Morbillivirus

VIRION

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Enveloped, spherical. Diameter from 150nm to 300nm.

GENOME

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Negative-stranded RNA linear genome, about 15-16 kb in size. Encodes for eight proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and "polyadenylated" by the L protein during synthesis. The V protein is produced through RNA editing and the C protein is produced by Leaky scanning of The P mRNA.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through H glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. the ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of MDA-5 antiviral signaling

The V also blocks the type I interferon signaling pathway by interacting with and inhibiting host TYK2

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

90 entries grouped by strain (browse by keywords)

5 entries

Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus) reference strain

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FUS_MEASE Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HEMA_MEASE Hemagglutinin glycoprotein
NCAP_MEASE Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
MATRX_MEASE Matrix protein
L_MEASE RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

8 entries

Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain

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FUS_MEASC Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
PHOSP_MEASC Phosphoprotein (Protein P)
NCAP_MEASC Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
MATRX_MEASC Matrix protein
HEMA_MEASC Hemagglutinin glycoprotein
L_MEASC RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
V_MEASC Non-structural protein V
C_MEASC Protein C

2 entries

Canine distemper virus (strain Onderstepoort) (CDV) reference strain

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NCAP_CDVO Nucleoprotein (Protein N) (Nucleocapsid protein)
L_CDVO RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

3 entries

Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)

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PHOSP_MEASE Phosphoprotein (Protein P)
V_MEASE Non-structural protein V
C_MEASE Protein C

8 entries

Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)

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HEMA_MEASA Hemagglutinin glycoprotein
FUS_MEASA Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
PHOSP_MEASA Phosphoprotein (Protein P)
MATRX_MEASA Matrix protein
NCAP_MEASA Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
L_MEASA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
V_MEASA Non-structural protein V
C_MEASA Protein C

8 entries

Rinderpest virus (strain RBOK) (RDV)

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HEMA_RINDR Hemagglutinin glycoprotein
MATRX_RINDR Matrix protein
C_RINDR Protein C
PHOSP_RINDR Phosphoprotein (Protein P)
NCAP_RINDR Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
L_RINDR RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
V_RINDR Non-structural protein V
FUS_RINDR Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

5 entries

Canine distemper virus (strain Onderstepoort) (CDV)

Select_allDeselect_all
C_CDVO Protein C
FUS_CDVO Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HEMA_CDVO Hemagglutinin glycoprotein
PHOSP_CDVO Phosphoprotein (Protein P)
MATRX_CDVO Matrix protein

7 entries

Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)

Select_allDeselect_all
FUS_MEASI Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HEMA_MEASI Hemagglutinin glycoprotein
PHOSP_MEASI Phosphoprotein (Protein P)
NCAP_MEASI Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
MATRX_MEASI Matrix protein
V_MEASI Non-structural protein V
C_MEASI Protein C

7 entries

Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)

Select_allDeselect_all
FUS_MEASY Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HEMA_MEASY Hemagglutinin glycoprotein
PHOSP_MEASY Phosphoprotein (Protein P)
NCAP_MEASY Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
C_MEASY Protein C
MATRX_MEASY Matrix protein
V_MEASY Non-structural protein V

7 entries

Phocine distemper virus (PDV)

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HEMA_PHODV Hemagglutinin glycoprotein
NCAP_PHODV Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_PHODV Phosphoprotein (Protein P)
MATRX_PHODV Matrix protein
FUS_PHODV Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
V_PHODV Non-structural protein V
C_PHODV Protein C

6 entries

Rinderpest virus (strain Kabete O) (RDV)

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HEMA_RINDK Hemagglutinin glycoprotein
MATRX_RINDK Matrix protein
PHOSP_RINDK Phosphoprotein (Protein P)
V_RINDK Non-structural protein V
FUS_RINDK Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
C_RINDK Protein C

5 entries

Measles virus (strain Halle) (MeV) (Subacute sclerose panencephalitis virus)

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FUS_MEASH Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HEMA_MEASH Hemagglutinin glycoprotein
NCAP_MEASH Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
MATRX_MEASH Matrix protein
Y7K_MEASH Putative uncharacterized 7 kDa protein

3 entries

Rinderpest virus (strain L) (RDV)

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HEMA_RINDL Hemagglutinin glycoprotein
NCAP_RINDL Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
FUS_RINDL Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

2 entries

Measles virus (strain Edmonston B) (MeV) (Subacute sclerose panencephalitis virus)

Select_allDeselect_all
NCAP_MEASF Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
FUS_MEASF Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

1 entry

Canine distemper virus (strain A92-27/4) (CDV)

HEMA_CDVA4 Hemagglutinin glycoprotein

1 entry

Canine distemper virus (strain A92-6) (CDV)

HEMA_CDVA6 Hemagglutinin glycoprotein

1 entry

Canine distemper virus (strain Convac vaccine) (CDV)

HEMA_CDVC Hemagglutinin glycoprotein

1 entry

Measles virus (strain Biken) (MeV) (Subacute sclerosing panencephalitis virus (strain Biken))

MATRX_MEASB Matrix protein

1 entry

Measles virus (strain Edmonston-Moraten vaccine) (MeV) (Subacute sclerose panencephalitis virus)

NCAP_MEASM Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Measles virus (strain Edmonston-Schwarz vaccine) (MeV) (Subacute sclerose panencephalitis virus)

NCAP_MEASW Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Measles virus (strain Edmonston-Zagreb vaccine) (MeV) (Subacute sclerose panencephalitis virus)

FUS_MEASZ Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

1 entry

Measles virus (strain Hu2) (MeV) (Subacute sclerose panencephalitis virus)

MATRX_MEASU Matrix protein

1 entry

Measles virus (strain Leningrad-16) (MeV) (Subacute sclerose panencephalitis virus)

FUS_MEASL Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

1 entry

Measles virus (strain Philadelphia-26) (MeV) (Subacute sclerose panencephalitis virus)

FUS_MEASP Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

1 entry

Measles virus (strain Shanghai-191 vaccine) (MeV)

NCAP_MEASS Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Peste-des-petits-ruminants virus (PPRV)

NCAP_PPRV Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Rinderpest virus (strain Kuwait 82/1) (RDV)

NCAP_RINDU Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Rinderpest virus (strain RBT1) (RDV)

FUS_RINDB Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]