Inhibition of host TRAFs by virus

Several TRAF family members have been involved in the signaling pathway leading to the establishment of the antiviral state in the infected cells by viruses. For example, TRAF2(U12597:9606) has been shown to be essential in RIG-I(AF038963:9606) mediated expression of interferon upon Sendai virus infection in mouse fibroblasts. TRAF3(U21092:9606) and TRAF6(U78798:9606) are also key components of the signaling pathway downstream of MAVS.

RIGI RIGI STING TRIM25 MAVS TRADD TRADD TRAF3 TRAF6 TRAF2 FADD RIP1 TBK1 IKKe IRF3 IRF3 IRF7 IRF7 IKb IKb DDX3 IKKgamma IKKalpha IKKbeta NFKB NFKB NFKB NS5a VP4 HDAG VFLIP gn LMP1 M

Therefore a lot of viruses encode proteins which target the TRAF protein family. NS5A(P27958) from hepatitis C virus, rotavirus VP4(A2T3T2), hepatitis delta virus LHDAg(P29996) and SHDAg(P0C6L3), as well as vFLIP(P88961) from KSVH directly interact with TRAF2(U78798:9606). These interactions modulate production of cytokines by infected cells.

The TRAF3(U21092:9606) protein is also the target of many viral proteins. Hantavirus Gn(P08668), Severe acute respiratory syndrome coronavirus M(P59596), and herpes virus LMP1(P03230) interact with TRAF3(U21092:9606) and interfere with the TRAF3(U21092:9606) / TBK1(AF191838:9606) interaction required to activate IRF3(Z56281:9606) / IRF7(U73036:9606).

Matching UniProtKB/Swiss-Prot entries

53 entries grouped by protein (browse by keywords)

All proteins are shown (view only 42 complete proteome entries)

2 entries

Protein A52

Select_allDeselect_all
A52_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain
A52_VACCC
Vaccinia virus (strain Copenhagen) (VACV)

13 entries

Envelopment polyprotein (M polyprotein)

Select_allDeselect_all
GP_HANTV
Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus) reference strain

Envelopment polyprotein (Glycoprotein precursor) (M polyprotein)

GP_PUUMG
Puumala virus (strain Bank vole/Russia/CG1820/1984) reference strain
GP_HANTB
Hantaan virus (strain B-1) (Korean hemorrhagic fever virus)
GP_HANTH
Hantaan virus (strain Hojo) (Hojo virus) (Korean hemorrhagic fever virus)
GP_HANTL
Hantaan virus (strain Lee) (Lee virus) (Korean hemorrhagic fever virus)
GP_NYV
New York virus (NYV)
GP_PHV
Prospect Hill virus (PHV)
GP_PUUMK
Puumala virus (strain K27)
GP_PUUMP
Puumala virus (strain P360)
GP_PUUMS
Puumala virus (strain Sotkamo/V-2969/81)
GP_SEOU8
Seoul virus (strain 80-39)
GP_SEOUR
Seoul virus (strain R22)
GP_SEOUS
Seoul virus (strain SR-11) (Sapporo rat virus)

5 entries

Latent membrane protein 1 (LMP-1) (Protein p63)

Select_allDeselect_all
LMP1_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
LMP1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
LMP1_EBVC
Epstein-Barr virus (strain Cao) (HHV-4) (Human herpesvirus 4)
LMP1_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)
LMP1_EBVR
Epstein-Barr virus (strain Raji) (HHV-4) (Human herpesvirus 4)

33 entries

Genome polyprotein

Select_allDeselect_all
POLG_HCVH
Hepatitis C virus genotype 1a (isolate H) (HCV) reference strain
POLG_SVV1
Seneca Valley virus (isolate -/United States/SSV-001/2002) (SVV) reference strain
POLG_HCV1
Hepatitis C virus genotype 1a (isolate 1) (HCV)
POLG_HCV6A
Hepatitis C virus genotype 6a (isolate 6a33) (HCV)
POLG_HCVBB
Hepatitis C virus genotype 2c (isolate BEBE1) (HCV)
POLG_HCVCO
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
POLG_HCVED
Hepatitis C virus genotype 4a (isolate ED43) (HCV)
POLG_HCVEU
Hepatitis C virus genotype 6a (isolate EUHK2) (HCV)
POLG_HCVEV
Hepatitis C virus genotype 5a (isolate EUH1480) (HCV)
POLG_HCVH9
Hepatitis C virus genotype 1c (isolate HC-G9) (HCV)
POLG_HCVIN
Hepatitis C virus genotype 1c (isolate India) (HCV)
POLG_HCVJ1
Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)
POLG_HCVJ4
Hepatitis C virus genotype 1b (strain HC-J4) (HCV)
POLG_HCVJ6
Hepatitis C virus genotype 2a (isolate HC-J6) (HCV)
POLG_HCVJ8
Hepatitis C virus genotype 2b (isolate HC-J8) (HCV)
POLG_HCVJA
Hepatitis C virus genotype 1b (isolate Japanese) (HCV)
POLG_HCVJF
Hepatitis C virus genotype 2a (isolate JFH-1) (HCV)
POLG_HCVJK
Hepatitis C virus genotype 3k (isolate JK049) (HCV)
POLG_HCVJL
Hepatitis C virus genotype 6g (isolate JK046) (HCV)
POLG_HCVJP
Hepatitis C virus genotype 2b (isolate JPUT971017) (HCV)
POLG_HCVJT
Hepatitis C virus genotype 1b (isolate HC-JT) (HCV)
POLG_HCVK3
Hepatitis C virus genotype 3a (isolate k3a) (HCV)
POLG_HCVNZ
Hepatitis C virus genotype 3a (isolate NZL1) (HCV)
POLG_HCVR6
Hepatitis C virus genotype 1b (isolate HCR6) (HCV)
POLG_HCVSA
Hepatitis C virus genotype 5a (isolate SA13) (HCV)
POLG_HCVT5
Hepatitis C virus genotype 6b (isolate Th580) (HCV)
POLG_HCVTR
Hepatitis C virus genotype 3b (isolate Tr-Kj) (HCV)
POLG_HCVTW
Hepatitis C virus genotype 1b (isolate Taiwan) (HCV)
POLG_HCVVA
Hepatitis C virus genotype 2k (isolate VAT96) (HCV)
POLG_HCVVN
Hepatitis C virus genotype 6d (isolate VN235) (HCV)
POLG_HCVVO
Hepatitis C virus genotype 6k (isolate VN405) (HCV)
POLG_HCVVP
Hepatitis C virus genotype 6h (isolate VN004) (HCV)