Anelloviridae

VIRION

Non-enveloped, T=1 icosahedral symmetry, with a diameter of about 30-32nm.

GENOME

Circular ssDNA genome (-) genome of about 3.8 kb.
The genome is replicated through double-stranded intermediates. It may encode for 4 proteins: ORF1 (Rep protein?), ORF2, ORF3 and ORF4.

GENE EXPRESSION

The proteins are expressed by alternative splicing of pre-mRNA.

REPLICATION

NUCLEAR

  1. Virus penetrates into the host cell.
  2. Uncoating, the viral ssDNA genome penetrates into the nucleus.
  3. The ssDNA is converted into dsDNA with the participation of cellular factors. dsDNA transcription gives rise to viral mRNAs.
  4. viral mRNAs are transcribed and translated to produce viral proteins.
  5. Replication may be mediated by a “Rep-like” protein, and would occur by rolling circle producing ssDNA genomes.
  6. These newly synthesized ssDNA can either
    a) be converted to dsDNA and serve as a template for transcription/replication
    b) be encapsidated by capsid protein and form virions released from the cell by budding.

Host-virus interaction

NF-kappaB modulation

Torque teno virus ORF2 protein might suppress NF-kappaB pathways via interaction with IkappaB kinases .

Matching UniProtKB/Swiss-Prot entries

56 entries grouped by protein (browse by keywords)

Capsid protein

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CAPSD_TTVT1Torque teno canis virus (isolate Cf-TTV10) reference strain
CAPSD_TTVZ1Torque teno douroucouli virus (isolate At-TTV3) reference strain
CAPSD_TTVF1Torque teno felis virus (isolate Fc-TTV4) reference strain
CAPSD_TTVG1Torque teno midi virus 1 (isolate MD1-073) reference strain
CAPSD_TTVB1Torque teno mini virus 1 (isolate TLMV-CBD279) reference strain
CAPSD_TTVI1Torque teno sus virus 1 (isolate Sd-TTV31) reference strain
CAPSD_TTVE1Torque teno tamarin virus (isolate So-TTV2) reference strain
CAPSD_TTVD1Torque teno tupaia virus (isolate Tbc-TTV14) reference strain
CAPSD_TTVA1Torque teno virus 1 (isolate TA278) reference strain
CAPSD_TTVV8Torque teno virus (isolate Chimpanzee/Japan/Pt-TTV6/2000) (TTV)
CAPSD_TTVV6Torque teno virus (isolate Human/China/CT23F/2001) (TTV)
CAPSD_TTVV7Torque teno virus (isolate Human/China/CT39F/2001) (TTV)
CAPSD_TTVV3Torque teno virus (isolate Human/Finland/Hel32/2002) (TTV) (Torque teno virus ...
CAPSD_TTVV4Torque teno virus (isolate Human/Germany/KAV/2001) (TTV)
CAPSD_TTVVGTorque teno virus (isolate Human/Ghana/GH1/1996) (TTV)

Probable capsid and replication-associated protein

CAPSD_TTVV5Torque teno virus (isolate Human/Japan/SANBAN/1999) (TTV)
CAPSD_TTVV2Torque teno virus (isolate Human/Japan/TRM1/1999) (TTV) (Torque teno virus ...
CAPSD_TTVV9Torque teno virus (isolate Japanese macaque/Japan/Mf-TTV9/2000) (TTV)
CAPSD_TTVV1Torque teno virus (strain VT416) (TTV)

Probable capsid and replication-associated protein

ORF1/1 protein


ORF11_TTVV3Torque teno virus (isolate Human/Finland/Hel32/2002) (TTV) (Torque teno virus ...

ORF1/2 protein


ORF12_TTVV3Torque teno virus (isolate Human/Finland/Hel32/2002) (TTV) (Torque teno virus ...

Uncharacterized ORF2 protein

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ORF2_TTVT1Torque teno canis virus (isolate Cf-TTV10) reference strain
ORF2_TTVZ1Torque teno douroucouli virus (isolate At-TTV3) reference strain
ORF2_TTVF1Torque teno felis virus (isolate Fc-TTV4) reference strain
ORF2_TTVB1Torque teno mini virus 1 (isolate TLMV-CBD279) reference strain
ORF2_TTVI1Torque teno sus virus 1 (isolate Sd-TTV31) reference strain
ORF2_TTVE1Torque teno tamarin virus (isolate So-TTV2) reference strain
ORF2_TTVD1Torque teno tupaia virus (isolate Tbc-TTV14) reference strain
ORF2_TTVA1Torque teno virus 1 (isolate TA278) reference strain
ORF2_TTVV8Torque teno virus (isolate Chimpanzee/Japan/Pt-TTV6/2000) (TTV)
ORF2_TTVV3Torque teno virus (isolate Human/Finland/Hel32/2002) (TTV) (Torque teno virus ...

ORF2 protein

ORF2_TTVVGTorque teno virus (isolate Human/Ghana/GH1/1996) (TTV)

Probable protein VP2 (ORF2/3 protein)

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ORF23_TTVV6Torque teno virus (isolate Human/China/CT23F/2001) (TTV)
ORF23_TTVV7Torque teno virus (isolate Human/China/CT39F/2001) (TTV)
ORF23_TTVV4Torque teno virus (isolate Human/Germany/KAV/2001) (TTV)
ORF23_TTVV5Torque teno virus (isolate Human/Japan/SANBAN/1999) (TTV)
ORF23_TTVV2Torque teno virus (isolate Human/Japan/TRM1/1999) (TTV) (Torque teno virus ...
ORF23_TTVV1Torque teno virus (strain VT416) (TTV)

Uncharacterized ORF2/4 protein

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ORF24_TTVV6Torque teno virus (isolate Human/China/CT23F/2001) (TTV)
ORF24_TTVV7Torque teno virus (isolate Human/China/CT39F/2001) (TTV)
ORF24_TTVV3Torque teno virus (isolate Human/Finland/Hel32/2002) (TTV) (Torque teno virus ...

ORF2/4 protein

ORF24_TTVV4Torque teno virus (isolate Human/Germany/KAV/2001) (TTV)
ORF24_TTVV2Torque teno virus (isolate Human/Japan/TRM1/1999) (TTV) (Torque teno virus ...

ORF2/4 protein

ORF24_TTVV1Torque teno virus (strain VT416) (TTV)

Uncharacterized ORF3 protein

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ORF3_TTVT1Torque teno canis virus (isolate Cf-TTV10) reference strain

Uncharacterized ORF2 protein

ORF3_TTVZ1Torque teno douroucouli virus (isolate At-TTV3) reference strain
ORF3_TTVF1Torque teno felis virus (isolate Fc-TTV4) reference strain
ORF3_TTVG1Torque teno midi virus 1 (isolate MD1-073) reference strain
ORF3_TTVB1Torque teno mini virus 1 (isolate TLMV-CBD279) reference strain
ORF3_TTVI1Torque teno sus virus 1 (isolate Sd-TTV31) reference strain
ORF3_TTVE1Torque teno tamarin virus (isolate So-TTV2) reference strain
ORF3_TTVD1Torque teno tupaia virus (isolate Tbc-TTV14) reference strain

Uncharacterized ORF4 protein


ORF4_TTVE1Torque teno tamarin virus (isolate So-TTV2) reference strain

Uncharacterized ORF2 protein


YORF2_TTVV9Torque teno virus (isolate Japanese macaque/Japan/Mf-TTV9/2000) (TTV)

Uncharacterized ORF3 protein

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YORF3_TTVVGTorque teno virus (isolate Human/Ghana/GH1/1996) (TTV)
YORF3_TTVV9Torque teno virus (isolate Japanese macaque/Japan/Mf-TTV9/2000) (TTV)