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Host G2/M cell cycle arrest by virus (kw:KW-1079)

The G2/M checkpoint of the cell cycle prevents the cell from entering mitosis to repair the the damaged genome and participates on various pro-survival signaling pathways. During the G2 phase the CDK1 kinase is maintained in an inactive (phosphorylated at Tyr-15) state by Wee1-like protein kinase. As cells approach M phase, the phosphatase Cdc25 dephosphorylates and thus activates CDK1, step that promotes cell entry into mitosis. The complex cyclinB-CDK1 migrates to the nucleus where it activates several substates to allow cells enter mitosis.

wee1 wee2 N Ul24 agno cdk1 cdk1 cdk1 cycB cycB cycB p53 p21 sigma cdc25 E1E4 NS1 cdk1 VPR dcaf1 ddb1 cycB Image Map

A number of different viruses have been associated with G2/M arrest, including DNA viruses, RNA viruses and retroviruses. The arrest in G2/M allows viruses to replicate their genome before cells enter mitosis. Alternatively, it can inhibit the antiviral immune response by preventing the clonal expansion of infected lymphocytes. Some viral proteins including JCV agnoprotein or MMV NS1 increase the cyclin inhibitor p21 activity through interaction with p53 to inhibit the cyclinB-CDK1. The nucleoprotein from Bornavirus or the UL24 protein from herpesviridae directly inhibit the cyclinB-CDK1 complex, while E4 from HPV16 prevents its nuclear localization. Instead, the serotype 3 reovirus sigma1-s protein hyperphosphorylates cyclinB-CDK1 that becomes inactive.

Viral molecular biology Virion
Virus entry
Virus latency
Transcription and replication
Host-virus interactions
Virus exit
Modulation of host cell cycle Host G2/M cell cycle arrest by virus
G1/S host cell cycle checkpoint dysregulation by virus
G0/G1 host cell cycle checkpoint dysregulation by virus
Modulation of host cell cycle by viral cyclin-like protein
Inhibition of host mitotic exit by virus
Links Uniprot Keyword: KW-1079

GO ontology: GO:0039592

Virus -Herpesviridae
(Herpesviridae ,alpha beta and gammaviruses)
-HPV16
(Papillomavirus ,alphapapillomavirus)
-Borna disease virus
(Bornaviridae ,Bornavirus)
-Hepatitis B
(Hepadnaviridae ,Orthohepadnavirus)
-HIV
(Retroviridae ,Lentivirus)
-Reovirus
(Reoviridae ,orthoreovirus)
-Avian reovirus
(Reoviridae ,orthoreovirus)

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

162 entries grouped by strain

2 entries

Adeno-associated virus 2 (isolate Srivastava/1982) (AAV-2) reference strain

Select_allDeselect_all
REP68_AAV2S Protein Rep68 (EC 3.6.4.12)

pdb 1S9H; 1U0J; 4ZO0; 4ZQ9; 5DCX; 6XB8; 7JSE; 7JSF; 7JSG; 7JSH; 7JSI; 9BC5; 9BU7

REP78_AAV2S Protein Rep78

pdb 5BYG

1 entry

Borna disease virus (strain V) (BDV) reference strain

NCAP_BDVV Nucleoprotein (N protein) (Nucleocapsid protein) (p38) (p40)

1 entry

Bovine papillomavirus type 1 reference strain

VE4_BPV1 Protein E4

1 entry

Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) reference strain

UL24_GAHVM Protein UL24 homolog

1 entry

Hepatitis B virus genotype C subtype adr (isolate Japan/Nishioka/1983) (HBV-C) reference strain

X_HBVC1 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype C subtype ayr (isolate Human/Japan/Okamoto/-) (HBV-C) reference strain

X_HBVCJ Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype D (isolate Germany/1-91/1991) (HBV-D) reference strain

X_HBVD7 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) (HBV-D) reference strain

X_HBVD3 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype D subtype ayw (isolate Japan/JYW796/1988) (HBV-D) reference strain

