VIRION
Icosahedral virion with a diameter of about 250nm. Source:
- Hexons: Double jelly roll-fold major capsid protein [D2XAY2]
- Pentons: Single jelly roll-fold [D2XAB2?]
GENOME
Circular, dsDNA genome of about 368kb that encodes potentially for 457 ORFs.
GENE EXPRESSION
Undocumented
REPLICATION
NUCLEO-CYTOPLASMIC Replication cycle lasts 5 hours ex-vivo.
- Virion binds to host cell and enters into host cell by phagocytosis
- Fusion of viral envelope with cellular membrane, inducing the release of viral DNA into host cytoplasm.
- Host cell nucleus shrinks, indicating possible degradation of host chromosomes.
- Synthesis of early proteins.
- Replication of genomic DNA.
- Late proteins synthesis, assembly of new virions in the cytoplasmic factories
- Cell lysis and virion release in the extracellular space.