Inhibition of host STAT2 by virus

The signal transducer and activator of transcription STAT2 protein is a cytoplasmic latent transcription factor that becomes activated by various extracellular stimuli, including cytokines and growth factors that bind to specific cell surface receptors. The activation of STAT2 in IFN-α/β signaling pathways is largely mediated by phosphorylation of conserved tyrosine and serine residues in the C-terminal region. IFN-α/β stimulates heterodimerization of STAT1 and STAT2, leading to STAT2 activation and nuclear localization.

INFRA1 INFRA2 INFRG1 INFRG2 JAK1 JAK1 TYK2 JAK2 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT2 STAT2 STAT2 STAT2 IRF9 IRF9 IRF9 e1a P NS1 NS5 V C

Many viruses modulate the interferon mediated response by acting on STAT2. This regulation occurs in many different ways. NS5 protein from Dengue virus mediates STAT2 binding and degradation. Respiratory syncytial virus NS1 protein degrades STAT2 by using the elongin-cullin E3 Ligase. Nipah virus V protein instead prevents STAT2 activation through direct binding but without targeting it to degradation.

Matching UniProtKB/Swiss-Prot entries

124 entries grouped by strain (browse by keywords)

2 entries

Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain

Select_allDeselect_all
NS2_BRSVA Non-structural protein 2 (NS2) (Non-structural protein 1B)
NS1_BRSVA Non-structural protein 1 (Non-structural protein 1C)

2 entries

Human respiratory syncytial virus A (strain A2) reference strain

Select_allDeselect_all
NS1_HRSVA Non-structural protein 1 (NS1) (Non-structural protein 1C)
NS2_HRSVA Non-structural protein 2 (NS2) (Non-structural protein 1B)

2 entries

Human respiratory syncytial virus B (strain B1) reference strain

Select_allDeselect_all
NS2_HRSVB Non-structural protein 2 (NS2) (Non-structural protein 1B)
NS1_HRSVB Non-structural protein 1 (Non-structural protein 1C)

1 entry

Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain

PHOSP_ABLVB Phosphoprotein (Protein P) (Protein M1)

1 entry

Dengue virus type 1 (strain Nauru/West Pac/1974) (DENV-1) reference strain

POLG_DEN1W Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM ...

1 entry

European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain

PHOSP_EBLV1 Phosphoprotein (Protein P) (Protein M1)

1 entry

European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain

PHOSP_EBLV2 Phosphoprotein (Protein P) (Protein M1)

1 entry

Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain

V_HENDH Non-structural protein V

1 entry

Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

ICP22_HHV2H E3 ubiquitin ligase ICP22 (Immediate-early protein IE68) (Infected cell protein 22) (ICP22)

1 entry

Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain

V_PI2HT Non-structural protein V

1 entry

Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain

V_MEASC Non-structural protein V

1 entry

Mokola virus (MOKV) reference strain

PHOSP_MOKV Phosphoprotein (Protein P) (Protein M1)

1 entry

Mumps virus (strain Miyahara vaccine) (MuV) reference strain

V_MUMPM Non-structural protein V (Non-structural protein NS1)

1 entry

Nipah virus reference strain

V_NIPAV Non-structural protein V

1 entry

Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain

PHOSP_RABVP Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain SAD B19) (RABV) reference strain

PHOSP_RABVS Phosphoprotein (Protein P) (Protein M1)

1 entry

Sendai virus (strain Ohita) (SeV) reference strain

C_SENDO Protein C'

1 entry

Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain

C_SENDZ C' protein

1 entry

Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) reference strain

NS6_SARS2 ORF6 protein (ORF6) (Accessory protein 6) (Non-structural protein 6) (ns6) (Protein X3)

1 entry

West Caucasian bat virus (WCBV) reference strain

PHOSP_WCBV Phosphoprotein (Protein P) (Protein M1)

1 entry

Yellow fever virus (strain 17D vaccine) (YFV) reference strain

POLG_YEFV1 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Zika virus (ZIKV) reference strain

POLG_ZIKV Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM ...

