Orthomarburgvirus (taxid:3044783)

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Filamentous, greatly variable up to 1400 nm in length. Diameter is about 80nm.

GENOME

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Negative-stranded RNA linear genome, about 19 kb in size. Encodes for seven proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. RNA editing may occur at NP gene.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Attachment to host receptors through GP glycoprotein mediates is endocytosed into vesicles in the host cell by apoptotic mimicry.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane, buds via the host ESCRT complexes from the plasma membrane, releasing the virion.

Host-virus interaction

Inhibition of host interferon signaling

Vp40 protein prevents interferon signaling by preventing the tyrosine phosphorylation of JAK1 and subsequent phosphorylation of STAT1 and STAT2. .

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

35 entries grouped by strain

7 entries

Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain

Select_allDeselect_all
L_MABVM RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
VGP_MABVM Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein) [Cleaved into: GP1; GP2]
VP40_MABVM Matrix protein VP40 (Marburg VP40) (mVP40) (Membrane-associated protein VP40)
NCAP_MABVM Nucleoprotein (Nucleocapsid protein) (Protein N)
VP35_MABVM Polymerase cofactor VP35 (Marburg VP35) (mVP35)
VP24_MABVM Membrane-associated protein VP24 (Marburg VP24) (mVP24)
VP30_MABVM Transcriptional activator VP30 (Minor nucleoprotein VP30)

7 entries

Lake Victoria marburgvirus (strain Angola/2005) (MARV)

Select_allDeselect_all
VGP_MABVA Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein) [Cleaved into: GP1; GP2]
L_MABVA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
VP40_MABVA Matrix protein VP40 (Marburg VP40) (mVP40) (Membrane-associated protein VP40)
NCAP_MABVA Nucleoprotein (Nucleocapsid protein)
VP30_MABVA Transcriptional activator VP30 (Minor nucleoprotein VP30)
VP35_MABVA Polymerase cofactor VP35 (Marburg VP35) (mVP35)
VP24_MABVA Membrane-associated protein VP24 (Marburg VP24) (mVP24)

7 entries

Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))

Select_allDeselect_all
VGP_MABVO Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein) [Cleaved into: GP1; GP2]
L_MABVO RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
VP30_MABVO Transcriptional activator VP30 (Minor nucleoprotein VP30)
VP40_MABVO Matrix protein VP40 (Marburg VP40) (mVP40) (Membrane-associated protein VP40)
VP35_MABVO Polymerase cofactor VP35 (Marburg VP35) (mVP35)
NCAP_MABVO Nucleoprotein (Nucleocapsid protein)
VP24_MABVO Membrane-associated protein VP24 (Marburg VP24) (mVP24)

7 entries

Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))

Select_allDeselect_all
VGP_MABVP Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein) [Cleaved into: GP1; GP2]
L_MABVP RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_MABVP Nucleoprotein (Nucleocapsid protein) (Protein N)
VP30_MABVP Transcriptional activator VP30 (Minor nucleoprotein VP30)
VP40_MABVP Matrix protein VP40 (Marburg VP40) (mVP40) (Membrane-associated protein VP40)
VP24_MABVP Membrane-associated protein VP24 (Marburg VP24) (mVP24)
VP35_MABVP Polymerase cofactor VP35 (Marburg VP35) (mVP35)

7 entries

Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))

Select_allDeselect_all
VGP_MABVR Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein) [Cleaved into: GP1; GP2]
L_MABVR RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
VP30_MABVR Transcriptional activator VP30 (Minor nucleoprotein VP30)
VP40_MABVR Matrix protein VP40 (Marburg VP40) (mVP40) (Membrane-associated protein VP40)
NCAP_MABVR Nucleoprotein (Nucleocapsid protein)
VP24_MABVR Membrane-associated protein VP24 (Marburg VP24) (mVP24)
VP35_MABVR Polymerase cofactor VP35 (Marburg VP35) (mVP35)