Morbillivirus

VIRION

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Enveloped, spherical. Diameter from 150nm to 300nm.

GENOME

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Negative-stranded RNA linear genome, about 15-16 kb in size. Encodes for eight proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and "polyadenylated" by the L protein during synthesis. The V protein is produced through RNA editing and the C protein is produced by Leaky scanning of The P mRNA.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through H glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. the ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of MDA-5 antiviral signaling

The V also blocks the type I interferon signaling pathway by interacting with and inhibiting host TYK2

Matching UniProtKB/Swiss-Prot entries

90 entries grouped by strain (browse by keywords)

8 entries

Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain

Select_allDeselect_all
V_MEASC Non-structural protein V
C_MEASC Protein C
HEMA_MEASC Hemagglutinin glycoprotein
L_MEASC RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
PHOSP_MEASC Phosphoprotein (Protein P)
NCAP_MEASC Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
FUS_MEASC Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
MATRX_MEASC Matrix protein

7 entries

Rinderpest virus (strain RBOK) (RDV) reference strain

Select_allDeselect_all
L_RINDR RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_RINDR Matrix protein
PHOSP_RINDR Phosphoprotein (Protein P)
C_RINDR Protein C
HEMA_RINDR Hemagglutinin glycoprotein
NCAP_RINDR Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
FUS_RINDR Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

2 entries

Canine distemper virus (strain Onderstepoort) (CDV) reference strain

Select_allDeselect_all
L_CDVO RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_CDVO Nucleoprotein (Protein N) (Nucleocapsid protein)

1 entry

Measles virus (strain Edmonston-Schwarz vaccine) (MeV) (Subacute sclerose panencephalitis virus) reference strain

NCAP_MEASW Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

8 entries

Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)

Select_allDeselect_all
V_MEASE Non-structural protein V
FUS_MEASE Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
PHOSP_MEASE Phosphoprotein (Protein P)
NCAP_MEASE Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
C_MEASE Protein C
L_MEASE RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
HEMA_MEASE Hemagglutinin glycoprotein
MATRX_MEASE Matrix protein

8 entries

Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)

Select_allDeselect_all
V_MEASA Non-structural protein V
C_MEASA Protein C
NCAP_MEASA Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_MEASA Phosphoprotein (Protein P)
MATRX_MEASA Matrix protein
HEMA_MEASA Hemagglutinin glycoprotein
FUS_MEASA Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
L_MEASA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

1 entry

Rinderpest virus (strain RBOK) (RDV)

V_RINDR Non-structural protein V

5 entries

Canine distemper virus (strain Onderstepoort) (CDV)

Select_allDeselect_all
C_CDVO Protein C
PHOSP_CDVO Phosphoprotein (Protein P)
MATRX_CDVO Matrix protein
FUS_CDVO Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HEMA_CDVO Hemagglutinin glycoprotein

7 entries

Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)

Select_allDeselect_all
V_MEASI Non-structural protein V
C_MEASI Protein C
HEMA_MEASI Hemagglutinin glycoprotein
NCAP_MEASI Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_MEASI Phosphoprotein (Protein P)
FUS_MEASI Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
MATRX_MEASI Matrix protein

7 entries

Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)

Select_allDeselect_all
V_MEASY Non-structural protein V
C_MEASY Protein C
HEMA_MEASY Hemagglutinin glycoprotein
FUS_MEASY Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
NCAP_MEASY Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_MEASY Phosphoprotein (Protein P)
MATRX_MEASY Matrix protein

7 entries

Phocine distemper virus (PDV)

Select_allDeselect_all
V_PHODV Non-structural protein V
MATRX_PHODV Matrix protein
HEMA_PHODV Hemagglutinin glycoprotein
C_PHODV Protein C
PHOSP_PHODV Phosphoprotein (Protein P)
FUS_PHODV Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
NCAP_PHODV Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

6 entries

Rinderpest virus (strain Kabete O) (RDV)

Select_allDeselect_all
V_RINDK Non-structural protein V
C_RINDK Protein C
HEMA_RINDK Hemagglutinin glycoprotein
FUS_RINDK Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
PHOSP_RINDK Phosphoprotein (Protein P)
MATRX_RINDK Matrix protein

5 entries

Measles virus (strain Halle) (MeV) (Subacute sclerose panencephalitis virus)

Select_allDeselect_all
Y7K_MEASH Putative uncharacterized 7 kDa protein
FUS_MEASH Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
NCAP_MEASH Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
MATRX_MEASH Matrix protein
HEMA_MEASH Hemagglutinin glycoprotein

3 entries

Rinderpest virus (strain L) (RDV)

Select_allDeselect_all
FUS_RINDL Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
NCAP_RINDL Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
HEMA_RINDL Hemagglutinin glycoprotein

2 entries

Measles virus (strain Edmonston B) (MeV) (Subacute sclerose panencephalitis virus)

Select_allDeselect_all
FUS_MEASF Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
NCAP_MEASF Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Canine distemper virus (strain A92-27/4) (CDV)

HEMA_CDVA4 Hemagglutinin glycoprotein

1 entry

Canine distemper virus (strain A92-6) (CDV)

HEMA_CDVA6 Hemagglutinin glycoprotein

1 entry

Canine distemper virus (strain Convac vaccine) (CDV)

HEMA_CDVC Hemagglutinin glycoprotein

1 entry

Measles virus (strain Biken) (MeV) (Subacute sclerosing panencephalitis virus (strain Biken))

MATRX_MEASB Matrix protein

1 entry

Measles virus (strain Edmonston-Moraten vaccine) (MeV) (Subacute sclerose panencephalitis virus)

NCAP_MEASM Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Measles virus (strain Edmonston-Zagreb vaccine) (MeV) (Subacute sclerose panencephalitis virus)

FUS_MEASZ Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

1 entry

Measles virus (strain Hu2) (MeV) (Subacute sclerose panencephalitis virus)

MATRX_MEASU Matrix protein

1 entry

Measles virus (strain Leningrad-16) (MeV) (Subacute sclerose panencephalitis virus)

FUS_MEASL Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

1 entry

Measles virus (strain Philadelphia-26) (MeV) (Subacute sclerose panencephalitis virus)

FUS_MEASP Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

1 entry

Measles virus (strain Shanghai-191 vaccine) (MeV)

NCAP_MEASS Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Peste-des-petits-ruminants virus (PPRV)

NCAP_PPRV Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Rinderpest virus (strain Kuwait 82/1) (RDV)

NCAP_RINDU Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Rinderpest virus (strain RBT1) (RDV)

FUS_RINDB Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]