Morbillivirus (taxid:11229)
VIRION
Enveloped, spherical. Diameter from 150nm to 300nm.
GENOME
Negative-stranded RNA linear genome, about 15-16 kb in size. Encodes for eight proteins.
GENE EXPRESSION
The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and "polyadenylated" by the L protein during synthesis. The V protein is produced through RNA editing and the C protein is produced by Leaky scanning of The P mRNA.
ENZYMES
- RNA-dependent RNA polymerase [L]
- Mononega-type capping
- RNA TPase, GTase, N7 Mtase, 2'O Mtase [L]
REPLICATION
CYTOPLASMIC
- Virus attaches to host cell surface receptors through H glycoprotein.
- Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
- Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
- Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
- the ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.
Host-virus interaction
Inhibition of host Interferon induction
The V protein plays a role in inhibition of MDA-5 antiviral signaling 
The V also blocks the type I interferon signaling pathway by interacting with and inhibiting host TYK2
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)95 entries grouped by protein
9 entries
Protein C
16 entries
Fusion glycoprotein F0
14 entries
Hemagglutinin glycoprotein
5 entries
RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)
12 entries
Matrix protein
17 entries
Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
12 entries
Phosphoprotein (Protein P)
9 entries
Non-structural protein V
1 entry
Putative uncharacterized 7 kDa protein
Measles morbillivirus taxid:11234
Measles virus (strain Edmonston B) taxid:70146
| Protein | ModelArchive |
| Fusion glycoprotein F0 | ma-jd-viral-43011 |
Measles virus (strain Edmonston) taxid:11235
| Protein | ModelArchive |
| Fusion glycoprotein F0 | ma-jd-viral-43011 |