Inhibition of host STAT2 by virus

The signal transducer and activator of transcription STAT2 protein is a cytoplasmic latent transcription factor that becomes activated by various extracellular stimuli, including cytokines and growth factors that bind to specific cell surface receptors. The activation of STAT2 in IFN-α/β signaling pathways is largely mediated by phosphorylation of conserved tyrosine and serine residues in the C-terminal region. IFN-α/β stimulates heterodimerization of STAT1 and STAT2, leading to STAT2 activation and nuclear localization.

INFRA1 INFRA2 INFRG1 INFRG2 JAK1 JAK1 TYK2 JAK2 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT2 STAT2 STAT2 STAT2 IRF9 IRF9 IRF9 e1a P NS1 NS5 V C

Many viruses modulate the interferon mediated response by acting on STAT2. This regulation occurs in many different ways. NS5 protein from Dengue virus mediates STAT2 binding and degradation. Respiratory syncytial virus NS1 protein degrades STAT2 by using the elongin-cullin E3 Ligase. Nipah virus V protein instead prevents STAT2 activation through direct binding but without targeting it to degradation.

Matching UniProtKB/Swiss-Prot entries

124 entries grouped by protein (browse by keywords)

13 entries

Protein C'

Select_allDeselect_all
C_SENDO
Sendai virus (strain Ohita) (SeV) reference strain
C_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain

C' protein

C_PI1HB
Human parainfluenza 1 virus (strain C35) (HPIV-1)

Protein C

C_PI1HC
Human parainfluenza 1 virus (strain C39) (HPIV-1)

Protein C

C_PI1HD
Human parainfluenza 1 virus (strain CI-5/73) (HPIV-1)

Protein C

C_PI1HE
Human parainfluenza 1 virus (strain CI-14/83) (HPIV-1)

Protein C

C_PI3B
Bovine parainfluenza 3 virus (BPIV-3)

Protein C

C_PI3H4
Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human parainfluenza 3 virus (strain NIH 47885))

Protein C (VP18 protein)

C_SEND6
Sendai virus (strain 6/94) (SeV)
C_SENDA
Sendai virus (strain Hamamatsu) (SeV)
C_SENDF
Sendai virus (strain Fushimi) (SeV)
C_SENDH
Sendai virus (strain Harris) (SeV)
C_SENDN
Sendai virus (strain Nagoya) (SeV)

1 entry

E3 ubiquitin ligase ICP22 (Immediate-early protein IE68) (Infected cell protein 22) (ICP22)

ICP22_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

7 entries

Non-structural protein 1 (Non-structural protein 1C)

Select_allDeselect_all
NS1_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
NS1_HRSVA
Human respiratory syncytial virus A (strain A2) reference strain

Non-structural protein 1 (NS1) (Non-structural protein 1C)

NS1_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
NS1_HRSS2
Human respiratory syncytial virus A (strain S-2) (HRSV-S2)

Non-structural protein 1 (NS1) (Non-structural protein 1C)

NS1_HRSV1
Human respiratory syncytial virus B (strain 18537)
NS1_HRSVL
Human respiratory syncytial virus A (strain Long)
NS1_ORSVW
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

6 entries

Non-structural protein 2 (NS2) (Non-structural protein 1B)

Select_allDeselect_all
NS2_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
NS2_HRSVA
Human respiratory syncytial virus A (strain A2) reference strain
NS2_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
NS2_HRSV1
Human respiratory syncytial virus B (strain 18537)
NS2_HRSVL
Human respiratory syncytial virus A (strain Long)
NS2_ORSVW
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

1 entry

ORF6 protein (ORF6) (Accessory protein 6) (Non-structural protein 6) (ns6) (Protein X3)

NS6_SARS2
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) reference strain

23 entries

Phosphoprotein (Protein P) (Protein M1)

Select_allDeselect_all
PHOSP_ABLVB
Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain
PHOSP_EBLV1
European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain
PHOSP_EBLV2
European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain
PHOSP_MOKV
Mokola virus (MOKV) reference strain
PHOSP_RABVP
Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain
PHOSP_RABVS
Rabies virus (strain SAD B19) (RABV) reference strain
PHOSP_WCBV
West Caucasian bat virus (WCBV) reference strain
PHOSP_ABLVH
Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)
PHOSP_ARAV
Aravan virus (ARAV)
PHOSP_DUVV
Duvenhage virus (DUVV)
PHOSP_IRKV
Irkut virus (IRKV)
PHOSP_KHUV
Khujand virus (KHUV)
PHOSP_LBV
Lagos bat virus (LBV)
PHOSP_RABVA
Rabies virus (strain PM1503/AVO1) (RABV)
PHOSP_RABVB
Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)
PHOSP_RABVC
Rabies virus (strain CVS-11) (RABV)
PHOSP_RABVD
Rabies virus (strain China/DRV) (RABV)
PHOSP_RABVE
Rabies virus (strain ERA) (RABV)
PHOSP_RABVH
Rabies virus (strain HEP-Flury) (RABV)
PHOSP_RABVI
Rabies virus (strain India) (RABV)
PHOSP_RABVM
Rabies virus (strain PM) (RABV)
PHOSP_RABVN
Rabies virus (strain Nishigahara RCEH) (RABV)
PHOSP_RABVR
Rabies virus (strain China/MRV) (RABV)

