Betapolyomavirus (taxid:1891714)

VIRION

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Non-enveloped capsid with a T=7d icosahedral symmetry, about 50 nm in diameter.
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GENOME

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Circular dsDNA about 5 kb in size, associated with cellular histones in a chromatin-like complex. Encodes for 5-9 proteins.
On rare non-specific recombination, the viral genome can be integrated in host chromosome. This inactivates the integrated virus but can give the host cell a replicative advantage sometimes leading to malignant tumours.

GENE EXPRESSION

Transcription is nuclear, in two phases; early (replication), late (virion assembly/exit). 5-9 proteins are expressed from the two pre-MRNA by alternative splicing. All genes are transcribed by host RNA pol II.

REPLICATION

NUCLEAR

  1. Attachment of the viral proteins to host receptors triggers lipid-mediated endocytosis of the virus into the host cell.
  2. Virion transits through endoplasmic reticulum where host protein disulfide isomerases rearrange its capsid structure
  3. Export of misfolded virion to the cytoplasm possibly through host ERAD pathway
  4. Loss of VP1 in the low-calcium conditions of the cytosol
  5. Import of genomic DNA into host nucleus.
  6. Transcription of early genes (LT and sT genes)
  7. Replication of the DNA genome in the nucleus.
  8. Transcription of late genes encoding for structural proteins (VP1, VP2 and VP3).
  9. Assembly of new virions in nuclear viral factories.
  10. Virions are released by lysis of the cell.

Host-virus interaction

Cell-cycle modulation

The large T antigen binds to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53 and induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

46 entries grouped by strain

6 entries

Simian virus 40 (SV40) reference strain

Select_allDeselect_all
LT_SV40 Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)
VP1_SV40 Major capsid protein VP1 (Major structural protein VP1)
VP2_SV40 Minor capsid protein VP2 (Minor structural protein VP2)
ST_SV40 Small t antigen (ST) (ST-AG)
AGNO_SV40 Agnoprotein
SELP_SV40 SV40 early leader protein (SELP)

5 entries

Squirrel monkey polyomavirus reference strain

Select_allDeselect_all
LT_POVSM Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)
VP2_POVSM Minor capsid protein VP2 (Minor structural protein VP2)
VP1_POVSM Major capsid protein VP1 (Major structural protein VP1)
AGNO_POVSM Squirrel monkey agnoprotein (Agno)
ST_POVSM Small t antigen (ST) (ST-AG)

4 entries

WU polyomavirus (WUPyV) reference strain

Select_allDeselect_all
VP2_POVWU Minor capsid protein VP2 (Minor structural protein VP2)
LT_POVWU Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)
VP1_POVWU Major capsid protein VP1 (Major structural protein VP1)
ST_POVWU Small t antigen (ST) (ST-AG)

5 entries

BK polyomavirus (BKPyV) (Human polyomavirus 1)

Select_allDeselect_all
LT_POVBK Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)
VP2_POVBK Minor capsid protein VP2 (Minor structural protein VP2)
AGNO_POVBK Agnoprotein (Agno)
VP1_POVBK Major capsid protein VP1 (Major structural protein VP1)
ST_POVBK Small t antigen (ST) (ST-AG)

5 entries

BK polyomavirus (strain AS) (BKPyV)

Select_allDeselect_all
VP2_POVBA Minor capsid protein VP2 (Minor structural protein VP2)
LT_POVBA Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)
AGNO_POVBA Agnoprotein (Agno)
VP1_POVBA Major capsid protein VP1 (Major structural protein VP1)
ST_POVBA Small t antigen (ST) (ST-AG)

5 entries

JC polyomavirus (JCPyV) (JCV)

Select_allDeselect_all
LT_POVJC Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)
AGNO_POVJC Agnoprotein (Agno)
VP1_POVJC Major capsid protein VP1 (Major structural protein VP1)
VP2_POVJC Minor capsid protein VP2 (Minor structural protein VP2)
ST_POVJC Small t antigen (ST) (ST-AG)

4 entries

KI polyomavirus (isolate Stockholm 350) (KIPyV)

Select_allDeselect_all
LT_POVKI Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)
VP2_POVKI Minor capsid protein VP2 (Minor structural protein VP2)
VP1_POVKI Major capsid protein VP1 (Major structural protein VP1)
ST_POVKI Small t antigen (ST) (ST-AG)

4 entries

KI polyomavirus (isolate Stockholm 380) (KIPyV)

