Rubulavirus

Molecular biology

VIRION

Enveloped, spherical. Diameter from about 150nm nm.

GENOME

Negative-stranded RNA linear genome, about 15 kb in size. Encodes for eight proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. The V protein is produced through RNA editing of The P mRNA.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through HN glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of MDA-5 antiviral signaling

The V protein blocks also the type I and II interferon signaling pathways by interacting with and inhibiting host STAT1 and STAT2 .

Matching UniProtKB/Swiss-Prot entries

78 entries grouped by strain (browse by keywords)

All proteins are shown (view only 30 complete proteome entries)

8 entries

Mumps virus (strain Miyahara vaccine) (MuV) reference strain

Select_all Deselect_all  
FUS_MUMPMFusion glycoprotein F0
HN_MUMPMHemagglutinin-neuraminidase (EC 3.2.1.18)
L_MUMPMRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_MUMPMMatrix protein
NCAP_MUMPMNucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_MUMPMPhosphoprotein (Protein P)
SH_MUMPMSmall hydrophobic protein
V_MUMPMNon-structural protein V (Non-structural protein NS1)

8 entries

Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain

Select_all Deselect_all  
FUS_PIV5Fusion glycoprotein F0
HN_PIV5Hemagglutinin-neuraminidase (EC 3.2.1.18)
L_PIV5RNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_PIV5Matrix protein (Membrane protein)
NCAP_PIV5Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_PIV5Phosphoprotein (Protein P)
SH_PIV5Small hydrophobic protein
V_PIV5Non-structural protein V

7 entries

Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain

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FUS_PI2HTFusion glycoprotein F0
HN_PI2HTHemagglutinin-neuraminidase (EC 3.2.1.18)
L_PI2HTRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_PI2HTMatrix protein (Membrane protein)
NCAP_PI2HTNucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_PI2HTPhosphoprotein (Protein P)
V_PI2HTNon-structural protein V

7 entries

Simian virus 41 (SV41) reference strain

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FUS_SV41Fusion glycoprotein F0
HN_SV41Hemagglutinin-neuraminidase (EC 3.2.1.18)
L_SV41RNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_SV41Matrix protein
NCAP_SV41Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
V_SV41Non-structural protein V

7 entries

Mumps virus (strain SBL-1) (MuV)

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FUS_MUMP1Fusion glycoprotein F0
HN_MUMP1Hemagglutinin-neuraminidase (EC 3.2.1.18)
MATRX_MUMP1Matrix protein
NCAP_MUMP1Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_MUMP1Phosphoprotein (Protein P)
SH_MUMP1Small hydrophobic protein
V_MUMP1Non-structural protein V (Non-structural protein NS1)

7 entries

Simian virus 41 (SV41)


PHOSP_SV41Phosphoprotein (Protein P)

5 entries

Human parainfluenza 4a virus (strain Toshiba) (HPIV-4a)

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HN_PI4HAHemagglutinin-neuraminidase (EC 3.2.1.18)
MATRX_PI4HAMatrix protein
NCAP_PI4HANucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_PI4HAPhosphoprotein (Protein P)
V_PI4HANon-structural protein V

5 entries

Mumps virus (strain SBL) (MuV)

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FUS_MUMPSFusion glycoprotein F0
MATRX_MUMPSMatrix protein
PHOSP_MUMPSPhosphoprotein (Protein P)
SH_MUMPSSmall hydrophobic protein
V_MUMPSNon-structural protein V (Non-structural protein NS1)

4 entries

Human parainfluenza 2 virus (HPIV-2)

Select_all Deselect_all  
FUS_PI2HFusion glycoprotein F0
HN_PI2HHemagglutinin-neuraminidase (EC 3.2.1.18)
PHOSP_PI2HPhosphoprotein (Protein P)
V_PI2HNon-structural protein V

4 entries

Human parainfluenza 4b virus (strain 68-333) (HPIV-4b)

Select_all Deselect_all  
MATRX_PI4HBMatrix protein
NCAP_PI4HBNucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_PI4HBPhosphoprotein (Protein P)
V_PI4HBNon-structural protein V

3 entries

Mumps virus (strain Enders) (MuV)

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PHOSP_MUMPEPhosphoprotein (Protein P)
SH_MUMPESmall hydrophobic protein
V_MUMPENon-structural protein V (Non-structural protein NS1)

3 entries

Mumps virus (strain RW) (MuV)

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FUS_MUMPRFusion glycoprotein F0
HN_MUMPRHemagglutinin-neuraminidase (EC 3.2.1.18)
SH_MUMPRSmall hydrophobic protein

2 entries

Mumps virus (strain Jeryl-Lynn) (MuV)

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NCAP_MUMPJNucleoprotein (Nucleocapsid protein) (NP) (Protein N)
SH_MUMPJSmall hydrophobic protein

1 entry

Human parainfluenza 2 virus (strain Greer) (HPIV-2)


FUS_PI2HGFusion glycoprotein F0

1 entry

La Piedad-Michoacan-Mexico virus (LPMV)


MATRX_LPMVMatrix protein

1 entry

Mumps virus (strain Belfast) (MuV)


SH_MUMPBSmall hydrophobic protein

1 entry

Mumps virus (strain Bristol 1) (MuV)


SH_MUMPLSmall hydrophobic protein

1 entry

Mumps virus (strain Edingburgh 2) (MuV)


SH_MUMP2Small hydrophobic protein

1 entry

Mumps virus (strain Edingburgh 4) (MuV)


SH_MUMP4Small hydrophobic protein

1 entry

Mumps virus (strain Edingburgh 6) (MuV)


SH_MUMP6Small hydrophobic protein

1 entry

Mumps virus (strain Kilham) (MuV)


SH_MUMPKSmall hydrophobic protein

1 entry

Mumps virus (strain Matsuyama) (MuV)


SH_MUMPASmall hydrophobic protein

1 entry

Mumps virus (strain Takahashi) (MuV)


SH_MUMPTSmall hydrophobic protein

1 entry

Mumps virus (strain Urabe vaccine AM9) (MuV)


SH_MUMPUSmall hydrophobic protein

1 entry

Parainfluenza virus 5 (isolate Canine/CPI+) (PIV5) (Simian virus 5)


HN_PIV5DHemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Parainfluenza virus 5 (isolate Canine/CPI-) (PIV5) (Simian virus 5)


HN_PIV5CHemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Parainfluenza virus 5 (isolate Human/LN) (PIV5) (Simian virus 5)


HN_PIV5LHemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Parainfluenza virus 5 (strain 21004-WR) (PIV5) (Simian virus 5)


L_PIV5WRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...