Inhibition of host STAT2 by virus (kw:KW-1106)
The signal transducer and activator of transcription STAT2 protein is a cytoplasmic latent transcription factor that becomes activated by various extracellular stimuli, including cytokines and growth factors that bind to specific cell surface receptors. The activation of STAT2 in IFN-α/β signaling pathways is largely mediated by phosphorylation of conserved tyrosine and serine residues in the C-terminal region. IFN-α/β stimulates heterodimerization of STAT1 and STAT2, leading to STAT2 activation and nuclear localization.
Many viruses modulate the interferon mediated response by acting on STAT2. This regulation occurs in many different ways. NS5 protein from Dengue virus mediates STAT2 binding and degradation. Respiratory syncytial virus NS1 protein degrades STAT2 by using the elongin-cullin E3 Ligase. Nipah virus V protein instead prevents STAT2 activation through direct binding but without targeting it to degradation.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)135 entries grouped by protein
4 entries
Protein MGF 360-9L
13 entries
Protein C'
3 entries
Cytoplasmic envelopment protein 2 (Tegument protein BGLF2)
1 entry
E3 ubiquitin ligase ICP22 (Immediate-early protein IE68) (Infected cell protein 22) (ICP22)
7 entries
Non-structural protein 1 (Non-structural protein 1C)
6 entries
Non-structural protein 2 (NS2) (Non-structural protein 1B)
1 entry
ORF6 protein (ORF6) (Accessory protein 6) (Non-structural protein 6) (ns6) (Protein X3)
2 entries
Non-structural protein NS-S (NSs)
23 entries
Phosphoprotein (Protein P) (Protein M1)
58 entries
Genome polyprotein
1 entry
Protein UL145
16 entries