Tombusviridae (taxid:39738)

VIRION

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Non-enveloped, spherical, icosahedral, about 28-34 nm in diameter, capsid with a T=3 icosahedral symmetry. 30 hexameric capsomers per nucleocapsid (virion composed of 180 protein subunits).
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GENOME

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Monopartite (except Dianthovirus which is bipartite), linear, ssRNA(+) genome of 4-5.4 kb, which lacks a cap structure and a poly(A)tail.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. Two 5'-proximal ORFs are directly translated to produce the viral constituents of the replicase complex. RdRp is translated through suppression of termination at the end of ORF1 (tombusvirus-like and carmovirus-like), or ribosomal frameshifting (Dianthovirus and umbravirus). The downstream genes encoding the movement protein, and capsid proteins are translated from subgenomic RNAs. viral suppressor of RNA silencing (VSRs) is expressed by leaky scanning of the MVP subgenomic mRNA.
Cap-independent translation is mediated possibly through the interaction between a 3'-cap-independent translation element and a 5'UTR stem-loop.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA is translated to produce the two proteins necessary for RNA synthesis (replication and transcription).
  4. Replication takes place in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. The RdRp recognizes internal subgenomic promoters on the negative-sense RNA to transcribe the 3'co-terminal subgenomic RNAs that will generate the capsid and movement protein.
  7. Virus assembly in the cytoplasm.
  8. Viral movement protein probably mediates virion cell-to-cell transfer.

Host-virus interaction

Suppression of RNA silencing

Viruses of the Tombusviridae family encode proteins acting as suppressors of RNA silencing. Examples are tombusvirus P19/P20 , aureusvirus P14 , dianthovirus movement protein , carmovirus capsid protein P38 .

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

98 entries grouped by strain

6 entries

Barley yellow dwarf virus (isolate PAV) (BYDV) reference strain

Select_allDeselect_all
MCAPS_BYDVP Readthrough protein P3-RTD (P3-P5 readthrough protein) (P72) (Readthrough protein) (RT protein) ...
RDRP_BYDVP Putative RNA-directed RNA polymerase (EC 2.7.7.48)
CAPSD_BYDVP Major capsid protein (Coat protein) (CP)
MVP_BYDVP Movement protein (MP) (17 kDa protein)
ORF6_BYDVP Uncharacterized protein ORF6
ORF7_BYDVP Uncharacterized protein ORF7

5 entries

Maize chlorotic mottle virus (isolate United States/Kansas/1987) (MCMV) reference strain

Select_allDeselect_all
RDRP_MCMVK RNA-directed RNA polymerase (EC 2.7.7.48) (111 kDa protein) (Protein p111) [Cleaved into: Protein ...
MP2_MCMVK p7b
MP1_MCMVK Protein p31 [Cleaved into: Movement protein p7a]
CAPSD_MCMVK Capsid protein (Coat protein) (p25)
P32_MCMVK Uncharacterized protein p32

5 entries

Panicum mosaic virus (strain United States/Kansas 109S) (PMV) reference strain

Select_allDeselect_all
RDRP_PMVK RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p112) [Cleaved into: Protein p48]
MP6_PMVK Putative movement protein p6.6
CAPSD_PMVK Capsid protein (Coat protein) (p26)
MP8_PMVK Probable movement protein p8
P15_PMVK Protein p15

5 entries

Tobacco necrosis virus (strain A) (TNV-A) reference strain

Select_allDeselect_all
CAPSD_TNVA Capsid protein (p30)
RDRP_TNVA RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p82) [Cleaved into: Protein p23]
MP8_TNVA Probable movement protein p8
P6_TNVA Uncharacterized protein p6
P7_TNVA Uncharacterized protein p7

4 entries

Carnation mottle virus (isolate China/Shanghai) (CarMV) reference strain

Select_allDeselect_all
MP1_CARMS Double gene block protein 1 (DGBp1) (Movement protein P7)
MP2_CARMS Double gene block protein 2 (DGBp2) (Movement protein P9)
RDRP_CARMS Probable RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p88) [Cleaved into: Protein p28]
CAPSD_CARMS Capsid protein (Coat protein) (p38)

4 entries

Melon necrotic spot virus (MNSV) reference strain

Select_allDeselect_all
RDRP_MNSV RNA-directed RNA polymerase (EC 2.7.7.48) (p89) [Cleaved into: p29]
MP1_MNSV Double gene block protein 1 (DGBp1) (Movement protein P7A)
CAPSD_MNSV Capsid protein (Coat protein) (p42)
MP2_MNSV Double gene block protein 2 (DGBp2) (Movement protein P7B)

4 entries

Pothos latent virus (isolate Pigeonpea/India) (PoLV) reference strain

Select_allDeselect_all
RDRP_POLVP RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p84) [Cleaved into: Protein p25]
P14_POLVP RNA silencing suppressor p14
MVP_POLVP Movement protein (p27)
CAPSD_POLVP Capsid protein (p40)

4 entries

Tomato bushy stunt virus (strain Cherry) (TBSV) reference strain

Select_allDeselect_all
P19_TBSVC RNA silencing suppressor p19 (19 kDa symptom severity modulator)
MVP_TBSVC Movement protein (p22)
CAPSD_TBSVC Capsid protein (Coat protein) (p41)
RDRP_TBSVC RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p92) [Cleaved into: Protein p33]

4 entries

Turnip crinkle virus (TCV) reference strain

Select_allDeselect_all
CAPSD_TCV Capsid protein (Coat protein) (p38)
RDRP_TCV RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p88) [Cleaved into: Protein p28]
MP1_TCV Double gene block protein 1 (DGBp1) (Movement protein P8)
MP2_TCV Double gene block protein 2 (DGBp2) (Movement protein P9)

3 entries

Barley yellow dwarf virus (isolate MAV) (BYDV) reference strain

Select_allDeselect_all
RDRP_BYDVM Putative RNA-directed RNA polymerase (EC 2.7.7.48)
CAPSD_BYDVM Major capsid protein (Coat protein) (CP)
MVP_BYDVM Movement protein (MP) (17 kDa protein)

3 entries

Carnation ringspot virus (isolate Lommel) (CRSV) reference strain

Select_allDeselect_all
RDRP_CRSVL RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p88)
MP_CRSVL Movement protein (MP)
CAPSD_CRSVL Capsid protein (Coat protein)

3 entries

Groundnut rosette virus (strain MC1) (GRV) reference strain

Select_allDeselect_all
ORF3_GRVMC Long-distance movement protein (ORF3 protein)
RDRP_GRVMC RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48)
MVP_GRVMC Movement protein

3 entries

Oat chlorotic stunt virus (isolate United Kingdom) (OCSV) reference strain

Select_allDeselect_all
RDRP_OCSVU RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p84) [Cleaved into: Protein p23]
CAPSD_OCSVU Capsid protein (p48)
P8_OCSVU Uncharacterized protein p8

3 entries

Red clover necrotic mosaic virus (RCNMV) reference strain

Select_allDeselect_all
RDRP_RCNMV RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p88)
MP_RCNMV Movement protein (MP)
CAPSD_RCNMV Capsid protein (Coat protein)

4 entries

Cucumber necrosis virus (CNV)

Select_allDeselect_all
CAPSD_CNV Capsid protein (Coat protein) (p41)
P19_CNV RNA silencing suppressor p19 (19 kDa symptom severity modulator)
MVP_CNV Movement protein (p22)
RDRP_CNV RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p92) [Cleaved into: Protein p33]

4 entries

Cymbidium ringspot virus (CymRSV)

Select_allDeselect_all
CAPSD_CRV Capsid protein (Coat protein) (p41)
P19_CRV RNA silencing suppressor p19 (19 kDa symptom severity modulator)
MVP_CRV Movement protein (p22)
RDRP_CRV RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p92) [Cleaved into: Protein p33]

4 entries

Tobacco necrosis virus (strain D) (TNV-D)

Select_allDeselect_all
RDRP_TNVD RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p82) [Cleaved into: Protein p23]
CAPSD_TNVD Capsid protein (p30)
MP8_TNVD Probable movement protein p8
P6_TNVD Uncharacterized protein p6

3 entries

Artichoke mottled crinkle virus (AMCV)

Select_allDeselect_all
CAPSD_AMCV Capsid protein (Coat protein) (p41)
P19_AMCV RNA silencing suppressor p19 (19 kDa symptom severity modulator)
MVP_AMCV Movement protein (p22)

