Parvoviridae (taxid:10780)
VIRION
Non-enveloped, round, T=1 icosahedral symmetry, 18-26 nm in diameter. The capsid consists of 60 copies of CP protein.
GENOME
Linear, ssDNA genome of about 4 to 6 kb in size.
The genome is replicated through rolling-hairpin mechanism.
GENE EXPRESSION
Host proteins transcribe the genome into mRNAs. Depending on the virus there can be one (Erythrovirus and Iteravirus), two (Densovirus and Brevidensovirus) or three (Dependovirus) promoters for mRNA transcription. Alternative splicing allows expression of both structural and non-structural proteins. Leaky scanning is used as well by densoviruses.
ENZYMES
REPLICATION
NUCLEAR
- Attachement to host receptors initiates clathrin-mediated endocytosis of the virion into the host cell.
- The virion penetrates into the cytoplasm via permeabilization of host endosomal membrane.
- Microtubular transport of the virion toward the nucleus.
- The viral ssDNA genome penetrates into the nucleus.
- The ssDNA is converted into dsDNA by cellular proteins.
- dsDNA transcription gives rise to viral mRNAs when host cell enters S phase and translated to produce viral proteins.
- Replication occurs through rolling-hairpin mechanism, with NS1 endonuclease binding covalently to the 5' genomic end.
- Individual ssDNA genomes are excised from replication concatemers by a process called junction resolution.
- These newly synthesized ssDNA can either
a) be converted to dsDNA and serve as a template for transcription/replication
b) be encapsidated to form new virions that are released by cell lysis.
Host-virus interaction
Apoptosis modulation
Parvoviruses infection induces host cell death, which is often directly associated with disease outcomes. Apoptosis is the major form of cell death induced by parvovirus infection, mostly associated with caspases activation. However, necrosis, has also been reported during infection of the minute virus of mice, parvovirus H-1 and bovine parvovirus.

Cell-cycle modulation
Many parvoviruses induce G2/M checkpoint arrest.

Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)74 entries grouped by protein
1 entry
Host-modulation protein 11K (Host-modulation protein of 11 kDa)
1 entry
Uncharacterized protein 7.5K (Uncharacterized protein of 7.5 kDa)
1 entry
Assembly activating protein AAP
29 entries
Capsid protein VP1 (Coat protein VP1)
5 entries
Non-structural protein NP-1 (NP1)
22 entries
Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (Non-structural protein 1) (Non-structural protein NS1)
3 entries
Non-structural protein NS2
1 entry
Non-structural protein NS3
1 entry
Protein Rep40 (EC 3.6.4.12)
1 entry
Protein Rep52
1 entry
Protein Rep68 (EC 3.6.4.12)
1 entry
Protein Rep78
1 entry
Putative non-structural protein (ORF1)
2 entries
Non-structural protein NS2
3 entries
Non-structural protein NS3
1 entry
Uncharacterized protein X
Acheta domestica mini ambidensovirus taxid:1404345
| Protein | ModelArchive |
| Nonstructural protein 1 | ma-jd-viral-23479 |
| Nonstructural protein 2 | ma-jd-viral-67106 |
| Nonstructural protein 3 | ma-jd-viral-44528 |
| Structural protein | ma-jd-viral-36628 |
Adeno-associated virus 2 taxid:10804
| Protein | ModelArchive |
| X protein | ma-jd-viral-50472 |
Adeno-associated virus 2 (isolate Srivastava/1982) taxid:648242
Adeno-associated virus 8 taxid:202813
| Protein | ModelArchive |
| Capsid protein | ma-jd-viral-07306 |
| Nonstructural protein | ma-jd-viral-23504 |
Aedes aegypti densovirus 2 taxid:1513196
| Protein | ModelArchive |
| Capsid protein | ma-jd-viral-53335 |
| Nonstructural protein 1 | ma-jd-viral-46229 |
| Nonstructural protein 2 | ma-jd-viral-56724 |
Amdoparvovirus sp. taxid:1908805
| Protein | ModelArchive |
| Initiator protein NS1 (EC 3.6.4.12) (Non-structural protein NS1) | ma-jd-viral-23459 |
| VP1 | ma-jd-viral-07356 |
Anopheles gambiae densovirus taxid:487311
Artibeus jamaicensis parvovirus 1 taxid:1131485
| Protein | ModelArchive |
| Putative capsid protein VP1 | ma-jd-viral-41352 |
| Putative non structural protein NS1 | ma-jd-viral-23498 |
Bat adeno-associated virus YNM taxid:727962
| Protein | ModelArchive |
| Cap protein | ma-jd-viral-07334 |
| Rep protein | ma-jd-viral-23494 |
Bat bocavirus taxid:1329649
| Protein | ModelArchive |
| Minor capsid protein VP1 (EC 3.1.1.4) | ma-jd-viral-07352 |
| Non-structural protein 1 | ma-jd-viral-23439 |
| Non-structural protein NP-1 | ma-jd-viral-43847 |
| VP2 protein | ma-jd-viral-07317 |
Bearded dragon parvovirus taxid:1670662
| Protein | ModelArchive |
| Assembly activating protein | ma-jd-viral-47455 |
| Capsid protein | ma-jd-viral-41350 |
| Nonstructural protein | ma-jd-viral-23472 |
Bocavirus gorilla/GBoV1/2009 taxid:864686
| Protein | ModelArchive |
| Capsid protein | ma-jd-viral-07324 |
| Minor capsid protein VP1 (EC 3.1.1.4) | ma-jd-viral-07278 |
| Non-structural protein 1 | ma-jd-viral-23420 |
| Non-structural protein NP-1 | ma-jd-viral-43833 |
Bombyx mori densovirus 5 (isolate Shinshu) taxid:648251
| Protein | ModelArchive |
| Nonstructural protein | ma-jd-viral-50375 |
| Nonstructural protein | ma-jd-viral-48527 |
| Nonstructural protein | ma-jd-viral-40765 |
Bufavirus-3 taxid:1391667
Canine bocavirus 1 taxid:1511885
| Protein | ModelArchive |
| Minor capsid protein VP1 (EC 3.1.1.4) | ma-jd-viral-07297 |
| Non-structural protein 1 | ma-jd-viral-23418 |
| Non-structural protein NP-1 | ma-jd-viral-43845 |
| VP2 | ma-jd-viral-07350 |
Cherax quadricarinatus densovirus taxid:1642018
| Protein | ModelArchive |
| Non-structural protein 1 | ma-jd-viral-23483 |
| Non-structural protein 2 | ma-jd-viral-47099 |
| Non-structural protein 3 | ma-jd-viral-38010 |
| Viral protein | ma-jd-viral-31984 |
Culex pipiens densovirus taxid:185638
| Protein | ModelArchive |
| Nonstructural protein NS-1 | ma-jd-viral-23484 |
| Nonstructural protein NS-2 | ma-jd-viral-62025 |
| Nonstructural protein NS-3 | ma-jd-viral-60231 |
| Structural protein VP1 | ma-jd-viral-36627 |
Danaus plexippus plexippus iteravirus taxid:1469956
| Protein | ModelArchive |
| Nonstructural protein NS1 | ma-jd-viral-48526 |
| Nonstructural protein NS2 | ma-jd-viral-50376 |
| Structural protein VP | ma-jd-viral-66425 |
Desmodus rotundus parvovirus taxid:1926498
| Protein | ModelArchive |
| Capsid protein 1 | ma-jd-viral-28006 |
| Nonstructural protein 1 | ma-jd-viral-23407 |
Diaphorina citri densovirus taxid:1776153
Diatraea saccharalis densovirus taxid:72003
Feline bocaparvovirus 2 taxid:1417756
| Protein | ModelArchive |
| Minor capsid protein VP1 (EC 3.1.1.4) | ma-jd-viral-07345 |
