Metapneumovirus

VIRION

Enveloped, spherical. Diameter from about 150 nm.

GENOME

Negative-stranded RNA linear genome, about 13 kb in size. Encodes for eight proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through F and G glycoproteins.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. the ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The G protein plays a role in inhibition of RIG-I antiviral signaling

The M2-2 protein plays a role in inhibition of MAVS antiviral signaling

Matching UniProtKB/Swiss-Prot entries

23 entries grouped by strain (browse by keywords)

9 entries

Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain

Select_allDeselect_all
SH_AMPV1 Small hydrophobic protein
MTRX_AMPV1 Matrix protein
PHOSP_AMPV1 Phosphoprotein
VGLG_AMPV1 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)
M22_AMPV1 Matrix M2-2
NCAP_AMPV1 Nucleoprotein (Protein N) (Nucleocapsid protein)
M21_AMPV1 Matrix M2-1 (Envelope-associated 22 kDa protein)
L_AMPV1 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
FUS_AMPV1 Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

9 entries

Human metapneumovirus (strain CAN97-83) (HMPV) reference strain

Select_allDeselect_all
VGLG_HMPVC Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)
MTRX_HMPVC Matrix protein
L_HMPVC RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
PHOSP_HMPVC Phosphoprotein (Protein P)
SH_HMPVC Small hydrophobic protein
M22_HMPVC Matrix protein M2-2
NCAP_HMPVC Nucleoprotein (Protein N) (Nucleocapsid protein)
M21_HMPVC Matrix M2-1 (Envelope-associated 22 kDa protein)
FUS_HMPVC Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

5 entries

Turkey rhinotracheitis virus (TRTV)

Select_allDeselect_all
VGLG_TRTV Major surface glycoprotein G (Attachment glycoprotein G)
FUS_TRTV Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
VMA2_TRTV Matrix M2 (Envelope-associated 22 kDa protein)
SH_TRTV Small hydrophobic protein
MATRX_TRTV Matrix protein