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Anelloviridae (taxid:687329)

VIRION

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Non-enveloped, T=1 icosahedral symmetry, with a diameter of about 30-32nm.

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GENOME

Circular ssDNA genome (-) genome of about 3.8 kb.
The genome is replicated through double-stranded intermediates. It may encode for 4 proteins: ORF1 (Rep protein?), ORF2, ORF3 and ORF4.

GENE EXPRESSION

The proteins are expressed by alternative splicing of pre-mRNA.

REPLICATION

NUCLEAR

  1. Virus penetrates into the host cell.
  2. Uncoating, the viral ssDNA genome penetrates into the nucleus.
  3. The ssDNA is converted into dsDNA with the participation of cellular factors. dsDNA transcription gives rise to viral mRNAs.
  4. viral mRNAs are transcribed and translated to produce viral proteins.
  5. Replication may be mediated by a "Rep-like" protein, and would occur by rolling circle producing ssDNA genomes.
  6. These newly synthesized ssDNA can either
    a) be converted to dsDNA and serve as a template for transcription/replication
    b) be encapsidated by capsid protein and form virions released by cell lysis.
DB LINKS image image

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TAXONOMY Group II: ssDNA viruses
Realm: Monodnaviria
Kingdom: Shotokuvirae
Phylum: Commensaviricota
Class: Cardeaviricetes
Order: Sanitavirales
Family: Anelloviridae
Genus: Alphatorquevirus
Betatorquevirus
Gammatorquevirus
Deltatorquevirus
Epsilontorquevirus
Etatorquevirus
Iotatorquevirus
Kappatorquevirus
Lambdatorquevirus
Thetatorquevirus
Zetatorquevirus
VIRUS
REFERENCE STRAIN Torque teno virus 1
Sequence | Genome assembly | Proteome
Torque teno mini virus 1
Sequence | Genome assembly | Proteome
Torque teno midi virus 1
Sequence | Genome assembly | Proteome
Torque teno tupaia virus
Sequence | Genome assembly | Proteome
Torque teno tamarin virus
Sequence | Genome assembly | Proteome
Torque teno felis virus
Sequence | Genome assembly | Proteome
Torque teno sus virus 1
Sequence | Genome | Proteome
Torque teno sus virus k2 (isolate 38E05)
Sequence | Genome assembly | Proteome
Torque teno canis virus
Sequence | Genome assembly | Proteome
Torque teno douroucouli virus
Sequence | Genome assembly | Proteome
Torque teno virus sus virus k2 (isolate 38E05)
Sequence | Genome | Proteome

Host

NATURAL HOSTS Human, Chimpanzee, African monkey, Tupaia, Pig, Cow, Sheep and Chicken.
TROPISM
INTERACTIONS Cell receptors: -
Host-virus interaction

Ecology and disease

GEOGRAPHY Ubiquitous, >90% of adults infected worldwide.
ASSOCIATED DISEASES Asymptomatic.
May be associated with various diseases: hepatitis, pulmonary diseases, hematologic disorders, myopathy and lupus.
TRANSMISSION Sexual, blood, possibly also fecal-oral.
VACCINE No
ANTIVIRAL DRUGS No

Host-virus interaction

NF-kappaB modulation

Torque teno virus ORF2 protein might suppress NF-kappaB pathways via interaction with IkappaB kinases .

GENERAL Back to anelloviridae page
NATURAL HOSTS Human, Chimpanzee, African monkey, Tupaia, Pig, Cow, Sheep and Chicken.
TROPISM
INTERACTIONS Cell receptors: -
ASSOCIATED DISEASES Asymptomatic.
May be associated with various diseases: hepatitis, pulmonary diseases, hematologic disorders, myopathy and lupus.
TRANSMISSION Sexual, blood, possibly also fecal-oral.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

72 entries grouped by strain

5 entries

Torque teno virus (isolate Human/Finland/Hel32/2002) (TTV) (Torque teno virus genotype 6) reference strain

Select_allDeselect_all
CAPSD_TTVV3 Capsid protein
ORF24_TTVV3 ORF2/4 protein
ORF2_TTVV3 ORF2 protein
ORF12_TTVV3 ORF1/2 protein
ORF11_TTVV3 ORF1/1 protein

