Inhibition of host NF-kappa-B by virus (kw:KW-1100)
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. In unstimulated cells, NF-kappa-B dimers are sequestered in the cytoplasm via physical association with NF-kappa-B inhibitory proteins, called I-kappa-Bs. Upon activation, NF-kappa-B separates from I-kappa-B and migrates to the nucleus to activate gene transcription.
Given the importance of controlling NF-kappa-B during viral infection, many viruses encode proteins that act on different cellular targets to ultimately inhibit the NF-kappa-B pathway. For example, several large DNA viruses including african swine virus, vaccinia virus or bracovirus encode proteins containing ankyrin repeats able to inhibit NF-kappa-B. Indeed, Vaccinia K1 inhibits NF-kappa-B by preventing I-kappa-B degradation. A238L from African swine fever virus interacts with free NF-kappa-B to prevent its nuclear translocation. Microplitis demolitor bracovirus encodes I-kappa-B-like genes. These viral proteins function as I-kappa-Bs and acts as inhibitors of NF-kappa-B, the HIV accessory protein Vpu was shown to inhibit NF-kappa-B activation by interfering with b-TrCP-mediated degradation of I-kappa-B and to promote apoptosis of the infected cell by suppressing NF-kBdependent expression of anti-apoptotic factors.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)149 entries grouped by protein
1 entry
Protein A49R
2 entries
Protein A52
3 entries
TBK1 inhibitor DP96R
1 entry
Early E1A protein (Early E1A 29.5 kDa protein)
1 entry
Early 3 14.7 kDa protein (E3-14.7k)
3 entries
Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1) (EC 3.1.21.-)
1 entry
I-Kappa-B like protein C1
1 entry
I-Kappa-B like protein C2
1 entry
I-Kappa-B like protein F1
1 entry
I-Kappa-B like protein F2
1 entry
I-Kappa-B like protein G1
1 entry
I-Kappa-B like protein G2
1 entry
I-Kappa-B like protein H1
1 entry
I-Kappa-B like protein I1
1 entry
I-Kappa-B like protein J1
5 entries
IkB-like protein (Ankyrin repeat domain-containing protein A238L) (p28)
1 entry
I-Kappa-B like protein N1
1 entry
I-kappa-B like protein N2
1 entry
I-Kappa-B like protein N3
1 entry
Protein LANA1
1 entry
Protein MC005
1 entry
Protein MC132
1 entry
Protein MC160
8 entries
Nucleoprotein (Protein N) (Nucleocapsid protein)
15 entries
Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)
1 entry
Non-structural protein ORF4a (ORF4a)
1 entry
Non-structural protein ORF4b (ORF4b)
3 entries
Ankyrin repeat domain-containing protein OPG023 (Host range protein 1)
4 entries
Protein OPG035 (Protein N1)
5 entries
Early protein OPG038 (Protein M2)
3 entries
Interferon antagonist OPG039
2 entries
Protein K7
4 entries
Protein OPG176
5 entries
Protein OPG200
5 entries
Phosphoprotein (Protein P)
3 entries
Genome polyprotein
1 entry
Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)
21 entries
Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
1 entry
Ribonucleoside-diphosphate reductase large subunit-like protein (Viral inhibitor of RIP activation)
6 entries
Replicase polyprotein 1ab (ORF1ab polyprotein)
15 entries
Small hydrophobic protein
1 entry
Ubiquitin-conjugating enzyme E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme) (UBCv1) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) (pI215L)
1 entry
Protein ORFV073
5 entries
Late protein I226R (pI226R)
5 entries
Protein D345L (pD345L)
2 entries