3 entries

Barley yellow dwarf virus (isolate P-PAV) (BYDV)

Select_allDeselect_all
RDRP_BYDVR Putative RNA-directed RNA polymerase (EC 2.7.7.48)
MVP_BYDVR Movement protein (MP) (17 kDa protein)
CAPSD_BYDVR Major capsid protein (Coat protein) (CP)

3 entries

Carnation mottle virus (CarMV)

Select_allDeselect_all
CAPSD_CARMV Capsid protein (Coat protein) (p38)
RDRP_CARMV RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p88) [Cleaved into: Protein p28]
MP1_CARMV Double gene block protein 1 (DGBp1) (Movement protein P7)

3 entries

Tomato bushy stunt virus (strain BS-3) (TBSV)

Select_allDeselect_all
CAPSD_TBSVB Capsid protein (Coat protein) (p41)
P19_TBSVB RNA silencing suppressor p19 (19 kDa symptom severity modulator)
MVP_TBSVB Movement protein (p22)

2 entries

Barley yellow dwarf virus (isolate NY-RPV) (BYDV)

Select_allDeselect_all
CAPSD_BYDVN Major capsid protein (Coat protein) (CP)
MVP_BYDVN Movement protein (MP) (17 kDa protein)

2 entries

Bean leafroll virus (BLRV)

Select_allDeselect_all
CAPSD_BLRV Major capsid protein (Coat protein) (CP)
MVP_BLRV Movement protein (MP) (16 kDa protein)

2 entries

Tomato bushy stunt virus (strain A23) (TBSV)

Select_allDeselect_all
P19_TBSVA RNA silencing suppressor p19 (19 kDa symptom severity modulator)
MVP_TBSVA Movement protein (p22)

2 entries

Tomato bushy stunt virus (strain B8) (TBSV)

Select_allDeselect_all
P19_TBSV8 RNA silencing suppressor p19 (19 kDa symptom severity modulator)
MVP_TBSV8 Movement protein (p22)

2 entries

Tomato bushy stunt virus (strain Ja6) (TBSV)

Select_allDeselect_all
MVP_TBSVJ Movement protein (p22)
P19_TBSVJ RNA silencing suppressor p19 (19 kDa symptom severity modulator)

2 entries

Tomato bushy stunt virus (strain Ja9) (TBSV)

Select_allDeselect_all
MP22_TBSVK Movement protein p22 (p21)
P19_TBSVK RNA silencing suppressor p19 (19 kDa symptom severity modulator)

2 entries

Tomato bushy stunt virus (strain type) (TBSV)

Select_allDeselect_all
P19_TBSVT RNA silencing suppressor p19 (19 kDa symptom severity modulator)
MP22_TBSVT Movement protein p22 (p21)

1 entry

Carnation Italian ringspot virus (CIRV)

P19_CIRV RNA silencing suppressor p19 (19 kDa symptom severity modulator)

1 entry

Havel river virus (HaRV)

P19_HARV RNA silencing suppressor p19 (19 kDa symptom severity modulator)

1 entry

Pear latent virus (PeLV)

P19_PLV RNA silencing suppressor p19 (19 kDa symptom severity modulator)

1 entry

Pelargonium necrotic spot virus (PeNSV)

P19_PENSV RNA silencing suppressor p19 (19 kDa symptom severity modulator)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Angelonia flower break virus taxid:352882

Protein ModelArchive
Capsid protein ma-jd-viral-27135
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19660
p10 ma-jd-viral-55383
p27 ma-jd-viral-11327
p7 ma-jd-viral-32738

Bermuda grass latent virus taxid:1930269

Protein ModelArchive
Capsid protein ma-jd-viral-27206
Putative accessory movemet protein ma-jd-viral-55644
Putative movement protein 1 ma-jd-viral-63972
Putative movement protein 2 ma-jd-viral-43314
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19653
Replicase protein ma-jd-viral-11542

Calibrachoa mottle virus taxid:204928

Protein ModelArchive
Capsid protein ma-jd-viral-27144
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19646
p28 ma-jd-viral-11330
p8 ma-jd-viral-30491
p9 ma-jd-viral-55384

Carrot mottle virus taxid:68033

Protein ModelArchive
Cell-to-cell movement protein ma-jd-viral-28423
Long-distance movement protein ma-jd-viral-47126
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19258

Cherry-associated luteovirus taxid:1912598

Protein ModelArchive
Capsid protein ma-jd-viral-28477
Movement protein ma-jd-viral-01306
Polymerase P1 ma-jd-viral-37515
Putative P6 protein ma-jd-viral-41118
Putative P7 protein ma-jd-viral-52963
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19631
Readthrough protein ma-jd-viral-05297

Cocksfoot mild mosaic virus taxid:479060

Protein ModelArchive
Capsid protein ma-jd-viral-27204
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19666
p15 ma-jd-viral-55645
p41 ma-jd-viral-30471
p6.8 ma-jd-viral-43312
p8 ma-jd-viral-63971

Cowpea mottle virus taxid:12627

Protein ModelArchive
Capsid protein ma-jd-viral-27141
Movement protein ma-jd-viral-38171
Movement protein ma-jd-viral-55379
ORF1; Method: conceptual translation supplied by author ma-jd-viral-11319
ORF6; Method: conceptual translation supplied by author ma-jd-viral-33981

Eggplant mottled crinkle virus taxid:270256

Protein ModelArchive
Capsid protein (Coat protein) (p41) ma-jd-viral-27125
Movement protein ma-jd-viral-27235
RNA polymerase ma-jd-viral-37347
RNA silencing suppressor p19 (19 kDa symptom severity modulator) ma-jd-viral-59731
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19256

Elderberry latent virus taxid:167018

Protein ModelArchive
Capsid protein ma-jd-viral-27142
Putative movement protein 1 ma-jd-viral-66438
Putative movement protein 2 ma-jd-viral-35073
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19636
Replicase protein ma-jd-viral-11337

Ethiopian tobacco bushy top virus taxid:1538549

Protein ModelArchive
Cell-to-cell movement protein ma-jd-viral-28425
Long-distance movement protein ma-jd-viral-37736
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19255

Gompholobium virus A taxid:1884832

Protein ModelArchive
Capsid protein ma-jd-viral-27143
Movement protein 1 ma-jd-viral-39800
Movement protein 2 ma-jd-viral-50736
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19665
Replication-associated protein ma-jd-viral-11325

Honeysuckle ringspot virus taxid:943272

Protein ModelArchive
Capsid protein ma-jd-viral-27132
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19640
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19651
p13 ma-jd-viral-55382
p27 ma-jd-viral-11323
p7 ma-jd-viral-59135

Japanese iris necrotic ring virus taxid:77344

Protein ModelArchive
Capsid protein ma-jd-viral-27146
Movement protein (P12) ma-jd-viral-36354
Movement protein (P8) ma-jd-viral-30958
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19629
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19649
Replicase (P26) ma-jd-viral-11322

Maize necrotic streak virus taxid:137556

Protein ModelArchive
Capsid protein ma-jd-viral-28789
RNA silencing suppressor p19 (19 kDa symptom severity modulator) ma-jd-viral-59730
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19264
p21 protein ma-jd-viral-27236
p30 protein ma-jd-viral-37349

Maize white line mosaic virus taxid:445227

Protein ModelArchive
Capsid protein ma-jd-viral-27131
Movement protein ma-jd-viral-27010
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19667
Silencing suppressor protein ma-jd-viral-40760
p30 ma-jd-viral-62360

Moroccan pepper virus taxid:208086

Protein ModelArchive
22 kDa protein ma-jd-viral-27237
33 kDa protein ma-jd-viral-37348
Capsid protein (Coat protein) (p41) ma-jd-viral-27147
Putative 3.7 kDa protein ma-jd-viral-36394
RNA silencing suppressor p19 (19 kDa symptom severity modulator) ma-jd-viral-59728
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19257

Nootka lupine vein clearing virus taxid:283876

Protein ModelArchive
Capsid protein ma-jd-viral-27145
MP1 ma-jd-viral-43591
MP2 ma-jd-viral-55386
N-terminus replicase ma-jd-viral-11328
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19426

Olive mild mosaic virus taxid:295090

Protein ModelArchive
Capsid protein ma-jd-viral-28783
Movement protein 2 (p6) ma-jd-viral-38706
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19413
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19656
p23 ma-jd-viral-11316
p8 ma-jd-viral-41448

