Mastadenovirus (taxid:10509)

Mastadenovirus is a genus od dsDNA viruses in Adenoviridae family that infect various epithelia in vertebrates. Human adenovirus can cause respiratory, gastrointestinal and eye infections.

VIRION

image

Non-enveloped capsid with a pseudo T=25 icosahedral symmetry . The capsid diameter is about 90 nm. The capsid shell consists of 720 hexon subunits arranged as 240 trimers and 12 vertex penton capsomers each with a fiber protruding from the surface.
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PDB-101

GENOME

image Monopartite, linear double-stranded DNA of 35-36kb encoding about 40 proteins. The genome has terminally redundant sequences which have inverted terminal repetitions (ITR). The terminal protein (TP) is covalently attached to each end of the genome.

GENE EXPRESSION

Transcription is nuclear, in three phases; early, intermediate (replication), and late (virion assembly). All genes are transcribed by host RNA pol II except virus-associated (VA) gene(s) of some primate adenoviruses transcribed by RNA pol III. Genes transcribed by RNA pol II give rise to multiple mRNA that are produced by alternative splicing and use of different poly(A) sites.

ENZYMES

REPLICATION

NUCLEUS

  1. Attachment of the viral fibers to the host CAR adhesion receptor. Subsequent binding of the penton protein to host integrin entry receptors mediates internalization into the host cell by clathrin-mediated endocytosis of the virus and fiber shedding. Some serotypes also seem to use macropinocytosis.
  2. Disruption of host endosomal membrane by lytic protein VI releases the viral capsid in the cytosol.
  3. Microtubular transport toward nucleus of the viral genome still protected by the core protein VII and a partial capsid mainly composed of hexons and protein IX.
  4. Docking at the NPC and capsid disruption.
  5. Import of the viral genome into host nucleus mediated by core protein VII.
  6. Transcription of early genes (E genes) by host RNA pol II: these proteins optimize the cellular milieu for viral replication, and counteract a variety of antiviral defenses.
  7. Intermediate genes activate replication of the DNA genome by DNA strand displacement in the nucleus.
  8. Expression of L4-22K and L4-33K causes early to late switch. Transcription of late genes (L genes) by host RNA pol II, mostly encoding structural proteins.
  9. Host translation shutoff performed by the viral 100K protein.
  10. Assembly of new virions in the nucleus.
  11. Virions are released by lysis of the cell.
  12. Virion maturation by the viral protease.

Host-virus interaction

Adaptive immune response inhibition

The adenovirus E19 protein downregulates cell-surface expression of MHC-I by binding and retains the heavy chain in ER. E19 binds TAP and acts as a tapasin inhibitor, preventing class I/TAP association .

Apoptosis modulation

Soon after infection, the expression of E1A protein drives the cell cycle into S-phase so that the virus can replicate its genome optimally . However, this arrest leads to the accumulation of host p53 protein and subsequently apoptosis. The apoptosis is then inhibited by different viral proteins including E1B 55K, E4 orf6 or the bcl-2 homolog E1B 19K .

Autophagy modulation

Autophagy is triggered after adenoviral infection and may facilitate viral replication and/or cell lysis. The E1B 19K viral protein interacts with host Beclin 1, removes Bcl-2 (a negative regulator of autophagy) from Beclin-1 and thereby promotes autophagy .

Cell-cycle modulation

The expression of E1A protein drives the cell cycle into S-phase so that the virus can replicate its genome optimally .

Innate immune response inhibition

Adenoviruses do not inhibit the cascade leading to production of interferon-beta directly. However, they evade the host innate immunity by targeting a cellular histone modification. Indeed, the E1A viral protein blocks the IFN-induced H2B mono-ubiquitination and thereby associated ISGs expression .

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

326 entries grouped by strain

45 entries

Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

Select_allDeselect_all
E4RF4_ADE02 Early 4 ORF4 protein (E4 ORF4) (Early E4 13 kDa protein)
PRO_ADE02 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
E1A_ADE02 Early E1A protein (Early E1A 32 kDa protein)
DNB2_ADE02 DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
TERM_ADE02 Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...
PKG1_ADE02 Packaging protein 1 (Packaging protein IVa2)
CAP6_ADE02 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]
E3RDA_ADE02 Pre-early 3 receptor internalization and degradation alpha protein (Pre-E3-RID-alpha protein) ...
SHUT_ADE02 Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
E3GL_ADE02 Early E3 18.5 kDa glycoprotein (E3-19K) (E3gp 19 kDa) (E19) (GP19K)
E1B55_ADE02 E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
E1BS_ADE02 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K) (E1B-175R)
E3RDB_ADE02 Early 3 receptor internalization and degradation beta protein (E3 RID-beta protein) (Early E3B 14.5 ...
DPOL_ADE02 DNA polymerase (EC 2.7.7.7)
PKG3_ADE02 Packaging protein 3 (L1-52/55 kDa protein) (Packaging protein 52K)
CORE5_ADE02 Core-capsid bridging protein (Core protein V)
SPIKE_ADE02 Fiber protein (SPIKE) (Protein IV)
CAPSP_ADE02 Penton protein (CP-P) (Penton base protein) (Protein III)
CAPSH_ADE02 Hexon protein (CP-H) (Protein II)
CAP3_ADE02 Pre-hexon-linking protein IIIa (Capsid vertex-specific component IIIa) (CVSC) (Protein IIIa) (pIIIa) ...
CAP9_ADE02 Hexon-interlacing protein (Protein IX)
COR10_ADE02 Pre-core protein X (pX) (11 kDa core protein) (Protein mu) (pMu) [Cleaved into: Core protein X]
ADP_ADE02 Adenovirus death protein (ADP) (Early-3 11.6 kDa glycoprotein) (E3-11.6K)
SF33K_ADE02 Protein 33K (L4-33K) (Splicing factor 33K) (Terminase, small subunit)
NP_ADE02 Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
E4RF5_ADE02 Early 4 ORF6/7 control protein (E4-ORF6/7) (Early E4 17 kDa protein)
E434_ADE02 Early 4 ORF6 protein (E4-ORF6) (Early 4 34 kDa protein) (E4-34k)
E4RF3_ADE02 Early 4 ORF3 protein (E4-ORF3) (E4 ORF3 control protein) (Early 4 11 kDa protein) (E4-11k)
E4RF1_ADE02 Early 4 ORF1 protein (E4-ORF1) (E4 ORF1 control protein)
CAP8_ADE02 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
PKG2_ADE02 Packaging protein 2 (Packaging protein 22K) (L4-22K)
E3145_ADE02 Early 3 14.7 kDa protein (E3-14.7k)
UXP_ADE02 U exon protein (UXP)
LEAD_ADE02 I-leader protein
Y172_ADE02 Uncharacterized protein D-172
Y95_ADE02 Uncharacterized protein E-95
Y116_ADE02 Uncharacterized 11.6 kDa early protein
Y112_ADE02 Uncharacterized protein F-112
Y115_ADE02 Uncharacterized protein E-115
Y215_ADE02 Uncharacterized protein F-215
Y168_ADE02 Uncharacterized protein C-168
Y137_ADE02 Uncharacterized protein B-137
Y121_ADE02 Uncharacterized protein F-121
E4RF2_ADE02 Early 4 ORF2 protein (E4-ORF2)
E312_ADE02 Early E3A 12.5 kDa protein (E3-12,5K)

1 entry

Human adenovirus D serotype 17 (HAdV-17) (Human adenovirus 17) reference strain

PRO_ADE17 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)

1 entry

Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)

E3CR1_ADE02 Early 3 Conserved Region 1-alpha protein (E3 CR1-alpha) (Early 3 6.7K protein) (E3-6.7k)

31 entries

Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)

Select_allDeselect_all
E1B55_ADE05 E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
E1A_ADE05 Early E1A protein (Early E1A 32 kDa protein)
DNB2_ADE05 DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
TERM_ADE05 Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...
CAP6_ADE05 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]
SF33K_ADE05 Protein 33K (L4-33K) (Splicing factor 33K) (Terminase, small subunit)
E1BS_ADE05 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
PRO_ADE05 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
PKG1_ADE05 Packaging protein 1 (Packaging protein IVa2)
E3GL_ADE05 Early E3 18.5 kDa glycoprotein (E3-19K) (E3gp 19 kDa) (E19) (GP19K)
DPOL_ADE05 DNA polymerase (EC 2.7.7.7)
CAP3_ADE05 Pre-hexon-linking protein IIIa (Capsid vertex-specific component IIIa) (CVSC) (Protein IIIa) (pIIIa) ...
CAPSP_ADE05 Penton protein (CP-P) (Penton base protein) (Protein III)
SHUT_ADE05 Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
CAP8_ADE05 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
CORE5_ADE05 Core-capsid bridging protein (Core protein V)
PKG2_ADE05 Packaging protein 2 (Packaging protein 22K) (L4-22K)
CAP9_ADE05 Hexon-interlacing protein (Protein IX)
CAPSH_ADE05 Hexon protein (CP-H) (Protein II)
PKG3_ADE05 Packaging protein 3 (L1-52/55 kDa protein) (Packaging protein 52K)
E3B14_ADE05 Early E3B 14.6 kDa protein
SPIKE_ADE05 Fiber protein (SPIKE) (Protein IV)
NP_ADE05 Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
COR10_ADE05 Pre-core protein X (pX) (11 kDa core protein) (Protein mu) (pMu) [Cleaved into: Core protein X]
UXP_ADE05 U exon protein (UXP)
E411_ADE05 Probable early E4 11 kDa protein
E3145_ADE05 Early E3 14.5 kDa protein
E310_ADE05 Early E3B 10.4 kDa protein
E311_ADE05 Early E3A 10.5 kDa glycoprotein
E312_ADE05 Early E3A 12.5 kDa protein
LEAD_ADE05 I-leader protein

26 entries

Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)

Select_allDeselect_all
E1A_ADE12 Early E1A protein (Early E1A 29.5 kDa protein)
CAP6_ADE12 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]
E1B55_ADE12 E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
DNB2_ADE12 DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
DPOL_ADE12 DNA polymerase (EC 2.7.7.7)
PRO_ADE12 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
PKG1_ADE12 Packaging protein 1 (Packaging protein IVa2)
TERM_ADE12 Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...
CAPSH_ADE12 Hexon protein (CP-H) (Protein II)
L2MU_ADE12 Late L2 mu core protein (11 kDa core protein) (Protein X) (pX) (pMu)
SPIKE_ADE12 Fiber protein (SPIKE) (Protein IV)
CAP3_ADE12 Pre-hexon-linking protein IIIa (Capsid vertex-specific component IIIa) (CVSC) (Protein IIIa) (pIIIa) ...
CAP8_ADE12 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
SHUT_ADE12 Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
CAP9_ADE12 Hexon-interlacing protein (Protein IX)
E1BS_ADE12 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
E310_ADE12 Early E3B 10.4 kDa protein
E3B14_ADE12 Early E3B 12.7 kDa protein
PKG3_ADE12 Packaging protein 3 (L1-52/55 kDa protein) (Packaging protein 52K)
CAPSP_ADE12 Penton protein (CP-P) (Penton base protein) (Protein III)
CORE5_ADE12 Core-capsid bridging protein (Core protein V)
DNBI_ADE12 Probable DNA-binding protein (Agnoprotein)
E312_ADE12 Early E3A 12.1 kDa protein
E411_ADE12 Probable early E4 11 kDa protein
E413_ADE12 Probable early E4 13 kDa protein
E434_ADE12 Early E4 34 kDa protein

25 entries

Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7)

Select_allDeselect_all
E1B55_ADE07 E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
E1A_ADE07 Early E1A protein (Early E1A 28 kDa protein)
TERM_ADE07 Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...
PKG1_ADE07 Packaging protein 1 (Packaging protein IVa2)
DNB2_ADE07 DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
DPOL_ADE07 DNA polymerase (EC 2.7.7.7)
SPIKE_ADE07 Fiber protein (SPIKE) (Protein IV)
CAPSH_ADE07 Hexon protein (CP-H) (Protein II)
E1BS_ADE07 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
E310_ADE07 Early E3B 10.4 kDa protein
E3145_ADE07 Early E3 15.3 kDa protein
E3B14_ADE07 Early E3B 14.9 kDa protein
E321_ADE07 Early E3 20.5 kDa glycoprotein
CAP9_ADE07 Hexon-interlacing protein (Protein IX)
Y115_ADE07 Uncharacterized 11.5 kDa early protein
E1B9_ADE07 Early E1B 9 kDa protein
DNBI_ADE07 Probable DNA-binding protein (Agnoprotein)
Y206_ADE07 Uncharacterized 20.6 kDa early protein
Y104_ADE07 Uncharacterized 10.4 kDa early protein
Y145_ADE07 Uncharacterized 14.5 kDa early protein
Y97_ADE07 Uncharacterized 9.7 kDa early protein
Y190_ADE07 Uncharacterized 19.0 kDa early protein
Y126_ADE07 Uncharacterized 12.6 kDa early protein
Y113_ADE07 Uncharacterized 11.3 kDa early protein
E311_ADE07 Early E3 7.7 kDa protein

22 entries

Canine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL))

Select_allDeselect_all
CAP6_ADECC Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]
CAP8_ADECC Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
SHUT_ADECC Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
PRO_ADECC Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
PKG1_ADECC Packaging protein 1 (Packaging protein IVa2)
DPOL_ADECC DNA polymerase (EC 2.7.7.7)
TERM_ADECC Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...
CAP3_ADECC Pre-hexon-linking protein IIIa (Capsid vertex-specific component IIIa) (CVSC) (Protein IIIa) (pIIIa) ...
NP_ADECC Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
CAPSH_ADECC Hexon protein (CP-H) (Protein II)
DNB2_ADECC DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
CAPSP_ADECC Penton protein (CP-P) (Penton base protein) (Protein III)
CAP9_ADECC Hexon-interlacing protein (Protein IX)
PKG3_ADECC Packaging protein 3 (L1-52/55 kDa protein) (Packaging protein 52K)
L2MU_ADECC Late L2 mu core protein (Protein X) (pX) (pMu)
E1A_ADECC Early E1A protein (Early E1A 25 kDa protein)
E1B55_ADECC E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
CORE5_ADECC Core-capsid bridging protein (Core protein V)
SPIKE_ADECC Fiber protein (SPIKE) (Protein IV)
E1BS_ADECC E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
E325_ADECC Early E3 25 kDa glycoprotein
E434_ADECC Early E4 31 kDa protein

22 entries

Canine adenovirus serotype 1 (strain RI261) (CAdV-1) (Canine adenovirus 1 (strain RI261))

Select_allDeselect_all
CAP6_ADECR Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]
CAPSH_ADECR Hexon protein (CP-H) (Protein II)
CAP8_ADECR Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
NP_ADECR Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
SHUT_ADECR Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
PRO_ADECR Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
PKG1_ADECR Packaging protein 1 (Packaging protein IVa2)
TERM_ADECR Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...
CAP3_ADECR Pre-hexon-linking protein IIIa (Capsid vertex-specific component IIIa) (CVSC) (Protein IIIa) (pIIIa) ...
DNB2_ADECR DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
CAPSP_ADECR Penton protein (CP-P) (Penton base protein) (Protein III)
CAP9_ADECR Hexon-interlacing protein (Protein IX)
PKG3_ADECR Packaging protein 3 (L1-52/55 kDa protein) (Packaging protein 52K)
L2MU_ADECR Late L2 mu core protein (Protein X) (pX) (pMu)
E1A_ADECR Early E1A protein (Early E1A 20 kDa protein)
E1B55_ADECR E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
CORE5_ADECR Core-capsid bridging protein (Core protein V)
SPIKE_ADECR Fiber protein (SPIKE) (Protein IV)
E313_ADECR Early E3 13.3 kDa protein
E1BS_ADECR E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
E322_ADECR Early E3 22.1 kDa glycoprotein
E434_ADECR Early E4 31 kDa protein

20 entries

Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40)