Select_allDeselect_all
LT_POVK3 Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)
VP2_POVK3 Minor capsid protein VP2 (Minor structural protein VP2)
VP1_POVK3 Major capsid protein VP1 (Major structural protein VP1)
ST_POVK3 Small t antigen (ST) (ST-AG)

4 entries

KI polyomavirus (isolate Stockholm 60) (KIPyV)

Select_allDeselect_all
LT_POVK6 Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)
VP2_POVK6 Minor capsid protein VP2 (Minor structural protein VP2)
VP1_POVK6 Major capsid protein VP1 (Major structural protein VP1)
ST_POVK6 Small t antigen (ST) (ST-AG)

4 entries

Murine polyomavirus (strain Kilham) (MPyV) (Murine pneumotropic virus)

Select_allDeselect_all
VP2_POVMK Minor capsid protein VP2 (Minor structural protein VP2)
LT_POVMK Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)
VP1_POVMK Major capsid protein VP1 (Major structural protein VP1)
ST_POVMK Small t antigen (ST) (ST-AG)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

African elephant polyomavirus 1 taxid:1399914

Protein ModelArchive
Large T antigen ma-jd-viral-21194
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14806
Minor capsid protein ma-jd-viral-31182
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-29807
Small T antigen ma-jd-viral-16625

BK polyomavirus taxid:1891762

Protein ModelArchive
Agnoprotein ma-jd-viral-59844
Agnoprotein (Agno) ma-jd-viral-59844
Capsid protein VP1 ma-jd-viral-14726
Large T antigen (LT) (LT-AG) (EC 3.6.4.-) ma-jd-viral-21153
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14726
Minor capsid protein ma-jd-viral-29763
Minor capsid protein ma-jd-viral-29803
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-29803
Small t antigen ma-jd-viral-16584
Small t antigen ma-jd-viral-16584
Small t antigen (ST) (ST-AG) ma-jd-viral-16584

Bank vole polyomavirus taxid:1737522

Protein ModelArchive
Large T antigen ma-jd-viral-21142
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14700
Small t antigen ma-jd-viral-16543
VP2 ma-jd-viral-37809
VP3 ma-jd-viral-38151

Bat polyomavirus 6a taxid:1623685

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14724
Large T antigen ma-jd-viral-21152
Minor capsid protein ma-jd-viral-31177
Small t antigen ma-jd-viral-16540

Bat polyomavirus 6b taxid:1623689

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14711
Large T antigen ma-jd-viral-21112
Minor capsid protein ma-jd-viral-31138
Small t antigen ma-jd-viral-16577

Bat polyomavirus 6c taxid:1623688

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14741
Large T antigen ma-jd-viral-21195
Minor capsid protein ma-jd-viral-31176
Small t antigen ma-jd-viral-16572

Betapolyomavirus calbifrons taxid:1236392

Protein ModelArchive
Large T antigen ma-jd-viral-21205
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14713
Minor capsid protein ma-jd-viral-31157
Small t antigen ma-jd-viral-16607

Betapolyomavirus cercopitheci taxid:1236395

Protein ModelArchive
Agnoprotein ma-jd-viral-59846
Capsid protein VP1 ma-jd-viral-14797
Large T antigen ma-jd-viral-21107
Minor capsid protein ma-jd-viral-29840
Small t antigen ma-jd-viral-16538

Betapolyomavirus equi taxid:1891761

Protein ModelArchive
Large T antigen ma-jd-viral-21162
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14798
Minor capsid protein ma-jd-viral-31152
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-29774
Small t antigen ma-jd-viral-16598

Betapolyomavirus lepweddellii taxid:1925019

Protein ModelArchive
ALTO ma-jd-viral-66403
Agno ma-jd-viral-59788
Large T antigen ma-jd-viral-21124
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14796
Minor capsid protein ma-jd-viral-31155
Minor capsid protein ma-jd-viral-29823
Small t antigen ma-jd-viral-16642

Betapolyomavirus mafricanus taxid:1891769

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14793
Large T antigen ma-jd-viral-21116
Minor capsid protein ma-jd-viral-31146
Minor capsid protein ma-jd-viral-29761
Small t antigen ma-jd-viral-16624

Betapolyomavirus mastomysis taxid:1891768

Protein ModelArchive
Agnoprotein ma-jd-viral-49865
Capsid protein VP1 ma-jd-viral-14729
Large T antigen ma-jd-viral-21215
Minor capsid protein ma-jd-viral-31160
Minor capsid protein ma-jd-viral-29783
Small T antigen ma-jd-viral-16537

Betapolyomavirus ptedavyi taxid:1891773

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14811
Large T antigen ma-jd-viral-21120
Minor capsid protein ma-jd-viral-31165
Minor capsid protein ma-jd-viral-29798
Small t antigen ma-jd-viral-16593

Betapolyomavirus secuchlopygerythrus taxid:1891758

Protein ModelArchive
Agnoprotein ma-jd-viral-59842
Capsid protein VP1 ma-jd-viral-14737
Large T antigen ma-jd-viral-21201
Minor capsid protein ma-jd-viral-29796
Minor capsid protein ma-jd-viral-29825
Small t antigen ma-jd-viral-16550

Betapolyomavirus securanorvegicus taxid:1919247

Protein ModelArchive
ALTO ma-jd-viral-40309
Large T antigen ma-jd-viral-21212
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14777
Small t antigen ma-jd-viral-16549
VP2 ma-jd-viral-37808
VP3 ma-jd-viral-38152

Betapolyomavirus tertihominis taxid:1891764

Protein ModelArchive
Large T antigen ma-jd-viral-21159
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14807
Small t antigen ma-jd-viral-16626
VP2 ma-jd-viral-37811
VP3 ma-jd-viral-38153

California sea lion polyomavirus 1 taxid:715223

Protein ModelArchive
Large T antigen ma-jd-viral-21206
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14720
Minor capsid protein ma-jd-viral-31154
Minor capsid protein ma-jd-viral-29788
Putative agnoprotein ma-jd-viral-41574
Small t antigen ma-jd-viral-16578

Common vole polyomavirus taxid:1737523

Protein ModelArchive
Large T antigen ma-jd-viral-21132
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14758
Small t antigen ma-jd-viral-16539
VP2 ma-jd-viral-38155
VP3 ma-jd-viral-38154

JC polyomavirus taxid:10632

Protein ModelArchive
Agnoprotein ma-jd-viral-59845
Agnoprotein (Agno) ma-jd-viral-59845
Capsid protein VP1 ma-jd-viral-14787
Large T antigen ma-jd-viral-21189
Large T antigen (LT) (LT-AG) (EC 3.6.4.-) ma-jd-viral-21189
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14787
Minor capsid protein ma-jd-viral-29812
Minor capsid protein ma-jd-viral-29833
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-29812
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-29833
Small t antigen ma-jd-viral-16620
Small t antigen (ST) (ST-AG) ma-jd-viral-16620

Meles meles polyomavirus 1 taxid:1608323

Protein ModelArchive
Large T antigen ma-jd-viral-21182
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14742
Minor capsid protein ma-jd-viral-31136
Minor capsid protein ma-jd-viral-29775
Small t antigen ma-jd-viral-16569

Pan troglodytes verus polyomavirus 8 taxid:1762023

Protein ModelArchive
Agnoprotein ma-jd-viral-59841
Capsid protein VP1 ma-jd-viral-14730
Large T antigen ma-jd-viral-21108
Minor capsid protein ma-jd-viral-29771
Minor capsid protein ma-jd-viral-29821
Small t antigen ma-jd-viral-16542

Squirrel monkey polyomavirus taxid:452475

Protein ModelArchive
Agno ma-jd-viral-53217
Capsid protein VP1 ma-jd-viral-14795
Large T antigen (LT) (LT-AG) (EC 3.6.4.-) ma-jd-viral-21125
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14795
Minor capsid protein ma-jd-viral-29772
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-31170
Small t antigen (ST) (ST-AG) ma-jd-viral-16650
Squirrel monkey agnoprotein (Agno) ma-jd-viral-53217

WU polyomavirus taxid:440266

Protein ModelArchive
Large T antigen ma-jd-viral-21122
Large T antigen (LT) (LT-AG) (EC 3.6.4.-) ma-jd-viral-21122
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14709
Major capsid protein VP1 (Major structural protein VP1) ma-jd-viral-14709
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-37804
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-38157
Small t antigen ma-jd-viral-16629
Small t antigen (ST) (ST-AG) ma-jd-viral-16629
VP2 ma-jd-viral-37804
VP3 ma-jd-viral-38157

bat polyomavirus 2a taxid:2758131

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14703
Large T antigen ma-jd-viral-21190
Minor capsid protein ma-jd-viral-31180
Minor capsid protein ma-jd-viral-29790
Small t antigen ma-jd-viral-16621

bat polyomavirus 2b taxid:2758132

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14743
Large T antigen ma-jd-viral-21192
Minor capsid protein ma-jd-viral-31162
Minor capsid protein ma-jd-viral-29773
Small t antigen ma-jd-viral-16631