2 entries

Human respiratory syncytial virus A (strain Long)

Select_allDeselect_all
NS2_HRSVL Non-structural protein 2 (NS2) (Non-structural protein 1B)
NS1_HRSVL Non-structural protein 1 (Non-structural protein 1C)

2 entries

Human respiratory syncytial virus B (strain 18537)

Select_allDeselect_all
NS1_HRSV1 Non-structural protein 1 (Non-structural protein 1C)
NS2_HRSV1 Non-structural protein 2 (NS2) (Non-structural protein 1B)

2 entries

Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

Select_allDeselect_all
NS2_ORSVW Non-structural protein 2 (NS2) (Non-structural protein 1B)
NS1_ORSVW Non-structural protein 1 (Non-structural protein 1C)

1 entry

Alkhumra hemorrhagic fever virus (ALKV) (Alkhurma hemorrhagic fever virus)

POLG_ALKV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Aravan virus (ARAV)

PHOSP_ARAV Phosphoprotein (Protein P) (Protein M1)

1 entry

Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)

PHOSP_ABLVH Phosphoprotein (Protein P) (Protein M1)

1 entry

Banzi virus (BANV)

POLG_BANV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Bovine parainfluenza 3 virus (BPIV-3)

C_PI3B Protein C

1 entry

Bussuquara virus (BUSV)

POLG_BUSV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 1 (strain Brazil/97-11/1997) (DENV-1)

POLG_DEN1B Genome polyprotein [Cleaved into: Protein C (Core protein); Protein prM; Peptide pr; Small envelope ...

1 entry

Dengue virus type 1 (strain Singapore/S275/1990) (DENV-1)

POLG_DEN1S Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 2 (isolate Thailand/0168/1979) (DENV-2)

POLG_DEN28 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 2 (strain 16681-PDK53) (DENV-2)

POLG_DEN27 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 2 (strain Jamaica/1409/1983) (DENV-2)

POLG_DEN2J Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 2 (strain Peru/IQT2913/1996) (DENV-2)

POLG_DEN2Q Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 2 (strain Puerto Rico/PR159-S1/1969) (DENV-2)

POLG_DEN2P Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 2 (strain Thailand/16681/1984) (DENV-2)

POLG_DEN26 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)

POLG_DEN2N Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 3 (strain China/80-2/1980) (DENV-3)

POLG_DEN3C Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 3 (strain Martinique/1243/1999) (DENV-3)

POLG_DEN3M Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 3 (strain Philippines/H87/1956) (DENV-3)

POLG_DEN3P Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 3 (strain Singapore/8120/1995) (DENV-3)

POLG_DEN3I Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 3 (strain Sri Lanka/1266/2000) (DENV-3)

POLG_DEN3S Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 4 (strain Dominica/814669/1981) (DENV-4)

POLG_DEN4D Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 4 (strain Philippines/H241/1956) (DENV-4)

POLG_DEN4P Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 4 (strain Singapore/8976/1995) (DENV-4)

POLG_DEN4S Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 4 (strain Thailand/0348/1991) (DENV-4)

POLG_DEN4T Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 4 (strain Thailand/0476/1997) (DENV-4)

POLG_DEN4H Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Duvenhage virus (DUVV)

PHOSP_DUVV Phosphoprotein (Protein P) (Protein M1)

1 entry

Edge Hill virus (EHV)

POLG_EHV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Human parainfluenza 1 virus (strain C35) (HPIV-1)

C_PI1HB Protein C

1 entry

Human parainfluenza 1 virus (strain C39) (HPIV-1)

C_PI1HC Protein C

1 entry

Human parainfluenza 1 virus (strain CI-14/83) (HPIV-1)

C_PI1HE Protein C

1 entry

Human parainfluenza 1 virus (strain CI-5/73) (HPIV-1)

C_PI1HD Protein C

1 entry

Human parainfluenza 2 virus (HPIV-2)

V_PI2H Non-structural protein V

1 entry

Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human parainfluenza 3 virus (strain NIH 47885))

C_PI3H4 Protein C (VP18 protein)

1 entry

Human respiratory syncytial virus A (strain S-2) (HRSV-S2)

NS1_HRSS2 Non-structural protein 1 (NS1) (Non-structural protein 1C)

1 entry

Ilheus virus (ILHV)

POLG_ILHV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Irkut virus (IRKV)

PHOSP_IRKV Phosphoprotein (Protein P) (Protein M1)

1 entry

Japanese encephalitis virus (strain Jaoars982) (JEV)

POLG_JAEVJ Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Japanese encephalitis virus (strain M28) (JEV)

POLG_JAEVM Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Japanese encephalitis virus (strain SA(v)) (JEV)

POLG_JAEV5 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Japanese encephalitis virus (strain SA-14) (JEV)

POLG_JAEV1 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Khujand virus (KHUV)

PHOSP_KHUV Phosphoprotein (Protein P) (Protein M1)

1 entry

Kokobera virus (KOKV)

POLG_KOKV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Kunjin virus (strain MRM61C)

POLG_KUNJM Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

Kyasanur forest disease virus (KFDV)

POLG_KFDV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Lagos bat virus (LBV)

PHOSP_LBV Phosphoprotein (Protein P) (Protein M1)

1 entry

Langat virus (strain TP21)

POLG_LANVT Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

Louping ill virus (Li)

POLG_LIV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASE Non-structural protein V

1 entry

Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASA Non-structural protein V

1 entry

Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASI Non-structural protein V

1 entry

Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASY Non-structural protein V

1 entry

Mosquito cell fusing agent (CFA flavivirus)

POLG_MCFA Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM; ...

