Henipavirus (taxid:260964)

Henipavirus is a genus of ssRNA- viruses in the PAramyxoviridae family that infect bats and occasionally other mammals. In humans, these viruses can cause encephalitis or respiratory disease.

VIRION

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Enveloped, spherical. Diameter from about 150nm.

GENOME

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Negative-stranded RNA linear genome, about 18 kb in size. Encodes for nine proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. The V protein is produced through RNA editing and the C protein is produced by Leaky scanning of The P mRNA.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through G glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. the ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of MDA-5 antiviral signaling

The P,V and W proteins play a role in inhibition of STAT1 antiviral signaling

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

18 entries grouped by protein

2 entries

Protein C

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C_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
C_NIPAV
Nipah virus

2 entries

Fusion glycoprotein F0 (Protein F)

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FUS_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain

2 entries

Glycoprotein G

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GLYCP_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
GLYCP_NIPAV
Nipah virus

2 entries

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

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L_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
L_NIPAV
Nipah virus

2 entries

Matrix protein (Protein M)

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MATRX_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
MATRX_NIPAV
Nipah virus

2 entries

Nucleoprotein (Protein N) (Nucleocapsid protein)

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NCAP_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
NCAP_NIPAV
Nipah virus

2 entries

Phosphoprotein (Protein P)

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PHOSP_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
PHOSP_NIPAV
Nipah virus

2 entries

Non-structural protein V

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V_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
V_NIPAV
Nipah virus

2 entries

Protein W

Select_allDeselect_all
W_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
W_NIPAV
Nipah virus
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Cedar virus taxid:1221391

Protein ModelArchive
Attachment glycoprotein ma-jd-viral-13179
Fusion glycoprotein F0 ma-jd-viral-42992
Matrix protein ma-jd-viral-03351
Nonstructural protein C ma-jd-viral-01378
Nucleocapsid (Nucleocapsid protein) ma-jd-viral-15294
Phosphoprotein ma-jd-viral-43525

Ghana virus taxid:2847089

Protein ModelArchive
C protein ma-jd-viral-01389
Fusion glycoprotein F0 ma-jd-viral-43017
Glycoprotein ma-jd-viral-13177
Matrix protein ma-jd-viral-03309
Nucleocapsid (Nucleocapsid protein) ma-jd-viral-15305
Phosphoprotein ma-jd-viral-30315

Hendra virus (isolate Horse/Autralia/Hendra/1994) taxid:928303

Protein ModelArchive
Fusion glycoprotein F0 (Protein F) ma-jd-viral-43007
Glycoprotein G ma-jd-viral-13178
Matrix protein (Protein M) ma-jd-viral-03334
Non-structural protein V ma-jd-viral-60049
Nucleoprotein (Protein N) (Nucleocapsid protein) ma-jd-viral-15254
Phosphoprotein (Protein P) ma-jd-viral-30316
Protein C ma-jd-viral-01390

Henipavirus hendraense taxid:3052223

Protein ModelArchive
Glycoprotein ma-jd-viral-13178
Nonstructural protein C ma-jd-viral-01390
Nonstructural protein V ma-jd-viral-60049
Nucleocapsid (Nucleocapsid protein) ma-jd-viral-15254
Phosphoprotein ma-jd-viral-30316

Mojiang virus taxid:1474807

Protein ModelArchive
Attachment glycoprotein ma-jd-viral-13180
C protein ma-jd-viral-01386
Fusion glycoprotein F0 ma-jd-viral-42966
Matrix protein ma-jd-viral-03298
Nucleocapsid (Nucleocapsid protein) ma-jd-viral-15272
Phosphoprotein ma-jd-viral-30317
V protein ma-jd-viral-41507
W protein ma-jd-viral-41508

Nipah virus taxid:3052225

Protein ModelArchive
C protein ma-jd-viral-01387
Fusion glycoprotein F0 ma-jd-viral-42985
Fusion glycoprotein F0 (Protein F) ma-jd-viral-42985
Glycoprotein ma-jd-viral-13181
Glycoprotein G ma-jd-viral-13181
Matrix protein ma-jd-viral-03329
Matrix protein (Protein M) ma-jd-viral-03329
Non-structural protein V ma-jd-viral-60047
Nucleocapsid (Nucleocapsid protein) ma-jd-viral-15268
Nucleoprotein (Protein N) (Nucleocapsid protein) ma-jd-viral-15268
Phosphoprotein ma-jd-viral-30318
Phosphoprotein (Protein P) ma-jd-viral-30318
Protein C ma-jd-viral-01387
V protein ma-jd-viral-60047
W protein ma-jd-viral-60048