Select_allDeselect_all
CAP6_ADE40 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]
E1A_ADE40 Early E1A protein (Early E1A 27 kDa protein)
E1B55_ADE40 E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
SF33K_ADE40 Protein 33K (L4-33K) (Splicing factor 33K) (Terminase, small subunit)
DNB2_ADE40 DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
CAPSH_ADE40 Hexon protein (CP-H) (Protein II)
CAP8_ADE40 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
SHUT_ADE40 Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
PRO_ADE40 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
DPOL_ADE40 DNA polymerase (EC 2.7.7.7)
TERM_ADE40 Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...
PKG1_ADE40 Packaging protein 1 (Packaging protein IVa2)
NP_ADE40 Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
E1BS_ADE40 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
SPIK1_ADE40 Fiber protein 1 (SPIKE)
SPIK2_ADE40 Fiber protein 2
CAP9_ADE40 Hexon-interlacing protein (Protein IX)
CORE5_ADE40 Core-capsid bridging protein (Core protein V)
L2MU_ADE40 Late L2 mu core protein (Protein X) (pX) (pMu)
E434_ADE40 Early E4 34 kDa protein

18 entries

Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41)

Select_allDeselect_all
CAP6_ADE41 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]
E1A_ADE41 Early E1A protein (Early E1A 27 kDa protein)
DNB2_ADE41 DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
CAPSH_ADE41 Hexon protein (CP-H) (Protein II)
CAP8_ADE41 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
SHUT_ADE41 Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
PRO_ADE41 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
SF33K_ADE41 Protein 33K (L4-33K) (Splicing factor 33K) (Terminase, small subunit)
E1BS_ADE41 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
E1B55_ADE41 E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
SPIK1_ADE41 Fiber protein 1
SPIK2_ADE41 Fiber protein 2
CAP9_ADE41 Hexon-interlacing protein (Protein IX)
YL11_ADE41 Uncharacterized 16.5 kDa protein in 100 kDa protein region
YL12_ADE41 Uncharacterized 8.0 kDa protein in 100 kDa protein region
YL13_ADE41 Uncharacterized 6.9 kDa protein in 100 kDa protein region
YL14_ADE41 Uncharacterized 7.3 kDa protein in 100 kDa protein region
YL15_ADE41 Uncharacterized 12.4 kDa protein in 33 kDa protein region

17 entries

Murine adenovirus A serotype 1 (MAdV-1) (Murine adenovirus 1)

Select_allDeselect_all
CAP6_ADEM1 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]
CAP3_ADEM1 Pre-hexon-linking protein IIIa (Capsid vertex-specific component IIIa) (CVSC) (Protein IIIa) (pIIIa) ...
NP_ADEM1 Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
PKG1_ADEM1 Packaging protein 1 (Packaging protein IVa2)
CAP8_ADEM1 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
PRO_ADEM1 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
CAPSH_ADEM1 Hexon protein (CP-H) (Protein II)
CAPSP_ADEM1 Penton protein (CP-P) (Penton base protein) (Protein III)
CORE5_ADEM1 Core-capsid bridging protein (Core protein V)
L2MU_ADEM1 Late L2 mu core protein (Protein X) (pX) (pMu)
E1A_ADEM1 Early E1A 21 kDa protein
E1B55_ADEM1 E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
SPIKE_ADEM1 Fiber protein (SPIKE) (Protein IV)
E111_ADEM1 Early E1A 11 kDa protein
E1BS_ADEM1 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
E3GL_ADEM1 Early E3 17.7 kDa glycoprotein
E434_ADEM1 Probable early E4 33 kDa protein (ORF A/B protein)

13 entries

Human adenovirus B serotype 3 (HAdV-3) (Human adenovirus 3)

Select_allDeselect_all
SPIKE_ADE03 Fiber protein (SPIKE) (Protein IV)
PRO_ADE03 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
E3GL_ADE03 Early E3 18.5 kDa glycoprotein (E3-19K) (E3gp 19 kDa) (E19) (Early E3 19.2 kDa glycoprotein) (GP19K)
CAPSH_ADE03 Hexon protein (CP-H) (Protein II)
E3145_ADE03 Early E3 15.3 kDa protein
E3B14_ADE03 Early E3B 14.5 kDa protein (Early E3B 15.2 kDa glycoprotein)
E311_ADE03 Early E3 9.0 kDa glycoprotein
E310_ADE03 Early E3B 10.4 kDa protein
E312_ADE03 Probable early E3 12.1 kDa glycoprotein
E320_ADE03 Early E3 20.1 kDa glycoprotein
E321_ADE03 Early E3 20.5 kDa glycoprotein
CAP9_ADE03 Hexon-interlacing protein (Protein IX)
E316_ADE03 Early E3 16 kDa glycoprotein

12 entries

Canine adenovirus serotype 2 (strain Toronto A 26-61) (CAdV-2) (Canine adenovirus 2 (strain Toronto A 26-61))

Select_allDeselect_all
CAP8_ADECT Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
PKG1_ADECT Packaging protein 1 (Packaging protein IVa2)
DPOL_ADECT DNA polymerase (EC 2.7.7.7)
NP_ADECT Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
PRO_ADECT Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
E1A_ADECT Early E1A protein (Early E1A 25 kDa protein)
E1B55_ADECT E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
CAP9_ADECT Hexon-interlacing protein (Protein IX)
SPIKE_ADECT Fiber protein (SPIKE) (Protein IV)
E1BS_ADECT E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
E313_ADECT Early E3 13.3 kDa protein
E434_ADECT Early E4 30 kDa protein

7 entries

Bovine adenovirus 2 (BAdV-2) (Mastadenovirus bos2)

Select_allDeselect_all
TERM_ADEB2 Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...
DPOL_ADEB2 DNA polymerase (EC 2.7.7.7)
CAP8_ADEB2 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
NP_ADEB2 Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
PRO_ADEB2 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
CORE5_ADEB2 Core-capsid bridging protein (Core protein V)
L2MU_ADEB2 Late L2 mu core protein (Protein X) (pX) (pMu)

7 entries

Human adenovirus E serotype 4 (HAdV-4) (Human adenovirus 4)

Select_allDeselect_all
DNB2_ADE04 DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
PRO_ADE04 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
E1A_ADE04 Early E1A protein (Early E1A 28 kDa protein)
DPOL_ADE04 DNA polymerase (EC 2.7.7.7)
NP_ADE04 Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
E1BS_ADE04 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
SPIKE_ADE04 Fiber protein (SPIKE) (Protein IV)

6 entries

Bovine adenovirus B serotype 3 (BAdV-3) (Mastadenovirus bos3)

Select_allDeselect_all
TERM_ADEB3 Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...
DPOL_ADEB3 DNA polymerase (EC 2.7.7.7)
CAPSH_ADEB3 Hexon protein (CP-H) (Protein II)
PRO_ADEB3 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
E3145_ADEB3 Early E3 14.5 kDa protein
SPIKE_ADEB3 Fiber protein (SPIKE) (Protein IV)

6 entries

Porcine adenovirus A serotype 3 (PAdV-3) (Porcine adenovirus 3)

Select_allDeselect_all
CAP8_ADEP3 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
PRO_ADEP3 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
SHUT_ADEP3 Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
CAPSH_ADEP3 Hexon protein (CP-H) (Protein II)
SPIKE_ADEP3 Fiber protein (SPIKE) (Protein IV)
CAPSP_ADEP3 Penton protein (CP-P) (Penton base protein) (Protein III)

5 entries

Canine adenovirus serotype 1 (strain Glaxo) (CAdV-1) (Canine adenovirus 1 (strain Glaxo))

Select_allDeselect_all
SPIKE_ADECG Fiber protein (SPIKE) (Protein IV)
E1A_ADECG Early E1A protein (Early E1A 20 kDa protein)
E1BS_ADECG E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
E322_ADECG Early E3 22.2 kDa glycoprotein
E313_ADECG Early E3 13.3 kDa protein

5 entries

Human adenovirus C serotype 6 (HAdV-6) (Human adenovirus 6)

Select_allDeselect_all
E3GL_ADE06 Early E3 18.5 kDa glycoprotein (E3-19K) (E3gp 19 kDa) (E19) (GP19K)
E311_ADE06 Early E3A 11.6 kDa glycoprotein
E310_ADE06 Early E3B 10.4 kDa protein
E3B14_ADE06 Early E3B 14.5 kDa protein
E3145_ADE06 Early E3B 14 kDa protein

5 entries

Human adenovirus D serotype 9 (HAdV-9) (Human adenovirus 9)

Select_allDeselect_all
E4OR1_ADE09 E4-ORF1 (EC 3.6.1.23) (Early E4 14.0 kDa protein) (ORF1) (Probable dUTPase E4 ORF1)
CAPSH_ADE09 Hexon protein (CP-H) (Protein II)
PRO_ADE09 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
SPIKE_ADE09 Fiber protein (SPIKE) (Protein IV)
E434_ADE09 Early E4 34 kDa protein

4 entries

Canine adenovirus serotype 1 (strain Utrecht) (CAdV-1) (Canine adenovirus 1 (strain Utrecht))

Select_allDeselect_all
CAP8_ADECU Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
NP_ADECU Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
PRO_ADECU Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
E313_ADECU Early E3 13.3 kDa protein

4 entries

Human adenovirus B serotype 11 (strain BC34) (HAdV-11) (Human adenovirus 11A (strain BC34))

Select_allDeselect_all
E3GL_ADE1A Early E3 18.5 kDa glycoprotein (E3-19K) (E3gp 19 kDa) (E19) (GP19K)
SPIKE_ADE1A Fiber protein (SPIKE) (Protein IV)
E320_ADE1A Early E3 20.3 kDa glycoprotein
E321_ADE1A Early E3 20.2 kDa glycoprotein

4 entries

Human adenovirus B serotype 11 (strain Slobiski) (HAdV-11) (Human adenovirus 11P (strain Slobiski))

Select_allDeselect_all
SPIKE_ADE1P Fiber protein (SPIKE) (Protein IV)
E3GL_ADE1P Early E3 18.5 kDa glycoprotein (E3-19K) (E3gp 19 kDa) (E19) (GP19K)
E320_ADE1P Early E3 20.3 kDa glycoprotein
E321_ADE1P Early E3 20.6 kDa glycoprotein

4 entries

Human adenovirus B serotype 35 (HAdV-35) (Human adenovirus 35)

Select_allDeselect_all
E3GL_ADE35 Early E3 18.5 kDa glycoprotein (E3-19K) (E3gp 19 kDa) (E19) (GP19K)
E320_ADE35 Early E3 20.3 kDa glycoprotein
E321_ADE35 Early E3 20.6 kDa glycoprotein
E306_ADE35 Early E3 6.4 kDa protein

4 entries

Tree shrew adenovirus serotype 1 (TSAdV-1) (Tupaia adenovirus 1)

Select_allDeselect_all
CAP9_ADET1 Hexon-interlacing protein (Protein IX)
E1B55_ADET1 E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B protein, large T-antigen homolog) ...
E1BS_ADET1 E1B protein, small T-antigen homolog (E1B 19 kDa protein) (E1B-19K)
E118_ADET1 Early E1A 18 kDa protein

2 entries

Canine adenovirus serotype 2 (CAdV-2) (Canine adenovirus 2)

Select_allDeselect_all
E1A_ADEC2 Early E1A protein (Early E1A 20 kDa protein)
E1BS_ADEC2 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)

2 entries

Simian adenovirus serotype 7 (SAdV-7) (Simian adenovirus 7)

Select_allDeselect_all
E1A_ADES7 Early E1A protein (Early E1A 28 kDa protein)
E1BS_ADES7 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)

1 entry

Bovine adenovirus C serotype 10 (BAdV-10) (Mastadenovirus bos10)

PRO_ADEBA Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)

1 entry

Equine adenovirus B serotype 2 (EAdV-2) (Equine adenovirus 2)

PRO_ADEE2 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)

1 entry

Human adenovirus A serotype 31 (HAdV-31) (Human adenovirus 31)

SPIKE_ADE31 Fiber protein (SPIKE) (Protein IV)

1 entry

Human adenovirus B serotype 16 (HAdV-16) (Human adenovirus 16)

CAPSH_ADE16 Hexon protein (CP-H) (Protein II)

1 entry

Human adenovirus D serotype 15 (HAdV-15) (Human adenovirus 15)

SPIKE_ADE15 Fiber protein (SPIKE) (Protein IV)

1 entry

Human adenovirus D serotype 15/H9 (HAdV-15/H9) (Human adenovirus 15/H9)

SPIKE_ADE1H Fiber protein (SPIKE) (Protein IV)

1 entry

Human adenovirus D serotype 8 (HAdV-8) (Human adenovirus 8)

SPIKE_ADE08 Fiber protein (SPIKE) (Protein IV)

1 entry

Porcine adenovirus B serotype 4 (PAdV-4) (Porcine adenovirus 4)

CAP8_ADEP4 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...