Latency-replication decision (kw:KW-1252)

Viruses that have the ability to lie latent within a cell have two options when infecting a cell: they can either enter the latency or the lytic pathway (productive replication). The decision between lytic and latent pathways is regulated by expression of regulatory proteins part of a genetic switch system. The outcome of the followed pathways depends on the ratio of these key regulators in Lambda. This ratio may be determined by environmental factors such as the host cell type, its shape, or the nutriment availability.
Bacteriophage lambda includes at least a repressor of the lytic promoter, a repressor of the latency promotor and two key regulators . Mu phage switch system involves two proteins, a repressor of early promoter called RepC and a repressor of RepC expression called Ner.
In phi3T bacteriophage, the decision between latency and replication depends on the concentration of a small peptide that is secreted by infecting viruses and an intracellular receptor that acts as a transcriptional regulator. When a virus infects an as-yet-uninfected bacteria in which the peptide has accumulated, latency will be promoted.

image

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

9 entries grouped by protein

2 entries

Protein AimP (YopL protein)

Select_allDeselect_all
AIMP_BPSPB
Bacillus phage SPbeta (Bacillus phage SPBc2) (Bacteriophage SP-beta) reference strain
AIMP_BPPHT
Bacillus phage phi3T (Bacteriophage phi-3T)

Protein AimP

2 entries

AimR transcriptional regulator (Arbitrium communication peptide receptor)

Select_allDeselect_all
AIMR_BPSPB
Bacillus phage SPbeta (Bacillus phage SPBc2) (Bacteriophage SP-beta) reference strain

AimR transcriptional regulator (Arbitrium communication peptide receptor) (YopK protein)

AIMR_BPPHT
Bacillus phage phi3T (Bacteriophage phi-3T)

1 entry

Regulatory protein cro

RCRO_LAMBD
Escherichia phage lambda (Bacteriophage lambda) reference strain

2 entries

Repressor c protein (Repc) (CI)

Select_allDeselect_all
REPC_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

Repressor protein c (Repc) (CI) (Gene product 1) (gp1) (Mu repressor) (MuR)

REPC_BPD10
Escherichia phage D108 (Bacteriophage D108)

1 entry

Repressor protein cI

RPC1_LAMBD
Escherichia phage lambda (Bacteriophage lambda) reference strain

1 entry

DDE-recombinase A (EC 3.1.22.-) (EC 6.5.1.-) (DDE-transposase A) (Gene product 03) (gp03) (Gene product A) (gpA) (MuA)

TNPA_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain