Polyomaviridae

VIRION

Non-enveloped capsid with a T=7d icosahedral symmetry, about 50 nm in diameter.

GENOME

Circular dsDNA about 5 kb in size, associated with cellular histones in a chromatin-like complex. Encodes for 5-9 proteins.
On rare non-specific recombination, the viral genome can be integrated in host chromosome. This inactivates the integrated virus but can give the host cell a replicative advantage sometimes leading to malignant tumours.

GENE EXPRESSION

Transcription is nuclear, in two phases; early (replication), late (virion assembly/exit). 5-9 proteins are expressed from the two pre-MRNA by alternative splicing. All genes are transcribed by host RNA pol II.

REPLICATION

NUCLEAR

  1. Attachement of the viral proteins to host receptors triggers lipid-mediated endocytosis of the virus into the host cell.
  2. Virion transits through endoplasmic reticulum where host protein disulfide isomerases rearrange its capsid structure
  3. Export of misfolded virion to the cytoplasm possibly through host ERAD pathway
  4. Loss of VP1 in the low-calcium conditions of the cytosol
  5. Import of genomic DNA into host nucleus.
  6. Transcription of early genes (LT and sT genes)
  7. Replication of the DNA genome in the nucleus.
  8. Transcription of late genes encoding for structural proteins (VP1, VP2 and VP3).
  9. Assembly of new virions in nuclear viral factories.
  10. Virions are released by lysis of the cell.

Host-virus interaction

Cell-cycle modulation

The large T antigen binds to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53 and induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes.

Matching UniProtKB/Swiss-Prot entries

91 entries grouped by strain (browse by keywords)

All proteins are shown (view only 75 complete proteome entries)

5 entries

Budgerigar fledgling disease virus (BFPyV) (Aves polyomavirus 1) reference strain

Select_allDeselect_all
LT_BFPYV Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
VP1_BFPYV Major capsid protein VP1 (Major structural protein VP1)
VP2_BFPYV Minor capsid protein VP2 (Minor structural protein VP2)
AGNO2_BFPYV Avian agnoprotein 2b (Agno-2b)
ST_BFPYV Small t antigen (ST) (ST-AG)

6 entries

Simian virus 40 (SV40) reference strain

Select_allDeselect_all
ST_SV40 Small t antigen (ST) (ST-AG)
SELP_SV40 SV40 early leader protein (SELP)
LT_SV40 Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
VP2_SV40 Minor capsid protein VP2 (Minor structural protein VP2)
VP1_SV40 Major capsid protein VP1 (Major structural protein VP1)
AGNO_SV40 Agnoprotein

5 entries

Bovine polyomavirus (BPyV) (Bos taurus polyomavirus 1) reference strain

Select_allDeselect_all
ST_POVBO Small t antigen (ST) (ST-AG)
VP2_POVBO Minor capsid protein VP2 (Minor structural protein VP2)
LT_POVBO Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
VP1_POVBO Major capsid protein VP1 (Major structural protein VP1)
AGNO_POVBO Bovine agnoprotein (Agno)

4 entries

Hamster polyomavirus (HaPyV) (Mesocricetus auratus polyomavirus 1) reference strain

Select_allDeselect_all
VP2_POVHA Minor capsid protein VP2 (Minor structural protein VP2)
LT_POVHA Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
MT_POVHA Middle T antigen (MT) (MT-AG)
ST_POVHA Small t antigen (ST) (ST-AG)

5 entries

Murine polyomavirus (strain A2) (MPyV) reference strain

Select_allDeselect_all
ST_POVMA Small t antigen (ST) (ST-AG)
VP2_POVMA Minor capsid protein VP2 (Minor structural protein VP2)
MT_POVMA Middle T antigen (MT) (MT-AG)
LT_POVMA Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
VP1_POVMA Major capsid protein VP1 (Major structural protein VP1)

5 entries

Squirrel monkey polyomavirus reference strain

Select_allDeselect_all
LT_POVSM Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
VP1_POVSM Major capsid protein VP1 (Major structural protein VP1)
AGNO_POVSM Squirrel monkey agnoprotein (Agno)
ST_POVSM Small t antigen (ST) (ST-AG)
VP2_POVSM Minor capsid protein VP2 (Minor structural protein VP2)

4 entries

KI polyomavirus (isolate Stockholm 60) (KIPyV) reference strain

Select_allDeselect_all
VP2_POVK6 Minor capsid protein VP2 (Minor structural protein VP2)
LT_POVK6 Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
VP1_POVK6 Major capsid protein VP1 (Major structural protein VP1)
ST_POVK6 Small t antigen (ST) (ST-AG)

1 entry

Budgerigar fledgling disease virus (BFPyV) (Aves polyomavirus 1)

AGNO1_BFPYV Avian agnoprotein 1a (Agno-1a)

5 entries

BK polyomavirus (BKPyV) (Human polyomavirus 1)

Select_allDeselect_all
ST_POVBK Small t antigen (ST) (ST-AG)
VP2_POVBK Minor capsid protein VP2 (Minor structural protein VP2)
LT_POVBK Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
VP1_POVBK Major capsid protein VP1 (Major structural protein VP1)
AGNO_POVBK Agnoprotein (Agno)

5 entries

BK polyomavirus (strain AS) (BKPyV)

Select_allDeselect_all
ST_POVBA Small t antigen (ST) (ST-AG)
VP2_POVBA Minor capsid protein VP2 (Minor structural protein VP2)
LT_POVBA Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
VP1_POVBA Major capsid protein VP1 (Major structural protein VP1)
AGNO_POVBA Agnoprotein (Agno)

1 entry

Hamster polyomavirus (HaPyV) (Mesocricetus auratus polyomavirus 1)

VP1_POVHA Major capsid protein VP1 (Major structural protein VP1)

5 entries

JC polyomavirus (JCPyV) (JCV)

Select_allDeselect_all
ST_POVJC Small t antigen (ST) (ST-AG)
LT_POVJC Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
VP1_POVJC Major capsid protein VP1 (Major structural protein VP1)
AGNO_POVJC Agnoprotein (Agno)
VP2_POVJC Minor capsid protein VP2 (Minor structural protein VP2)

5 entries

Murine polyomavirus (strain A3) (MPyV)

Select_allDeselect_all
VP2_POVM3 Minor capsid protein VP2 (Minor structural protein VP2)
MT_POVM3 Middle T antigen (MT) (MT-AG)
LT_POVM3 Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
VP1_POVM3 Major capsid protein VP1 (Major structural protein VP1)
ST_POVM3 Small t antigen (ST) (ST-AG)

5 entries

Murine polyomavirus (strain Crawford small-plaque) (MPyV)

Select_allDeselect_all
ST_POVMC Small t antigen (ST) (ST-AG)
MT_POVMC Middle T antigen (MT) (MT-AG)
LT_POVMC Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
VP1_POVMC Major capsid protein VP1 (Major structural protein VP1)
VP2_POVMC Minor capsid protein VP2 (Minor structural protein VP2)

5 entries

Simian virus 12 (strain wt100) (SV-12) (Baboon polyomavirus 1)

Select_allDeselect_all
VP2_POVS1 Minor capsid protein VP2 (Minor structural protein VP2)
LT_POVS1 Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
VP1_POVS1 Major capsid protein VP1 (Major structural protein VP1)
AGNO_POVS1 Agnoprotein (Agno)
ST_POVS1 Small t antigen (ST) (ST-AG)

4 entries

B-lymphotropic polyomavirus (LPV)

Select_allDeselect_all
ST_POVLY Small t antigen (ST) (ST-AG)
VP2_POVLY Minor capsid protein VP2 (Minor structural protein VP2)
LT_POVLY Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
VP1_POVLY Major capsid protein VP1 (Major structural protein VP1)

4 entries

KI polyomavirus (isolate Stockholm 350) (KIPyV)

Select_allDeselect_all
VP2_POVKI Minor capsid protein VP2 (Minor structural protein VP2)
LT_POVKI Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
VP1_POVKI Major capsid protein VP1 (Major structural protein VP1)
ST_POVKI Small t antigen (ST) (ST-AG)

4 entries

KI polyomavirus (isolate Stockholm 380) (KIPyV)

Select_allDeselect_all
VP2_POVK3 Minor capsid protein VP2 (Minor structural protein VP2)
LT_POVK3 Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
VP1_POVK3 Major capsid protein VP1 (Major structural protein VP1)
ST_POVK3 Small t antigen (ST) (ST-AG)

4 entries

Murine polyomavirus (strain Kilham) (MPyV) (Murine pneumotropic virus)

Select_allDeselect_all
VP2_POVMK Minor capsid protein VP2 (Minor structural protein VP2)
LT_POVMK Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
VP1_POVMK Major capsid protein VP1 (Major structural protein VP1)
ST_POVMK Small t antigen (ST) (ST-AG)

4 entries

WU polyomavirus (WUPyV)

Select_allDeselect_all
ST_POVWU Small t antigen (ST) (ST-AG)
VP2_POVWU Minor capsid protein VP2 (Minor structural protein VP2)
LT_POVWU Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
VP1_POVWU Major capsid protein VP1 (Major structural protein VP1)

2 entries

Murine polyomavirus (strain BG) (MPyV)

Select_allDeselect_all
LT_POVBG Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
MT_POVBG Middle T antigen (MT) (MT-AG)

2 entries

Mus musculus polyomavirus 1 (MPyV)

Select_allDeselect_all
MT_POVM1 Middle T antigen (MT) (MT-AG)
LT_POVM1 Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

Murine polyomavirus (strain P16 small-plaque) (MPyV)

VP1_POVMP Capsid protein VP1