X_HBVD4 Protein X (HBx) (Peptide X) (pX)

1 entry

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

UL76_HCMVA Protein UL76

1 entry

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

UL76_HCMVM Protein UL76

1 entry

Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

DR6_HHV6U G2/M cell-cycle inhibitor DR6

1 entry

Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

UL24_HHV8P Protein UL24 homolog

1 entry

Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1) reference strain

VPR_HV1MA Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) reference strain

VPR_HV1A2 Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) reference strain

VPR_HV1BR Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) reference strain

VPR_HV1H2 Protein Vpr (R ORF protein) (Viral protein R)

pdb 4U1S

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate MN) (HIV-1) reference strain

VPR_HV1MN Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3) (HIV-1) reference strain

VPR_HV1RH Protein Vpr (R ORF protein) (Viral protein R)

pdb 1FI0

1 entry

Human immunodeficiency virus type 1 group M subtype B (strain 89.6) (HIV-1) reference strain

VPR_HV1B9 Protein Vpr (R ORF protein) (Viral protein R)

pdb 1CEU; 1ESX; 1M8L; 1VPC; 1X9V; 5B56

1 entry

Human immunodeficiency virus type 1 group M subtype C (isolate 92BR025) (HIV-1) reference strain

VPR_HV192 Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype C (isolate ETH2220) (HIV-1) reference strain

VPR_HV1ET Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate ELI) (HIV-1) reference strain

VPR_HV1EL Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020) (HIV-1) reference strain

VPR_HV193 Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1) reference strain

VPR_HV1VI Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype H (isolate 90CF056) (HIV-1) reference strain

VPR_HV190 Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group N (isolate YBF30) (HIV-1) reference strain

VPR_HV1YF Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1) reference strain

VPR_HV1AN Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2) reference strain

VPR_HV2BE Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human papillomavirus 11 reference strain

VE4_HPV11 Protein E4

1 entry

Human papillomavirus 29 reference strain

VE4_HPV29 Protein E4

1 entry

Human papillomavirus 31 reference strain

VE4_HPV31 Protein E4

1 entry

Human papillomavirus 39 reference strain

VE4_HPV39 Protein E4

1 entry

Human papillomavirus 4 reference strain

VE4_HPV04 Protein E4

1 entry

Human papillomavirus 5 reference strain

VE4_HPV05 Protein E4

1 entry

Human papillomavirus type 1 (Human papillomavirus type 1a) reference strain

VE4_HPV1 Protein E4

1 entry

Human papillomavirus type 16 reference strain

VE4_HPV16 Protein E4 (E1^E4)

1 entry

Human papillomavirus type 18 reference strain

VE4_HPV18 Protein E4

1 entry

Human papillomavirus type 41 reference strain

VE4_HPV41 Protein E4

1 entry

Human papillomavirus type 54 reference strain

VE4_HPV54 Protein E4

1 entry

Human papillomavirus type 63 reference strain

VE4_HPV63 Protein E4

1 entry

Human parvovirus B19 (strain HV) (HPV B19) reference strain

NS1_PAVHV Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...

pdb 8F2Q

1 entry

Murine minute virus (strain MVM prototype) (MVM) (Murine minute virus (strain MVM(p))) reference strain

NS1_MUMIP Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...

pdb 3WRN; 3WRO; 3WRQ; 3WRR; 3WRS; 4PP4; 4R94

1 entry

Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus) reference strain

UL24_PSHV1 Protein UL24

1 entry

Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1) reference strain

SIG1S_REOVL Protein sigma-1-small (Sigma1s) (Sigma-s) (Sigma1NS) (Sigma1bNS) (p14)

1 entry

SFTS phlebovirus (isolate SFTSV/Human/China/HB29/2010) (Severe fever with thrombocytopenia virus) reference strain

NSS_SFTSV Non-structural protein NS-S (NSs)

1 entry

Simian immunodeficiency virus (isolate CPZ GAB1) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

VPR_SIVCZ Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Simian immunodeficiency virus (isolate EK505) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

