Avulavirus

Molecular biology

VIRION

Enveloped, spherical. Diameter from about 150nm nm.

GENOME

Negative-stranded RNA linear genome, about 15 kb in size. Encodes for seven proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. The V protein is produced through RNA editing of The P mRNA.

REPLICATION

CYTOPLASMIC

  1. Attachment to host cell surface receptors through HN glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of antiviral signaling through STAT1

Matching UniProtKB/Swiss-Prot entries

43 entries grouped by strain (browse by keywords)

All proteins are shown (view only 8 complete proteome entries)

8 entries

Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain

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FUS_NDVB1Fusion glycoprotein F0
HN_NDVB1Hemagglutinin-neuraminidase (EC 3.2.1.18)
L_NDVB1RNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_NDVB1Matrix protein
NCAP_NDVB1Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_NDVB1Phosphoprotein (Protein P)
V_NDVB1Protein V
W_NDVB1Protein W

6 entries

Newcastle disease virus (strain Beaudette C/45) (NDV)

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FUS_NDVBFusion glycoprotein F0
HN_NDVBHemagglutinin-neuraminidase (EC 3.2.1.18)
L_NDVBRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_NDVBMatrix protein
NCAP_NDVBNucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_NDVBPhosphoprotein (Protein P)

4 entries

Newcastle disease virus (strain Chicken/Australia-Victoria/32) (NDV)

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FUS_NDVAFusion glycoprotein F0
HN_NDVAHemagglutinin-neuraminidase (EC 3.2.1.18)
MATRX_NDVAMatrix protein
PHOSP_NDVAPhosphoprotein (Protein P) (Non-structural protein C, 38 kDa/29 kDa)

2 entries

Newcastle disease virus (strain B1-Hitchner/47) (NDV)

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FUS_NDVH4Fusion glycoprotein F0
HN_NDVH4Hemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Newcastle disease virus (strain Chicken/Northern Ireland/Ulster/67) (NDV)

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FUS_NDVUFusion glycoprotein F0
HN_NDVUHemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Newcastle disease virus (strain Chicken/United States(TX)/GB/48) (NDV) (Newcastle disease virus (strain Texas g.b./48))

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FUS_NDVTGFusion glycoprotein F0
HN_NDVTGHemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Newcastle disease virus (strain Chicken/United States/LaSota/46) (NDV)

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FUS_NDVLFusion glycoprotein F0
HN_NDVLHemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Newcastle disease virus (strain D26/76) (NDV)

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FUS_NDVDFusion glycoprotein F0
HN_NDVDHemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Newcastle disease virus (strain Her/33) (NDV)

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FUS_NDVH3Fusion glycoprotein F0
HN_NDVH3Hemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Newcastle disease virus (strain Italien/45) (NDV)

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FUS_NDVIFusion glycoprotein F0
HN_NDVIHemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Newcastle disease virus (strain Miyadera/51) (NDV)

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FUS_NDVMFusion glycoprotein F0
HN_NDVMHemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Newcastle disease virus (strain Queensland/66) (NDV)

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FUS_NDVQFusion glycoprotein F0
HN_NDVQHemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Newcastle disease virus (strain Ulster/2C) (NDV)

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PHOSP_NDVU2Phosphoprotein (Protein P)
V_NDVU2Non-structural protein V

1 entry

Newcastle disease virus (isolate AF2240) (NDV)


NCAP_NDVAFNucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Newcastle disease virus (strain Chi/85) (NDV)


HN_NDVCHemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Newcastle disease virus (strain Iba/85) (NDV)


HN_NDVJHemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Newcastle disease virus (strain Kansas) (NDV)


HN_NDVKHemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Newcastle disease virus (strain Texas) (NDV)


FUS_NDVTFusion glycoprotein F0