1 entry

Mumps virus (strain Enders) (MuV)

V_MUMPE Non-structural protein V (Non-structural protein NS1)

1 entry

Mumps virus (strain SBL) (MuV)

V_MUMPS Non-structural protein V (Non-structural protein NS1)

1 entry

Mumps virus (strain SBL-1) (MuV)

V_MUMP1 Non-structural protein V (Non-structural protein NS1)

1 entry

Murray valley encephalitis virus (strain MVE-1-51) (MVEV)

POLG_MVEV5 Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

Omsk hemorrhagic fever virus (OHFV)

POLG_OHFV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Phocine distemper virus (PDV)

V_PHODV Non-structural protein V

1 entry

Rabies virus (strain CVS-11) (RABV)

PHOSP_RABVC Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain China/DRV) (RABV)

PHOSP_RABVD Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain China/MRV) (RABV)

PHOSP_RABVR Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain ERA) (RABV)

PHOSP_RABVE Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain HEP-Flury) (RABV)

PHOSP_RABVH Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain India) (RABV)

PHOSP_RABVI Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain Nishigahara RCEH) (RABV)

PHOSP_RABVN Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain PM) (RABV)

PHOSP_RABVM Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain PM1503/AVO1) (RABV)

PHOSP_RABVA Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)

PHOSP_RABVB Phosphoprotein (Protein P) (Protein M1)

1 entry

Rinderpest virus (strain Kabete O) (RDV)

V_RINDK Non-structural protein V

1 entry

Rocio virus (ROCV)

POLG_ROCV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Sendai virus (strain 6/94) (SeV)

C_SEND6 Protein C'

1 entry

Sendai virus (strain Fushimi) (SeV)

C_SENDF Protein C'

1 entry

Sendai virus (strain Hamamatsu) (SeV)

C_SENDA Protein C'

1 entry

Sendai virus (strain Harris) (SeV)

C_SENDH Protein C'

1 entry

Sendai virus (strain Nagoya) (SeV)

C_SENDN Protein C'

1 entry

Tick-borne encephalitis virus (strain Hypr) (TBEV)

POLG_TBEVH Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

Tick-borne encephalitis virus European subtype (strain Neudoerfl) (NEUV) (Neudoerfl virus)

POLG_TBEVW Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

Tick-borne encephalitis virus Far Eastern subtype (strain Sofjin) (SOFV) (Sofjin virus)

POLG_TBEVS Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

Tick-borne powassan virus (strain LB) (POWV) (Powassan virus)

POLG_POWVL Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

Usutu virus (USUV)

POLG_USUV Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

Wesselsbron virus (WSLV)

POLG_WSLV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

West Nile virus (WNV)

POLG_WNV Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

West Nile virus (strain NY-99) (WNV) (West Nile virus (strain NY-1999))

POLG_WNV9 Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

Yellow fever virus (isolate Angola/14FA/1971) (YFV)

POLG_YEFVN Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Yellow fever virus (isolate Ethiopia/Couma/1961) (YFV)

POLG_YEFVE Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Yellow fever virus (isolate Ivory Coast/1999) (YFV)

POLG_YEFVC Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Yellow fever virus (isolate Ivory Coast/85-82H/1982) (YFV)

POLG_YEFVI Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Yellow fever virus (isolate Uganda/A7094A4/1948) (YFV)

POLG_YEFVU Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Yellow fever virus (strain French neurotropic vaccine FNV) (YFV)

POLG_YEFVF Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Yellow fever virus (strain Ghana/Asibi/1927) (YFV)

POLG_YEFVA Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Yellow fever virus (strain Trinidad/TRINID79A/1979) (YFV)

POLG_YEFVT Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Zika virus (isolate ZIKV/Human/Cambodia/FSS13025/2010) (ZIKV)

POLG_ZIKVK Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM ...

1 entry

Zika virus (isolate ZIKV/Human/French Polynesia/10087PF/2013) (ZIKV)

POLG_ZIKVF Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM ...