Lambdavirus (taxid:186765)

VIRION

Non-enveloped, head-tail structure. The head is about 60 nm in diameter and consists of 72 capsomers (T=7, laevo).

GENOME

Linear, dsDNA genome of about 48 kb, containing about 70 genes.

GENE EXPRESSION

ENZYMES

Terminase [TermS, TermL]
Integrase
Exonuclease [P03697]
Serine protease (Peptidase S49) [P03711]
Endolysin [P03706]
Phosphatase [P03772]
REPLICATION

CYTOPLASMIC
1. Adsorption: The phage attaches to target cell adhesion receptors through its tail fibers.
2. The baseplate of the virion attaches to the entry receptor.
3. Ejection of the viral DNA into host cell cytoplasm by long flexible tail ejection system.
4. Transcription and translation of early genes.
5. Replication of genomic DNA by theta replication.
6. Replication of genomic DNA by rolling circle.
7. Transcription and translation of late genes.
8. Assembly of empty procapsids and viral genome packaging.
9. Mature virions are released from the cell by lysis.

DB LINKS

TAXONOMY Group I: dsDNA viruses

Realm:	Duplodnaviria
Kingdom:	Heunggongvirae
Phylum:	Uroviricota
Class:	Caudoviricetes
Order:	Unassigned
Family:	Unassigned
Genus:	Lambdavirus

SPECIES

Escherichia virus Lambda
Escherichia virus DE3
Escherichia virus HK629
Escherichia virus HK630

REFERENCE STRAIN Enterobacteria phage λ
Sequence | Genome assembly | Proteome

Host

NATURAL HOSTS Bacteria.

Ecology and disease

GEOGRAPHY Worldwide

TRANSMISSION Passive diffusion through medium

ANTIVIRAL DRUGS None

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

107 entries grouped by protein

reorder by strain

1 entry

Lipoprotein bor

2 entries

Major capsid protein (Gene product 7) (Gene product E) (gpE) (Major head protein)

CAPSD_LAMBD

Escherichia phage lambda (Bacteriophage lambda) reference strain

Major capsid protein (Gene product E) (gpE) (Major head protein)

7SJ5; 7VI9; 7VIA; 7VII; 7VIK; 8K39; 8XOU; 8XQB

CAPSD_BPP21

Enterobacteria phage P21 (Bacteriophage 21) (Bacteriophage P21)

1 entry

Tail completion protein Z (Gene product Z) (GpZ) (Minor tail protein Z) (Tail terminator protein)

2 entries

Capsid decoration protein (Auxiliary protein D) (Gene product D) (gpD) (Major capsid protein D)

DECO_LAMBD

Escherichia phage lambda (Bacteriophage lambda) reference strain

1C5E; 1TCZ; 1VD0; 5MFD; 7VII; 7VIK; 8XQB

DECO_BPP21

Enterobacteria phage P21 (Bacteriophage 21) (Bacteriophage P21)

Head decoration protein (Head protein GPshp)

1TD0; 1TD3; 1TD4

1 entry

DNA polymerase (EC 2.7.7.7) (EC 3.1.11.-)

2 entries

Diphtheria toxin (DT) (NAD(+)--diphthamide ADP-ribosyltransferase) (EC 2.4.2.36)

DTX_CORBE

Corynephage beta

1DDT; 1DTP; 1F0L; 1MDT; 1SGK; 1TOX; 1XDT; 4AE0; 4AE1

DTX_COROM

Corynephage omega

1 entry

Diphtheria toxin homolog CRM228

1 entry

Protein ea10

1 entry

Protein ea22

1 entry

Protein ea31

1 entry

Protein ea47

1 entry

Protein ea59

1 entry

Protein ea8.5

4 entries

SAR-endolysin (EC 3.2.1.17) (Endolysin) (Lysis protein) (Lysozyme) (Muramidase)

ENLYS_LAMBD

Escherichia phage lambda (Bacteriophage lambda) reference strain

Endolysin (EC 4.2.2.n2) (Lysis protein) (Lysozyme) (Transglycosylase)

1AM7; 1D9U; 3D3D

ENLYS_BPH19

Enterobacteria phage H19B (Bacteriophage H19B)

ENLYS_BPP21

Enterobacteria phage P21 (Bacteriophage 21) (Bacteriophage P21)

3HDE; 3HDF

ENLYS_BPPA2

Enterobacteria phage PA-2 (Bacteriophage PA-2)

1 entry

Exonuclease (EC 3.1.11.3)

1 entry

DNA-packaging protein FI

1 entry

Tail fiber protein (stf) (Gene product 27) (gp27)

1 entry

Head-tail connector protein FII (Head-tail joining protein) (Minor capsid protein FII)