VPR_SIVEK Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Simian immunodeficiency virus (isolate MB66) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

VPR_SIVMB Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Woodchuck hepatitis B virus (isolate 8) (WHV) reference strain

X_WHV5 Protein X (HBx) (Peptide X) (pX)

1 entry

Arctic squirrel hepatitis virus (ASHV)

X_ASHV Protein X (HBx) (Peptide X) (pX)

1 entry

Borna disease virus 1 (BoDV-1)

NCAP_BDV1 Nucleoprotein (N protein) (Nucleocapsid protein) (p38) (p40)

pdb 1N93; 1PP1

1 entry

Bos taurus papillomavirus 2 (Bovine papillomavirus 2)

VE4_BPV2 Probable protein E4

1 entry

Canine parvovirus type 2 (isolate Dog/United States/CPV-N/1978) (CPV-2)

NS1_PAVCN Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...

1 entry

Chimpanzee hepatitis B virus (isolate United Kingdom/LSH/1988) (HBVcpz)

X_HBVCP Protein X (HBx) (Peptide X) (pX)

1 entry

Equine herpesvirus 1 (strain HVS25A) (EHV-1) (Equine abortion virus)

UL24_EHV1 Protein UL24 homolog

1 entry

Feline panleukopenia virus (strain 193) (FPV)

NS1_FPV19 Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...

1 entry

Gibbon hepatitis B virus subtype ayw3q (isolate Hope) (HBVgbn)

X_HBVGB Protein X (HBx) (Peptide X) (pX)

1 entry

Gorilla hepatitis B virus (isolate Cameroon/gor97) (HBVgor)

X_HBVGO Protein X (HBx) (Peptide X) (pX)

1 entry

Ground squirrel hepatitis virus (strain 27) (GSHV)

X_GSHV Protein X (HBx) (Peptide X) (pX)

1 entry

Hamster parvovirus H1

NS1_PAVHH Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...

1 entry

Hepatitis B virus genotype A1 subtype adw2 (isolate South Africa/84/2001) (HBV-A)

X_HBVA6 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype A2 (isolate Japan/11D11HCCW/1998) (HBV-A)

X_HBVA7 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype A2 subtype adw (isolate Japan/Nishioka/1983) (HBV-A)

X_HBVA2 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype A2 subtype adw2 (isolate Germany/991/1990) (HBV-A)

X_HBVA4 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979) (HBV-A)

X_HBVA3 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype A3 (isolate Cameroon/CMR711/1994) (HBV-A)

X_HBVA9 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype A3 (isolate Cameroon/CMR983/1994) (HBV-A)

X_HBVA8 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype B/C subtype adw (isolate Okinawa/pODW282/1998) (HBV-B)

X_HBVB4 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype B1 (isolate Japan/Ry30/2002) (HBV-B)

X_HBVB8 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype B1 (isolate Japan/Yamagata-2/1998) (HBV-B)

X_HBVB7 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype B1 subtype adw (isolate Japan/pJDW233/1988) (HBV-B)

X_HBVB1 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype B2 (isolate Indonesia/pIDW420/1988) (HBV-B)

X_HBVB2 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype B2 (isolate Vietnam/16091/1992) (HBV-B)

X_HBVB5 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype B2 (isolate Vietnam/9873/1997) (HBV-B)

X_HBVB3 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype B2 subtype adw (isolate China/patient4/1996) (HBV-B)

X_HBVB6 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype C (isolate Vietnam/3270/2000) (HBV-C)

X_HBVC0 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype C subtype ad (isolate Japan/S-179/1988) (HBV-C)

X_HBVC5 Protein X (HBx) (Peptide X) (pX)

pdb 8WLS

1 entry

Hepatitis B virus genotype C subtype adr (isolate Japan/A4/1994) (HBV-C)

X_HBVC8 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype C subtype adr (strain Japan/adr4/1983) (HBV-C)

