Evasion of host immunity by viral interleukin-like protein (kw:KW-1125)

Interleukins are secreted regulatory proteins that are members of the family of cytokines (immune system molecules) that regulates immune cell activity. Interleukins are produced by immune system cells such as lymphocytes, macrophages and monocytes, and modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells.

Several viruses encode interleukin-like protein that play a role in immune evasion. They have also been shown to activate cellular signaling cascades that enhance virus replication. EBV, HCMV, EHV and orf virus encode for a homolog of interleukin-10 that is able to downregulate Th1 response. HHV-8 protein K2 shares strong homology with IL6 and was thus also named vIL6. Unlike the human IL6, vIL6 does not require the alpha-subunit receptor IL-R6 for signal transduction. Therefore, vIL6 is able to induce antiapoptotic signaling in cells that do not express IL-6R.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

12 entries grouped by protein

7 entries

Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

Viral interleukin-10 homolog (vIL-10)

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Viral interleukin-10 homolog (cmvIL-10) (vIL-10)

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Viral interleukin-10 homolog (cmvIL-10) (vIL-10)

Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)
Equine herpesvirus 2 (strain T400/3) (EHV-2)

Viral interleukin-10 homolog (vIL-10)

1 entry

Viral interleukin-8 homolog (vIL8)

Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) reference strain

1 entry

ORF8 protein (ORF8) (Non-structural protein 8) (ns8)

Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) reference strain

2 entries

Accessory protein p12I

Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) reference strain
Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1)

1 entry

Viral interleukin-6 homolog (vIL-6)

Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain