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Orthoflavivirus (taxid:3044782)

Former name: Flavivirus
Orthoflavivirus is a genus of ssRNA+ viruses in the Flaviviridae family that infect vertebrates and are transmitted by arthropods (arbovirus). In humans, these viruses can cause fevers with variable symptoms.

VIRION

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Enveloped, spherical, about 50 nm in diameter. The surface proteins are arranged in an icosahedral-like symmetry. Mature virions contain two virus-encoded membrane proteins (M and E), while immature virions contain a membrane protein precursor.
Source: Zhang et al("Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14528291)
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GENOME

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Monopartite, linear, ssRNA(+) genome of of 10-11 kb. The genome 5' end has a methylated nucleotide cap for canonical cellular translation. The 3' terminus is not polyadenylated but forms a loop structure. This secondary structure leads to the formation of a subgenomic flavivirus RNA (sfRNA) through genomic RNA degradation by host XRN1. sfRNA is essential for pathogenicity, and may play a role in inhibiting host RIG-I antiviral activity as shown for Dengue virus

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and the viral messenger RNA. The whole genome is translated in a polyprotein, which is processed co- and post-translationally by host and viral proteases.

ENZYMES

REPLICATION

  1. Attachement of the viral envelope protein E to host receptors mediates internalization into the host cell by clathrin-mediated endocytosis, or by apoptotic mimicry
  2. Fusion of virus membrane with host endosomal membrane. RNA genome is released into the cytoplasm.
  3. The positive-sense genomic ssRNA is translated into a polyprotein, which is cleaved into all structural and non structural proteins (to yield the replication proteins).
  4. Replication takes place at the surface of endoplasmic reticulum in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Virus assembly occurs at the endoplasmic reticulum. The virion buds at the endoplasmic reticulum and is transported to the Golgi apparatus.
  7. The prM protein is cleaved in the Golgi, thereby maturing the virion which is fusion competent.
  8. Release of new virions by exocytosis.
DB LINKS image image

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Dengue virus: BV-BRC Dengue Virus, NCBI Dengue, DengueMap, Dengue typing tool
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Yellow fever virus: typing tool image

West Nile virus: NCBI West nile image image

Zika virus: typing tool, NCBI Zika
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TAXONOMY Group IV; ssRNA positive-strand viruses
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Kitrinoviricota
Class: Flasuviricetes
Order:Amarillovirales
Family:Flaviridae
Genus: Flavivirus
VIRUS
REFERENCE STRAINS Zika virus (ZIKV)(strain MR 766)
Sequence | Genome assembly | Proteome
Yellow fever virus (YFV)(strain 17D vaccine)
Sequence | Genome assembly | Proteome
Dengue virus (DENV)(train Nauru/West Pac/1974)
Sequence | Genome assembly | Proteome
West nile virus (WNV) (lineage 2, strain 956)
Sequence | Genome assembly | Proteome

Host

NATURAL HOSTS Human, mammals, mosquitoes and ticks (arthropod-borne)
(DENV): Reservoir: Human, mosquitoes
(WNV): Reservoir: Birds, mosquitoes; Occasional: Human
(YFV): Reservoir: Monkeys, mosquitoes; Occasional: Human, mammals
(ZIKV); Reservoir: Monkeys, mosquitoes; Occasional: Human, mammals
TROPISM Dengue virus:phagocytes, hepatocytes
West Nile virus: epithelial cells in the skin, kidney, intestine, and testes.
INTERACTIONS Cell receptors:
DENV: heparan sulfate
Host-virus interaction

Ecology and disease

GEOGRAPHY DENV: South America, Africa, India, Oceania.
YFV: South America, Central Africa.
ZIKV: African and Asian tropical regions, Oceania.
ASSOCIATED DISEASES YFV: Hemorrhagic fever, encephalitis
DENV: Dengue fever
ZIKV: Zika fever
TRANSMISSION Zoonosis, arthropod bite, mainly mosquitoes
VACCINE Japanese encephalitis virus, Tick-borne encephalitis virus, West Nile virus, Yellow fever virus.
ANTIVIRAL DRUGS Ribavirin (Guanosine analog)
[YFV, WNV]"Favipiravir":http://en.wikipedia.org/wiki/Favipiravir (Experimental, nucleotide analog)
[YFV] Galidesivir (Experimental, adenosine analog)
[DENV]"Celgosivir":https://en.wikipedia.org/wiki/Celgosivir (Experimental, glycosyl transferase inhibitor)
[DENV]"Lactimidomycin":https://en.wikipedia.org/wiki/Lactimidomycin (Experimental, translation inhibitor)
NITD008 (Toxic in animals, adenosine analog)
[TEBV] Triazavirin (Experimental, RdRp inhibitor)

Host-virus interaction

Adaptive immune response inhibition

Dengue NS1 protein inhibits host complement by binding C4 and reducing C4b deposition and C3 convertase activity. Through this mechanism, NS1 protects DENV from complement-dependent neutralization in solution .