1 entry

Tail assembly protein G (Gene product G) (gpG) (Minor tail protein G) (Tail assembly chaperone) (TAC)

1 entry

Host-nuclease inhibitor protein gam

1 entry

Tail assembly protein GT (Gene product 15) (gp15) (Gene product GT) (gpGT) (Minor tail protein GT)

1 entry

Head completion protein (HCP) (Head-tail joining protein W) (gpW)

2 entries

Antiholin

HOLIN_LAMBD

Escherichia phage lambda (Bacteriophage lambda) reference strain

Antiholin (Lysis inhibitor S-107)

HOLIN_BPP21

Enterobacteria phage P21 (Bacteriophage 21) (Bacteriophage P21)

1 entry

Orphan methyltransferase M.Rho11sI (M.Rho11sI) (EC 2.1.1.37) (Bsu P11s) (Cytosine-specific methyltransferase Rho11sI) (Modification methylase Rho11sI)

2 entries

Protein ninB

NINB_LAMBD

Escherichia phage lambda (Bacteriophage lambda) reference strain

1PC6

NINB_BPP21

Enterobacteria phage P21 (Bacteriophage 21) (Bacteriophage P21)

1 entry

Protein ninD

4 entries

Protein ninE

NINE_LAMBD

Escherichia phage lambda (Bacteriophage lambda) reference strain

Protein ninE (Nin60)

NINE_BP82

Enterobacteria phage 82 (Bacteriophage 82)

NINE_BPH19

Enterobacteria phage H19B (Bacteriophage H19B)

NINE_BPP21

Enterobacteria phage P21 (Bacteriophage 21) (Bacteriophage P21)

3 entries

Protein ninF

NINF_LAMBD

Escherichia phage lambda (Bacteriophage lambda) reference strain

NINF_BPH19

Enterobacteria phage H19B (Bacteriophage H19B)

NINF_BPP21

Enterobacteria phage P21 (Bacteriophage 21) (Bacteriophage P21)

3 entries

Protein ninG

NING_LAMBD

Escherichia phage lambda (Bacteriophage lambda) reference strain

NING_BPH19

Enterobacteria phage H19B (Bacteriophage H19B)

NING_BPP21

Enterobacteria phage P21 (Bacteriophage 21) (Bacteriophage P21)

2 entries

Protein ninH

NINH_LAMBD

Escherichia phage lambda (Bacteriophage lambda) reference strain

NINH_BPH19

Enterobacteria phage H19B (Bacteriophage H19B)

1 entry

Outer membrane porin protein LC

2 entries

Portal protein B (GpB) (Minor capsid protein B)

PORTL_LAMBD

Escherichia phage lambda (Bacteriophage lambda) reference strain

8K38; 8K39; 8XOT; 8XOU; 8XOW; 8XPM; 8XQB

PORTL_BPP21

Enterobacteria phage P21 (Bacteriophage 21) (Bacteriophage P21)

1 entry

Serine/threonine-protein phosphatase (EC 3.1.3.16)

1 entry

Restriction inhibitor protein ral (Antirestriction protein)

2 entries

Regulatory protein cro

RCRO_LAMBD

Escherichia phage lambda (Bacteriophage lambda) reference strain

1COP; 1D1L; 1D1M; 1ORC; 2A63; 2ECS; 2ORC; 2OVG; 3ORC; 4CRO; 5CRO; 6CRO

RCRO_BP434

Enterobacteria phage 434 (Bacteriophage 434)

Regulatory protein cro (Antirepressor)

1ZUG; 2CRO; 3CRO

1 entry

Antitermination protein N (Regulatory protein N) (PN)

3 entries

Antitermination protein Q

REGQ_LAMBD

Escherichia phage lambda (Bacteriophage lambda) reference strain

4MO1; 7UBJ; 7UBK; 7UBL; 7UBM; 7UBN

REGQ_BP82

Enterobacteria phage 82 (Bacteriophage 82)

REGQ_BPH19

Enterobacteria phage H19B (Bacteriophage H19B)

2 entries

Protein rexA

REXA_LAMBD

Escherichia phage lambda (Bacteriophage lambda) reference strain

REXA_BP434

Enterobacteria phage 434 (Bacteriophage 434)

1 entry

Protein rexB

1 entry

Repressor protein cI

2 entries

Regulatory protein CII

RPC2_LAMBD

Escherichia phage lambda (Bacteriophage lambda) reference strain

Transcriptional activator II

1XWR; 1ZPQ; 1ZS4; 8IGR

RPC2_BP434

Enterobacteria phage 434 (Bacteriophage 434)