4 entries

Torque teno tamarin virus (isolate So-TTV2) reference strain

Select_allDeselect_all
CAPSD_TTVE1 Capsid protein
ORF4_TTVE1 Uncharacterized ORF4 protein
ORF3_TTVE1 Uncharacterized ORF3 protein
ORF2_TTVE1 Uncharacterized ORF2 protein

3 entries

Chicken anemia virus (isolate Germany Cuxhaven-1) (CAV) reference strain

Select_allDeselect_all
VP2_CAVC1 Dual specificity protein phosphatase VP2 (EC 3.1.3.16) (EC 3.1.3.48)
VP3_CAVC1 Apoptin
CAPSD_CAVC1 Capsid protein (CA1) (Coat protein)

3 entries

Torque teno canis virus (isolate Cf-TTV10) reference strain

Select_allDeselect_all
CAPSD_TTVT1 Capsid protein
ORF2_TTVT1 Uncharacterized ORF2 protein
ORF3_TTVT1 Uncharacterized ORF2 protein

3 entries

Torque teno douroucouli virus (isolate At-TTV3) reference strain

Select_allDeselect_all
CAPSD_TTVZ1 Capsid protein
ORF3_TTVZ1 Uncharacterized ORF3 protein
ORF2_TTVZ1 Uncharacterized ORF2 protein

3 entries

Torque teno felis virus (isolate Fc-TTV4) reference strain

Select_allDeselect_all
CAPSD_TTVF1 Capsid protein
ORF2_TTVF1 Uncharacterized ORF2 protein
ORF3_TTVF1 Uncharacterized ORF3 protein

3 entries

Torque teno mini virus 1 (isolate TLMV-CBD279) reference strain

Select_allDeselect_all
ORF3_TTVB1 Uncharacterized ORF3 protein
CAPSD_TTVB1 Capsid protein
ORF2_TTVB1 Uncharacterized ORF2 protein

3 entries

Torque teno sus virus 1 (isolate Sd-TTV31) reference strain

Select_allDeselect_all
CAPSD_TTVI1 Capsid protein
ORF2_TTVI1 Uncharacterized ORF2 protein
ORF3_TTVI1 Uncharacterized ORF3 protein

3 entries

Torque teno tupaia virus (isolate Tbc-TTV14) reference strain

Select_allDeselect_all
CAPSD_TTVD1 Capsid protein
ORF2_TTVD1 Uncharacterized ORF2 protein
ORF3_TTVD1 Uncharacterized ORF3 protein

3 entries

Torque teno virus (isolate Human/China/CT23F/2001) (TTV) reference strain

Select_allDeselect_all
CAPSD_TTVV6 Capsid protein
ORF23_TTVV6 Probable protein VP2 (ORF2/3 protein)
ORF24_TTVV6 Uncharacterized ORF2/4 protein

3 entries

Torque teno virus (isolate Human/China/CT39F/2001) (TTV) reference strain

Select_allDeselect_all
CAPSD_TTVV7 Capsid protein
ORF23_TTVV7 Probable protein VP2 (ORF2/3 protein)
ORF24_TTVV7 Uncharacterized ORF2/4 protein

3 entries

Torque teno virus (isolate Human/Germany/KAV/2001) (TTV) reference strain

Select_allDeselect_all
CAPSD_TTVV4 Capsid protein
ORF23_TTVV4 Probable protein VP2 (ORF2/3 protein)
ORF24_TTVV4 Uncharacterized ORF2/4 protein

3 entries

Torque teno virus (isolate Human/Ghana/GH1/1996) (TTV) reference strain

Select_allDeselect_all
CAPSD_TTVVG Probable capsid and replication-associated protein
ORF2_TTVVG Uncharacterized ORF2 protein
YORF3_TTVVG Uncharacterized ORF3 protein

3 entries

Torque teno virus (isolate Human/Japan/TRM1/1999) (TTV) (Torque teno virus genotype 1a) reference strain

Select_allDeselect_all
ORF23_TTVV2 Probable protein VP2 (ORF2/3 protein)
CAPSD_TTVV2 Capsid protein
ORF24_TTVV2 ORF2/4 protein

3 entries

Torque teno virus (isolate Japanese macaque/Japan/Mf-TTV9/2000) (TTV) reference strain

Select_allDeselect_all
YORF3_TTVV9 Uncharacterized ORF3 protein
CAPSD_TTVV9 Capsid protein
YORF2_TTVV9 Uncharacterized ORF2 protein

2 entries

Torque teno midi virus 1 (isolate MD1-073) reference strain

Select_allDeselect_all
ORF3_TTVG1 Uncharacterized ORF3 protein
CAPSD_TTVG1 Capsid protein

2 entries

Torque teno virus (isolate Chimpanzee/Japan/Pt-TTV6/2000) (TTV) reference strain

Select_allDeselect_all
CAPSD_TTVV8 Capsid protein
ORF2_TTVV8 Uncharacterized ORF2 protein

2 entries

Torque teno virus (isolate Human/Japan/SANBAN/1999) (TTV) reference strain

Select_allDeselect_all
CAPSD_TTVV5 Capsid protein
ORF23_TTVV5 Probable protein VP2 (ORF2/3 protein)

2 entries

Torque teno virus 1 (isolate TA278) reference strain

Select_allDeselect_all
CAPSD_TTVA1 Capsid protein
ORF2_TTVA1 Uncharacterized ORF2 protein

3 entries

Chicken anemia virus (isolate Australia/CAU269-7/2000) (CAV)

Select_allDeselect_all
CAPSD_CAVCA Capsid protein (CA1) (Coat protein)
VP2_CAVCA Dual specificity protein phosphatase VP2 (EC 3.1.3.16) (EC 3.1.3.48)
VP3_CAVCA Apoptin

3 entries

Chicken anemia virus (isolate Japan 82-2) (CAV)

Select_allDeselect_all
CAPSD_CAV82 Capsid protein (CA1) (Coat protein)
VP2_CAV82 Dual specificity protein phosphatase VP2 (EC 3.1.3.16) (EC 3.1.3.48)
VP3_CAV82 Apoptin

3 entries

Chicken anemia virus (isolate USA 26p4) (CAV)

Select_allDeselect_all
CAPSD_CAV26 Capsid protein (CA1) (Coat protein)
VP2_CAV26 Dual specificity protein phosphatase VP2 (EC 3.1.3.16) (EC 3.1.3.48)
VP3_CAV26 Apoptin

3 entries

Chicken anemia virus (isolate USA CIA-1) (CAV)

Select_allDeselect_all
CAPSD_CAVCI Capsid protein (CA1) (Coat protein)
VP2_CAVCI Dual specificity protein phosphatase VP2 (EC 3.1.3.16) (EC 3.1.3.48)
VP3_CAVCI Apoptin

3 entries

Torque teno virus (strain VT416) (TTV)

Select_allDeselect_all
CAPSD_TTVV1 Probable capsid and replication-associated protein
ORF23_TTVV1 Probable protein VP2 (ORF2/3 protein)
ORF24_TTVV1 Uncharacterized ORF2/4 protein

1 entry

Chicken anemia virus (isolate Australia) (CAV)

CAPSD_CAVAU Capsid protein (CA1) (Coat protein)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Avian gyrovirus 2 taxid:1002273

Protein ModelArchive
Apoptin ma-jd-viral-47567
Capsid protein (CA1) (Coat protein) ma-jd-viral-36700
Dual specificity protein phosphatase VP2 (EC 3.1.3.16) (EC 3.1.3.48) ma-jd-viral-59473

Gorilla anellovirus taxid:1743411

Protein ModelArchive
Capsid protein ma-jd-viral-04584
ORF2 ma-jd-viral-57846

Gyrovirus 4 taxid:1214955

Protein ModelArchive
Capsid protein (CA1) (Coat protein) ma-jd-viral-36699
Dual specificity protein phosphatase VP2 (EC 3.1.3.16) (EC 3.1.3.48) ma-jd-viral-38362

Gyrovirus GyV3 taxid:1163715

Protein ModelArchive
Apoptin ma-jd-viral-47568
Capsid protein (CA1) (Coat protein) ma-jd-viral-36701
Dual specificity protein phosphatase VP2 (EC 3.1.3.16) (EC 3.1.3.48) ma-jd-viral-59471

Gyrovirus GyV8 taxid:1670973

Protein ModelArchive
Capsid protein (CA1) (Coat protein) ma-jd-viral-36698
Uncharacterized protein ma-jd-viral-54954
VP2 ma-jd-viral-32010

Gyrovirus Tu243 taxid:1415627

Protein ModelArchive
Capsid protein (CA1) (Coat protein) ma-jd-viral-36696
Dual specificity protein phosphatase VP2 (EC 3.1.3.16) (EC 3.1.3.48) ma-jd-viral-38361
Uncharacterized protein ma-jd-viral-33694

Gyrovirus Tu789 taxid:1415628

Protein ModelArchive
Apoptin ma-jd-viral-47566
Capsid protein (CA1) (Coat protein) ma-jd-viral-36697
Dual specificity protein phosphatase VP2 (EC 3.1.3.16) (EC 3.1.3.48) ma-jd-viral-59472

Rodent Torque teno virus 2 taxid:1514665

Protein ModelArchive
Capsid protein ma-jd-viral-04556
ORF2 ma-jd-viral-54818
ORF3 ma-jd-viral-32972

Seal anellovirus 2 taxid:1427157

Protein ModelArchive
Capsid protein ma-jd-viral-04613
ORF2 ma-jd-viral-41007
ORF3 ma-jd-viral-61288

Seal anellovirus 3 taxid:1427156

Protein ModelArchive
Capsid protein ma-jd-viral-04612
ORF2 ma-jd-viral-61634
ORF3 ma-jd-viral-39604

Seal anellovirus 4 taxid:1566011

Protein ModelArchive
Capsid protein ma-jd-viral-04568

Seal anellovirus TFFN/USA/2006 taxid:991022

Protein ModelArchive
Capsid protein ma-jd-viral-04614
Orf2 ma-jd-viral-58704
Orf3 ma-jd-viral-39603

Simian torque teno virus 30 taxid:1619218

Protein ModelArchive
Capsid protein ma-jd-viral-04604
ORF2 ma-jd-viral-32711
ORF3 ma-jd-viral-55086

Simian torque teno virus 31 taxid:1619219

Protein ModelArchive
Capsid protein ma-jd-viral-04569
ORF2 ma-jd-viral-34684
ORF3 ma-jd-viral-30248
ORF4 ma-jd-viral-61743

Simian torque teno virus 32 taxid:1619220

Protein ModelArchive
Capsid protein ma-jd-viral-04575
ORF2 ma-jd-viral-34690
ORF3 ma-jd-viral-63052
ORF4 ma-jd-viral-61745

Simian torque teno virus 33 taxid:1629656

Protein ModelArchive
Capsid protein ma-jd-viral-04574
ORF2 ma-jd-viral-34686
ORF3 ma-jd-viral-53506
ORF4 ma-jd-viral-61744

Simian torque teno virus 34 taxid:1629657

Protein ModelArchive
Capsid protein ma-jd-viral-04587
ORF2 ma-jd-viral-64873
ORF3 ma-jd-viral-62659
ORF4 ma-jd-viral-46794

Small anellovirus 1 taxid:289366

Protein ModelArchive
Capsid protein ma-jd-viral-04600
ORF1 ma-jd-viral-37340
ORF3 ma-jd-viral-40375

Small anellovirus 2 taxid:289367

Protein ModelArchive
Capsid protein ma-jd-viral-04583
Capsid protein ma-jd-viral-38694
ORF1 ma-jd-viral-37332
ORF4 ma-jd-viral-66112
ORF5 ma-jd-viral-38815

TTV-like mini virus taxid:93678

Protein ModelArchive
Capsid protein ma-jd-viral-04594
Uncharacterized protein ma-jd-viral-55634
Uncharacterized protein ma-jd-viral-57836

Torque teno Tadarida brasiliensis virus taxid:1543419

Protein ModelArchive
Capsid protein ma-jd-viral-04552
ORF2 ma-jd-viral-44856
ORF3 ma-jd-viral-40106

Torque teno canis virus taxid:687385

Protein ModelArchive
ORF2 ma-jd-viral-44232

Torque teno canis virus (isolate Cf-TTV10) taxid:766189

Protein ModelArchive
Capsid protein ma-jd-viral-04564
Uncharacterized ORF2 protein ma-jd-viral-44232
Uncharacterized ORF2 protein ma-jd-viral-60341

