Inhibition of host STAT2 by virus (kw:KW-1106)
The signal transducer and activator of transcription STAT2 protein is a cytoplasmic latent transcription factor that becomes activated by various extracellular stimuli, including cytokines and growth factors that bind to specific cell surface receptors. The activation of STAT2 in IFN-α/β signaling pathways is largely mediated by phosphorylation of conserved tyrosine and serine residues in the C-terminal region. IFN-α/β stimulates heterodimerization of STAT1 and STAT2, leading to STAT2 activation and nuclear localization.

Many viruses modulate the interferon mediated response by acting on STAT2. This regulation occurs in many different ways. NS5 protein from Dengue virus mediates STAT2 binding and degradation. Respiratory syncytial virus NS1 protein degrades STAT2 by using the elongin-cullin E3 Ligase. Nipah virus V protein instead prevents STAT2 activation through direct binding but without targeting it to degradation.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)135 entries grouped by strain
2 entries
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
2 entries
Human respiratory syncytial virus B (strain B1) reference strain
1 entry
African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV) reference strain
1 entry
Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain
1 entry
Dengue virus type 1 (strain Nauru/West Pac/1974) (DENV-1) reference strain
1 entry
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
1 entry
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
1 entry
European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain
1 entry
European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain
1 entry
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
1 entry
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
1 entry
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
1 entry
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
1 entry
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
1 entry
Mokola virus (MOKV) reference strain
1 entry
Mumps virus genotype B (strain Miyahara vaccine) (MuV) reference strain
1 entry
Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain
1 entry
SFTS phlebovirus (isolate SFTSV/Human/China/HB29/2010) (Severe fever with thrombocytopenia virus) reference strain
1 entry
Sendai virus (strain Ohita) (SeV) reference strain
1 entry
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) reference strain
1 entry
West Caucasian bat virus (WCBV) reference strain
1 entry
Yellow fever virus (strain 17D vaccine) (YFV) reference strain
1 entry
Zika virus (ZIKV) reference strain
2 entries
Human respiratory syncytial virus
2 entries
Human respiratory syncytial virus A (strain A2)
2 entries
Human respiratory syncytial virus B (strain 18537)
2 entries
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)
1 entry
African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV)
1 entry
African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV)
1 entry
African swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV)
1 entry
Alkhumra hemorrhagic fever virus (ALKV) (Alkhurma hemorrhagic fever virus)
1 entry
Aravan virus (ARAV)
1 entry
Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)
1 entry
Banzi virus (BANV)
1 entry
Bovine parainfluenza 3 virus (BPIV-3)
1 entry
Bussuquara virus (BUSV)
1 entry
Dengue virus type 1 (strain Brazil/97-11/1997) (DENV-1)
1 entry
Dengue virus type 1 (strain Singapore/S275/1990) (DENV-1)
1 entry
Dengue virus type 2 (isolate Thailand/0168/1979) (DENV-2)
1 entry
Dengue virus type 2 (strain 16681-PDK53) (DENV-2)
1 entry
Dengue virus type 2 (strain Jamaica/1409/1983) (DENV-2)
1 entry
Dengue virus type 2 (strain Peru/IQT2913/1996) (DENV-2)
1 entry
Dengue virus type 2 (strain Puerto Rico/PR159-S1/1969) (DENV-2)
1 entry
Dengue virus type 2 (strain Thailand/16681/1984) (DENV-2)
1 entry
Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)
1 entry
Dengue virus type 3 (strain China/80-2/1980) (DENV-3)
1 entry
Dengue virus type 3 (strain Martinique/1243/1999) (DENV-3)
1 entry
Dengue virus type 3 (strain Philippines/H87/1956) (DENV-3)
1 entry
Dengue virus type 3 (strain Singapore/8120/1995) (DENV-3)
