Coccolithovirus (taxid:346673)

VIRION

Double-enveloped virion. The inner membrane is surrounded by a capsid with an icosahedral symmetry (T=169), 100-220 nm in diameter. Dense material are present at each 5-fold symmetry vertex
Source: Van Etten 2003 (Pubmed), Mackinder et al (Pubmed)

• Hexons: Double? jelly roll-fold major capsid protein [A430L]
• Pentons: Single jelly roll-fold [A533R]

GENOME

Linear, dsDNA genome of 410-415 kb with crosslinked hairpin ends. EhV-86 genome encodes about 472 proteins.

GENE EXPRESSION

ENZYMES

• DNA-directed DNA polymerase
• Cell-type capping
• Protease (Peptidase S74)
• Ribonucleoside-diphosphate reductase

REPLICATION

NUCLEO-CYTOPLASMIC

1. Virus attaches to host receptors , inducing release of viral genome into the cell.
2. Migration of the DNA core to the nucleus?
3. Synthesis of early proteins.
4. Replication of genomic DNA..
5. Late proteins synthesis, assembly of new virions in the cytoplasm
6. Virion budding and release in the extracellular space.