Bracoviriform (taxid:2946836)
VIRION
Enveloped, prolate ellipsoid form (ichnoviriform) and cylindrical (bracoviriform). Depending on the species, a virion contains one or several nucleocapsids.
GENOME
Segmented, circular supercoiled dsDNAs ranging from 2.0-31kb. Each virion contains multiple copies of the genome.
GENE EXPRESSION
REPLICATION
NUCLEAR
a) replicative: occurs in the calyx cells of the ovary.
- Excision and circularization of viral DNA in the ovary cells.
- Viral DNA synthesis.
- Appearance of viral envelopes and nucleocapsids in the nucleus.
- Mature virions are released into the lumen of the oviduct probably by lysis (brachoviriform) or budding through the cell membrane (ichnoviriform).
b) vegetative: occurs in all non-reproductive cells.
The viral genome is transmitted in proviral linear form integrated in the wasp's chromosomes. The virus DNA is replicated, just like any other part of the wasp's genome.
Host-virus interaction
Apoptosis modulation
PTP-H2 triggers mitochondrial membrane depolarization and caspase-dependent apoptosis suggesting that apoptosis is induced through a mitochondria-dependent death pathway.
NF-kappa-B modulation
Polydnavirus Ank proteins bind NF-kappa-B homodimers and inhibit processing of relish/NF-kappa-B p110 subunit 
.
Innate immune response inhibition
Microplitis demolitor cracovirus PTP-H2 and PTP-H3 are functional tyrosine phosphatases whose expression inhibit phagocytosis . Another protein, Glc1.8 is also involved in suppression of the insect cellular immune response .
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)52 entries grouped by protein
1 entry
Probable protease inhibitor Egf0.4a
1 entry
Probable protease inhibitor Egf0.4b
1 entry
Protease inhibitor Egf1.0
1 entry
Protease inhibitor Egf1.5a
1 entry
Protease inhibitor Egf1.5b
1 entry
Mucin-like protein Glc1.8a
1 entry
Mucin-like protein Glc1.8b (Glc1.8b)
1 entry
I-Kappa-B like protein C1
1 entry
I-Kappa-B like protein C2
1 entry
I-Kappa-B like protein F1
1 entry
I-Kappa-B like protein F2
1 entry
I-Kappa-B like protein G1
1 entry
I-Kappa-B like protein G2
1 entry
I-Kappa-B like protein H1
1 entry
I-Kappa-B like protein I1
1 entry
I-Kappa-B like protein J1
1 entry
I-Kappa-B like protein N1
1 entry
I-kappa-B like protein N2
1 entry
I-Kappa-B like protein N3
1 entry
Truncated tyrosine phosphatase D1 (PTP-D1)
1 entry
Tyrosine phosphatase-like protein H1 (PTP-H1)
1 entry
Tyrosine phosphatase H2 (PTP-H2) (EC 3.1.3.48)
1 entry
Tyrosine phosphatase H3 (PTP-H3) (EC 3.1.3.48)
1 entry
Probable tyrosine phosphatase protein H4 (PTP-H4) (EC 3.1.3.48)
1 entry
Tyrosine phosphatase-like protein H5 (PTP-H5)
1 entry
Tyrosine phosphatase-like protein J1 (PTP-J1)
1 entry
Probable tyrosine phosphatase protein J2 (PTP-J2) (EC 3.1.3.48)
1 entry
Tyrosine phosphatase-like protein J3 (PTP-J3)
1 entry
Probable tyrosine phosphatase protein J4 (PTP-J4) (EC 3.1.3.48)
1 entry
Probable tyrosine phosphatase protein N1 (PTP-N1) (EC 3.1.3.48)
1 entry
Tyrosine phosphatase-like protein N2 (PTP-N2)
1 entry
Tyrosine phosphatase-like protein N3 (PTP-N3)
1 entry
Uncharacterized protein A1
1 entry
Uncharacterized protein A2
1 entry
Putative BEN domain-containing protein B1
1 entry
Uncharacterized protein C3
1 entry
Uncharacterized protein D2
1 entry
Uncharacterized protein D3
1 entry
Uncharacterized protein E1
1 entry
Uncharacterized protein E2
1 entry
Uncharacterized protein F1
1 entry
Uncharacterized protein G1
1 entry
Uncharacterized protein G2
1 entry
Uncharacterized protein I2
1 entry
Uncharacterized protein K1
1 entry
Uncharacterized protein L1
1 entry
Uncharacterized protein M1
1 entry
Uncharacterized protein M2
1 entry
Uncharacterized protein M3
1 entry
Uncharacterized protein M4
1 entry
Uncharacterized protein M5
1 entry