Apoptosis modulation

Flaviviruses NS3 induces apoptosis through host caspases activation .

Autophagy modulation

Flaviviruses NS4A and NS4B induces autophagy signaling .

Innate immune response inhibition

Dengue virus blocks STAT2 .

GENERAL Back to flavivirus page
NATURAL HOSTS Human, mammals, mosquitoes and ticks (arthropod-borne)
TROPISM Dengue virus:phagocytes, hepatocytes
West Nile virus: epithelial cells in the skin, kidney, intestine, and testes.
INTERACTIONS Cell receptors:
DENV: heparan sulfate
ASSOCIATED DISEASES YFV:Hemorrhagic fever, encephalitis
DENV: Dengue fever
ZIKV: Zika fever
TRANSMISSION Zoonosis, arthropod bite, mainly mosquitoes
VMR1009056 Orthoflavivirus apoiense ICTV19710089 E Apoi virus APOIV ApMAR AF160193 Complete genome vertebrates Q9J9C2
VMR1009057 Orthoflavivirus aroaense ICTV19990811 E Aroa virus AROAV BeAn 4073 AY632536 Complete genome invertebrates, vertebrates Q32ZE0
VMR1012783 Orthoflavivirus aroaense ICTV19990811 A Aroa virus AROAV VenA-1809 AF013362 Partial genome invertebrates, vertebrates O55786
VMR1012784 Orthoflavivirus aroaense ICTV19990811 A Bussuquara virus BSQV BeAn 4073 AF013366 Partial genome invertebrates, vertebrates O55790
VMR1012785 Orthoflavivirus aroaense ICTV19990811 A Iguape virus IGUV SP An71686 AF013375 Partial genome invertebrates, vertebrates O55799
VMR1012786 Orthoflavivirus aroaense ICTV19990811 A Naranjal virus NJLV 25008 AF013390 Partial genome invertebrates, vertebrates O55814
VMR1009058 Orthoflavivirus bagazaense ICTV19790887 E Bagaza virus BAGV DakAr B209 AY632545 Complete genome invertebrates, vertebrates Q32ZD1
VMR1009059 Orthoflavivirus banziense ICTV19710090 E Banzi virus BANV SAH 366 DQ859056 Complete genome invertebrates, vertebrates C8XPA8
VMR1009060 Orthoflavivirus boubouiense ICTV19760589 E Bouboui virus BOUV DAK AR B490 DQ859057 Complete genome invertebrates, vertebrates C8XPA9
VMR1009061 Orthoflavivirus bravoense ICTV19760625 E Rio Bravo virus RBV RiMAR AF144692 Complete genome vertebrates Q9JAD5
VMR1009062 Orthoflavivirus bukalasaense ICTV19710091 E Bukalasa bat virus BBV UGBP-111 AF013365 Partial genome vertebrates O55789
VMR1009063 Orthoflavivirus cacipacoreense ICTV19990816 E Cacipacor? virus CPCV BeAn 3276000 KF917536 Complete genome invertebrates, vertebrates A0A0C4PNF2
VMR1009064 Orthoflavivirus careyense ICTV19760592 E Carey Island virus CIV P70-1215 AF013368 Partial genome vertebrates O55792
VMR1009065 Orthoflavivirus cowboneense ICTV19710093 E Cowbone Ridge virus CRV W-10986 AF013370 Partial genome vertebrates O55794
VMR1009066 Orthoflavivirus dakarense ICTV19710094 E Dakar bat virus DBV 209 AF013371 Partial genome vertebrates O55795
VMR1009067 Orthoflavivirus denguei ICTV19990820 E dengue virus type 2 DENV-2 16681 U87411 Complete genome invertebrates, vertebrates O09234
VMR1012787 Orthoflavivirus denguei ICTV19990820 A dengue virus type 1 DENV-1 45AZ5 U88536 Complete genome invertebrates, vertebrates P17763
