Norovirus (taxid:142786)

VIRION

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Non-enveloped, capsid of about 38-40 nm in diameter, with T=3 icosahedral symmetry. The capsid is composed of 180 VP1 proteins. Small empty virions are about 23nm in diameter, and would be of T=1 icosahedral symmetry, composed of 60 VP1 proteins.
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GENOME

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Monopartite, linear ssRNA(+) genome of 7.3 to 8.3 kb. The 5'-terminus is linked to a VPg protein and the 3'-terminus has a poly(A) tract.n (VPg)is covalently linked to genome, whereas 3'-terminus is polyadenylated.

GENE EXPRESSION

The virion RNA is infectious and serves as both genome and viral messenger RNA. Cleavage of ORF1 polyprotein by the virus-encoded 3C-like cysteine proteinase yields the mature nonstructural proteins. Subgenomic RNA encodes the capsid protein and VP2 minor structural protein which is expressed through RNA termination-reinitiation. Murine norovirus express an alternative ORF from the CP mRNA by leaky scanning.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Attachement to host receptors mediates clathrin- and caveolin-independent endocytosis of the virus.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. VPg is removed from the viral RNA, which is then translated into a processed ORF1 polyprotein to yield the replication proteins.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Subgenomic RNA translation gives rise to the capsid protein and VP2.
  7. Assembly of new virus particles and release by cell lysis.

Host-virus interaction

Apoptosis modulation

Murine norovirus induces host cell apoptosis .

Host gene expression shutoff by virus

Noroviruses mediate host translation shutoff by cleaving PABP1 .

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

12 entries grouped by protein

4 entries

Capsid protein VP1 (CP) (Coat protein)

Select_allDeselect_all
CAPSD_NVN68
Norovirus (strain Human/NoV/United States/Norwalk/1968/GI) (Hu/NV/NV/1968/US) reference strain

Capsid protein VP1 (CP) (Coat protein) (p59)

CAPSD_LORDV
Lordsdale virus (strain GII/Human/United Kingdom/Lordsdale/1993) (Human enteric calicivirus) (Hu/NV/LD/1993/UK)

Capsid protein VP1 (CP) (Coat protein) (VP1)

CAPSD_MNV1
Norovirus (isolate Mouse/NoV/United States/MNV1/2002/GV) (MNV-1) (Murine Norovirus 1)
CAPSD_SOUV3
Southampton virus (strain GI/Human/United Kingdom/Southampton/1991) (SHV) (Hu/NV/SHV/1991/UK)

4 entries

Genome polyprotein

Select_allDeselect_all
POLG_NVN68
Norovirus (strain Human/NoV/United States/Norwalk/1968/GI) (Hu/NV/NV/1968/US) reference strain
POLG_LORDV
Lordsdale virus (strain GII/Human/United Kingdom/Lordsdale/1993) (Human enteric calicivirus) (Hu/NV/LD/1993/UK)
POLG_MNV1
Norovirus (isolate Mouse/NoV/United States/MNV1/2002/GV) (MNV-1) (Murine Norovirus 1)
POLG_SOUV3
Southampton virus (strain GI/Human/United Kingdom/Southampton/1991) (SHV) (Hu/NV/SHV/1991/UK)

1 entry

Virulence factor 1 (VF1)

VF1_MNV1
Norovirus (isolate Mouse/NoV/United States/MNV1/2002/GV) (MNV-1) (Murine Norovirus 1)

3 entries

Minor capsid protein VP2

Select_allDeselect_all
VP2_NVN68
Norovirus (strain Human/NoV/United States/Norwalk/1968/GI) (Hu/NV/NV/1968/US) reference strain
VP2_LORDV
Lordsdale virus (strain GII/Human/United Kingdom/Lordsdale/1993) (Human enteric calicivirus) (Hu/NV/LD/1993/UK)
VP2_SOUV3
Southampton virus (strain GI/Human/United Kingdom/Southampton/1991) (SHV) (Hu/NV/SHV/1991/UK)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Norovirus GIII taxid:340017

Protein ModelArchive
Capsid ma-jd-viral-54537
VP2 ma-jd-viral-36156