Inhibition of host STAT2 by virus

The signal transducer and activator of transcription STAT2(M97934:9606) protein is a cytoplasmic latent transcription factor that becomes activated by various extracellular stimuli, including cytokines and growth factors that bind to specific cell surface receptors. The activation of STAT2(M97934:9606) in IFN-α/β signaling pathways is largely mediated by phosphorylation of conserved tyrosine and serine residues in the C-terminal region. IFN-α/β stimulates heterodimerization of STAT1(M97935:9606) and STAT2(M97934:9606), leading to STAT2(M97934:9606) activation and nuclear localization.

INFRA1 INFRA2 INFRG1 INFRG2 JAK1 JAK1 TYK2 JAK2 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT2 STAT2 STAT2 STAT2 IRF9 IRF9 IRF9 e1a P NS1 NS5 V C

Many viruses modulate the interferon mediated response by acting on STAT2(M97934:9606). This regulation occurs in many different ways. NS5 protein from Dengue virus mediates STAT2(M97934:9606) binding and degradation. Respiratory syncytial virus NS1(O42083) protein degrades STAT2(M97934:9606) by using the elongin-cullin E3 Ligase. Nipah virus V(Q997F2) protein instead prevents STAT2(M97934:9606) activation through direct binding but without targeting it to degradation.

Matching UniProtKB/Swiss-Prot entries

111 entries grouped by strain (browse by keywords)

All proteins are shown (view only 88 complete proteome entries)

1 entry

Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain

PHOSP_ABLVB Phosphoprotein (Protein P) (Protein M1)

1 entry

Bovine parainfluenza 3 virus (BPIV-3) reference strain

C_PI3B Protein C

1 entry

Dengue virus type 1 (strain Nauru/West Pac/1974) (DENV-1) reference strain

POLG_DEN1W Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM ...

1 entry

European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain

PHOSP_EBLV1 Phosphoprotein (Protein P) (Protein M1)

1 entry

European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain

PHOSP_EBLV2 Phosphoprotein (Protein P) (Protein M1)

1 entry

Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain

V_HENDH Non-structural protein V

1 entry

Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain

V_MEASC Non-structural protein V

1 entry

Mokola virus (MOKV) reference strain

PHOSP_MOKV Phosphoprotein (Protein P) (Protein M1)

1 entry

Mumps virus (strain Miyahara vaccine) (MuV) reference strain

V_MUMPM Non-structural protein V (Non-structural protein NS1)

1 entry

Murine pneumonia virus (strain 15) (MPV) reference strain

NS1_MPV15 Non-structural protein 1 (Non-structural protein 1C)

1 entry

Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain

PHOSP_RABVP Phosphoprotein (Protein P) (Protein M1)

1 entry

Sendai virus (strain Ohita) (SeV) reference strain

C_SENDO Protein C'

1 entry

Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain

C_SENDZ C' protein

1 entry

West Caucasian bat virus (WCBV) reference strain

PHOSP_WCBV Phosphoprotein (Protein P) (Protein M1)

1 entry

Yellow fever virus (strain 17D vaccine) (YFV) reference strain

POLG_YEFV1 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Zika virus (strain Mr 766) (ZIKV) reference strain

POLG_ZIKV Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM ...

1 entry

Alkhumra hemorrhagic fever virus (ALKV) (Alkhurma hemorrhagic fever virus)

POLG_ALKV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Aravan virus (ARAV)

PHOSP_ARAV Phosphoprotein (Protein P) (Protein M1)

1 entry

Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)

PHOSP_ABLVH Phosphoprotein (Protein P) (Protein M1)

1 entry

Banzi virus (BANV)

POLG_BANV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Bussuquara virus (BUSV)

POLG_BUSV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 1 (strain Brazil/97-11/1997) (DENV-1)

POLG_DEN1B Genome polyprotein [Cleaved into: Protein C (Core protein); Protein prM; Peptide pr; Small envelope ...

1 entry

Dengue virus type 1 (strain Singapore/S275/1990) (DENV-1)

POLG_DEN1S Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 2 (isolate Thailand/0168/1979) (DENV-2)

POLG_DEN28 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 2 (strain 16681-PDK53) (DENV-2)

POLG_DEN27 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 2 (strain Jamaica/1409/1983) (DENV-2)

POLG_DEN2J Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 2 (strain Peru/IQT2913/1996) (DENV-2)

POLG_DEN2Q Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 2 (strain Puerto Rico/PR159-S1/1969) (DENV-2)

POLG_DEN2P Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 2 (strain Thailand/16681/1984) (DENV-2)

POLG_DEN26 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)

POLG_DEN2N Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 3 (strain China/80-2/1980) (DENV-3)

POLG_DEN3C Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 3 (strain Martinique/1243/1999) (DENV-3)

POLG_DEN3M Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 3 (strain Philippines/H87/1956) (DENV-3)

POLG_DEN3P Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 3 (strain Singapore/8120/1995) (DENV-3)

POLG_DEN3I Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 3 (strain Sri Lanka/1266/2000) (DENV-3)

POLG_DEN3S Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 4 (strain Dominica/814669/1981) (DENV-4)

POLG_DEN4D Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 4 (strain Philippines/H241/1956) (DENV-4)

POLG_DEN4P Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 4 (strain Singapore/8976/1995) (DENV-4)

POLG_DEN4S Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 4 (strain Thailand/0348/1991) (DENV-4)

POLG_DEN4T Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 4 (strain Thailand/0476/1997) (DENV-4)

POLG_DEN4H Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Duvenhage virus (DUVV)

PHOSP_DUVV Phosphoprotein (Protein P) (Protein M1)

1 entry

Edge Hill virus (EHV)

POLG_EHV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Human parainfluenza 1 virus (strain C35) (HPIV-1)

C_PI1HB Protein C

1 entry

Human parainfluenza 1 virus (strain C39) (HPIV-1)

C_PI1HC Protein C

1 entry

Human parainfluenza 1 virus (strain CI-14/83) (HPIV-1)

C_PI1HE Protein C

1 entry

Human parainfluenza 1 virus (strain CI-5/73) (HPIV-1)

C_PI1HD Protein C

1 entry

Human parainfluenza 2 virus (HPIV-2)

V_PI2H Non-structural protein V

1 entry

Human parainfluenza 2 virus (strain Toshiba) (HPIV-2)

V_PI2HT Non-structural protein V

1 entry

Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human parainfluenza 3 virus (strain NIH 47885))

C_PI3H4 Protein C (VP18 protein)

1 entry

Human respiratory syncytial virus A (strain Long)

NS1_HRSVL Non-structural protein 1 (Non-structural protein 1C)

1 entry

Human respiratory syncytial virus B (strain 18537)

NS1_HRSV1 Non-structural protein 1 (Non-structural protein 1C)

1 entry

Ilheus virus (ILHV)

POLG_ILHV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Irkut virus (IRKV)

PHOSP_IRKV Phosphoprotein (Protein P) (Protein M1)

1 entry

Japanese encephalitis virus (strain Jaoars982)

POLG_JAEVJ Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Japanese encephalitis virus (strain SA(v))

POLG_JAEV5 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Japanese encephalitis virus (strain SA-14)

POLG_JAEV1 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Khujand virus (KHUV)

PHOSP_KHUV Phosphoprotein (Protein P) (Protein M1)

1 entry

Kokobera virus (KOKV)

POLG_KOKV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Kunjin virus (strain MRM61C)

POLG_KUNJM Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

Kyasanur forest disease virus (KFDV)

POLG_KFDV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Lagos bat virus (LBV)

PHOSP_LBV Phosphoprotein (Protein P) (Protein M1)

1 entry

Langat virus (strain TP21)

POLG_LANVT Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

Louping ill virus (Li)

POLG_LIV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASE Non-structural protein V

1 entry

Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASA Non-structural protein V

1 entry

Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASI Non-structural protein V

1 entry

Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASY Non-structural protein V

1 entry

Mosquito cell fusing agent (CFA flavivirus)

POLG_MCFA Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM; ...