VMR1012788 Orthoflavivirus denguei ICTV19990820 A dengue virus type 3 DENV-3 H87 M93130 Complete genome invertebrates, vertebrates P27915
VMR1012789 Orthoflavivirus denguei ICTV19990820 A dengue virus type 4 DENV-4 814669 AF326573 Complete genome invertebrates, vertebrates P09866
VMR1009068 Orthoflavivirus edgehillense ICTV19710099 E Edge Hill virus EHV YMP 48 DQ859060 Complete genome invertebrates, vertebrates C8XPB2
VMR1009069 Orthoflavivirus encephalitidis ICTV19790934 E tick-borne encephalitis virus-European subtype TBEV-Eur Neudoerfl U27495 Complete genome invertebrates, vertebrates P14336
VMR1012790 Orthoflavivirus encephalitidis ICTV19790934 A tick-borne encephalitis virus - Far Eastern subtype TBEV-FE Sofjin X07755 Partial genome invertebrates, vertebrates P07720
VMR1012791 Orthoflavivirus encephalitidis ICTV19790934 A tick-borne encephalitis virus-Siberian subtype TBEV-Sib Vasilchenko L40361 Complete genome invertebrates, vertebrates Q9DUT7
VMR1009070 Orthoflavivirus entebbeense ICTV19710100 E Entebbe bat virus ENTV UgIL-30 DQ837641 Complete genome vertebrates Q32ZD9
VMR1012792 Orthoflavivirus entebbeense ICTV19710100 A Sokuluk virus SOKV LEIV-400K AF013405 Partial genome vertebrates O55829
VMR1009071 Orthoflavivirus flavi ICTV19710125 E yellow fever virus YFV 17D X03700 Complete genome invertebrates, vertebrates P03314
VMR1009072 Orthoflavivirus gadgetsense ICTV19990823 E Gadgets Gully virus GGYV Aus DQ235145 Complete genome invertebrates, vertebrates A0EKU2
VMR1009073 Orthoflavivirus ilheusense ICTV19990824 E Ilh?us virus ILHV Original AY632539 Complete genome invertebrates, vertebrates Q32ZD7
VMR1012793 Orthoflavivirus ilheusense ICTV19990824 A Rocio virus ROCV H-34675 AF013397 Partial genome invertebrates, vertebrates O55821
VMR1009074 Orthoflavivirus israelense ICTV19710102 E Israel turkey meningoencephalomyelitis virus ITV AF013377 Partial genome invertebrates, vertebrates O55801
VMR1009075 Orthoflavivirus japonicum ICTV19710103 E Japanese encephalitis virus JEV JaOArS982 M18370 Complete genome invertebrates, vertebrates P32886
VMR1009076 Orthoflavivirus jugraense ICTV19990827 E Jugra virus JUGV P-9-314 DQ859066 Complete genome invertebrates, vertebrates C8XPB8
VMR1009077 Orthoflavivirus jutiapaense ICTV19760607 E Jutiapa virus JUTV JG-128 KJ469371 Complete genome vertebrates A0A0C4W3V9
VMR1009078 Orthoflavivirus kadamense ICTV19990829 E Kadam virus KADV Uganda DQ235146 Complete genome invertebrates, vertebrates A0EKU3
VMR1009079 Orthoflavivirus kedougouense ICTV19990830 E K?dougou virus KEDV DakAar D1470 AY632540 Complete genome invertebrates, vertebrates Q32ZD6
VMR1009080 Orthoflavivirus kokoberaorum ICTV19990831 E Kokobera virus KOKV AusMRM 32 AY632541 Complete genome invertebrates, vertebrates Q32ZD5
VMR1012794 Orthoflavivirus kokoberaorum ICTV19990831 A Stratford virus STRV AUSC-338 AF013407 Partial genome invertebrates, vertebrates O55831
VMR1009081 Orthoflavivirus koutangoense ICTV19760611 E Koutango virus KOUV Dak Ar D1470 AF013384 Partial genome invertebrates, vertebrates O55808
VMR1009082 Orthoflavivirus kyasanurense ICTV19710106 E Kyasanur Forest disease virus KFDV AY323490 Complete genome invertebrates, vertebrates D7RF80
VMR1012795 Orthoflavivirus kyasanurense ICTV19710106 A Alkhumra hemorrhagic fever virus AHFV 1176 AF331718 Complete genome invertebrates, vertebrates Q91B85
VMR1009083 Orthoflavivirus langatense ICTV19710107 E Langat virus LGTV TP21 AF253419 Complete genome invertebrates, vertebrates Q9IG40
VMR1009084 Orthoflavivirus louisense ICTV19710117 E St. Louis encephalitis virus SLEV Kern217 DQ525916 Complete genome invertebrates, vertebrates A1BQD2
VMR1009085 Orthoflavivirus loupingi ICTV19710108 E louping ill virus LIV 369/T2 Y07863 Complete genome invertebrates, vertebrates P22338
VMR1012800 Orthoflavivirus loupingi ICTV19710108 A Greek goat encephalitits virus subtype GGEV Vergina DQ235153 Coding-complete genome invertebrates, vertebrates
VMR1012796 Orthoflavivirus loupingi ICTV19710108 A louping ill virus-British subtype LIV-Brit LI/31 D12937 Partial genome invertebrates, vertebrates P35764
VMR1012797 Orthoflavivirus loupingi ICTV19710108 A louping ill virus-Irish subtype LIV-Ir LI/MA54 X86784 Partial genome invertebrates, vertebrates O40972
VMR1012798 Orthoflavivirus loupingi ICTV19710108 A louping ill virus-Spanish subtype LIV-Spain 87/2617 DQ235152 Coding-complete genome invertebrates, vertebrates
VMR1012799 Orthoflavivirus loupingi ICTV19710108 A Turkish sheep encephalitis virus subtype TSEV TTE80 DQ235151 Coding-complete genome invertebrates, vertebrates A0EKU8
VMR1009086 Orthoflavivirus meabanense ICTV19910741 E Meaban virus MEAV France DQ235144 Complete genome invertebrates, vertebrates A0EKU1
VMR1009087 Orthoflavivirus modocense ICTV19710109 E Modoc virus MODV M544 AJ242984 Complete genome vertebrates Q8QL64
VMR1009088 Orthoflavivirus montanaense ICTV19990838 E Montana myotis leukoencephalitis virus MMLV USA AJ299445 Complete genome vertebrates Q8JJZ3
VMR1009089 Orthoflavivirus murrayense ICTV19990839 E Murray Valley encephalitis virus MVEV 18629 AF161266 Complete genome invertebrates, vertebrates P05769
VMR1012801 Orthoflavivirus murrayense ICTV19990839 A Alfuy virus ALFV MRM-3929 AF013360 Partial genome invertebrates, vertebrates A0A7G0QMU0
VMR1009090 Orthoflavivirus nilense ICTV19990858 E West Nile virus WNV 956 M12294 Complete genome invertebrates, vertebrates P06935
VMR1012802 Orthoflavivirus nilense ICTV19990858 A Kunjin virus KUNV MRM61C D00246 Complete genome invertebrates, vertebrates P14335
VMR1009091 Orthoflavivirus ntayaense ICTV19710113 E Ntaya virus NTAV IPDIA JX236040 Complete genome invertebrates, vertebrates K0BRZ6
VMR1009092 Orthoflavivirus omskense ICTV19710114 E Omsk hemorrhagic fever virus OHFV Bogoluvovska AY193805 Complete genome invertebrates, vertebrates Q7T6D2
VMR1009093 Orthoflavivirus perlitaense ICTV19910755 E San Perlita virus SPV 71V-1251 AF013402 Partial genome vertebrates O55826
VMR1009094 Orthoflavivirus phnompenhense ICTV19760623 E Phnom Penh bat virus PPBV CAMA-38D AF013394 Partial genome vertebrates O55818
VMR1012803 Orthoflavivirus phnompenhense ICTV19760623 A Batu Cave virus BCV P70-1459 AF013369 Partial genome vertebrates O55793
VMR1009095 Orthoflavivirus powassanense ICTV19710115 E Powassan virus POWV LB L06436 Complete genome invertebrates, vertebrates Q04538
VMR1012804 Orthoflavivirus powassanense ICTV19710115 A deer tick virus DTV ctb30 AF311056 Coding-complete genome invertebrates, vertebrates Q8VBK7
VMR1009096 Orthoflavivirus royalense ICTV19990845 E Royal Farm virus RFV Afghanistan DQ235149 Complete genome invertebrates, vertebrates A0EKU6
VMR1009097 Orthoflavivirus saboyaense ICTV19760628 E Saboya virus SABV Dak AR D4600 DQ859062 Complete genome invertebrates, vertebrates C8XPB4
VMR1012805 Orthoflavivirus saboyaense ICTV19760628 A Potiskum virus POTV IBAN 10069 DQ859067 Coding-complete genome invertebrates, vertebrates C8XPB9
VMR1009098 Orthoflavivirus saumarezense ICTV19790927 E Saumarez Reef virus SREV Australia DQ235150 Complete genome invertebrates, vertebrates A0EKU7
VMR1009099 Orthoflavivirus sepikense ICTV19990850 E Sepik virus SEPV MK7148 DQ837642 Complete genome invertebrates, vertebrates A1Y2M8
VMR1009100 Orthoflavivirus tembusu ICTV19760634 E Tembusu virus TMUV JS804 JF895923 Complete genome invertebrates, vertebrates G1CRV4
VMR1009101 Orthoflavivirus tyuleniyense ICTV19760635 E Tyuleniy virus TYUV LEIV-6C KF815939 Complete genome invertebrates, vertebrates W5VK97
VMR1009102 Orthoflavivirus ugandaense ICTV19710120 E Uganda S virus UGSV Uganda DQ859065 Complete genome invertebrates, vertebrates C8XPB7
VMR1009103 Orthoflavivirus usutuense ICTV19710122 E Usutu virus USUV Vienna 2001 AY453411 Complete genome invertebrates, vertebrates Q5WPU5
VMR1009104 Orthoflavivirus viejaense ICTV19910756 E Sal Vieja virus SVV 38TWM-106 AF013401 Partial genome vertebrates O55825
VMR1009105 Orthoflavivirus wesselsbronense ICTV19990857 E Wesselsbron virus WESSV SAH177 EU707555 Complete genome invertebrates, vertebrates C5H431
VMR1009106 Orthoflavivirus yaoundeense ICTV19990859 E Yaound? virus YAOV DakArY 276 AF013413 Partial genome invertebrates, vertebrates O55837
VMR1009107 Orthoflavivirus yokoseense ICTV19910772 E Yokose virus YOKV Oita 36 AB114858 Complete genome vertebrates Q7T918
VMR1009108 Orthoflavivirus zikaense ICTV19990862 E Zika virus ZIKV MR 766 AY632535 Complete genome invertebrates, vertebrates P0DXN9
VMR1012806 Orthoflavivirus zikaense ICTV19990862 A Zika virus ZIKV Pf13/251013-18 KY766069 Complete genome invertebrates, vertebrates A0A2H4GY08
VMR1012807 Orthoflavivirus zikaense ICTV19990862 A Zika virus ZIKV H/PF/2013 KJ776791 Complete genome invertebrates, vertebrates A0A024B7W1
VMR1012808 Orthoflavivirus zikaense ICTV19990862 A Zika virus ZIKV PRVABC59 KX377337 Complete genome invertebrates, vertebrates A0AA97PZD4

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

68 entries grouped by strain

2 entries

Zika virus (ZIKV) reference strain

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POLG_ZIKV Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM ...

pdb 5GJ4; 5GPI; 5GXJ; 5JPS; 5JRZ; 5K6K; 5RHG; 5RHH; 5RHI; 5RHJ; 5RHK; 5RHL; 5RHM; 5RHO; 5RHP; 5RHQ; 5RHR; 5RHS; 5RHT; 5RHU; 5RHV; 5RHW; 5RHX; 5RHY; 5T1V; 5TFN; 5TFO; 5TFR; 5TMH; 5U04; 5U0B; 5U0C; 5VI7; 5VIM; 5W41; 5Y4Z; 5YOD; 5YOF; 5Z0R; 5Z0V; 5ZMQ; 5ZMS; 5ZOB; 6ADW; 6ADX; 6ADY; 6JPW; 6KK2; 6KK3; 6KK4; 6KK5; 6KK6; 6KPQ; 6L50; 6MH3; 6UX2; 6WCZ; 6Y3B; 7G9K; 7G9L; 7G9M; 7G9N; 7G9O; 7G9P; 7G9Q; 7G9R; 7G9S; 7G9T; 7G9U; 7G9V; 7G9W; 7G9X; 7G9Y; 7G9Z; 7GA0; 7GA1; 7GA2; 7GA3; 7GA4; 7GA5; 7GA6; 7GA7; 7H1H; 7H1I; 7H1J; 7H1K; 7H1L; 7H1M; 7H1N; 7H1O; 7H1P; 7H1Q; 7H1R; 7H1S; 7H1T; 7H1U; 7H1V; 7H1W; 7H1X; 7H1Y; 7H1Z; 7H20; 7H21; 7H22; 7H23; 7H24; 7H25; 7H26; 7H27; 7H28; 7H29; 7H2A; 7H2B; 7H2C; 7H2D; 7H2E; 7H2F; 7H2G; 7H2H; 7H2I; 7H2J; 7H2K; 7H2L; 7H2M; 7H2N; 7H2O; 7H2P; 7H2Q; 7H2R; 7H2S; 7HOJ; 7HOK; 7HOL; 7HOM; 7HOP; 7HOQ; 7HOR; 7HOS; 7HOT; 7HOU; 7HOV; 7HOW; 7HOX; 7HOZ; 7HP0; 7HP1; 7HP2; 7HP4; 7HP5; 7HP6; 7HP7; 7HP8; 7HP9; 7HPA; 7HPB; 7HPC; 7HPD; 7HPE; 7HPF; 7HPG; 7HPH; 7I1K; 7I1L; 7I1M; 7I1N; 7I1O; 7I1P; 7I1Q; 7I1S; 7I1T; 7I1V; 7I1W; 7I1Y; 7I1Z; 7I20; 7I21; 7I22; 7O2M; 7O55; 7OBV; 7OC2; 7PFQ; 7PFY; 7PFZ; 7PG1; 7PGC; 7VLG; 7VLH; 7VLI; 7VXX; 7VXY; 7ZLC; 7ZLD; 7ZMI; 7ZNO; 7ZPD; 7ZQ1; 7ZQF; 7ZTM; 7ZUM; 7ZV4; 7ZVV; 7ZW5; 7ZWK; 7ZYS; 8A15; 8AQA; 8AQB; 8AQK; 8PEM; 8PN6; 8UM3; 8V7R; 8V7U; 8WN8; 8WNP; 8WNU; 8WO0; 8WO4

UORF_ZIKV uORF protein

1 entry

Dengue virus type 1 (strain Nauru/West Pac/1974) (DENV-1) reference strain

POLG_DEN1W Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM ...

pdb 3J8D; 3L6P; 3LKW; 4AL8; 4GSX; 4GT0; 4LCY; 4OIG; 5VIC; 5WJL; 5WKF; 7DWT; 7DWU; 8VPR

1 entry

Yellow fever virus (strain 17D vaccine) (YFV) reference strain

POLG_YEFV1 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 1NA4; 1YKS; 3EVA; 3EVB; 3EVC; 3EVD; 3EVE; 3EVF; 5FFM; 5N6B; 6EPK; 6IW0; 6IW1; 6IW2; 6IW4; 6QSN; 6SS7; 6SS8; 6SS9; 6SSA; 8ZB9; 8ZBA

3 entries

Zika virus (isolate ZIKV/Human/Cambodia/FSS13025/2010) (ZIKV)

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POLG_ZIKVK Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM ...

pdb 6UTA; 7BPK; 7BQ5

ORF1_ZIKVK uORF1 protein
ORF2_ZIKVK uORF2 protein

3 entries

Zika virus (isolate ZIKV/Human/French Polynesia/10087PF/2013) (ZIKV)

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POLG_ZIKVF Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM ...

pdb 5GOZ; 5GP1; 5H30; 5H32; 5H37; 5IRE; 5IZ7; 5JMT; 5KQR; 5KQS; 5KVE; 5LBS; 5LBV; 5LCV; 5M5B; 5MRK; 5NJU; 5NJV; 5U4W; 5UHY; 5ULP; 5Y0A; 5Y6M; 5Y6N; 6CO8; 6I7P; 6JFH; 6JFI; 6LD1; 6LD2; 6LD3; 6LD4; 6LD5; 6NIP; 6NIU; 6PLK; 6RWZ; 6S0J; 6UM3; 7A3N; 7A3U; 7BSD; 7BU8; 7BUA; 7M1V; 7T17; 7V2Z; 7YAR; 7YW7; 7YW8; 8EE5; 8EE8; 8EED; 8EEE

ORF1_ZIKVF uORF1 protein
ORF2_ZIKVF uORF2 protein

2 entries

Japanese encephalitis virus (strain Jaoars982) (JEV)

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POLS_JAEVJ Structural polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; ...
POLG_JAEVJ Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 5YWO; 5YWP

2 entries

Japanese encephalitis virus (strain M28) (JEV)

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POLG_JAEVM Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...
POLS_JAEVM Structural polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; ...

2 entries

Japanese encephalitis virus (strain SA(v)) (JEV)

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POLS_JAEV5 Structural polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; ...
POLG_JAEV5 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

2 entries

Japanese encephalitis virus (strain SA-14) (JEV)

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POLS_JAEV1 Structural polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; ...
POLG_JAEV1 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 2Z83; 3P54; 4HDG; 4HDH; 4K6M; 4MTP; 5MV1; 5MV2; 5O19; 5O36; 5OW2; 5WSN; 5YWO; 5YWP

1 entry

Alkhumra hemorrhagic fever virus (ALKV) (Alkhurma hemorrhagic fever virus)

POLG_ALKV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Banzi virus (BANV)

POLG_BANV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Bussuquara virus (BUSV)

POLG_BUSV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 1 (strain Brazil/97-11/1997) (DENV-1)

POLG_DEN1B Genome polyprotein [Cleaved into: Protein C (Core protein); Protein prM; Peptide pr; Small envelope ...

pdb 3UZQ

1 entry

Dengue virus type 1 (strain Singapore/S275/1990) (DENV-1)

POLG_DEN1S Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 3L6P; 3LKW

1 entry

Dengue virus type 2 (isolate Thailand/0168/1979) (DENV-2)

POLG_DEN28 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 1P58; 2M9P; 2M9Q; 3C6D

1 entry

Dengue virus type 2 (strain 16681-PDK53) (DENV-2)

POLG_DEN27 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 2R29; 3EVG; 6FLA

1 entry

Dengue virus type 2 (strain Jamaica/1409/1983) (DENV-2)

POLG_DEN2J Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 3UZV; 6VG5; 6VSO

1 entry

Dengue virus type 2 (strain Peru/IQT2913/1996) (DENV-2)

POLG_DEN2Q Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 3IXY

1 entry

Dengue virus type 2 (strain Puerto Rico/PR159-S1/1969) (DENV-2)

POLG_DEN2P Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 1L9K; 1OAN; 1OK8; 1OKE; 1P58; 1R6A; 1R6R; 1THD; 2P1D; 2P3L; 2P3O; 2P3Q; 2P40; 2P41; 3J8D; 3ZKO; 4M9F; 4M9I; 4M9K; 4M9M; 4M9T; 5HHG

1 entry

Dengue virus type 2 (strain Thailand/16681/1984) (DENV-2)

POLG_DEN26 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 2R69; 4O6B; 6WER; 6WY1; 6ZQU; 7K93

1 entry

Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)

POLG_DEN2N Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 3IYA; 3J27; 3J2P; 4CBF; 4UIH; 6FLA; 6FLB; 6FLC; 6IZX; 6IZY; 9DOF; 9DOG; 9DTT

1 entry

Dengue virus type 3 (strain China/80-2/1980) (DENV-3)

POLG_DEN3C Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 3 (strain Martinique/1243/1999) (DENV-3)

POLG_DEN3M Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 3 (strain Philippines/H87/1956) (DENV-3)

POLG_DEN3P Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 1UZG; 2J7U; 2J7W; 3P8Z; 3P97; 3UZE; 3VTT; 5CCV; 5E9Q; 5EC8; 5EHG; 5EHI; 5EIF; 5EIW; 5EKX; 7A3S; 7A3T

1 entry

Dengue virus type 3 (strain Singapore/8120/1995) (DENV-3)

POLG_DEN3I Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 3U1I; 3U1J; 4CTJ; 4CTK; 4V0Q; 4V0R

1 entry

Dengue virus type 3 (strain Sri Lanka/1266/2000) (DENV-3)

POLG_DEN3S Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 2J7U; 2J7W; 3VWS; 4C11; 4HHJ; 5DTO; 5EIW; 5F3T; 5F3Z; 5F41; 5HMW; 5HMX; 5HMY; 5HMZ; 5HN0; 5I3P; 5I3Q; 5IQ6; 5JJR; 5JJS; 5WJN; 5WKH; 6H80; 6H9R; 6XD0; 6XD1

1 entry

Dengue virus type 4 (strain Dominica/814669/1981) (DENV-4)

POLG_DEN4D Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 2H0P; 3UAJ; 3UC0; 3WE1; 4X42; 5B1C; 7A3Q

1 entry

Dengue virus type 4 (strain Philippines/H241/1956) (DENV-4)

POLG_DEN4P Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 4AM0; 7VMV; 8WBB; 8WBC; 8WBD; 8WBE

