Viral short tail ejection system (kw:KW-1244)

The short tail of Podoviridae acts as a molecular machine that ejects the viral DNA from the capsid into the host cell cytoplasm.

The ejection system consists of a central tube, the connector which attaches the tail to the phage capsid and released inner core proteins

.

Upon binding to the host cell surface, podoviruses display a tube-like extension of their short tail that penetrates both host membranes. This tail extension comes from the release of viral core proteins with channel forming properties

.

The source of the forces that drive viral genome ejection is probably in part due to osmotic pressure imbalance between the virus inside and the host cytoplasm

Gram(-) hosts:

Attachment to a host cell outer membrane (OM) receptor.
Ejection proteins in the head form a channel that penetrates the OM. Virion-associated exolysin (if present) hydrolyzes the peptidoglycan layer.
Channel extends through the inner membrane (IM). Some viruses may use an IM receptor.
Viral DNA translocation into the host cytoplasm.

Gram(+) hosts:

Attachment to a host cell wall receptor.
Virion-associated exolysin (if present)hydrolyzes the peptidoglycan layer.
? Channel formation or tunneling of a way through the host cell wall ?
Viral DNA translocation into the host cytoplasm.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

35 entries grouped by protein

reorder by strain

4 entries

Tail knob protein gp9 (Distal tube protein) (Gene product 9) (gp9) (Protein p9)

DIT9_BPNF

Bacillus phage Nf (Bacteriophage Nf) reference strain

Tail knob protein gp9 (Distal tube protein) (Gene product 9) (gp9) (Protein p9) (Tail protein)

DIT9_BPPH2

Bacillus phage phi29 (Bacteriophage phi-29) reference strain

5FB4; 5FB5; 5FEI

DIT9_BPB03

Bacillus phage B103 (Bacteriophage B103)

DIT9_BPPZA

Bacillus phage PZA (Bacteriophage PZA)

5 entries

Head-to-tail adapter protein gp4 (Gene product 4) (Gp4) (Internal virion protein gp4) (Peptidoglycan hydrolase gp4) (Tail adapter protein gp4)

EXLYS_BPAPS

Acyrthosiphon pisum secondary endosymbiont phage 1 (Bacteriophage APSE-1) reference strain

Peptidoglycan hydrolase gp27 (Gene product 27) (Gp27) (Internal virion protein gp27)

EXLYS_BPKMV

Pseudomonas phage phiKMV reference strain

Peptidoglycan hydrolase gp36 (EC 3.2.1.17) (Gene product 36) (Gp36)

EXLYS_BPP22

Salmonella phage P22 (Bacteriophage P22) reference strain

4V4K; 5GAI; 8EAO; 8EB7; 8TVU; 8U10; 8U11

EXLYS_BPSP6

Enterobacteria phage SP6 (Bacteriophage SP6) reference strain

Peptidoglycan hydrolase gp36 (Gene product 36) (Gp36)

EXLYS_BPT7

Escherichia phage T7 (Bacteriophage T7) reference strain

Peptidoglycan transglycosylase gp16 (EC 4.2.2.n1) (Internal core protein gp16)

6YT5; 7EYB; 7K5C; 9JYY

1 entry

Morphogenesis protein 1 (Gene product 13) (gp13) (Protein p13)

1 entry

Internal virion protein gp14 (Gene product 14) (Gp14)

1 entry

Internal virion protein gp15 (Gene product 15) (Gp15)

1 entry

Internal virion protein gp16 (Ejection protein gp16) (E protein gp16)

3 entries

Tail needle protein gp26 (Head completion protein) (Packaged DNA stabilization protein) (Tail accessory factor gp26)

NEEDL_BPHK6

Enterobacteria phage HK620 (Bacteriophage HK620) reference strain

5BU5; 5BU8; 5BVZ

NEEDL_BPP22

Salmonella phage P22 (Bacteriophage P22) reference strain

2POH; 3C9I; 4LIN; 4ZKP; 4ZKU; 4ZXQ; 8EAP

NEEDL_BPSFV

Shigella phage Sf6 (Shigella flexneri bacteriophage VI) (Bacteriophage SfVI) reference strain

Tail needle protein (Head completion protein) (Packaged DNA stabilization protein) (Tail accessory factor gp9)

3RWN

14 entries

Portal protein (Head-to-tail connector)

PORTL_BP44A

Staphylococcus phage 44AHJD reference strain

Portal protein (Connector protein) (Gene product 19) (gp19) (Head-to-tail connector) (Probable portal protein) (Upper collar protein)

