G1/S host cell cycle checkpoint dysregulation by virus (kw:KW-1078)
Upon infection, viruses alter the environment of infected cells in order to replicate more efficiently. Modulation of host cell cycle progression is commonly used to maximize viral replication. Among the key steps, transition from the G1 to S phase is deregulated by many viral proteins. Members of the retinoblastoma (Rb) family of tumors repressors are transcriptional regulators that critically regulate the G1 phase.

Many viruses deregulate G1/S transition of the host cell cycle either to inhibit or to activate the transition.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)201 entries grouped by protein
1 entry
Lytic switch protein BZLF1 (EB1) (Protein Z) (Trans-activator protein BZLF1) (Zta) (bZIP transcription factor ZEBRA)
3 entries
Cytoplasmic envelopment protein 2 (Tegument protein BGLF2)
14 entries
Early E1A protein (Early E1A 20 kDa protein)
3 entries
DNA polymerase processivity factor BMRF1 (Early Antigen Diffused) (EA-D) (Polymerase accessory subunit)
3 entries
Epstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr nuclear antigen 3C) (EBNA-3C) (EBV nuclear antigen 3C) (Epstein-Barr nuclear antigen 4B) (EBNA-4B) (EBV nuclear antigen 4B)
5 entries
mRNA export factor (Immediate-early protein IE63) (Infected cell protein 27) (ICP27) (VMW63)
1 entry
45 kDa immediate-early protein 2 (IE2)
1 entry
E3 SUMO-protein ligase K-bZIP (EC 2.3.2.-) (E3 SUMO-protein transferase K-bZIP)
20 entries
Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)
1 entry
Oncoprotein MEQ (MEQ)
9 entries
Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) (Non-structural protein 1) (Non-structural protein NS1)
32 entries
Genome polyprotein
2 entries
Protein pp71
1 entry
Protein Rep68 (EC 3.6.4.12)
1 entry
Protein Rep78
14 entries
Replication-associated protein A (RepA) (EC 3.1.21.-)
4 entries
Protein Tax-1 (Protein X-LOR) (Protein PX) (Trans-activating transcriptional regulatory protein of HTLV-1)
79 entries
Protein E7
3 entries
Immediate early protein IE1 (IE1) (55 kDa immediate-early protein 1) (IE1p72) (IE72)
3 entries
Viral transcription factor IE2 (IE2) (Protein UL122)
1 entry