X_HBVC3 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype C subtype ar (isolate Japan/S-207/1988) (HBV-C)

X_HBVC2 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype C subtype ayw (isolate Australia/AustRC/1992) (HBV-C)

X_HBVC9 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype C subtype ayw (isolate China/Tibet127/2002) (HBV-C)

X_HBVC7 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype D (isolate France/alpha1/1989) (HBV-D)

X_HBVD2 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype D subtype ayw (isolate Australia/AustKW/1991) (HBV-D)

X_HBVD5 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype D subtype ayw (isolate Italy/CI/1992) (HBV-D)

X_HBVD6 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype E (isolate Chimpanzee/Ch195/1999) (HBV-E)

X_HBVE3 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-129/2003) (HBV-E)

X_HBVE2 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-212/2003) (HBV-E)

X_HBVE4 Protein X (HBx) (Peptide X) (pX)

pdb 3I7H

1 entry

Hepatitis B virus genotype E subtype ayw4 (isolate Kou) (HBV-E)

X_HBVE1 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype F1 subtype adw4 (isolate El Salvador/1116Sal/1997) (HBV-F)

X_HBVF2 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype F2 (isolate Argentina/sa16/2000) (HBV-F)

X_HBVF4 Protein X (HBx) (Peptide X) (pX)

pdb 5FCG

1 entry

Hepatitis B virus genotype F2 (isolate Brazil/w4B) (HBV-F)

X_HBVF1 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype F2 subtype adw4q (isolate Senegal/9203) (HBV-F)

X_HBVF6 Protein X (HBx) (Peptide X) (pX)

pdb 8GTX

1 entry

Hepatitis B virus genotype G (isolate IG29227/2000) (HBV-G)

X_HBVG3 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype H (isolate United States/LAS2523/2002) (HBV-H)

X_HBVH1 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/1853Nic/1997) (HBV-H)

X_HBVH2 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/2928Nic/1997) (HBV-H)

X_HBVH3 Protein X (HBx) (Peptide X) (pX)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)

VPR_HV1B1 Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BH5) (HIV-1)

VPR_HV1B5 Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate HXB3) (HIV-1)

VPR_HV1H3 Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1)

VPR_HV1JR Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)

VPR_HV1N5 Protein Vpr (R ORF protein) (Viral protein R)

pdb 1BDE; 1DSJ; 1DSK; 1KZS; 1KZT; 1KZV; 5JK7; 6XQI; 6XQJ; 7V7C

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate OYI) (HIV-1)

VPR_HV1OY Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate PCV12) (HIV-1)

VPR_HV112 Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate SC) (HIV-1)

VPR_HV1SC Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate SF33) (HIV-1)

VPR_HV1S3 Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1)

VPR_HV1Y2 Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate Z2/CDC-Z34) (HIV-1)

VPR_HV1Z2 Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype F2 (isolate MP255) (HIV-1)

VPR_HV1MP Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype F2 (isolate MP257) (HIV-1)

VPR_HV1M2 Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype G (isolate 92NG083) (HIV-1)

VPR_HV19N Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype G (isolate SE6165) (HIV-1)

VPR_HV1SE Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype H (isolate VI991) (HIV-1)

VPR_HV1V9 Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype J (isolate SE9173) (HIV-1)

VPR_HV1S9 Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype J (isolate SE9280) (HIV-1)

VPR_HV1S2 Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype K (isolate 96CM-MP535) (HIV-1)

VPR_HV196 Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group M subtype K (isolate 97ZR-EQTB11) (HIV-1)

VPR_HV197 Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group N (isolate YBF106) (HIV-1)

VPR_HV1YB Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 1 group O (isolate MVP5180) (HIV-1)

VPR_HV1MV Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate CAM2) (HIV-2)

VPR_HV2CA Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate D194) (HIV-2)

VPR_HV2D1 Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate Ghana-1) (HIV-2)

VPR_HV2G1 Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate KR) (HIV-2)

