Polyomavirus

VIRION

Non-enveloped capsid with a T=7d icosahedral symmetry, about 45 nm in diameter.

GENOME

Circular dsDNA about 5 kb in size, associated with cellular histones in a chromatin-like complex. Encodes for 5-9 proteins.
On rare non-specific recombination, the viral genome can be integrated in host chromosome. This inactivates the integrated virus but can gives the host cell a replicative advantage sometimes leading to malignant tumours.

GENE EXPRESSION

Transcription is nuclear, in two phases; early (replication), late (virion assembly/exit). 5-9 proteins are expressed from the two pre-MRNA by alternative splicing. All genes are transcribed by host RNA pol II.

REPLICATION

NUCLEAR

  1. Attachement of the viral proteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Virion transits through endoplasmic reticulum where host protein disulfide isomerases rearrange its capsid structure
  3. Export of misfolded virion to the cytoplasm possibly through host ERAD pathway
  4. Loss of VP1 in the low-calcium conditions of the cytosol
  5. Import of genomic DNA into host nucleus.
  6. Transcription of early genes (LT and sT genes)
  7. Replication of the DNA genome in the nucleus.
  8. Transcription of late genes encoding for structural proteins (VP1, VP2 and VP3).
  9. Assembly of new virions in nuclear viral factories.
  10. Virions are released by lysis of the cell.

Host-virus interaction

Cell-cycle modulation

The large T antigen binds to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53 and induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes.

Matching UniProtKB/Swiss-Prot entries

79 entries grouped by strain (browse by keywords)

All proteins are shown (view only 50 complete proteome entries)

6 entries

Simian virus 40 (SV40) reference strain

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AGNO_SV40Agnoprotein
LT_SV40Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
SELP_SV40SV40 early leader protein (SELP)
ST_SV40Small t antigen (ST) (ST-AG)
VP1_SV40Major capsid protein VP1 (Major structural protein VP1)
VP2_SV40Minor capsid protein VP2 (Minor structural protein VP2)

6 entries

Budgerigar fledgling disease virus (BFPyV)

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AGNO1_BFPYVAvian agnoprotein 1a (Agno-1a)
AGNO2_BFPYVAvian agnoprotein 2b (Agno-2b)
LT_BFPYVLarge T antigen (LT) (LT-AG) (EC 3.6.4.-)
ST_BFPYVSmall t antigen (ST) (ST-AG)
VP1_BFPYVMajor capsid protein VP1 (Major structural protein VP1)
VP2_BFPYVMinor capsid protein VP2 (Minor structural protein VP2)

5 entries

BK polyomavirus (BKPyV)

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AGNO_POVBKAgnoprotein (Agno)
LT_POVBKLarge T antigen (LT) (LT-AG) (EC 3.6.4.-)
ST_POVBKSmall t antigen (ST) (ST-AG)
VP1_POVBKMajor capsid protein VP1 (Major structural protein VP1)
VP2_POVBKMinor capsid protein VP2 (Minor structural protein VP2)

5 entries

BK polyomavirus (strain AS) (BKPyV)

Select_all Deselect_all  
AGNO_POVBAAgnoprotein (Agno)
LT_POVBALarge T antigen (LT) (LT-AG) (EC 3.6.4.-)
ST_POVBASmall t antigen (ST) (ST-AG)
VP1_POVBAMajor capsid protein VP1 (Major structural protein VP1)
VP2_POVBAMinor capsid protein VP2 (Minor structural protein VP2)

5 entries

Bovine polyomavirus (BPyV)

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AGNO_POVBOBovine agnoprotein (Agno)
LT_POVBOLarge T antigen (LT) (LT-AG) (EC 3.6.4.-)
ST_POVBOSmall t antigen (ST) (ST-AG)
VP1_POVBOMajor capsid protein VP1 (Major structural protein VP1)
VP2_POVBOMinor capsid protein VP2 (Minor structural protein VP2)

5 entries

Hamster polyomavirus (HaPyV)

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LT_POVHALarge T antigen (LT) (LT-AG) (EC 3.6.4.-)
MT_POVHAMiddle T antigen (MT) (MT-AG)
ST_POVHASmall t antigen (ST) (ST-AG)
VP1_POVHAMajor capsid protein VP1 (Major structural protein VP1)
VP2_POVHAMinor capsid protein VP2 (Minor structural protein VP2)

5 entries

JC polyomavirus (JCPyV) (JCV)

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AGNO_POVJCAgnoprotein (Agno)
LT_POVJCLarge T antigen (LT) (LT-AG) (EC 3.6.4.-)
ST_POVJCSmall t antigen (ST) (ST-AG)
VP1_POVJCMajor capsid protein VP1 (Major structural protein VP1)
VP2_POVJCMinor capsid protein VP2 (Minor structural protein VP2)

5 entries

Murine polyomavirus (strain 3) (MPyV)

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LT_POVM3Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
MT_POVM3Middle T antigen (MT) (MT-AG)
ST_POVM3Small t antigen (ST) (ST-AG)
VP1_POVM3Major capsid protein VP1 (Major structural protein VP1)
VP2_POVM3Minor capsid protein VP2 (Minor structural protein VP2)

5 entries

Murine polyomavirus (strain A2) (MPyV)

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LT_POVMALarge T antigen (LT) (LT-AG) (EC 3.6.4.-)
MT_POVMAMiddle T antigen (MT) (MT-AG)
ST_POVMASmall t antigen (ST) (ST-AG)
VP1_POVMAMajor capsid protein VP1 (Major structural protein VP1)
VP2_POVMAMinor capsid protein VP2 (Minor structural protein VP2)

5 entries

Murine polyomavirus (strain Crawford small-plaque) (MPyV)

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LT_POVMCLarge T antigen (LT) (LT-AG) (EC 3.6.4.-)
MT_POVMCMiddle T antigen (MT) (MT-AG)
ST_POVMCSmall t antigen (ST) (ST-AG)
VP1_POVMCMajor capsid protein VP1 (Major structural protein VP1)
VP2_POVMCMinor capsid protein VP2 (Minor structural protein VP2)

5 entries

Simian virus 12 (strain wt100) (SV-12) (Baboon polyomavirus 1)

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AGNO_POVS1Agnoprotein (Agno)
LT_POVS1Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
ST_POVS1Small t antigen (ST) (ST-AG)
VP1_POVS1Major capsid protein VP1 (Major structural protein VP1)
VP2_POVS1Minor capsid protein VP2 (Minor structural protein VP2)

5 entries

Squirrel monkey polyomavirus

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AGNO_POVSMSquirrel monkey agnoprotein (Agno)
LT_POVSMLarge T antigen (LT) (LT-AG) (EC 3.6.4.-)
ST_POVSMSmall t antigen (ST) (ST-AG)
VP1_POVSMMajor capsid protein VP1 (Major structural protein VP1)
VP2_POVSMMinor capsid protein VP2 (Minor structural protein VP2)

4 entries

B-lymphotropic polyomavirus (LPV)

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LT_POVLYLarge T antigen (LT) (LT-AG) (EC 3.6.4.-)
ST_POVLYSmall t antigen (ST) (ST-AG)
VP1_POVLYMajor capsid protein VP1 (Major structural protein VP1)
VP2_POVLYMinor capsid protein VP2 (Minor structural protein VP2)

4 entries

KI polyomavirus (isolate Stockholm 350) (KIPyV)

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LT_POVKILarge T antigen (LT) (LT-AG) (EC 3.6.4.-)
ST_POVKISmall t antigen (ST) (ST-AG)
VP1_POVKIMajor capsid protein VP1 (Major structural protein VP1)
VP2_POVKIMinor capsid protein VP2 (Minor structural protein VP2)

4 entries

Murine polyomavirus (strain Kilham) (MPyV) (Murine pneumotropic virus)

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LT_POVMKLarge T antigen (LT) (LT-AG) (EC 3.6.4.-)
ST_POVMKSmall t antigen (ST) (ST-AG)
VP1_POVMKMajor capsid protein VP1 (Major structural protein VP1)
VP2_POVMKMinor capsid protein VP2 (Minor structural protein VP2)

4 entries

WU polyomavirus (WUPyV)

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LT_POVWULarge T antigen (LT) (LT-AG) (EC 3.6.4.-)
ST_POVWUSmall t antigen (ST) (ST-AG)
VP1_POVWUMajor capsid protein VP1 (Major structural protein VP1)
VP2_POVWUMinor capsid protein VP2 (Minor structural protein VP2)

1 entry

Murine polyomavirus (strain P16 small-plaque) (MPyV)


VP1_POVMPCapsid protein VP1