Torque teno douroucouli virus (isolate At-TTV3) taxid:766187

Protein ModelArchive
Capsid protein ma-jd-viral-04580
Uncharacterized ORF2 protein ma-jd-viral-35999
Uncharacterized ORF3 protein ma-jd-viral-55870

Torque teno felis virus (isolate Fc-TTV4) taxid:766188

Protein ModelArchive
Capsid protein ma-jd-viral-04608
Uncharacterized ORF2 protein ma-jd-viral-41006
Uncharacterized ORF3 protein ma-jd-viral-61334

Torque teno midi virus 1 taxid:687379

Protein ModelArchive
Capsid protein ma-jd-viral-04588
Capsid protein ma-jd-viral-31804
Capsid protein ma-jd-viral-31805
Capsid protein ma-jd-viral-37338

Torque teno midi virus 2 taxid:687380

Protein ModelArchive
Capsid protein ma-jd-viral-04589
Capsid protein ma-jd-viral-37345
Capsid protein ma-jd-viral-40489
Capsid protein ma-jd-viral-40496

Torque teno mini virus 1 (isolate TLMV-CBD279) taxid:766183

Protein ModelArchive
Capsid protein ma-jd-viral-04566
Uncharacterized ORF2 protein ma-jd-viral-57845
Uncharacterized ORF3 protein ma-jd-viral-55636

Torque teno mini virus 18 taxid:1859149

Protein ModelArchive
Capsid protein ma-jd-viral-04570
ORF2 ma-jd-viral-57842
ORF3 ma-jd-viral-34856

Torque teno mini virus 5 taxid:687373

Protein ModelArchive
Capsid protein ma-jd-viral-04591
Capsid protein ma-jd-viral-55638
Capsid protein ma-jd-viral-57844

Torque teno mini virus 6 taxid:687374

Protein ModelArchive
Capsid protein ma-jd-viral-04579
Capsid protein ma-jd-viral-55637
Capsid protein ma-jd-viral-57839

Torque teno mini virus 8 taxid:687376

Protein ModelArchive
Capsid protein ma-jd-viral-04605
ORF2 ma-jd-viral-57837

Torque teno mini virus ALA22 taxid:1535290

Protein ModelArchive
Capsid protein ma-jd-viral-04599
Capsid protein ma-jd-viral-55633
Uncharacterized protein ma-jd-viral-57841

Torque teno mini virus ALH8 taxid:1535291

Protein ModelArchive
Capsid protein ma-jd-viral-04571
Uncharacterized protein ma-jd-viral-57835

Torque teno sus virus 1 (isolate Sd-TTV31) taxid:766190

Protein ModelArchive
Capsid protein ma-jd-viral-04560
Uncharacterized ORF2 protein ma-jd-viral-11519
Uncharacterized ORF3 protein ma-jd-viral-38517

Torque teno sus virus 1b taxid:687387

Protein ModelArchive
Capsid protein ma-jd-viral-04607
ORF2 ma-jd-viral-11520
ORF3 ma-jd-viral-38518

Torque teno tamarin virus (isolate So-TTV2) taxid:766186

Protein ModelArchive
Capsid protein ma-jd-viral-04572
Uncharacterized ORF2 protein ma-jd-viral-46204
Uncharacterized ORF3 protein ma-jd-viral-54555
Uncharacterized ORF4 protein ma-jd-viral-60626

Torque teno virus (strain VT416) taxid:486280

Protein ModelArchive
Probable capsid and replication-associated protein ma-jd-viral-04596
Probable protein VP2 (ORF2/3 protein) ma-jd-viral-51106
Uncharacterized ORF2/4 protein ma-jd-viral-51105

Torque teno virus 14 taxid:687353

Protein ModelArchive
Capsid protein ma-jd-viral-04603
Capsid protein ma-jd-viral-34685

Torque teno virus 2 taxid:687341

Protein ModelArchive
Capsid protein ma-jd-viral-04577
ORF2, ORF1 genes, isolate: s-TTV CH71 ma-jd-viral-34687

Torque teno zalophus virus 1 taxid:1218490

Protein ModelArchive
Capsid protein ma-jd-viral-04609
Orf2 ma-jd-viral-57023
Orf3 ma-jd-viral-62352