H5N1 subtype

VIRION

Molecular biology

Enveloped. Usually rounded but can be filamentous. The virions are 80-120 nm in diameter.

GENOME

Segmented ssRNA(-) linear genome, encapsidated by nucleoprotein (NP). Contains 8 segments coding for 12-13 proteins depending on strains. Segments size range from 890 to 2,341nt. Genome total size is 13.5Kb

GENE EXPRESSION

Viral RNA polymerase (PB1, PB2 and PA) transcribes one mRNA from each genome segment. Transcription is primed by cap cleaved from cellular mRNAS by Cap snatching. mRNA are polyadenylated by the viral polymerase stuttering on a poly U track MP and NS mRNA can be alternately spliced, giving rise to mRNA coding for M2 and NEP proteins. PB1 mRNA encode three proteins by leaky scanning: PB1, N40 and PB1-F2 . Pa-X protein is translated by ribosomal frameshift on the PA gene .

REPLICATION

NUCLEUS

  1. Virus attaches to sialic acid receptor though HA protein and is endocytosed by clathrins in the host cell.
  2. endosome acidification induces fusion of virus membrane with the vesicle membrane; encapsidated RNA segments migrate to the nucleus.
  3. Transcription of genomic segments by the viral polymerase produces mRNAs that are capped and polyadenylated by the viral polymerase.
  4. Replication of genomic segments.
  5. High level of M1 protein induces genomes segments export from nucleus by NEP protein.
  6. Virus assembly and budding occurs at the plasma membrane.

Host-virus interaction

Innate immune response inhibition

Influenza A virus inhibits the cascade leading to production of interferon-beta by targeting different cellular proteins. NS1 inhibits host RIG-I activation upon recognition of viral RNA, and subsequent induction of IFN-beta expression.

Host protein shutoff

NS1 induces host gene expression shutoff by inducing host mRNA suppression through polyadenlyation inhibition. The viral mRNA are not affected because their polyA tail is generated by polymerase stuttering.

Matching UniProtKB/Swiss-Prot entries

173 entries grouped by protein (browse by keywords)

All proteins are shown (view only 48 complete proteome entries)

Hemagglutinin

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HEMA_I96A0Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
HEMA_I97A0Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)
HEMA_I59A0Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
HEMA_I00A0Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
HEMA_I97A1Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)

Matrix protein 1 (M1)

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M1_I96A0Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
M1_I97A0Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)
M1_I02A2Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
M1_I02A3Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)
M1_I01A3Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
M1_I02A5Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
M1_I01A2Influenza A virus (strain A/Chicken/Hong Kong/FY150/2001 H5N1 genotype D)
M1_I02A6Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
M1_I01A1Influenza A virus (strain A/Chicken/Hong Kong/YU562/2001 H5N1 genotype B)
M1_I59A0Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
M1_I03A1Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
M1_I00A0Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
M1_I05A1Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
M1_I97A1Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
M1_I03A0Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
M1_I01A0Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
M1_I02A4Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)

Matrix protein 2 (Proton channel protein M2)

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M2_I96A0Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
M2_I97A0Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)
M2_I02A2Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
M2_I02A3Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)
M2_I01A3Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
M2_I02A5Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
M2_I01A2Influenza A virus (strain A/Chicken/Hong Kong/FY150/2001 H5N1 genotype D)
M2_I02A6Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
M2_I01A1Influenza A virus (strain A/Chicken/Hong Kong/YU562/2001 H5N1 genotype B)
M2_I59A0Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
M2_I03A1Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
M2_I00A0Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
M2_I05A1Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
M2_I97A1Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
M2_I03A0Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
M2_I01A0Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
M2_I02A4Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)

Nucleoprotein (Nucleocapsid protein) (Protein N)

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NCAP_I96A0Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
NCAP_I02A2Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
NCAP_I02A3Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)
NCAP_I01A3Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)

Nucleoprotein

NCAP_I02A5Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)

Nucleoprotein

NCAP_I01A2Influenza A virus (strain A/Chicken/Hong Kong/FY150/2001 H5N1 genotype D)
NCAP_I02A6Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)

Nucleoprotein

NCAP_I01A1Influenza A virus (strain A/Chicken/Hong Kong/YU562/2001 H5N1 genotype B)
NCAP_I59A0Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
NCAP_I03A1Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)

Nucleoprotein

NCAP_I00A0Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
NCAP_I02A1Influenza A virus (strain A/Guinea fowl/Hong Kong/38/2002 H5N1 genotype X0)
NCAP_I97A1Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
NCAP_I03A0Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
NCAP_I01A0Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)

Nucleoprotein

NCAP_I02A4Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)
NCAP_I02A7Influenza A virus (strain A/Teal/China/2978.1/2002 H5N1 genotype W)

Nucleoprotein

Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

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NEP_I96A0Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain

Nuclear export protein (NEP) (Non structural protein 2) (NS2)

NEP_I97A0Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)

Nuclear export protein (NEP) (Non structural protein 2) (NS2)

NEP_I02A2Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
NEP_I02A3Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)
NEP_I01A3Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
NEP_I02A5Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
NEP_I01A2Influenza A virus (strain A/Chicken/Hong Kong/FY150/2001 H5N1 genotype D)
NEP_I02A6Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
NEP_I01A1Influenza A virus (strain A/Chicken/Hong Kong/YU562/2001 H5N1 genotype B)
NEP_I59A0Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
NEP_I03A1Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
NEP_I00A0Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
NEP_I02A1Influenza A virus (strain A/Guinea fowl/Hong Kong/38/2002 H5N1 genotype X0)
NEP_I97A1Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
NEP_I03A0Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
NEP_I01A0Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
NEP_I02A4Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)

Neuraminidase (EC 3.2.1.18)

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NRAM_I96A0Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
NRAM_I97A0Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)
NRAM_I02A2Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
NRAM_I02A3Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)
NRAM_I01A3Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
NRAM_I02A5Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
NRAM_I01A2Influenza A virus (strain A/Chicken/Hong Kong/FY150/2001 H5N1 genotype D)
NRAM_I02A6Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
NRAM_I59A0Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
NRAM_I03A1Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
NRAM_I00A0Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
NRAM_I97A1Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
NRAM_I01A0Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
NRAM_I02A4Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)

Non-structural protein 1 (NS1) (NS1A)

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NS1_I96A0Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
NS1_I97A0Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)
NS1_I02A2Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
NS1_I02A3Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)
NS1_I01A3Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
NS1_I02A5Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
NS1_I01A2Influenza A virus (strain A/Chicken/Hong Kong/FY150/2001 H5N1 genotype D)
NS1_I02A6Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
NS1_I01A1Influenza A virus (strain A/Chicken/Hong Kong/YU562/2001 H5N1 genotype B)
NS1_I59A0Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
NS1_I03A1Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
NS1_I00A0Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
NS1_I02A1Influenza A virus (strain A/Guinea fowl/Hong Kong/38/2002 H5N1 genotype X0)
NS1_I97A1Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
NS1_I03A0Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
NS1_I01A0Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
NS1_I02A4Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)

Polymerase acidic protein (RNA-directed RNA polymerase subunit P2)

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PA_I96A0Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
PA_I97A0Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)
PA_I02A2Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
PA_I01A3Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
PA_I02A5Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
PA_I02A6Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
PA_I59A0Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
PA_I00A0Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
PA_I05A1Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
PA_I02A1Influenza A virus (strain A/Guinea fowl/Hong Kong/38/2002 H5N1 genotype X0)
PA_I97A1Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
PA_I01A0Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
PA_I02A4Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)

Protein PA-X

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PAX_I96A0Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
PAX_I97A0Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)
PAX_I02A2Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
PAX_I01A3Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
PAX_I02A5Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
PAX_I02A6Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
PAX_I59A0Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
PAX_I00A0Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
PAX_I05A1Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
PAX_I02A1Influenza A virus (strain A/Guinea fowl/Hong Kong/38/2002 H5N1 genotype X0)
PAX_I97A1Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
PAX_I01A0Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
PAX_I02A4Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)

Protein PB1-F2

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PB1F2_I96A0Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
PB1F2_I02A2Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
PB1F2_I02A3Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)
PB1F2_I01A3Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
PB1F2_I02A5Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
PB1F2_I01A2Influenza A virus (strain A/Chicken/Hong Kong/FY150/2001 H5N1 genotype D)
PB1F2_I02A6Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
PB1F2_I01A1Influenza A virus (strain A/Chicken/Hong Kong/YU562/2001 H5N1 genotype B)
PB1F2_I59A0Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
PB1F2_I03A1Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
PB1F2_I00A0Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
PB1F2_I05A1Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
PB1F2_I02A1Influenza A virus (strain A/Guinea fowl/Hong Kong/38/2002 H5N1 genotype X0)
PB1F2_I97A1Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
PB1F2_I03A0Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
PB1F2_I01A0Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
PB1F2_I02A4Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)
PB1F2_I02A7Influenza A virus (strain A/Teal/China/2978.1/2002 H5N1 genotype W)

Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

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PB2_I96A0Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
PB2_I02A5Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
PB2_I02A6Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
PB2_I59A0Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
PB2_I03A1Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
PB2_I00A0Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
PB2_I05A1Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
PB2_I97A1Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
PB2_I03A0Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
PB2_I02A7Influenza A virus (strain A/Teal/China/2978.1/2002 H5N1 genotype W)

RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) (RNA-directed RNA polymerase subunit P1)

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RDRP_I96A0Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
RDRP_I97A0Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)
RDRP_I02A2Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
RDRP_I02A3Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)
RDRP_I01A3Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
RDRP_I02A6Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
RDRP_I59A0Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
RDRP_I03A1Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
RDRP_I00A0Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
RDRP_I05A1Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
RDRP_I97A1Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
RDRP_I03A0Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
RDRP_I01A0Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
RDRP_I02A4Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)
RDRP_I02A7Influenza A virus (strain A/Teal/China/2978.1/2002 H5N1 genotype W)