| Non-structural protein 1 | ma-jd-viral-23424 |
| Non-structural protein NP-1 | ma-jd-viral-43849 |
| VP2 | ma-jd-viral-07336 |
Feline bocavirus taxid:1174530
| Protein | ModelArchive |
| Minor capsid protein VP1 (EC 3.1.1.4) | ma-jd-viral-07355 |
| Non-structural protein 1 | ma-jd-viral-23433 |
| Non-structural protein NP-1 | ma-jd-viral-43827 |
| VP2 | ma-jd-viral-07295 |
Goose parvovirus taxid:38251
| Protein | ModelArchive |
| REP | ma-jd-viral-23502 |
| VP1 | ma-jd-viral-07314 |
| VP2 | ma-jd-viral-07276 |
| VP3 | ma-jd-viral-07320 |
Helicoverpa armigera densovirus taxid:1045778
| Protein | ModelArchive |
| NS1 | ma-jd-viral-48528 |
| NS2 | ma-jd-viral-41668 |
| VP | ma-jd-viral-66426 |
Human bocavirus 2 taxid:573977
| Protein | ModelArchive |
| Minor capsid protein VP1 (EC 3.1.1.4) | ma-jd-viral-07304 |
| Non-structural protein NP-1 (NP1) | ma-jd-viral-43832 |
Human bocavirus 3 taxid:638313
| Protein | ModelArchive |
| Minor capsid protein VP1 (EC 3.1.1.4) | ma-jd-viral-07279 |
| Minor capsid protein VP1 (EC 3.1.1.4) | ma-jd-viral-07327 |
| Non-structural protein NP-1 (NP1) | ma-jd-viral-43850 |
Human bocavirus 4 taxid:1511883
Human erythrovirus V9 taxid:72197
Human parvovirus 4 G1 taxid:1511919
| Protein | ModelArchive |
| ORF1 | ma-jd-viral-23474 |
| ORF2 | ma-jd-viral-41330 |
Human parvovirus B19 taxid:10798
Human parvovirus B19 (isolate AU) taxid:648238
| Protein | ModelArchive |
| X protein | ma-jd-viral-48977 |
Human parvovirus B19 (strain HV) taxid:648237
| Protein | ModelArchive |
| Minor capsid protein VP1 (EC 3.1.1.4) (Coat protein VP1) | ma-jd-viral-41349 |
Megabat bufavirus 1 taxid:1756191
| Protein | ModelArchive |
| Capsid protein VP1 (Coat protein VP1) | ma-jd-viral-07369 |
| Capsid protein VP2 | ma-jd-viral-07372 |
| Initiator protein NS1 (EC 3.6.4.12) (Non-structural protein NS1) | ma-jd-viral-23456 |
Muscovy duck parvovirus taxid:37325
| Protein | ModelArchive |
| Capsid protein VP | ma-jd-viral-07281 |
| Capsid protein VP | ma-jd-viral-07331 |
| Capsid protein VP | ma-jd-viral-07338 |
| REP protein | ma-jd-viral-23491 |
Penaeus monodon hepandensovirus 1 taxid:1513204
| Protein | ModelArchive |
| Non-structural protein 1 | ma-jd-viral-39053 |
| Non-structural protein 2 | ma-jd-viral-48703 |
| Structural protein | ma-jd-viral-33223 |
Penaeus monodon hepandensovirus 4 taxid:1513208
| Protein | ModelArchive |
| Non-structural protein 1 | ma-jd-viral-39051 |
| Non-structural protein 2 | ma-jd-viral-48701 |
| Structural protein | ma-jd-viral-33224 |
Planococcus citri densovirus taxid:159153
Porcine bocavirus taxid:1165907
| Protein | ModelArchive |
| Minor capsid protein VP1 (EC 3.1.1.4) | ma-jd-viral-07310 |
| Non-structural protein 1 | ma-jd-viral-23445 |
| Non-structural protein NP-1 | ma-jd-viral-43843 |
| VP2 | ma-jd-viral-07354 |
Porcine bocavirus 1 pig/ZJD/China/2006 taxid:795694
| Protein | ModelArchive |
| Minor capsid protein VP1 (EC 3.1.1.4) | ma-jd-viral-07305 |
| Non-structural protein 1 | ma-jd-viral-23429 |
| Non-structural protein NP-1 | ma-jd-viral-43822 |
| VP2 | ma-jd-viral-07289 |
Porcine bocavirus 3 taxid:1084715
| Protein | ModelArchive |
| Minor capsid protein VP1 (EC 3.1.1.4) | ma-jd-viral-07330 |
| Non-structural protein 1 | ma-jd-viral-23414 |
| Non-structural protein NP-1 | ma-jd-viral-43835 |
| VP2 | ma-jd-viral-07293 |
Porcine bocavirus 4-1 taxid:1084717
| Protein | ModelArchive |
| Minor capsid protein VP1 (EC 3.1.1.4) | ma-jd-viral-07349 |
| Non-structural protein 1 | ma-jd-viral-23436 |
| Non-structural protein NP-1 | ma-jd-viral-43841 |
| VP2 | ma-jd-viral-07307 |
Porcine bocavirus 5/JS677 taxid:1131622
| Protein | ModelArchive |
| Minor capsid protein VP1 (EC 3.1.1.4) | ma-jd-viral-07340 |
| Non-structural protein 1 | ma-jd-viral-23447 |
| Non-structural protein NP-1 | ma-jd-viral-43840 |
| VP2 | ma-jd-viral-07321 |
Porcine partetravirus taxid:1208310
| Protein | ModelArchive |
| Major structural protein | ma-jd-viral-07280 |
| Minor structural protein | ma-jd-viral-41351 |
| Nonstructural protein 1 | ma-jd-viral-23473 |
Porcine parvovirus 2 taxid:1126383
| Protein | ModelArchive |
| Non-structural protein | ma-jd-viral-23471 |
| Structural protein CDS | ma-jd-viral-41344 |
Porcine parvovirus 4 taxid:707546
| Protein | ModelArchive |
| Capsid | ma-jd-viral-41337 |
| ORF3 | ma-jd-viral-66782 |
| Replicase | ma-jd-viral-23485 |
Porcine parvovirus 5 taxid:1241957
| Protein | ModelArchive |
| Capsid protein VP1 (Coat protein VP1) | ma-jd-viral-41339 |
| Replicase | ma-jd-viral-23500 |
Porcine parvovirus 6 taxid:1472911
| Protein | ModelArchive |
| NS1 (Nonstructural protein) | ma-jd-viral-23497 |
Pseudoplusia includens densovirus taxid:185637
Raccoon dog amdovirus taxid:1513315
| Protein | ModelArchive |
| Initiator protein NS1 (EC 3.6.4.12) (Non-structural protein NS1) | ma-jd-viral-23457 |
| NS2 | ma-jd-viral-50510 |
| NS3 | ma-jd-viral-38762 |
| VP1 | ma-jd-viral-07378 |
| VP2 | ma-jd-viral-07360 |
Rat bocavirus taxid:1788315
Rat bufavirus SY-2015 taxid:1763507
| Protein | ModelArchive |
| Capsid protein VP1 (Coat protein VP1) | ma-jd-viral-07357 |
| Initiator protein NS1 (EC 3.6.4.12) (Non-structural protein NS1) | ma-jd-viral-23462 |
| VP2 | ma-jd-viral-07370 |
Rhinolophus sinicus bocaparvovirus taxid:1911555
Sea otter parvovirus 1 taxid:1882382
| Protein | ModelArchive |
| Initiator protein NS1 (EC 3.6.4.12) (Non-structural protein NS1) | ma-jd-viral-23461 |
| VP1 | ma-jd-viral-07373 |
| VP2 | ma-jd-viral-07376 |
Sesavirus CSL10538 taxid:1519097
| Protein | ModelArchive |
| NS1 | ma-jd-viral-23506 |
| VP1 | ma-jd-viral-41333 |
Slow loris parvovirus 1 taxid:1581151
| Protein | ModelArchive |
| NS1 | ma-jd-viral-23496 |
| VP1 | ma-jd-viral-41336 |
Solenopsis invicta densovirus taxid:1414671
| Protein | ModelArchive |
| NS1 | ma-jd-viral-23476 |
| NS2 | ma-jd-viral-62024 |
| NS3 | ma-jd-viral-06920 |
| VP1 | ma-jd-viral-66590 |
| VP2 | ma-jd-viral-27693 |
Tetraparvovirus sp. taxid:1908804
| Protein | ModelArchive |
| NS1 | ma-jd-viral-23470 |
| VP1 | ma-jd-viral-41331 |
Tetraparvovirus ungulate1 taxid:3052771
| Protein | ModelArchive |
| Major structural protein | ma-jd-viral-07322 |
| Minor structural protein | ma-jd-viral-41354 |
| Nonstructural protein | ma-jd-viral-23468 |
adeno-associated virus 7 taxid:202812
| Protein | ModelArchive |
| Capsid protein | ma-jd-viral-07348 |
| Nonstructural protein | ma-jd-viral-23487 |
bovine bocaparvovirus 2 taxid:1864484
| Protein | ModelArchive |
| Minor capsid protein VP1 (EC 3.1.1.4) | ma-jd-viral-07290 |
| Non-structural protein 1 | ma-jd-viral-23431 |