VIRION
Rod-shaped, enveloped virions that measure 65-80 x 550-680 nm with an inner, 50 nm diameter nucleocapsid containing a DNA-protein core.
GENOME
Circular, dsDNA genome of about 124 kb with 108 putative non-overlapping ORFs that are almost equally distributed over both DNA strands.
GENE EXPRESSION
Codes for 108 open reading frames.
ENZYMES
- DNA dependent DNA polymerase family B [DdDp]
- Protease (Peptidase M10) [Protease]
- Thymidylate synthase [MdSGHV012]
REPLICATION
NUCLEUS
- Virus attachment to host receptors and internalization.
- Fusion of virus membrane with the vesicle membrane occurs; DNA genome is released into the nucleus.
- Transcription of viral genes, replication of the DNA genome in the nucleus.
- Assembly of new virions in the nucleus and cytoplasm.
- Virions bud from the cell membrane.