58 entries

Genome polyprotein

Select_allDeselect_all
POLG_DEN1W
Dengue virus type 1 (strain Nauru/West Pac/1974) (DENV-1) reference strain
POLG_YEFV1
Yellow fever virus (strain 17D vaccine) (YFV) reference strain
POLG_ALKV
Alkhumra hemorrhagic fever virus (ALKV) (Alkhurma hemorrhagic fever virus)
POLG_BANV
Banzi virus (BANV)
POLG_BUSV
Bussuquara virus (BUSV)
POLG_DEN1B
Dengue virus type 1 (strain Brazil/97-11/1997) (DENV-1)
POLG_DEN1S
Dengue virus type 1 (strain Singapore/S275/1990) (DENV-1)
POLG_DEN26
Dengue virus type 2 (strain Thailand/16681/1984) (DENV-2)
POLG_DEN27
Dengue virus type 2 (strain 16681-PDK53) (DENV-2)
POLG_DEN28
Dengue virus type 2 (isolate Thailand/0168/1979) (DENV-2)
POLG_DEN2J
Dengue virus type 2 (strain Jamaica/1409/1983) (DENV-2)
POLG_DEN2N
Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)
POLG_DEN2P
Dengue virus type 2 (strain Puerto Rico/PR159-S1/1969) (DENV-2)
POLG_DEN2Q
Dengue virus type 2 (strain Peru/IQT2913/1996) (DENV-2)
POLG_DEN3C
Dengue virus type 3 (strain China/80-2/1980) (DENV-3)
POLG_DEN3I
Dengue virus type 3 (strain Singapore/8120/1995) (DENV-3)
POLG_DEN3M
Dengue virus type 3 (strain Martinique/1243/1999) (DENV-3)
POLG_DEN3P
Dengue virus type 3 (strain Philippines/H87/1956) (DENV-3)
POLG_DEN3S
Dengue virus type 3 (strain Sri Lanka/1266/2000) (DENV-3)
POLG_DEN4D
Dengue virus type 4 (strain Dominica/814669/1981) (DENV-4)
POLG_DEN4H
Dengue virus type 4 (strain Thailand/0476/1997) (DENV-4)
POLG_DEN4P
Dengue virus type 4 (strain Philippines/H241/1956) (DENV-4)
POLG_DEN4S
Dengue virus type 4 (strain Singapore/8976/1995) (DENV-4)
POLG_DEN4T
Dengue virus type 4 (strain Thailand/0348/1991) (DENV-4)
POLG_EHV
Edge Hill virus (EHV)
POLG_ILHV
Ilheus virus (ILHV)
POLG_JAEV1
Japanese encephalitis virus (strain SA-14) (JEV)
POLG_JAEV5
Japanese encephalitis virus (strain SA(v)) (JEV)
POLG_JAEVJ
Japanese encephalitis virus (strain Jaoars982) (JEV)
POLG_JAEVM
Japanese encephalitis virus (strain M28) (JEV)
POLG_KFDV
Kyasanur forest disease virus (KFDV)
POLG_KOKV
Kokobera virus (KOKV)
POLG_KUNJM
Kunjin virus (strain MRM61C)
POLG_LANVT
Langat virus (strain TP21)
POLG_LIV
Louping ill virus (Li)
POLG_MCFA
Mosquito cell fusing agent (CFA flavivirus)
POLG_MVEV5
Murray valley encephalitis virus (strain MVE-1-51) (MVEV)
POLG_OHFV
Omsk hemorrhagic fever virus (OHFV)
POLG_POWVL
Tick-borne powassan virus (strain LB) (POWV) (Powassan virus)
POLG_ROCV
Rocio virus (ROCV)
POLG_TBEVH
Tick-borne encephalitis virus (strain Hypr) (TBEV)
POLG_TBEVS
Tick-borne encephalitis virus Far Eastern subtype (strain Sofjin) (SOFV) (Sofjin virus)
POLG_TBEVW
Tick-borne encephalitis virus European subtype (strain Neudoerfl) (NEUV) (Neudoerfl virus)
POLG_USUV
Usutu virus (USUV)
POLG_WNV
West Nile virus (WNV)
POLG_WNV9
West Nile virus (strain NY-99) (WNV) (West Nile virus (strain NY-1999))
POLG_WSLV
Wesselsbron virus (WSLV)
POLG_YEFVA
Yellow fever virus (strain Ghana/Asibi/1927) (YFV)
POLG_YEFVC
Yellow fever virus (isolate Ivory Coast/1999) (YFV)
POLG_YEFVE
Yellow fever virus (isolate Ethiopia/Couma/1961) (YFV)
POLG_YEFVF
Yellow fever virus (strain French neurotropic vaccine FNV) (YFV)
POLG_YEFVI
Yellow fever virus (isolate Ivory Coast/85-82H/1982) (YFV)
POLG_YEFVN
Yellow fever virus (isolate Angola/14FA/1971) (YFV)
POLG_YEFVT
Yellow fever virus (strain Trinidad/TRINID79A/1979) (YFV)
POLG_YEFVU
Yellow fever virus (isolate Uganda/A7094A4/1948) (YFV)
POLG_ZIKVF
Zika virus (isolate ZIKV/Human/French Polynesia/10087PF/2013) (ZIKV)
POLG_ZIKVK
Zika virus (isolate ZIKV/Human/Cambodia/FSS13025/2010) (ZIKV)

15 entries

Non-structural protein V

Select_allDeselect_all
V_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
V_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
V_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain

Non-structural protein V (Non-structural protein NS1)

V_NIPAV
Nipah virus reference strain
V_PI2HT
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
V_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASI
Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASY
Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)
V_MUMP1
Mumps virus (strain SBL-1) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_MUMPE
Mumps virus (strain Enders) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_MUMPS
Mumps virus (strain SBL) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_PHODV
Phocine distemper virus (PDV)
V_PI2H
Human parainfluenza 2 virus (HPIV-2)
V_RINDK
Rinderpest virus (strain Kabete O) (RDV)