VPR_HV2KR Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate NIH-Z) (HIV-2)

VPR_HV2NZ Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate ROD) (HIV-2)

VPR_HV2RO Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate SBLISY) (HIV-2)

VPR_HV2SB Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate ST) (HIV-2)

VPR_HV2ST Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 2 subtype B (isolate D205) (HIV-2)

VPR_HV2D2 Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human immunodeficiency virus type 2 subtype B (isolate EHO) (HIV-2)

VPR_HV2EH Protein Vpr (Viral protein R)

1 entry

Human immunodeficiency virus type 2 subtype B (isolate UC1) (HIV-2)

VPR_HV2UC Protein Vpr (R ORF protein) (Viral protein R)

1 entry

Human papillomavirus 13

VE4_HPV13 Protein E4

1 entry

Human papillomavirus 28

VE4_HPV28 Protein E4

1 entry

Human papillomavirus 33

VE4_HPV33 Protein E4 (E1^E4)

1 entry

Human papillomavirus 35

VE4_HPV35 Protein E4

1 entry

Human papillomavirus 42

VE4_HPV42 Protein E4

1 entry

Human papillomavirus 47

VE4_HPV47 Protein E4

1 entry

Human papillomavirus 51

VE4_HPV51 Protein E4

1 entry

Human papillomavirus 57

VE4_HPV57 Protein E4

1 entry

Human papillomavirus 58

VE4_HPV58 Protein E4

1 entry

Human papillomavirus 65

VE4_HPV65 Protein E4

1 entry

Human papillomavirus type 2a

VE4_HPV2A Protein E4

1 entry

Human papillomavirus type 5b

VE4_HPV5B Protein E4

1 entry

Human papillomavirus type 6a

VE4_HPV6A Protein E4

1 entry

Human papillomavirus type 6b

VE4_HPV6B Protein E4 (E1^E4)

1 entry

Human papillomavirus type 8

VE4_HPV08 Protein E4

1 entry

Human parvovirus B19 (isolate AU) (HPV B19)

NS1_PAVHU Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...

1 entry

Mink enteritis virus (strain Abashiri) (MEV)

NS1_MEVA Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...

1 entry

Murine minute virus (strain MVMi) (MVM) (Murine parvovirus)

NS1_MUMIM Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...

1 entry

Orangutan hepatitis B virus (isolate Somad) (HBVoru)

X_HBVOR Protein X (HBx) (Peptide X) (pX)

1 entry

Parvovirus LuIII

NS1_PAVL3 Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...

1 entry

Porcine parvovirus (strain Kresse) (PPV)

NS1_PAVPK Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...

1 entry

Porcine parvovirus (strain NADL-2) (PPV)

NS1_PAVPN Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...

1 entry

Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)

SIG1S_REOVJ Protein sigma-1-small (Sigma1s) (Sigma-s) (Sigma1NS) (Sigma1bNS) (p14)

1 entry

Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)

SIG1S_REOVD Protein sigma-1-small (Sigma1s) (Sigma-s) (Sigma1NS) (Sigma1bNS) (p14)

1 entry

Woodchuck hepatitis B virus (isolate 1) (WHV)

X_WHV1 Protein X (HBx) (Peptide X) (pX)

pdb 3I7K

1 entry

Woodchuck hepatitis B virus (isolate 2) (WHV)

X_WHV2 Protein X (HBx) (Peptide X) (pX)

1 entry

Woodchuck hepatitis B virus (isolate 59) (WHV)

X_WHV3 Protein X (HBx) (Peptide X) (pX)

1 entry

Woodchuck hepatitis B virus (isolate 7) (WHV)

X_WHV4 Protein X (HBx) (Peptide X) (pX)

1 entry

Woodchuck hepatitis B virus (isolate w64/pWS23) (WHV)

X_WHV6 Protein X (HBx) (Peptide X) (pX)

1 entry

Woolly monkey hepatitis B virus (isolate Louisville) (WMHBV)

X_WMHBV Protein X (HBx) (Peptide X) (pX)