1 entry
Dengue virus type 3 (strain Sri Lanka/1266/2000) (DENV-3)
1 entry
Dengue virus type 4 (strain Dominica/814669/1981) (DENV-4)
1 entry
Dengue virus type 4 (strain Philippines/H241/1956) (DENV-4)
1 entry
Dengue virus type 4 (strain Singapore/8976/1995) (DENV-4)
1 entry
Dengue virus type 4 (strain Thailand/0348/1991) (DENV-4)
1 entry
Dengue virus type 4 (strain Thailand/0476/1997) (DENV-4)
1 entry
Duvenhage virus (DUVV)
1 entry
Edge Hill virus (EHV)
1 entry
Epstein-Barr virus (strain GD1) (HHV-4) (Human gammaherpesvirus 4)
1 entry
Heartland virus (HTRV)
1 entry
Human parainfluenza 1 virus (strain C35) (HPIV-1)
1 entry
Human parainfluenza 1 virus (strain C39) (HPIV-1)
1 entry
Human parainfluenza 1 virus (strain CI-14/83) (HPIV-1)
1 entry
Human parainfluenza 1 virus (strain CI-5/73) (HPIV-1)
1 entry
Human parainfluenza 2 virus (HPIV-2)
1 entry
Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human parainfluenza 3 virus (strain NIH 47885))
1 entry
Human respiratory syncytial virus A (strain S-2) (HRSV-S2)
1 entry
Ilheus virus (ILHV)
1 entry
Irkut virus (IRKV)
1 entry
Japanese encephalitis virus (strain Jaoars982) (JEV)
1 entry
Japanese encephalitis virus (strain M28) (JEV)
1 entry
Japanese encephalitis virus (strain SA(v)) (JEV)
1 entry
Japanese encephalitis virus (strain SA-14) (JEV)
1 entry
Khujand virus (KHUV)
1 entry
Kokobera virus (KOKV)
1 entry
Kunjin virus (strain MRM61C)
1 entry
Kyasanur forest disease virus (KFDV)
1 entry
Lagos bat virus (LBV)
1 entry
Langat virus (strain TP21)
1 entry
Louping ill virus (Li)
1 entry
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
1 entry
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
1 entry
Measles virus (strain Edmonston-Schwarz vaccine) (MeV) (Subacute sclerose panencephalitis virus)
1 entry
Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)
1 entry
Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)
1 entry
Mosquito cell fusing agent (CFA flavivirus)
1 entry
Mumps virus (strain Enders) (MuV)
1 entry
Mumps virus (strain SBL) (MuV)
1 entry
Mumps virus (strain SBL-1) (MuV)
1 entry
Murray valley encephalitis virus (strain MVE-1-51) (MVEV)
1 entry
Nipah virus
1 entry
Omsk hemorrhagic fever virus (OHFV)
1 entry
Phocine distemper virus (PDV)
1 entry
Rabies virus (strain CVS-11) (RABV)
1 entry
Rabies virus (strain China/DRV) (RABV)
1 entry
Rabies virus (strain China/MRV) (RABV)
1 entry
Rabies virus (strain ERA) (RABV)
1 entry
Rabies virus (strain HEP-Flury) (RABV)
1 entry
Rabies virus (strain India) (RABV)
1 entry
Rabies virus (strain Nishigahara RCEH) (RABV)
1 entry
Rabies virus (strain PM) (RABV)
1 entry
Rabies virus (strain PM1503/AVO1) (RABV)
1 entry
Rabies virus (strain SAD B19) (RABV)
1 entry
Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)
1 entry
Rinderpest virus (strain Kabete O) (RDV)
1 entry
Rocio virus (ROCV)
1 entry
Sendai virus (strain 6/94) (SeV)
1 entry
Sendai virus (strain Fushimi) (SeV)
1 entry
Sendai virus (strain Hamamatsu) (SeV)
1 entry
Sendai virus (strain Harris) (SeV)
1 entry
Sendai virus (strain Nagoya) (SeV)
1 entry
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ))
1 entry
Tick-borne encephalitis virus (strain Hypr) (TBEV)
1 entry
Tick-borne encephalitis virus European subtype (strain Neudoerfl) (NEUV) (Neudoerfl virus)
1 entry
Tick-borne encephalitis virus Far Eastern subtype (strain Sofjin) (SOFV) (Sofjin virus)
1 entry
Tick-borne powassan virus (strain LB) (POWV) (Powassan virus)
1 entry
Usutu virus (USUV)
1 entry
Wesselsbron virus (WSLV)
1 entry
West Nile virus (WNV)
1 entry
West Nile virus (strain NY-99) (WNV) (West Nile virus (strain NY-1999))
1 entry
Yellow fever virus (isolate Angola/14FA/1971) (YFV)
1 entry
Yellow fever virus (isolate Ethiopia/Couma/1961) (YFV)
1 entry
Yellow fever virus (isolate Ivory Coast/1999) (YFV)
1 entry
Yellow fever virus (isolate Ivory Coast/85-82H/1982) (YFV)
1 entry
Yellow fever virus (isolate Uganda/A7094A4/1948) (YFV)
1 entry
Yellow fever virus (strain French neurotropic vaccine FNV) (YFV)
1 entry
Yellow fever virus (strain Ghana/Asibi/1927) (YFV)
1 entry
Yellow fever virus (strain Trinidad/TRINID79A/1979) (YFV)
1 entry
Zika virus (isolate ZIKV/Human/Cambodia/FSS13025/2010) (ZIKV)
1 entry