Skip to main content
ViralZone logo emblem ViralZone

Inhibition of host TRAFs by virus (kw:KW-1110)

Several TRAF family members have been involved in the signaling pathway leading to the establishment of the antiviral state in the infected cells by viruses. For example, TRAF2 has been shown to be essential in RIG-I mediated expression of interferon upon Sendai virus infection in mouse fibroblasts. TRAF3 and TRAF6 are also key components of the signaling pathway downstream of MAVS.

RIGI RIGI STING TRIM25 MAVS TRADD TRADD TRAF3 TRAF6 TRAF2 FADD RIP1 TBK1 IKKe IRF3 IRF3 IRF7 IRF7 IKb IKb DDX3 IKKgamma IKKalpha IKKbeta NFKB NFKB NFKB NS5a VP4 HDAG VFLIP gn LMP1 M

Therefore a lot of viruses encode proteins which target the TRAF protein family. NS5A from hepatitis C virus, rotavirus VP4, hepatitis delta virus LHDAg and SHDAg, as well as vFLIP from KSVH directly interact with TRAF2. These interactions modulate production of cytokines by infected cells.

The TRAF3 protein is also the target of many viral proteins. Hantavirus Gn, Severe acute respiratory syndrome coronavirus M, and herpes virus LMP1 interact with TRAF3 and interfere with the TRAF3 / TBK1 interaction required to activate IRF3 / IRF7.

Viral molecular biology Virion
Virus entry
Virus latency
Transcription and replication
Host-virus interactions
Virus exit
Inhibition of MDA5/RIG-I pathway Inhibition of RIG-I
Inhibition of MDA5
Inhibition of MAVS
Inhibition of host TRAFs
Inhibition of host IRF3
Inhibition of host IRF7
Inhibition of host TBK1-IKBKE-DDX3 complex
Links Uniprot Keyword: KW-1110
GO ontology: GO:0039527
Virus -Epstein-Barr virus
(Herpesviridae, Lymphocryptovirus)

-NY-1 hantavirus
(Bunyaviridae, Hantavirus)

-Hepatitis C
(Flaviviridae, Hepacivirus)

-SARS-CoV
(Coronaviridae, Betacoronavirus)

-Kaposi's sarcoma herpesvirus
(Herpesviridae, Rhadinovirus)

-Vaccinia virus
(Poxviridae, Orthopoxvirus)

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

58 entries grouped by strain

1 entry

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain

LMP1_EBVA8 Latent membrane protein 1 (LMP-1) (Protein p63)

1 entry

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

LMP1_EBVB9 Latent membrane protein 1 (LMP-1) (Protein p63) [Cleaved into: Protein p25]

pdb 1CZY

1 entry

Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus) reference strain

GP_HANTV Envelopment polyprotein (Glycoprotein precursor) (M polyprotein) [Cleaved into: Glycoprotein N (Gn) ...

pdb 5LJX; 5LJY; 5LJZ; 5LK0; 5LK1; 5LK2; 5LK3; 6Y6P

1 entry

Hepatitis C virus genotype 1a (isolate H77) (HCV) reference strain

POLG_HCV77 Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 1A1R; 1A1V; 1CWX; 1HEI; 1JR6; 1N1L; 1ONB; 1R7C; 1R7D; 1R7E; 1R7F; 1R7G; 1RGQ; 2A4R; 2F9V; 2HD0; 2JXF; 2KDR; 2N1P; 2O8M; 2OBO; 2OBQ; 2OC0; 2OC1; 2OC7; 2OC8; 2OIN; 2P59; 2QV1; 2XI2; 2XI3; 2XNI; 3RC4; 3RC5; 4CL1; 4JZN; 4JZO; 4MWF; 4N0Y; 4Q0X; 4XVJ; 4Z0X; 5EOC; 5ERW; 5FGB; 5FGC; 5JZI; 5YXN; 5YXU; 6BQJ; 6BQK; 6BZU; 6BZV; 6BZW; 6BZY; 6UYD; 6WO5; 6WOQ; 7DUU

1 entry

Puumala virus (strain Sotkamo/V-2969/81) reference strain

GP_PUUMS Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

1 entry

Seneca Valley virus (isolate -/United States/SSV-001/2002) (SVV) reference strain

POLG_SVV1 Genome polyprotein [Cleaved into: Leader protein; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 ...

pdb 3CJI; 6ADL; 6CX1; 6L0T

1 entry

Vaccinia virus (strain Copenhagen) (VACV) reference strain

A52_VACCC Protein A52

1 entry

Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

A52_VACCW Protein A52

pdb 2VVW; 2VVX

1 entry

Andes orthohantavirus (ANDV) (Andes virus)

GP_ANDV Envelopment polyprotein (Glycoprotein precursor) (M polyprotein) [Cleaved into: Glycoprotein N (Gn) ...

pdb 2K9H; 6Y5F; 6Y5W; 6Y6Q; 6YRB; 6YRQ; 6ZJM; 8DBZ

1 entry

Black Creek Canal orthohantavirus (BCCV) (Black Creek Canal virus)

GP_BCCV Envelopment polyprotein (Glycoprotein precursor) (M polyprotein) [Cleaved into: Glycoprotein N (Gn) ...

1 entry

Dobrava-Belgrade orthohantavirus (DOBV) (Dobrava virus)

GP_DOBV Envelopment polyprotein (Glycoprotein precursor) (M polyprotein) [Cleaved into: Glycoprotein N (Gn) ...

1 entry

Epstein-Barr virus (strain Cao) (HHV-4) (Human herpesvirus 4)

LMP1_EBVC Latent membrane protein 1 (LMP-1) (Protein p63)

1 entry

Epstein-Barr virus (strain GD1) (HHV-4) (Human gammaherpesvirus 4)

LMP1_EBVG Latent membrane protein 1 (LMP-1) (Protein p63)

pdb 8XH6; 8XH7

1 entry

Epstein-Barr virus (strain Raji) (HHV-4) (Human herpesvirus 4)

LMP1_EBVR Latent membrane protein 1 (LMP-1) (Protein p63)

pdb 1ZMS

1 entry

Hantaan virus (strain B-1) (Korean hemorrhagic fever virus)

GP_HANTB Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

1 entry

Hantaan virus (strain Hojo) (Hojo virus) (Korean hemorrhagic fever virus)

GP_HANTH Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

1 entry

Hantaan virus (strain Lee) (Lee virus) (Korean hemorrhagic fever virus)

GP_HANTL Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

1 entry

Hepatitis C virus genotype 1a (isolate 1) (HCV)

POLG_HCV1 Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 1RTL; 2A4G; 2GVF; 3EYD; 3HKW; 3KN2; 3QGH; 3QGI; 3RC4; 3RC5; 3SU4; 6MVO; 6N4N; 6VDO; 7MM3; 7MM4; 7MM9; 7MMA; 7MMB; 7MMC; 7MMD; 7MME; 7MMK; 7MML

1 entry

Hepatitis C virus genotype 1b (isolate BK) (HCV)

POLG_HCVBK Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 1A1Q; 1BT7; 1C2P; 1CSJ; 1CU1; 1GX5; 1GX6; 1JXP; 1NHU; 1NHV; 1NS3; 1OS5; 1QUV; 2AWZ; 2AX0; 2AX1; 2BRK; 2BRL; 2DXS; 2GIQ; 2GIR; 2HAI; 2HWH; 2HWI; 2I1R; 2JC0; 2JC1; 2O5D; 2WCX; 2WHO; 2WRM; 2XWY; 2ZKU; 3BR9; 3BSA; 3BSC; 3CDE; 3CIZ; 3CJ0; 3CJ2; 3CJ3; 3CJ4; 3CJ5; 3CO9; 3CVK; 3CWJ; 3D28; 3D5M; 3E51; 3FQK; 3FRZ; 3G86; 3GYN; 3H2L; 3H59; 3H5S; 3H5U; 3H98; 3IGV; 3MF5; 3RVB; 3UA7; 3UDL; 3VQS; 4A92; 4B6E; 4B6F; 4B71; 4B73; 4B74; 4B75; 4B76; 4DGV; 4DGY; 4EO6; 4EO8; 4IH5; 4IH6; 4IH7; 4K8B; 4KAI; 4KB7; 4KBI; 4KE5; 4MIA; 4MIB; 4MK7; 4MK8; 4MK9; 4MKA; 4MKB; 4TN2; 4WXP; 5FPS; 5FPT; 5FPY; 5KZP; 5W2E; 6MVP; 6W4G; 8OHM

1 entry

Hepatitis C virus genotype 1b (isolate Con1) (HCV)

POLG_HCVCO Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 1ZH1; 2JY0; 2KWT; 2KWZ; 3FQL; 3FQM; 3FQQ; 3KN2; 3KQH; 3KQK; 3KQL; 3KQN; 3KQU; 3Q0Z; 3QGD; 3QGE; 3QGF; 3QGG; 4NLD; 4U01; 5E4F; 5PZK; 5PZL; 5PZM; 5PZN; 5PZO; 5PZP; 5TRH; 5TRI; 5TRJ; 5TRK; 5TWN

1 entry

Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)

POLG_HCVJ1 Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 2KNU; 3MRG; 3MRH; 3MRI; 3MRJ; 3MRL

1 entry

Hepatitis C virus genotype 1b (isolate HC-JT) (HCV)

POLG_HCVJT Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 1b (isolate HCR6) (HCV)

POLG_HCVR6 Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 1b (isolate Japanese) (HCV)

POLG_HCVJA Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 1DXP; 1DY8; 1DY9; 1W3C; 2K8J; 3OYP; 3P8N; 3P8O; 4A1T; 4A1V; 4A1X; 4I31; 4I32; 4I33; 4JMY; 4KTC

1 entry

Hepatitis C virus genotype 1b (isolate Taiwan) (HCV)

POLG_HCVTW Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 1N64; 2ZJO

1 entry

Hepatitis C virus genotype 1b (strain HC-J4) (HCV)

POLG_HCVJ4 Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 1NB4; 1NB6; 1NB7; 2F55; 2MTS; 2XHU; 2XHV; 2XHW; 2YOJ; 3CSO; 3GNV; 3GNW; 3GOL; 3HKY; 3LKH; 3MWV; 3MWW; 3SKA; 3SKE; 3SKH; 3TYQ; 3TYV; 3U4O; 3U4R; 3UPH; 3UPI; 4DRU; 4EAW; 4GMC; 4IZ0; 4J02; 4J04; 4J06; 4J08; 4J0A; 4JJS; 4JJU; 4JTW; 4JTY; 4JTZ; 4JU1; 4JU2; 4JU3; 4JU4; 4JU6; 4JU7; 4JVQ; 4JY0; 4JY1; 4MZ4; 4OOW; 4RY4; 4RY5; 4RY6; 4RY7; 5CZB; 5NPH; 5NPI

1 entry

Hepatitis C virus genotype 1c (isolate HC-G9) (HCV)

POLG_HCVH9 Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 1c (isolate India) (HCV)

POLG_HCVIN Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 2a (isolate HC-J6) (HCV)

POLG_HCVJ6 Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 1YUY; 1YV2; 1YVX; 1YVZ; 2XWH; 4ADP

1 entry

Hepatitis C virus genotype 2a (isolate JFH-1) (HCV)

POLG_HCVJF Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 2KZQ; 2LIF; 2LVG; 2XXD; 2XYM; 3I5K; 4AEP; 4AEX; 4E76; 4E78; 4E7A; 4J1V; 4OBC; 4WT9; 4WTA; 4WTC; 4WTD; 4WTE; 4WTF; 4WTG; 4WTI; 4WTJ; 4WTK; 4WTL; 4WTM; 5NPJ; 5QJ0; 5QJ1; 5TWM; 5UJ2; 6HT4

1 entry

Hepatitis C virus genotype 2b (isolate HC-J8) (HCV)

POLG_HCVJ8 Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 1XCQ; 1XCT; 1XF5; 3GSZ; 3HVO

1 entry

Hepatitis C virus genotype 2b (isolate JPUT971017) (HCV)

POLG_HCVJP Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 2c (isolate BEBE1) (HCV)

POLG_HCVBB Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 2k (isolate VAT96) (HCV)

POLG_HCVVA Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 3a (isolate NZL1) (HCV)

POLG_HCVNZ Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 6P6S

1 entry

Hepatitis C virus genotype 3a (isolate k3a) (HCV)

POLG_HCVK3 Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 3b (isolate Tr-Kj) (HCV)

POLG_HCVTR Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 3k (isolate JK049) (HCV)

POLG_HCVJK Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 4a (isolate ED43) (HCV)

POLG_HCVED Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 6P6Z

1 entry

Hepatitis C virus genotype 5a (isolate EUH1480) (HCV)

POLG_HCVEV Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 2M6X

1 entry

Hepatitis C virus genotype 5a (isolate SA13) (HCV)

POLG_HCVSA Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 6a (isolate 6a33) (HCV)

POLG_HCV6A Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 6a (isolate EUHK2) (HCV)

POLG_HCVEU Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 6b (isolate Th580) (HCV)

POLG_HCVT5 Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 6d (isolate VN235) (HCV)

POLG_HCVVN Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 6g (isolate JK046) (HCV)

POLG_HCVJL Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 6h (isolate VN004) (HCV)

POLG_HCVVP Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 6k (isolate VN405) (HCV)

POLG_HCVVO Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

New York virus (NYV)

GP_NYV Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

1 entry

Prospect Hill virus (PHV)

GP_PHV Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

1 entry

Puumala virus (strain Bank vole/Russia/CG1820/1984)

GP_PUUMG Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

1 entry

Puumala virus (strain K27)

GP_PUUMK Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

1 entry

Puumala virus (strain P360)

GP_PUUMP Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

pdb 5J81; 5J9H

1 entry

Seoul virus (strain 80-39)

GP_SEOU8 Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

1 entry

Seoul virus (strain R22)

GP_SEOUR Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

1 entry

Seoul virus (strain SR-11) (Sapporo rat virus)

GP_SEOUS Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

1 entry

Sin Nombre orthohantavirus (SNV) (Sin Nombre virus)

GP_SINV Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

1 entry

Tula orthohantavirus (TULV) (Tula virus)

GP_TULV Envelopment polyprotein (Glycoprotein precursor) (M polyprotein) [Cleaved into: Glycoprotein N (Gn) ...