Opium poppy mosaic virus taxid:473784

Protein ModelArchive
Putative cell-to-cell movement protein ma-jd-viral-28426
Putative phloem RNA movement protein ma-jd-viral-37737
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19262
Replicase-associated protein ma-jd-viral-43198

Pea enation mosaic virus-2 taxid:193120

Protein ModelArchive
26kDa protein ma-jd-viral-37738
27kDa protein ma-jd-viral-28427
33kDa protein ma-jd-viral-43194

Pea stem necrosis virus taxid:199361

Protein ModelArchive
Capsid protein ma-jd-viral-27052
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19634
p25 product ma-jd-viral-11317
p6 product ma-jd-viral-38708
p7 product ma-jd-viral-41773

Pelargonium flower break virus taxid:35291

Protein ModelArchive
Capsid protein ma-jd-viral-27140
Movement protein 1 (Putative movement protein) (p7 protein) ma-jd-viral-59136
Putative movement protein (p12 protein) ma-jd-viral-55381
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19658
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19663
p27 protein ma-jd-viral-11326

Pelargonium leaf curl virus taxid:35280

Protein ModelArchive
Capsid protein (Coat protein) (p41) ma-jd-viral-27129
Movement protein ma-jd-viral-27238
RNA silencing suppressor p19 (19 kDa symptom severity modulator) ma-jd-viral-59729
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19260
p36 replicase ma-jd-viral-37350

Pelargonium line pattern virus taxid:167019

Protein ModelArchive
Capsid protein ma-jd-viral-27130
Movement protein (p7) ma-jd-viral-66442
Movement protein 2 (p9.7) ma-jd-viral-35071
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19648
Replicase protein ma-jd-viral-11336
p13 ma-jd-viral-42307

Pelargonium ringspot virus taxid:167020

Protein ModelArchive
Capsid protein ma-jd-viral-27139
Putative movement protein 1 ma-jd-viral-66439
Putative movement protein 2 ma-jd-viral-35070
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19654
Replicase protein ma-jd-viral-11333

Potato necrosis virus taxid:1725329

Protein ModelArchive
Capsid protein ma-jd-viral-28786
P6 ma-jd-viral-38705
P8 ma-jd-viral-41447
Pre-readthrough protein ma-jd-viral-11314
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19643

Rosa rugosa leaf distortion virus taxid:535898

Protein ModelArchive
Capsid protein ma-jd-viral-27127
Putative 8 kDa protein ma-jd-viral-37712
Putative movement protein ma-jd-viral-66441
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19659
Replicase protein ma-jd-viral-11334
p12 ma-jd-viral-51658

Rose spring dwarf-associated virus taxid:474454

Protein ModelArchive
Coat protein P3 ma-jd-viral-28492
Movement protein ma-jd-viral-01305
RNA-dependent RNA polymerase P1 ma-jd-viral-37509
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19664
Readthrough protein ma-jd-viral-05298

Soybean yellow mottle mosaic virus taxid:578361

Protein ModelArchive
Capsid protein ma-jd-viral-27136
P7 protein (Polyprotein) ma-jd-viral-38170
Polyprotein ma-jd-viral-33982
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19633
p10 protein ma-jd-viral-55385

Thin paspalum asymptomatic virus taxid:1352511

Protein ModelArchive
Capsid protein ma-jd-viral-27205
Putative accessory movement protein ma-jd-viral-55643
Putative movement protein 1 ma-jd-viral-33464
Putative movement protein 2 ma-jd-viral-43313
Putative replicase-associated protein ma-jd-viral-11541
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19639

Trailing lespedeza virus 1 taxid:944580

Protein ModelArchive
Capsid protein ma-jd-viral-27133
Putative movement protein 1 ma-jd-viral-62112
Putative movement protein 2 ma-jd-viral-31639
Putative replication-associated protein ma-jd-viral-11324
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19637

Yam spherical virus taxid:1421055

Protein ModelArchive
Capsid protein ma-jd-viral-27137
Movement protein ma-jd-viral-27011
RNA-directed RNA polymerase (EC 2.7.7.48) ma-jd-viral-19642
Silencing suppressor ma-jd-viral-40759