLG_HRV2 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human rhinovirus 3 (HRV-3)

POLG_HRV3 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Poliovirus type 1 (strain Sabin)

POLG_POL1S Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Poliovirus type 2 (strain Lansing)

POLG_POL2L Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Poliovirus type 2 (strain W-2)

POLG_POL2W Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Poliovirus type 3 (strain 23127)

POLG_POL32 Genome polyprotein [Cleaved into: P3; Protein 3AB; P1; Capsid protein VP0 (VP4-VP2); Capsid protein ...

1 entry

Poliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)

POLG_POL3L Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Porcine enterovirus 9 (strain UKG/410/73)

POLG_PEV9U Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Swine vesicular disease virus (strain H/3 '76) (SVDV)

POLG_SVDVH Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Swine vesicular disease virus (strain UKG/27/72) (SVDV)

POLG_SVDVU Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Theiler's murine encephalomyelitis virus (strain GDVII) (TMEV)

POLG_TMEVG Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0 (VP4-VP2); Capsid protein ...

1 entry

Venezuelan equine encephalitis virus (strain Trinidad donkey) (VEEV)

POLS_EEVVT Structural polyprotein (p130) [Cleaved into: Capsid protein (EC 3.4.21.90) (Coat protein) (C); ...

1 entry

Vesicular stomatitis Indiana virus (strain 85CLB South America) (VSIV)

MATRX_VSIVS Matrix protein

1 entry

Vesicular stomatitis Indiana virus (strain 94GUB Central America) (VSIV)

MATRX_VSIVC Matrix protein

1 entry

Vesicular stomatitis Indiana virus (strain 98COE North America) (VSIV)

MATRX_VSIVN Matrix protein

1 entry

Vesicular stomatitis Indiana virus (strain Glasgow) (VSIV)

MATRX_VSIVG Matrix protein