1 entry

Mumps virus (strain Enders) (MuV)

V_MUMPE Non-structural protein V (Non-structural protein NS1)

1 entry

Mumps virus (strain SBL) (MuV)

V_MUMPS Non-structural protein V (Non-structural protein NS1)

1 entry

Mumps virus (strain SBL-1) (MuV)

V_MUMP1 Non-structural protein V (Non-structural protein NS1)

1 entry

Murray valley encephalitis virus (strain MVE-1-51) (MVEV)

POLG_MVEV5 Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

Nipah virus

V_NIPAV Non-structural protein V

1 entry

Omsk hemorrhagic fever virus (OHFV)

POLG_OHFV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

NS1_ORSVW Non-structural protein 1 (Non-structural protein 1C)

1 entry

Phocine distemper virus (PDV)

V_PHODV Non-structural protein V

1 entry

Rabies virus (strain CVS-11) (RABV)

PHOSP_RABVC Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain China/DRV) (RABV)

PHOSP_RABVD Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain China/MRV) (RABV)

PHOSP_RABVR Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain ERA) (RABV)

PHOSP_RABVE Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain HEP-Flury) (RABV)

PHOSP_RABVH Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain India) (RABV)

PHOSP_RABVI Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain Nishigahara RCEH) (RABV)

PHOSP_RABVN Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain PM) (RABV)

PHOSP_RABVM Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain PM1503/AVO1) (RABV)

PHOSP_RABVA Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain SAD B19) (RABV)

PHOSP_RABVS Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)

PHOSP_RABVB Phosphoprotein (Protein P) (Protein M1)

1 entry

Rinderpest virus (strain Kabete O) (RDV)

V_RINDK Non-structural protein V

1 entry

Rocio virus (ROCV)

POLG_ROCV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Sendai virus (strain 6/94) (SeV)

C_SEND6 Protein C'

1 entry

Sendai virus (strain Fushimi) (SeV)

C_SENDF Protein C'

1 entry

Sendai virus (strain Hamamatsu) (SeV)

C_SENDA Protein C'

1 entry

Sendai virus (strain Harris) (SeV)

C_SENDH Protein C'

1 entry

Sendai virus (strain Nagoya) (SeV)

C_SENDN Protein C'

1 entry

Tick-borne encephalitis virus (strain Hypr) (TBEV)

POLG_TBEVH Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

Tick-borne encephalitis virus European subtype (strain Neudoerfl) (NEUV) (Neudoerfl virus)

POLG_TBEVW Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

Tick-borne encephalitis virus Far Eastern subtype (strain Sofjin) (SOFV) (Sofjin virus)

POLG_TBEVS Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

Tick-borne powassan virus (strain LB) (POWV) (Powassan virus)

POLG_POWVL Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

Usutu virus (USUV)

POLG_USUV Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

Wesselsbron virus (WSLV)

POLG_WSLV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

West Nile virus (WNV)

POLG_WNV Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

West Nile virus (strain NY-99) (WNV) (West Nile virus (strain NY-1999))

POLG_WNV9 Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

Yellow fever virus (isolate Angola/14FA/1971) (YFV)

POLG_YEFVN Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Yellow fever virus (isolate Ethiopia/Couma/1961) (YFV)

POLG_YEFVE Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Yellow fever virus (isolate Ivory Coast/1999) (YFV)

POLG_YEFVC Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Yellow fever virus (isolate Ivory Coast/85-82H/1982) (YFV)

POLG_YEFVI Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Yellow fever virus (isolate Uganda/A7094A4/1948) (YFV)

POLG_YEFVU Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Yellow fever virus (strain French neurotropic vaccine FNV) (YFV)

POLG_YEFVF Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Yellow fever virus (strain Ghana/Asibi/1927) (YFV)

POLG_YEFVA Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Yellow fever virus (strain Trinidad/TRINID79A/1979) (YFV)

POLG_YEFVT Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Zika virus (isolate ZIKV/Human/French Polynesia/10087PF/2013) (ZIKV)

POLG_ZIKVF Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM ...