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Inhibition of host PKR by virus (kw:KW-1102)

The protein kinase regulated by RNA, PKR, plays an important function in innate immune response. The N-terminal includes a repeated domain that confers dsRNA-binding activity while the C-terminal confers the kinase activity. The best characterized substrate of PKR is the alpha-subunit of protein synthesis initiator 2 (eIF-2alpha). When phosphorylated by PKR, eIF-2alpha leads to an inhibition of translation. Therefore, PKR is a key factor in the host antiviral response, through inhibition of protein synthesis during viral infection.


Viruses have evolved specific mechanisms to prevent the establishment of an antiviral state by inhibiting key components of the signaling pathway . For instance, several viral proteins antagonists of PKR have been identified, many of which are RNA-binding proteins. Among them, E3L and K3L from vaccinia and sigma3 protein from reoviruses. E3L was found to inhibit host PKR activity through direct interaction. Hepatitis C virus NS5A, Herpes simplex 1 US11, and Kaposi's sarcoma vIRF-2 protein also interact with and inhibit PKR. Some viruses including HCMV or MCMV alter PKR subcellular localization while others direct PKR to degradation like Rift valley fever virus NSs protein.

Viral molecular biology Virion
Virus entry
Virus latency
Transcription and replication
Host-virus interactions
Virus exit
Host PKR modulation PKR inhibition
PP1 modulation
Links Uniprot Keyword: KW-1102
GO ontology: GO:0039580
Virus -Rift valley fever virus
(Bunyaviridae ,Phlebovirus)
-Vaccinia virus
(Poxviridae ,Orthopoxvirus)
-Reovirus
(Reoviridae ,Orthoreovirus)
-Influenza A virus
(Orthomyxoviridae ,Influenza A virus)
-Influenza B virus
(Orthomyxoviridae ,Influenza B virus)
-Porcine rotavirus
(Reoviridae ,Rotavirus)
-Herpes simplex 1 virus
(Herpesviridae ,Simplexvirus)
(Herpesviridae ,Lymphocryptovirus)
(Flaviviridae ,Hepacivirus)
-Human papillomavirus 16
(Papillomaviridae ,alphapapillomavirus)
-Human Cytomegalovirus
(Herpesviridae ,Cytomegalovirus)
-Mouse Cytomegalovirus
(Herpesviridae ,Cytomegalovirus)
-Ranavirus
(Iridoviridae ,Ranavirus)
-Swinepox virus
(Poxviridae ,Suipoxvirus)
-Human adenovirus C
(Adenoviridae ,Mastadenovirus)
-HRSV
(Paramyxoviridae ,Pneumovirus)

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

178 entries grouped by strain

2 entries

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Select_allDeselect_all
BILF1_EBVB9 G-protein coupled receptor BILF1 (GPCR BILF1)

pdb 7JHJ

ICP27_EBVB9 mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein EB2) (Protein SM)

2 entries

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Select_allDeselect_all
TRS1_HCMVA Protein HHLF1
IRS1_HCMVA Protein IRS1 (HQRF1)

2 entries

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Select_allDeselect_all
TRS1_HCMVM Protein TRS1
IRS1_HCMVM Protein IRS1

2 entries

Vaccinia virus (strain Copenhagen) (VACV) reference strain

Select_allDeselect_all
PG041_VACCC Protein K3
PG065_VACCC RNA-binding protein OPG065 (RNA-binding protein E3) (p25)

2 entries

Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

Select_allDeselect_all
PG041_VACCW Protein K3 (Protein K2)

pdb 1LUZ

PG065_VACCW RNA-binding protein OPG065 (RNA-binding protein E3) (p25)

pdb 7C0I; 8I9J

1 entry

Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain

NCAP_BRSVA Nucleoprotein (Protein N) (Nucleocapsid protein)

1 entry

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain

ICP27_EBVA8 mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein EB2) (Protein SM)

1 entry

Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

E1B55_ADE02 E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)

1 entry

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

RNB_HHV11 Accessory factor US11 (Vmw21)

1 entry

Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

RNB_HHV2H Probable RNA-binding protein

1 entry

Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

VIRF2_HHV8P Viral IRF2-like protein (vIRF-2)

pdb 4P55

1 entry

Human respiratory syncytial virus B (strain B1) reference strain

NCAP_HRSVB Nucleoprotein (Protein N) (Nucleocapsid protein)

1 entry

Influenza A virus (strain A/Aichi/2/1968 H3N2) reference strain

NS1_I68A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain

NS1_I96A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain

NS1_I34A1 Non-structural protein 1 (NS1) (NS1A)

pdb 2GX9; 2ZKO; 3L4Q; 3O9Q; 3O9R; 3O9S; 3O9T; 3O9U; 3RVC; 5NT1; 5NT2

1 entry

Influenza B virus (strain B/Lee/1940) reference strain

NS1_INBLE Non-structural protein 1 (NS1) (NS1A)

pdb 1XEQ; 3R66; 3RT3; 3SDL; 6J62; 6JH0; 6JH1

1 entry

Monkeypox virus reference strain

PG065_MONPV RNA-binding protein OPG065

1 entry

Murine pneumonia virus (strain 15) (MPV) reference strain

NCAP_MPV15 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Porcine reproductive and respiratory syndrome virus (strain Lelystad) (PRRSV) reference strain

RPOA_PRRSL Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

1 entry

Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1) reference strain

SIGM3_REOVL Outer capsid protein sigma-3 (Sigma3)

pdb 1JMU; 2CSE; 6XF8; 6ZTY; 6ZTZ

1 entry

Rift valley fever virus (strain ZH-548 M12) (RVFV) reference strain

NSS_RVFVZ Non-structural protein S (NSs)

pdb 2N0Y; 5OOO; 8T2M; 8T2N

1 entry

Toscana virus (Tos) reference strain

NSS_TOSV Non-structural protein NS-S (NSs)

1 entry

Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain

PG065_VAR67 RNA-binding protein OPG065 (Protein E3)

1 entry

Bovine respiratory syncytial virus (strain 391-2) (BRS)

NCAP_BRSV3 Nucleoprotein (Protein N) (Nucleocapsid protein)

1 entry

Bovine respiratory syncytial virus (strain Rb94) (BRS)

NCAP_BRSVR Nucleoprotein (Protein N) (Nucleocapsid protein)

1 entry

Epstein-Barr virus (strain GD1) (HHV-4) (Human gammaherpesvirus 4)

ICP27_EBVG mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein EB2) (Protein SM)

pdb 3MRE; 3MRF; 3O4L

1 entry

Human herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)

RNB_HHV1M RNA-binding protein (Vmw21)

1 entry

Human respiratory syncytial virus

NCAP_HRSV Nucleoprotein (Protein N) (Nucleocapsid protein)

pdb 4V5V

1 entry

Human respiratory syncytial virus A (strain A2)

NCAP_HRSVA Nucleoprotein (Protein N) (Nucleocapsid protein)

pdb 2WJ8; 2YHM; 4BKK; 4UC6; 4UC7; 4UC8; 4UC9; 4UCA; 4UCB; 4UCC; 4UCD; 4UCE; 6YJL; 8OOU; 8OP1; 8OP2

1 entry

Human respiratory syncytial virus B (strain 18537)

NCAP_HRSV1 Nucleoprotein (Protein N) (Nucleocapsid protein)

1 entry

Influenza A virus (strain A/Alaska/6/1977 H3N2)

NS1_I77A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Anas acuta/Primorje/695/1976 H2N3)

NS1_I76A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)

NS1_I60A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Beijing/352/1989 H3N2)

NS1_I89A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Beijing/39/1975 H3N2)

NS1_I75A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Blue-winged teal/Minnesota/993/1980 H6N6)

NS1_I80AE Non-structural protein 1 (NS1)

pdb 4OPA; 4OPH; 6OQE

1 entry

Influenza A virus (strain A/Brazil/11/1978 H1N1)

NS1_I77AA Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))

NS1_I18A0 Non-structural protein 1 (NS1) (NS1A)

pdb 2N74; 5UL6; 6ATV; 6DGK; 6NU0; 6OX7; 6U28

1 entry

Influenza A virus (strain A/Budgerigar/Hokkaido/1/1977 H4N6)

NS1_I77AG Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Brescia/1902 H7N7)

NS1_I02A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Germany/n/1949 H10N7)

NS1_I49A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)

NS1_I97A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)

NS1_I02A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)

NS1_I02A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)

NS1_I01A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)

NS1_I02A5 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/FY150/2001 H5N1 genotype D)

NS1_I01A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)

NS1_I02A6 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/YU562/2001 H5N1 genotype B)

NS1_I01A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)

NS1_I83A5 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Pennsylvania/1370/1983 H5N2)

NS1_I83A6 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)

NS1_I59A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)

NS1_I03A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)

NS1_I85A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chile/1/1983 H1N1)

NS1_I83A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)

NS1_I96A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Duck/Alberta/60/1976 H12N5)

NS1_I76A2 Non-structural protein 1 (NS1) (NS1A)

pdb 3D6R; 3OA9

1 entry

Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)

NS1_I56A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Duck/England/1/1956 H11N6)

NS1_I56A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Duck/Germany/1949 H10N7)

NS1_I49A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)

NS1_I80A6 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)

NS1_I00A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/England/878/1969 H3N2)

NS1_I69A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Equine/Alaska/1/1991 H3N8)

NS1_I91A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Equine/Jillin/1/1989 H3N8)

NS1_I89A7 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Equine/London/1416/1973 H7N7)

NS1_I73A4 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Equine/New Market/1/1977 H7N7)

NS1_I77A9 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Equine/Prague/1/1956 H7N7)

NS1_I56A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Equine/Tennessee/5/1986 H3N8)

NS1_I86A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)

NS1_I47A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Fort Warren/1/1950 H1N1)

NS1_I50A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Fowl plague virus/Rostock/8/1934 H7N1)

NS1_I34A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)

NS1_I79A7 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Guinea fowl/Hong Kong/38/2002 H5N1 genotype X0)

NS1_I02A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Gull/Maryland/1824/1978 H13N6)

NS1_I78AF Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Gull/Maryland/704/1977 H13N6)

NS1_I77AF Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Gull/Massachusetts/26/1980 H13N6)

NS1_I80AC Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)

NS1_I80AD Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Henry/1936 H1N1)

NS1_I36A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Herring gull/DE/677/1988 H2N8)

NS1_I88A4 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Hickox/1940 H1N1)

NS1_I40A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Hong Kong/1/1968 H3N2)

NS1_I68A4 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)

NS1_I97A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)

NS1_I03A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Hong Kong/5/1983 H3N2)

NS1_I83A8 Non-structural protein 1 (NS1) (NS1A)

pdb 4O42

1 entry

Influenza A virus (strain A/India/6263/1980 H1N1)

NS1_I80AA Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Japan/305/1957 H2N2)

NS1_I57A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Korea/426/1968 H2N2)

NS1_I68A5 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Leningrad/1/1954 H1N1)

NS1_I54A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)

NS1_I57A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Leningrad/134/1957 H2N2)

NS1_I57A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)

NS1_I57A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)

NS1_I54A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Mallard/Alberta/827/1978 H8N4)

NS1_I78A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Mallard/Alberta/88/1976 H3N8)

NS1_I76A5 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)

NS1_I78A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Mallard/New York/6874/1978 H3N2)

NS1_I78A4 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Mallard/Ohio/556/1987 H5N9)

NS1_I87A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Memphis/1/1971 H3N2)

NS1_I71A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Memphis/101/1972 H3N2)

NS1_I72A4 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Memphis/102/1972 H3N2)

NS1_I72A3 Non-structural protein 1 (NS1) (NS1A)

pdb 8IZN

1 entry

Influenza A virus (strain A/Memphis/110/1976 H3N2)

NS1_I76A6 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Memphis/18/1978 H3N2)

NS1_I78A8 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Memphis/2/1978 H3N2)

NS1_I78A7 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Memphis/4/1980 H3N2)

NS1_I80A4 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)

NS1_I00A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Pintail/Alberta/119/1979 H4N6)

NS1_I79A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Pintail/Alberta/121/1979 H7N8)

NS1_I79A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Pintail/Alberta/268/1978 H6N2)

NS1_I78AA Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Pintail/Alberta/358/1979 H3N6)

NS1_I79A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)

NS1_I73A5 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Qu/7/1970 H3N2)

NS1_I70A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Ruddy Turnstone/New Jersey/47/1985 H4N6)

NS1_I85A7 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)

NS1_I06A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7)

NS1_I80A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Seal/Massachusetts/133/1982 H4N5)

NS1_I82A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Shearwater/Australia/1972 H6N5)

NS1_I72A5 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)

NS1_I01A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)

NS1_I02A4 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Singapore/1/1957 H2N2)

NS1_I57A5 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)

NS1_I77A4 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)

NS1_I30A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)

NS1_I61A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Tern/Turkmenia/18/1972 H3N3)

NS1_I72A6 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Tokyo/3/1967 H2N2)

NS1_I67A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Turkey/Bethlehem-Glilit/1492-B/1982 H1N1)

NS1_I82A8 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Turkey/Canada/1963 H6N8)

NS1_I63A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)

NS1_I83A4 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Turkey/Minnesota/501/1978 H6N8)

NS1_I78AC Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2)

NS1_I80A8 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)

NS1_I68A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Turkey/Ontario/7732/1966 H5N9)

NS1_I66A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Turkey/Oregon/1971 H7N3)

NS1_I71A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)

NS1_I66A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/USA:Albany/12/1951 H1N1)

NS1_I51A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)

NS1_I45A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/USA:Iowa/1943 H1N1)

NS1_I43A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)

NS1_I96A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/USA:Phila/1935 H1N1)

NS1_I35A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)

NS1_I07A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/USSR/90/1977 H1N1)

NS1_I77AB Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Udorn/307/1972 H3N2)

NS1_I72A2 Non-structural protein 1 (NS1) (NS1A)

pdb 1AIL; 1NS1; 2KKZ; 2RHK; 3EE8; 3EE9; 3KWG; 3KWI; 4NW2; 4O45

1 entry

Influenza A virus (strain A/Wa-182)

NS1_I000W Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Whale/Maine/328/1984 H13N2)

NS1_I84A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))

NS1_I33A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/X-31 H3N2)

NS1_I000X Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza B virus (strain B/Ann Arbor/1/1966 [cold-adapted])

NS1_INBAC Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza B virus (strain B/Ann Arbor/1/1966 [wild-type])

NS1_INBAD Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza B virus (strain B/BA/1978)

NS1_INBBA Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza B virus (strain B/GA/1986)

NS1_INBGA Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza B virus (strain B/GL/1954)

NS1_INBGL Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza B virus (strain B/HT/1984)

NS1_INBHT Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza B virus (strain B/Hong Kong/8/1973)

NS1_INBHK Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza B virus (strain B/ID/1986)

NS1_INBID Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza B virus (strain B/Maryland/1959)

NS1_INBMD Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza B virus (strain B/PA/1979)

NS1_INBPA Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza B virus (strain B/RU/1969)

NS1_INBRU Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza B virus (strain B/Singapore/1964)

NS1_INBSJ Non-structural protein 1 (NS1) (NS1A)

pdb 7S8S; 8TUB

1 entry

Influenza B virus (strain B/Singapore/222/1979)

NS1_INBSI Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza B virus (strain B/Victoria/1987)

NS1_INBVJ Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza B virus (strain B/Yamagata/1/1973)

NS1_INBYA Non-structural protein 1 (NS1) (NS1A)

1 entry

Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

NCAP_ORSVW Nucleoprotein (Protein N) (Nucleocapsid protein)

1 entry

Porcine reproductive and respiratory syndrome virus (PRRSV)

RPOA_PRRSV Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

1 entry

Porcine reproductive and respiratory syndrome virus (isolate Pig/United States/SD 01-08/2001) (PRRSV)

RPOA_PRRSS Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

1 entry

Porcine reproductive and respiratory syndrome virus (strain 16244B) (PRRSV)

RPOA_PRRS1 Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

pdb 5EYI; 5YLX

1 entry

Porcine reproductive and respiratory syndrome virus (strain HB-1) (PRRSV)

RPOA_PRRSB Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

1 entry

Porcine reproductive and respiratory syndrome virus (strain VR-2332) (PRRSV)

RPOA_PRRSR Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

1 entry

Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)

SIGM3_REOVJ Outer capsid protein sigma-3 (Sigma3)

1 entry

Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)

SIGM3_REOVD Outer capsid protein sigma-3 (Sigma3)

pdb 1FN9; 7LUP; 9CYT; 9CYY

1 entry

Swinepox virus (strain Kasza) (SWPV)

K3_SWPVK Protein K3 homolog

1 entry

Theiler's murine encephalomyelitis virus (strain BeAn 8386) (TMEV)

POLG_TMEVB Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0 (VP4-VP2); Capsid protein ...

pdb 1TMF

1 entry

Theiler's murine encephalomyelitis virus (strain GDVII) (TMEV)

POLG_TMEVG Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0 (VP4-VP2); Capsid protein ...

pdb 7NBV

1 entry

Yaba-like disease virus (YLDV)

E3_YLDV Protein E3 homolog (Protein E3L homolog)

pdb 1SFU