Inhibition of host MDA5 by virus (kw:KW-1089)

Upon viral infection, the cytosolic receptor MDA5 recognizes long viral dsRNAs and initiates an antiviral signaling cascade by interacting with the downstream partner MAVS, located to the mitochondria. This signaling pathway leads to the establishment of an antiviral state characterized by expression of antiviral cytokines and interferons. The MDA5 protein belongs to the RNA helicase family. ISGylation of MDA5 would be crutial for its function .

RIGI RIGI TRIM25 MAVS STING TRADD TRADD TRAF3 TRAF6 TRAF2 FADD RIP1 TBK1 IKKe IRF3 IRF3 IRF7 IRF7 IKb IKb DDX3 IKKgamma IKKalpha IKKbeta NFKB NFKB NFKB

Several viruses encode proteins that directly interfere with MDA5 to decrease interferon production by infected cells. For example, all viruses from paramyxovirinae subfamily encode a protein V able to interact with MDA5 and block MDA5 interaction with MAVS, its downstream partner in the cascade. The interaction has been investigated in detail and the C-terminal domain of the V proteins is responsible for the binding of the helicase domain of protein V.

Matching UniProtKB/Swiss-Prot entries

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53 entries grouped by protein

7 entries

Nucleoprotein (Protein N) (Nucleocapsid protein)

Select_allDeselect_all
NCAP_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
NCAP_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
NCAP_BRSV3
Bovine respiratory syncytial virus (strain 391-2) (BRS)
NCAP_BRSVR
Bovine respiratory syncytial virus (strain Rb94) (BRS)
NCAP_HRSV
Human respiratory syncytial virus
NCAP_HRSV1
Human respiratory syncytial virus B (strain 18537)
NCAP_HRSVA
Human respiratory syncytial virus A (strain A2)

14 entries

Genome polyprotein

Select_allDeselect_all
POLG_CX16G
Coxsackievirus A16 (strain G-10)
POLG_CX16T
Coxsackievirus A16 (strain Tainan/5079/98)
POLG_CXB3N
Coxsackievirus B3 (strain Nancy)
POLG_CXB3W
Coxsackievirus B3 (strain Woodruff)
POLG_HE71
Human enterovirus 71 (EV71) (EV-71)
POLG_HE71B
Human enterovirus 71 (strain USA/BrCr/1970) (EV71) (EV-71)
POLG_HE71M
Human enterovirus 71 (strain 7423/MS/87) (EV71) (EV-71)
POLG_HED68
Human enterovirus D68 (EV68) (EV-68)
POLG_POL1S
Poliovirus type 1 (strain Sabin)
POLG_POL2L
Poliovirus type 2 (strain Lansing)
POLG_POL2W
Poliovirus type 2 (strain W-2)
POLG_POL32
Poliovirus type 3 (strain 23127)
POLG_POL3L
Poliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)

1 entry

Non-structural polyprotein pORF1

POLN_HEVCH
Hepatitis E virus genotype 1 (isolate Human/China/HeBei/1987) (HEV) reference strain

3 entries

Accessory factor US11 (Vmw21)

Select_allDeselect_all
RNB_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
RNB_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Probable RNA-binding protein

RNB_HHV1M
Human herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)

RNA-binding protein (Vmw21)

28 entries

Non-structural protein V

Select_allDeselect_all
V_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
V_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
V_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain

Non-structural protein V (Non-structural protein NS1)

V_NDVB1
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain

Protein V

V_NIPAV
Nipah virus reference strain
V_PI2HT
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
V_PIV5
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
V_SENDA
Sendai virus (strain Hamamatsu) (SeV) reference strain

Protein V

V_SV41
Simian virus 41 (SV41) reference strain
V_TPMV
Tupaia paramyxovirus (TPMV) reference strain
V_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASI
Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASY
Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)
V_MUMP1
Mumps virus (strain SBL-1) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_MUMPE
Mumps virus (strain Enders) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_MUMPS
Mumps virus (strain SBL) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_NDVU2
Newcastle disease virus (strain Ulster/2C) (NDV)
V_PHODV
Phocine distemper virus (PDV)
V_PI2H
Human parainfluenza 2 virus (HPIV-2)
V_PI4HA
Human parainfluenza 4a virus (strain Toshiba) (HPIV-4a)
V_PI4HB
Human parainfluenza 4b virus (strain 68-333) (HPIV-4b)
V_RINDK
Rinderpest virus (strain Kabete O) (RDV)
V_RINDR
Rinderpest virus (strain RBOK) (RDV)
V_SENDF
Sendai virus (strain Fushimi) (SeV)

Protein V

V_SENDH
Sendai virus (strain Harris) (SeV)

Protein V

V_SENDO
Sendai virus (strain Ohita) (SeV)

Protein V

V_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ))

Protein V