1 entry

Dengue virus type 4 (strain Singapore/8976/1995) (DENV-4)

POLG_DEN4S Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 4 (strain Thailand/0348/1991) (DENV-4)

POLG_DEN4T Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 2JLQ; 2JLR; 2JLS; 2JLU; 2JLV; 2JLW; 2JLX; 2JLY; 2JLZ; 2WHX; 2WZQ; 3UYP; 5YVV; 5YVW

1 entry

Dengue virus type 4 (strain Thailand/0476/1997) (DENV-4)

POLG_DEN4H Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Edge Hill virus (EHV)

POLG_EHV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Ilheus virus (ILHV)

POLG_ILHV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 7WD4

1 entry

Kokobera virus (KOKV)

POLG_KOKV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 2V6I; 2V6J

1 entry

Kunjin virus (strain MRM61C)

POLG_KUNJM Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 1SFK; 2HCN; 2HCS; 2HFZ; 2OF6; 2QEQ

1 entry

Kyasanur forest disease virus (KFDV)

POLG_KFDV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 7V4Q; 7V4R

1 entry

Langat virus (strain TP21)

POLG_LANVT Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 1Z66; 2GG1; 7WNJ; 8YNJ; 9FK0; 9H28

1 entry

Louping ill virus (Li)

POLG_LIV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 6J5C

1 entry

Mosquito cell fusing agent (CFA flavivirus)

POLG_MCFA Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM; ...

1 entry

Murray valley encephalitis virus (strain MVE-1-51) (MVEV)

POLG_MVEV5 Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 2PX2; 2PX4; 2PX5; 2PX8; 2PXA; 2PXC; 2V8O; 2WV9

1 entry

Omsk hemorrhagic fever virus (OHFV)

POLG_OHFV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Rocio virus (ROCV)

POLG_ROCV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Tembusu virus (TMUV)

POLG_TMUV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Tick-borne encephalitis virus (strain Hypr) (TBEV)

POLG_TBEVH Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 5O6A; 5O6V; 7JNO; 7QS9; 7QSA; 8ECH; 8QRH

1 entry

Tick-borne encephalitis virus European subtype (strain Neudoerfl) (NEUV) (Neudoerfl virus)

POLG_TBEVW Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 1N6G; 1NA4; 1SVB; 1URZ; 6J5G; 6S8C; 7BLV; 7BM0; 7LSF; 7LSG; 7NXU; 7OJ4; 7QRE; 7QRF; 7QRG; 7YWQ

1 entry

Tick-borne encephalitis virus Far Eastern subtype (strain Sofjin) (SOFV) (Sofjin virus)

POLG_TBEVS Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 1K4R; 7LSE; 8QRH; 8R2L; 8R8L

1 entry

Tick-borne powassan virus (strain LB) (POWV) (Powassan virus)

POLG_POWVL Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 7SGT

1 entry

Usutu virus (USUV)

POLG_USUV Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 6A0P; 6S92; 6S93; 6S94; 8B51; 8B52

1 entry

Wesselsbron virus (WSLV)

POLG_WSLV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

West Nile virus (WNV)

POLG_WNV Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 2FP7; 2GGV; 2IJO; 2P5P; 2YOL; 3E90; 3I50; 5IDK

1 entry

West Nile virus (strain NY-99) (WNV) (West Nile virus (strain NY-1999))

POLG_WNV9 Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 2OY0; 3I50; 3IYW; 3J0B; 3LKZ; 4O6C; 4O6D; 4OIE; 4OII; 6UTE; 7E4K; 8CO8

1 entry

Yellow fever virus (isolate Angola/14FA/1971) (YFV)

POLG_YEFVN Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 5YXA; 8GPT; 8GPX

1 entry

Yellow fever virus (isolate Ethiopia/Couma/1961) (YFV)

POLG_YEFVE Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Yellow fever virus (isolate Ivory Coast/1999) (YFV)

POLG_YEFVC Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Yellow fever virus (isolate Ivory Coast/85-82H/1982) (YFV)

POLG_YEFVI Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Yellow fever virus (isolate Uganda/A7094A4/1948) (YFV)

POLG_YEFVU Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Yellow fever virus (strain French neurotropic vaccine FNV) (YFV)

POLG_YEFVF Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Yellow fever virus (strain Ghana/Asibi/1927) (YFV)

POLG_YEFVA Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 2JQM; 2JV6; 6EPK; 8OFN

1 entry

Yellow fever virus (strain Trinidad/TRINID79A/1979) (YFV)

POLG_YEFVT Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...