Avulavirus

Molecular biology

VIRION

Enveloped, spherical. Diameter from about 150nm nm.

GENOME

Negative-stranded RNA linear genome, about 15 kb in size. Encodes for seven proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. The V protein is produced through RNA editing of The P mRNA.

REPLICATION

CYTOPLASMIC

  1. Attachment to host cell surface receptors through HN glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of antiviral signaling through STAT1

Matching UniProtKB/Swiss-Prot entries

43 entries grouped by protein (browse by keywords)

All proteins are shown (view only 8 complete proteome entries)

Fusion glycoprotein F0

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FUS_NDVB1Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
FUS_NDVH4Newcastle disease virus (strain B1-Hitchner/47) (NDV)
FUS_NDVBNewcastle disease virus (strain Beaudette C/45) (NDV)
FUS_NDVANewcastle disease virus (strain Chicken/Australia-Victoria/32) (NDV)
FUS_NDVUNewcastle disease virus (strain Chicken/Northern Ireland/Ulster/67) (NDV)
FUS_NDVTGNewcastle disease virus (strain Chicken/United States(TX)/GB/48) (NDV) ...
FUS_NDVLNewcastle disease virus (strain Chicken/United States/LaSota/46) (NDV)
FUS_NDVDNewcastle disease virus (strain D26/76) (NDV)
FUS_NDVH3Newcastle disease virus (strain Her/33) (NDV)
FUS_NDVINewcastle disease virus (strain Italien/45) (NDV)
FUS_NDVMNewcastle disease virus (strain Miyadera/51) (NDV)
FUS_NDVQNewcastle disease virus (strain Queensland/66) (NDV)
FUS_NDVTNewcastle disease virus (strain Texas) (NDV)

Hemagglutinin-neuraminidase (EC 3.2.1.18)

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HN_NDVB1Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
HN_NDVH4Newcastle disease virus (strain B1-Hitchner/47) (NDV)
HN_NDVBNewcastle disease virus (strain Beaudette C/45) (NDV)
HN_NDVCNewcastle disease virus (strain Chi/85) (NDV)
HN_NDVANewcastle disease virus (strain Chicken/Australia-Victoria/32) (NDV)
HN_NDVUNewcastle disease virus (strain Chicken/Northern Ireland/Ulster/67) (NDV)
HN_NDVTGNewcastle disease virus (strain Chicken/United States(TX)/GB/48) (NDV) ...
HN_NDVLNewcastle disease virus (strain Chicken/United States/LaSota/46) (NDV)
HN_NDVDNewcastle disease virus (strain D26/76) (NDV)
HN_NDVH3Newcastle disease virus (strain Her/33) (NDV)
HN_NDVJNewcastle disease virus (strain Iba/85) (NDV)
HN_NDVINewcastle disease virus (strain Italien/45) (NDV)
HN_NDVKNewcastle disease virus (strain Kansas) (NDV)
HN_NDVMNewcastle disease virus (strain Miyadera/51) (NDV)
HN_NDVQNewcastle disease virus (strain Queensland/66) (NDV)

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

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L_NDVB1Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
L_NDVBNewcastle disease virus (strain Beaudette C/45) (NDV)

Matrix protein

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MATRX_NDVB1Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
MATRX_NDVBNewcastle disease virus (strain Beaudette C/45) (NDV)
MATRX_NDVANewcastle disease virus (strain Chicken/Australia-Victoria/32) (NDV)

Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

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NCAP_NDVB1Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
NCAP_NDVAFNewcastle disease virus (isolate AF2240) (NDV)
NCAP_NDVBNewcastle disease virus (strain Beaudette C/45) (NDV)

Phosphoprotein (Protein P)

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PHOSP_NDVB1Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
PHOSP_NDVBNewcastle disease virus (strain Beaudette C/45) (NDV)
PHOSP_NDVANewcastle disease virus (strain Chicken/Australia-Victoria/32) (NDV)

Phosphoprotein (Protein P) (Non-structural protein C, 38 kDa/29 kDa)

PHOSP_NDVU2Newcastle disease virus (strain Ulster/2C) (NDV)

Protein V

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V_NDVB1Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
V_NDVU2Newcastle disease virus (strain Ulster/2C) (NDV)

Non-structural protein V

Protein W


W_NDVB1Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain