Viral penetration via permeabilization of host membrane (kw:KW-1173)
Some non-enveloped viruses induce local permeabilization of host endosomal membrane to allow virus capsid penetration into the cytoplasm. This is
achieved through the interaction between the host membrane and a membrane-penetration protein associated with the capsid.
Viral membrane-penetration protein might require first to be activated, mostly through endosomal acidic pH or receptor binding to display its membrane penetrating activity.
Interestingly it has been shown for rotavirus that the proteins responsible for membrane permeabilization share common mechanisms with enveloped virus fusion proteins
.
Prokaryotic dsRNA viruses also have a membrane-interacting component associated to their capsid. Virus entry causes depolarization of the host cell membrane. As for other dsRNA viruses, this membrane-interacting component might thus induce permeabilization of the cell membrane
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Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)120 entries grouped by protein
29 entries
Capsid protein VP1 (Coat protein VP1)
3 entries
Outer capsid protein mu-1 (Mu1)
1 entry
Protein Rep68 (EC 3.6.4.12)
5 entries
Minor capsid protein VP2 (Minor structural protein VP2)
70 entries
Outer capsid protein VP4 (Hemagglutinin)
12 entries