Sipho-type tailed virion
Upon binding to the host cell surface, the baseplate changes its conformation and triggers genome ejection into the host cell cytoplasm.
The source of the forces that drive viral genome ejection is probably in part due to osmotic pressure imbalance between the virus inside and the host cytoplasm .
One membrane:
- Attachment to a host cell outer membrane (OM) receptor.
- Tail tip penetrates into host OM. Virion-associated exolysin (if present) hydrolyzes the peptidoglycan layer.
- Tail reaches host plasma membrane. Possible loss of tail tip.
- Creation (fusogenic activity?) or use of a hydrophilic pore for viral DNA translocation into host cytoplasm.
Two membranes hosts:
- Attachment to a host cell wall receptor.
- Tip-associated hydrolysis of the peptidoglycan layer.
- Tail reaches host plasma membrane. Possible loss of tail tip. Opening of the cap.
- Creation (fusogenic activity?) or use of a hydrophilic pore for viral DNA translocation into host cytoplasm.
Long noncontractile tail machines of bacteriophages
Alan R Davidson, Lia Cardarelli, Lisa G Pell, Devon R Radford, Karen L Maxwell
Adv. Exp. Med. Biol. 2012; 726: 115-142
Alan R Davidson, Lia Cardarelli, Lisa G Pell, Devon R Radford, Karen L Maxwell
Adv. Exp. Med. Biol. 2012; 726: 115-142
Popping the cork: mechanisms of phage genome ejection
Molineux IJ, Panja D
Nat Rev Microbiol. 2013 Mar;11(3):194-204
Molineux IJ, Panja D
Nat Rev Microbiol. 2013 Mar;11(3):194-204