Hpunavirus

VIRION

Non-enveloped, head-tail structure. Heads are about 60 nm in diameter and tails 135 × 18 nm. The tail is contractile, has 6 long terminal fibers, 6 short spikes and a small base plate. The capsid has an elongated icosahedral symmetry T=7, composed of 72 capsomers (60 hexamers and 12 pentamers). Upon contraction, the tail sheath becomes loose and slides along the tail core.

GENOME

Linear, dsDNA genome of about 33 kb, encoding for about 45 proteins.

GENE EXPRESSION

Genes are transcribed by operons.

REPLICATION

CYTOPLASMIC

  1. Adsorption: the phage attaches to the target cell through its tail fibers.
  2. Viral exolysin degrades cell wall locally
  3. Ejection of the viral DNA into host cell cytoplasm by contraction of the tail sheath.
  4. Transcription and translation of early genes.
  5. Replication of genomic DNA by rolling circle. Linear molecules are generated from closed circular monomer product by viral terminase proteins.
  6. Transcription and translation of late genes.
  7. Assembly of an empty procapsid and packaging of the genome.
  8. Viral tail fibers assembly and viral tail assembly.
  9. Mature virions are released from the cell by lysis.

Matching UniProtKB/Swiss-Prot entries

41 entries grouped by strain (browse by keywords)

41 entries

Haemophilus phage HP1 (strain HP1c1) (Bacteriophage HP1) reference strain

Select_allDeselect_all
CAPSD_BPHC1 Major capsid protein (Gene product 18) (gp18) (Major head protein) (ORF18)
YO22_BPHC1 Uncharacterized 26.0 kDa protein in rep-hol intergenic region (ORF22)
YO02_BPHC1 Uncharacterized 7.9 kDa protein in int-C1 intergenic region (ORF16) (ORF2)
YO10_BPHC1 Uncharacterized 11.1 kDa protein in rep-hol intergenic region (ORF10)
YO23_BPHC1 Putative tail sheath protein (ORF23)
YO33_BPHC1 Uncharacterized 28.3 kDa protein in lys 3'region (ORF33)
YO09_BPHC1 Uncharacterized 9.7 kDa protein in cox-rep intergenic region (ORF25) (ORF9)
YO07_BPHC1 Uncharacterized 7.3 kDa protein in cox-rep intergenic region (ORF23) (ORF7)
VPM_BPHC1 Probable terminase, endonuclease subunit (ORF19)
YO35_BPHC1 Uncharacterized 58.7 kDa protein in lys 3'region (ORF35)
ENLYS_BPHC1 SAR-endolysin (EC 3.2.1.17) (Endolysin) (Lysis protein) (Lysozyme) (Muramidase)
FIB31_BPHC1 Probable tail fiber protein (Gene product 31) (gp31) (ORF31)
HOLIN_BPHC1 Holin (Pinholin)
BP29_BPHC1 Putative baseplate protein gp29 (Gene 29 protein) (Gp29)
PORTL_BPHC1 Probable portal protein (ORF15)
RPC1_BPHC1 Repressor protein CI
VPP_BPHC1 Probable terminase, ATPase subunit (ORF16)
TAIL1_BPHC1 Putative tail protein gp30 (Gene product 30) (gp30)
REP_BPHC1 Replication protein (EC 3.1.-.-)
YO04_BPHC1 Uncharacterized 8.9 kDa protein in int-C1 intergenic region (ORF18) (ORF4)
YO28_BPHC1 Uncharacterized 12.7 kDa protein in lys 3'region (ORF28)
YO12_BPHC1 Uncharacterized 18.2 kDa protein in rep-hol intergenic region (ORF12)
YO11_BPHC1 Uncharacterized 8.3 kDa protein in rep-hol intergenic region (ORF11)
TMP_BPHC1 Probable tape measure protein (TMP) (Gene product 27) (gp27)
YO26_BPHC1 Uncharacterized 11.3 kDa protein in lys 3'region (ORF26)
YO05_BPHC1 Uncharacterized 19.2 kDa protein in cox-rep intergenic region (ORF21) (ORF5)
YO03_BPHC1 Uncharacterized 8.9 kDa protein in int-C1 intergenic region (ORF17) (ORF3)
VPL_BPHC1 Probable head completion/stabilization protein (ORF20)
YO32_BPHC1 Uncharacterized 23.3 kDa protein in lys 3'region (ORF32)
YO34_BPHC1 Uncharacterized 20.8 kDa protein in lys 3'region (ORF34)
YO25_BPHC1 Uncharacterized 13.1 kDa protein in lys 3'region (ORF25)
VINT_BPHC1 Integrase (EC 2.7.7.-) (EC 3.1.-.-)
SCAF_BPHC1 Capsid assembly scaffolding protein (Gene product 17) (Gp17) (Head morphogenesis protein) (Scaffold ...
YO01_BPHC1 Uncharacterized 23.2 kDa protein in int-C1 intergenic region (ORF1)
YO08_BPHC1 Uncharacterized 10.8 kDa protein in cox-rep intergenic region (ORF24) (ORF8)
YO24_BPHC1 Putative tail tube protein (ORF24)
YO06_BPHC1 Uncharacterized 14.1 kDa protein in cox-rep intergenic region (ORF22) (ORF6)
YO13_BPHC1 Uncharacterized adenine-specific methylase (EC 2.1.1.72) (ORF13)
YO14_BPHC1 Uncharacterized 14.9 kDa protein in rep-hol intergenic region (ORF14)
YO21_BPHC1 Uncharacterized 19.2 kDa protein in rep-hol intergenic region (ORF21)
VCOX_BPHC1 Regulatory protein cox