Comovirus

VIRION

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Non-enveloped, 28-30 nm in diameter, T=pseudo3 icosahedral capsid. The capsid is composed of 60 CPS (whih one jelly rolls domain) and 60 CPL proteins (with two jell rolls domains). Genomic RNAs are encapsidated separately into two different types of particle of similar size.
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GENOME

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Segmented, bipartite linear ssRNA(+) genome composed of RNA-1=6-8 kb and RNA-2=4-7 kb. Each genomic segment has a VPg linked to its 5' end and a 3' poly(A) tract.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and mRNA.
RNA-1 and RNA-2 are translated into two polyproteins, which are then processed into functional proteins. RNA-1 encodes proteins necessary for replication, while RNA2 encodes two capsid proteins and product(s) involved in cell-to-cell movement.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. Synthesis and proteolytic cleavage of the replicase polyprotein RNA-1.
  4. Replication occurs in viral factories made of membrane vesicles derived from the ER. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Assembly of new virus particles.
  7. Movement protein allows cell-to-cell movement.

Matching UniProtKB/Swiss-Prot entries

10 entries grouped by protein (browse by keywords)

4 entries

RNA1 polyprotein (Genome polyprotein B) (P1)

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POL1_CPMVS
Cowpea mosaic virus (strain SB) (CPMV) reference strain

RNA1 polyprotein (B RNA polyprotein) (Bottom component polyprotein) (Genome polyprotein B) (P1)

POL1_BPMV
Bean-pod mottle virus (strain Kentucky G7) (BPMV)
POL1_CPSMV
Cowpea severe mosaic virus (strain DG) (CPSMV)
POL1_RCMV
Red clover mottle virus (RCMV)

6 entries

RNA2 polyprotein (Genome polyprotein M) (M RNA polyprotein) (Middle component RNA polyprotein) (P2)

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POL2_CPMVS
Cowpea mosaic virus (strain SB) (CPMV) reference strain
POL2_APMV
Andean potato mottle virus (APMV)
POL2_BPMV
Bean-pod mottle virus (strain Kentucky G7) (BPMV)
POL2_CPSMV
Cowpea severe mosaic virus (strain DG) (CPSMV)
POL2_RCMV
Red clover mottle virus (RCMV)
POL2_SQMVM
Squash mosaic virus (strain melon) (SqMV)