PORTL_BPAPS

Acyrthosiphon pisum secondary endosymbiont phage 1 (Bacteriophage APSE-1) reference strain

Portal protein (Gene product 19) (Gp19) (Head-to-tail connector)

PORTL_BPBPP

Bordetella phage BPP-1 reference strain

Probable portal protein (Gene product 21) (gp21) (Head-to-tail connector)

PORTL_BPE15

Salmonella phage epsilon15 reference strain

PORTL_BPKHP

Helicobacter pylori bacteriophage KHP30 reference strain

Portal protein (Head-to-tail connector gp8) (Putative portal protein ORF17)

7WMP

PORTL_BPKMV

Pseudomonas phage phiKMV reference strain

PORTL_BPN4

Enterobacteria phage N4 (Bacteriophage N4) reference strain

Probable portal protein (94 kDa protein) (Gene product 59) (gp59) (Head-to-tail connector)

PORTL_BPP22

Salmonella phage P22 (Bacteriophage P22) reference strain

Portal protein (Gene product 1) (Gp1) (Head-to-tail connector)

3LJ5; 4V4K; 5GAI; 5JJ1; 5JJ3; 8EAO; 8TVU; 8U10; 8U11; 9KYW

PORTL_BPPH2

Bacillus phage phi29 (Bacteriophage phi-29) reference strain

Portal protein (Connector protein) (Gene product 10) (gp10) (Gene product 19) (gp19) (Head-to-tail connector) (Probable portal protein) (Protein p10) (Upper collar protein)

1FOU; 1H5W; 1IJG; 1JNB; 6QX7; 6QYJ; 6QYM; 6QZ9; 6QZF

PORTL_BPSP6

Enterobacteria phage SP6 (Bacteriophage SP6) reference strain

PORTL_BPT7

Escherichia phage T7 (Bacteriophage T7) reference strain

Portal protein (Gene product 8) (Gp8) (Head-to-tail connector)

3J4A; 6QWP; 6QX5; 6QXM; 6R21; 6TJP; 7BOU; 7BP0; 7EY6; 7EY8; 8E4G; 9JYZ; 9JZ0

PORTL_BPB03

Bacillus phage B103 (Bacteriophage B103)

Portal protein (Gene product 10) (gp10) (Head-to-tail connector) (Upper collar protein)

PORTL_BPPZA

Bacillus phage PZA (Bacteriophage PZA)

Portal protein (Connector protein) (Gene product 10) (gp10) (Gene product 19) (gp19) (Head-to-tail connector) (Probable portal protein) (Protein p10) (Upper collar protein)

PORTL_BPT3

Enterobacteria phage T3 (Bacteriophage T3)

Portal protein (Gene product 8) (Gp8) (Head-to-tail connector)

3 entries

Proximal tail tube connector protein (Gene product 11) (gp11) (Lower collar protein) (Protein p11)

TUB11_BPPH2

Bacillus phage phi29 (Bacteriophage phi-29) reference strain

6QZ9; 6QZF

TUB11_BPB03

Bacillus phage B103 (Bacteriophage B103)

TUB11_BPPZA

Bacillus phage PZA (Bacteriophage PZA)

1 entry

Tail tubular protein gp11 (Gene product 11) (Gp11)

1 entry

Viral short tail ejection system (kw:KW-1244)

Gram(-) hosts:

Gram(+) hosts:

Matching UniProtKB/Swiss-Prot entries

Tail knob protein gp9 (Distal tube protein) (Gene product 9) (gp9) (Protein p9)

Head-to-tail adapter protein gp4 (Gene product 4) (Gp4) (Internal virion protein gp4) (Peptidoglycan hydrolase gp4) (Tail adapter protein gp4)

Morphogenesis protein 1 (Gene product 13) (gp13) (Protein p13)

Internal virion protein gp14 (Gene product 14) (Gp14)

Internal virion protein gp15 (Gene product 15) (Gp15)

Internal virion protein gp16 (Ejection protein gp16) (E protein gp16)

Tail needle protein gp26 (Head completion protein) (Packaged DNA stabilization protein) (Tail accessory factor gp26)

Portal protein (Head-to-tail connector)

Proximal tail tube connector protein (Gene product 11) (gp11) (Lower collar protein) (Protein p11)

Tail tubular protein gp11 (Gene product 11) (Gp11)

Tail tubular protein gp12 (Gene product 12) (Gp12)