Morbillivirus

Molecular biology

VIRION

Enveloped, spherical. Diameter from 150nm to 300nm.

GENOME

Negative-stranded RNA linear genome, about 15-16 kb in size. Encodes for eight proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and “polyadenylated” by the L protein during synthesis. The V protein is produced through RNA editing and the C protein is produced by Leaky scanning of The P mRNA.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through H glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. the ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of MDA-5 antiviral signaling

The V also blocks the type I interferon signaling pathway by interacting with and inhibiting host TYK2

Matching UniProtKB/Swiss-Prot entries

90 entries grouped by strain (browse by keywords)

All proteins are shown (view only 29 complete proteome entries)

8 entries

Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain

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C_MEASCProtein C
FUS_MEASCFusion glycoprotein F0
HEMA_MEASCHemagglutinin glycoprotein
L_MEASCRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_MEASCMatrix protein
NCAP_MEASCNucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_MEASCPhosphoprotein (Protein P)
V_MEASCNon-structural protein V

8 entries

Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)

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C_MEASEProtein C
FUS_MEASEFusion glycoprotein F0
HEMA_MEASEHemagglutinin glycoprotein
L_MEASERNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_MEASEMatrix protein
NCAP_MEASENucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_MEASEPhosphoprotein (Protein P)
V_MEASENon-structural protein V

8 entries

Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)

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C_MEASAProtein C
FUS_MEASAFusion glycoprotein F0
HEMA_MEASAHemagglutinin glycoprotein
L_MEASARNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_MEASAMatrix protein
NCAP_MEASANucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_MEASAPhosphoprotein (Protein P)
V_MEASANon-structural protein V

8 entries

Rinderpest virus (strain RBOK) (RDV)

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C_RINDRProtein C
FUS_RINDRFusion glycoprotein F0
HEMA_RINDRHemagglutinin glycoprotein
L_RINDRRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_RINDRMatrix protein
NCAP_RINDRNucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_RINDRPhosphoprotein (Protein P)
V_RINDRNon-structural protein V

7 entries

Canine distemper virus (strain Onderstepoort) (CDV)

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C_CDVOProtein C
FUS_CDVOFusion glycoprotein F0
HEMA_CDVOHemagglutinin glycoprotein
L_CDVORNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_CDVOMatrix protein
NCAP_CDVONucleoprotein (Protein N) (Nucleocapsid protein)
PHOSP_CDVOPhosphoprotein (Protein P)

7 entries

Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)

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C_MEASIProtein C
FUS_MEASIFusion glycoprotein F0
HEMA_MEASIHemagglutinin glycoprotein
MATRX_MEASIMatrix protein
NCAP_MEASINucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_MEASIPhosphoprotein (Protein P)
V_MEASINon-structural protein V

7 entries

Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)

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C_MEASYProtein C
FUS_MEASYFusion glycoprotein F0
HEMA_MEASYHemagglutinin glycoprotein
MATRX_MEASYMatrix protein
NCAP_MEASYNucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_MEASYPhosphoprotein (Protein P)
V_MEASYNon-structural protein V

7 entries

Phocine distemper virus (PDV)

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C_PHODVProtein C
FUS_PHODVFusion glycoprotein F0
HEMA_PHODVHemagglutinin glycoprotein
MATRX_PHODVMatrix protein
NCAP_PHODVNucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_PHODVPhosphoprotein (Protein P)
V_PHODVNon-structural protein V

6 entries

Rinderpest virus (strain Kabete O) (RDV)

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C_RINDKProtein C
FUS_RINDKFusion glycoprotein F0
HEMA_RINDKHemagglutinin glycoprotein
MATRX_RINDKMatrix protein
PHOSP_RINDKPhosphoprotein (Protein P)
V_RINDKNon-structural protein V

5 entries

Measles virus (strain Halle) (MeV) (Subacute sclerose panencephalitis virus)

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FUS_MEASHFusion glycoprotein F0
HEMA_MEASHHemagglutinin glycoprotein
MATRX_MEASHMatrix protein
NCAP_MEASHNucleoprotein (Nucleocapsid protein) (NP) (Protein N)
Y7K_MEASHPutative uncharacterized 7 kDa protein

3 entries

Rinderpest virus (strain L) (RDV)

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FUS_RINDLFusion glycoprotein F0
HEMA_RINDLHemagglutinin glycoprotein
NCAP_RINDLNucleoprotein (Nucleocapsid protein) (NP) (Protein N)

2 entries

Measles virus (strain Edmonston B) (MeV) (Subacute sclerose panencephalitis virus)

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FUS_MEASFFusion glycoprotein F0
NCAP_MEASFNucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Canine distemper virus (strain A92-27/4) (CDV)


HEMA_CDVA4Hemagglutinin glycoprotein

1 entry

Canine distemper virus (strain A92-6) (CDV)


HEMA_CDVA6Hemagglutinin glycoprotein

1 entry

Canine distemper virus (strain Convac vaccine) (CDV)


HEMA_CDVCHemagglutinin glycoprotein

1 entry

Measles virus (strain Biken) (MeV) (Subacute sclerosing panencephalitis virus (strain Biken))


MATRX_MEASBMatrix protein

1 entry

Measles virus (strain Edmonston-Moraten vaccine) (MeV) (Subacute sclerose panencephalitis virus)


NCAP_MEASMNucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Measles virus (strain Edmonston-Schwarz vaccine) (MeV) (Subacute sclerose panencephalitis virus)


NCAP_MEASWNucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Measles virus (strain Edmonston-Zagreb vaccine) (MeV) (Subacute sclerose panencephalitis virus)


FUS_MEASZFusion glycoprotein F0

1 entry

Measles virus (strain Hu2) (MeV) (Subacute sclerose panencephalitis virus)


MATRX_MEASUMatrix protein

1 entry

Measles virus (strain Leningrad-16) (MeV) (Subacute sclerose panencephalitis virus)


FUS_MEASLFusion glycoprotein F0

1 entry

Measles virus (strain Philadelphia-26) (MeV) (Subacute sclerose panencephalitis virus)


FUS_MEASPFusion glycoprotein F0

1 entry

Measles virus (strain Shanghai-191 vaccine) (MeV)


NCAP_MEASSNucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Peste-des-petits-ruminants virus (PPRV)


NCAP_PPRVNucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Rinderpest virus (strain Kuwait 82/1) (RDV)


NCAP_RINDUNucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Rinderpest virus (strain RBT1) (RDV)


FUS_RINDBFusion glycoprotein F0