Deltavirus

Satellite virus: infection requires host cell to be co-infected with hepatitis B virus

Molecular biology

VIRION

Enveloped, spherical about 22 nm in diameter. Membrane proteins are originated from the HBV helper virus.

GENOME

Circular, ssRNA(-) genome of 1,68 kb. Most of the genome displays complementary strands. Replication occurs by rolling circle, single genome being cleaved/ligated by HDV ribozymes.

GENE EXPRESSION

A single ORF encodes for S-HDAg. Late in infection, genome editing by host ADAR1 extends the S-HDAg ORF by 19 amino acids, inducing production of L-HDAg. Edited genome seems to be unable to replicate.

REPLICATION

NUCLEAR

  1. Virus attaches to host receptors though Major surface antigen.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released in the cytoplasm and migrates to the nucleus.
  3. Transcription of S-HDAg, promoting viral transcription and replication
  4. Symmetrical rolling circle replication by host DNA-dependent RNA polymerase II
  5. later, genomic RNA is edited by host ADAR1, leading to L-HDAg expression which induce packaging of HDV genome at the RE.
  6. Budding by helper HBV proteins.

Host-virus interaction

Inhibition of host Interferon induction

HDV plays a role in inhibition of STAT1 antiviral signaling

Matching UniProtKB/Swiss-Prot entries

34 entries grouped by protein (browse by keywords)

Large delta antigen (L-HDAg) (p27)

Select_all Deselect_all  
LHDAG_HDVD3Hepatitis delta virus genotype I (isolate D380) (HDV) reference strain
LHDAG_HDVP1Hepatitis delta virus genotype III (isolate Peru-1) (HDV) reference strain
LHDAG_HDVAMHepatitis delta virus genotype I (isolate American) (HDV)
LHDAG_HDVITHepatitis delta virus genotype I (isolate Italian) (HDV)
LHDAG_HDVM1Hepatitis delta virus genotype I (isolate Japanese M-1) (HDV)
LHDAG_HDVM2Hepatitis delta virus genotype I (isolate Japanese M-2) (HDV)
LHDAG_HDVS2Hepatitis delta virus genotype I (isolate Japanese S-2) (HDV)
LHDAG_HDVL1Hepatitis delta virus genotype I (isolate Lebanon-1) (HDV)
LHDAG_HDVNAHepatitis delta virus genotype I (isolate Nauru) (HDV)
LHDAG_HDVU2Hepatitis delta virus genotype I (isolate US-2) (HDV)
LHDAG_HDVWOHepatitis delta virus genotype I (isolate Woodchuck) (HDV)
LHDAG_HDV83Hepatitis delta virus genotype II (isolate 7/18/83) (HDV)
LHDAG_HDVS1Hepatitis delta virus genotype II (isolate Japanese S-1) (HDV)
LHDAG_HDVTWHepatitis delta virus genotype II (isolate TW2476) (HDV)
LHDAG_HDVV2Hepatitis delta virus genotype III (isolate VnzD8349) (HDV)
LHDAG_HDVV3Hepatitis delta virus genotype III (isolate VnzD8375) (HDV)
LHDAG_HDVV1Hepatitis delta virus genotype III (isolate VnzD8624) (HDV)

Small delta antigen (S-HDAg) (p24)

Select_all Deselect_all  
SHDAG_HDVD3Hepatitis delta virus genotype I (isolate D380) (HDV) reference strain
SHDAG_HDVP1Hepatitis delta virus genotype III (isolate Peru-1) (HDV) reference strain
SHDAG_HDVAMHepatitis delta virus genotype I (isolate American) (HDV)
SHDAG_HDVITHepatitis delta virus genotype I (isolate Italian) (HDV)
SHDAG_HDVM1Hepatitis delta virus genotype I (isolate Japanese M-1) (HDV)
SHDAG_HDVM2Hepatitis delta virus genotype I (isolate Japanese M-2) (HDV)
SHDAG_HDVS2Hepatitis delta virus genotype I (isolate Japanese S-2) (HDV)
SHDAG_HDVL1Hepatitis delta virus genotype I (isolate Lebanon-1) (HDV)
SHDAG_HDVNAHepatitis delta virus genotype I (isolate Nauru) (HDV)
SHDAG_HDVU2Hepatitis delta virus genotype I (isolate US-2) (HDV)
SHDAG_HDVWOHepatitis delta virus genotype I (isolate Woodchuck) (HDV)
SHDAG_HDV83Hepatitis delta virus genotype II (isolate 7/18/83) (HDV)
SHDAG_HDVS1Hepatitis delta virus genotype II (isolate Japanese S-1) (HDV)
SHDAG_HDVTWHepatitis delta virus genotype II (isolate TW2476) (HDV)
SHDAG_HDVV2Hepatitis delta virus genotype III (isolate VnzD8349) (HDV)
SHDAG_HDVV3Hepatitis delta virus genotype III (isolate VnzD8375) (HDV)
SHDAG_HDVV1Hepatitis delta virus genotype III (isolate VnzD8624) (HDV)