Kolmioviridae

Satellite virus: infection requires host cell to be co-infected with helper virus

VIRION

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Enveloped, spherical about 22 nm in diameter. The virion is covered by helper virus membrane proteins.

GENOME

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Circular, ssRNA(-) genome of 1,68 kb. Most of the genome displays complementary strands. Replication occurs by rolling circle, single genome being cleaved/ligated by ribozymes.

GENE EXPRESSION

Encodes for one protein. in Deltavirus, genome editing by host ADAR1 extends the S-HDAg ORF by 19 amino acids, inducing production of L-HDAg. Edited genome seems to be unable to replicate.

REPLICATION

NUCLEAR

  1. Virion attaches to host receptors though helper virus surface protein.
  2. Fusion of virus membrane with the vesicle membrane; the RNA genome is released in the cytoplasm and migrates to the nucleus.
  3. Transcription of the single viral gene, promoting viral transcription and replication
  4. Symmetrical rolling circle replication by host DNA-dependent RNA polymerase II
  5. later, genomic RNA can be edited by host ADAR1, inducing packaging of viral genome at the RE.
  6. Budding by helper viral proteins.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

35 entries grouped by strain (browse by keywords)

2 entries

Hepatitis delta virus genotype I (isolate D380) (HDV) reference strain

Select_allDeselect_all
SHDAG_HDVD3 Small delta antigen (S-HDAg) (p24)
LHDAG_HDVD3 Large delta antigen (L-HDAg) (p27)

2 entries

Hepatitis delta virus genotype I (isolate American) (HDV)

Select_allDeselect_all
LHDAG_HDVAM Large delta antigen (L-HDAg) (p27)
SHDAG_HDVAM Small delta antigen (S-HDAg) (p24)

2 entries

Hepatitis delta virus genotype I (isolate Italian) (HDV)

Select_allDeselect_all
LHDAG_HDVIT Large delta antigen (L-HDAg) (p27)
SHDAG_HDVIT Small delta antigen (S-HDAg) (p24)

2 entries

Hepatitis delta virus genotype I (isolate Japanese M-1) (HDV)

Select_allDeselect_all
LHDAG_HDVM1 Large delta antigen (L-HDAg) (p27)
SHDAG_HDVM1 Small delta antigen (S-HDAg) (p24)

2 entries

Hepatitis delta virus genotype I (isolate Japanese M-2) (HDV)

Select_allDeselect_all
SHDAG_HDVM2 Small delta antigen (S-HDAg) (p24)
LHDAG_HDVM2 Large delta antigen (L-HDAg) (p27)

2 entries

Hepatitis delta virus genotype I (isolate Japanese S-2) (HDV)

Select_allDeselect_all
LHDAG_HDVS2 Large delta antigen (L-HDAg) (p27)
SHDAG_HDVS2 Small delta antigen (S-HDAg) (p24)

2 entries

Hepatitis delta virus genotype I (isolate Lebanon-1) (HDV)

Select_allDeselect_all
LHDAG_HDVL1 Large delta antigen (L-HDAg) (p27)
SHDAG_HDVL1 Small delta antigen (S-HDAg) (p24)

2 entries

Hepatitis delta virus genotype I (isolate Nauru) (HDV)

Select_allDeselect_all
LHDAG_HDVNA Large delta antigen (L-HDAg) (p27)
SHDAG_HDVNA Small delta antigen (S-HDAg) (p24)

2 entries

Hepatitis delta virus genotype I (isolate US-2) (HDV)

Select_allDeselect_all
LHDAG_HDVU2 Large delta antigen (L-HDAg) (p27)
SHDAG_HDVU2 Small delta antigen (S-HDAg) (p24)

2 entries

Hepatitis delta virus genotype I (isolate Woodchuck) (HDV)

Select_allDeselect_all
LHDAG_HDVWO Large delta antigen (L-HDAg) (p27)
SHDAG_HDVWO Small delta antigen (S-HDAg) (p24)

2 entries

Hepatitis delta virus genotype II (isolate 7/18/83) (HDV)

Select_allDeselect_all
LHDAG_HDV83 Large delta antigen (L-HDAg) (p27)
SHDAG_HDV83 Small delta antigen (S-HDAg) (p24)

2 entries

Hepatitis delta virus genotype II (isolate Japanese S-1) (HDV)

Select_allDeselect_all
LHDAG_HDVS1 Large delta antigen (L-HDAg) (p27)
SHDAG_HDVS1 Small delta antigen (S-HDAg) (p24)

2 entries

Hepatitis delta virus genotype II (isolate TW2476) (HDV)

Select_allDeselect_all
LHDAG_HDVTW Large delta antigen (L-HDAg) (p27)
SHDAG_HDVTW Small delta antigen (S-HDAg) (p24)

2 entries

Hepatitis delta virus genotype III (isolate Peru-1) (HDV)

Select_allDeselect_all
LHDAG_HDVP1 Large delta antigen (L-HDAg) (p27)
SHDAG_HDVP1 Small delta antigen (S-HDAg) (p24)

2 entries

Hepatitis delta virus genotype III (isolate VnzD8349) (HDV)

Select_allDeselect_all
LHDAG_HDVV2 Large delta antigen (L-HDAg) (p27)
SHDAG_HDVV2 Small delta antigen (S-HDAg) (p24)

2 entries

Hepatitis delta virus genotype III (isolate VnzD8375) (HDV)

Select_allDeselect_all
LHDAG_HDVV3 Large delta antigen (L-HDAg) (p27)
SHDAG_HDVV3 Small delta antigen (S-HDAg) (p24)

2 entries

Hepatitis delta virus genotype III (isolate VnzD8624) (HDV)

Select_allDeselect_all
LHDAG_HDVV1 Large delta antigen (L-HDAg) (p27)
SHDAG_HDVV1 Small delta antigen (S-HDAg) (p24)

1 entry

Hepatitis delta virus genotype I (isolate HDV/Human/Central African Republic/FH27/1985) (HDV)

SHDAG_HDV27 Small delta antigen (S-HDAg) (p24)