| All |
UL7 |
UL7 |
ORF53 |
UL103 |
U75 |
BBRF2 |
ORF42 |
Secondary envelopment |
| All | UL11 | UL11 | ORF49 | UL99 | U71 | BBLF1 | ORF38 | Secondary envelopment |
| All | UL13 | UL13 | ORF47 | UL97 | U69 | BGLF4 | ORF36 | Multifunctional kinase |
| All | UL16 | UL16 | ORF44 | UL94 | U65 | BGLF2 | ORF33 | Secondary envelopment |
| All | UL36 | UL36 | ORF22 | UL48 | U31 | BPLF1 | ORF64 | Secondary envelopment/trafficking |
| All | UL37 | UL37 | ORF21 | UL47 | U30 | BOLF1 | ORF63 | Secondary envelopment/trafficking |
| All | UL51 | UL51 | ORF7 | UL71 | U44 | BSRF1 | ORF55 | Second envelopment |
| Alpha | UL50 | UL50 | ORF8 | UL72 | U45 | x | x | dUTPase |
| Alpha | UL23 | UL23 | ORF36 | x | x | BXLF1 | ORF21 | Thymidine kinase |
| Alpha | US2 | US2 | x | x | x | x | x | - |
| Alpha | US3 | US3 | ORF66 | x | x | x | x | Inhibition of IRF3 |
| Alpha | ICP34.5 | ICP34.5 | x | x | x | x | x | Prevents EIF2A/PKR |
| Alpha | US10 | US10 | x | x | x | x | x | - |
| Alpha | US11 | US11 | x | x | x | x | x | Inhibition of host innate immune response by virus |
| Alpha | ICP0 | ICP0 | IE61 | x | x | x | x | PML modification |
| Alpha | RS1 | RS1 | ORF62/71 | x | x | x | x | Transcription modulation |
| Alpha | UL14 | UL14 | ORF46 | x | x | x | x | Nuclear import of capsids and VP16 |
| Alpha | UL21 | UL21 | ORF38 | x | x | x | x | DNA packaging/capsid maturation events |
| Alpha | VHS(UL41) | VHS(UL41) | ORF17 | x | x | x | x | translation initiation inhibitor |
| Alpha | UL46 | ORF12 | ORF12 | x | x | x | x | Activation of the host PI3K/AKT |
| Alpha | UL47 | UL47 | ORF11 | x | x | x | x | Modulates VHS and virion nuclear egress |
| Alpha | VP16 | VP16 | ORF10 | x | x | x | x | Transcription IE genes |
| Alpha | VP22 (UL49) | VP22 (UL49) | ORF9 | x | x | x | x | Modulates VHS and chromatin |
| Alpha | UL55 | UL55 | ORF3 | x | x | x | x | - |
| Beta | x | x | x | UL24 | U3 | x | x | - |
| Beta | x | x | x | UL25 (pp85) | U14 | x | x | - |
| Beta | x | x | x | UL26 | x | x | x | Transactivator of viral promoters |
| Beta | x | x | x | UL32(pp150) | U11 | x | x | Viral maturation and release |
| Beta | x | x | x | UL35 | x | x | x | Transcription IE genes/remodel PML bodies |
| Beta | x | x | x | UL43 | U25 | x | x | - |
| Beta | x | x | x | UL45 | U28 | x | x | Ribonucleoside-diphosphate reductase |
| Beta | ICP27 | ICP27 | ORF4 | UL69 | U42 | BMLF1 | ORF57 | - |
| Beta | x | x | x | UL82(pp71) | U54 | x | x | Counteracts DAXX |
| Beta | x | x | x | UL83(pp65) | U54 | x | x | Inhibition IRF3 |
| Beta | x | x | x | UL88 | U59 | x | x | - |
| Beta | x | x | x | UL93 | U64 | x | x | - |
| Beta | x | x | x | IRS1 | x | x | x | PKR inhibition |
| Beta | x | x | x | TSR1 | - | x | x | PKR inhibition/Autophagy modulation |
| Beta | x | x | x | US22 | DR7 | x | x | - |
| Gamma | x | x | x | x | x | BNRF1 | ORF75 | Inhibition of DAXX/PML |
| Gamma | x | x | x | x | x | BLRF2 | ORF52 | Viral maturation and release |
| Gamma | x | x | x | x | x | BRRF2 | x | - |
| Gamma | x | x | x | x | x | BKRF4 | ORF45 | IRF7 inhibition |