1 entry

Protease inhibitor III

1 entry

Crossover junction endodeoxyribonuclease rusA (EC 3.1.21.10) (Holliday junction nuclease rusA) (Holliday junction resolvase)

1 entry

Capsid assembly protease C (EC 3.4.21.-) (Gene product C) (GPC) (Minor capsid protein C)

1 entry

Superinfection exclusion protein B

2 entries

Spanin, inner membrane subunit (i-spanin) (Lysis protein Rz)

SPAN1_LAMBD

Escherichia phage lambda (Bacteriophage lambda) reference strain

SPAN1_BPP21

Enterobacteria phage P21 (Bacteriophage 21) (Bacteriophage P21)

2 entries

Spanin, outer lipoprotein subunit (o-spanin) (Lysis protein Rz1) (Outer membrane lipoprotein Rz1)

SPAN2_LAMBD

Escherichia phage lambda (Bacteriophage lambda) reference strain

SPAN2_BPP21

Enterobacteria phage P21 (Bacteriophage 21) (Bacteriophage P21)

1 entry

Shiga-like toxin 1 subunit A (SLT-1 A subunit) (SLT-1a) (SLT-Ia) (EC 3.2.2.22) (Verocytotoxin 1 subunit A) (Verotoxin 1 subunit A) (rRNA N-glycosidase 1)

1 entry

Shiga-like toxin 1 subunit B (SLT-1 B subunit) (SLT-1b) (SLT-Ib) (Verocytotoxin 1 subunit B) (Verotoxin 1 subunit B)

2 entries

Terminase, large subunit (DNA-packaging protein A) (Large terminase protein) (gpA)

TERL_LAMBD

Escherichia phage lambda (Bacteriophage lambda) reference strain

TERL_BPP21

Enterobacteria phage P21 (Bacteriophage 21) (Bacteriophage P21)

Terminase, large subunit (DNA-packaging protein) (DNA-packaging protein gp2) (Gene product 2) (gp2) (Large terminase protein)

2 entries

Terminase small subunit (EC 3.6.4.-) (DNA-packaging protein Nu1) (Gene product Nu1) (gpNu1)

TERS_LAMBD

Escherichia phage lambda (Bacteriophage lambda) reference strain

1J9I; 6HN7; 7LW0

TERS_BPP21

Enterobacteria phage P21 (Bacteriophage 21) (Bacteriophage P21)

Terminase, small subunit (Gp1)

7LWR

1 entry

Tail fiber assembly protein

1 entry

Tail tip assembly protein I

1 entry

Tip attachment protein J (Central tail fiber) (Host specificity protein J)

1 entry

Tail tip assembly protein K (Probable endopeptidase) (EC 3.4.-.-) (Tail assembly protein K)

1 entry

Tail tip protein L

1 entry

Tail tip protein M

1 entry

Tape measure protein (TMP) (Gene product H) (gpH) (Minor tail protein H)

1 entry

Tail tube terminator protein (TrP) (Gene product U) (gpU) (Minor tail protein U) (Tail sheath-stabilizing protein) (Tail-to-head joining protein) (THJP)

1 entry

Tail tube protein (TTP) (Gene product V) (gpV) (Major tail protein V)

1 entry

Recombination protein bet

1 entry

Head-tail preconnector protein GP5 (EC 3.4.21.-) (Putative peptidase GP5)

3 entries

Integrase (EC 2.7.7.-) (EC 3.1.-.-)

VINT_LAMBD

Escherichia phage lambda (Bacteriophage lambda) reference strain

1AE9; 1KJK; 1P7D; 1Z19; 1Z1B; 1Z1G; 2OXO; 2WCC; 5J0N

VINT_BP434

Enterobacteria phage 434 (Bacteriophage 434)

VINT_BPP21

Enterobacteria phage P21 (Bacteriophage 21) (Bacteriophage P21)

1 entry

Protein kil

1 entry

Outer membrane protein lom (ORF 206A)

1 entry

Protein ren

1 entry

Replication protein O

1 entry

Helicase loader (Lambda P helicase loader) (Replication protein P)

3 entries

Excisionase

VXIS_LAMBD

Escherichia phage lambda (Bacteriophage lambda) reference strain

1LX8; 1RH6; 2IEF; 2OG0; 5J0N; 6P0S; 6P0T; 6P0U

VXIS_BP434

Enterobacteria phage 434 (Bacteriophage 434)

VXIS_BPP21

Enterobacteria phage P21 (Bacteriophage 21) (Bacteriophage P21)

1 entry

Head completion protein gp3 (Gene product 3) (gp3) (Head-stabilizing protein) (Head-tail joining protein)

1 entry

Uncharacterized nin region protein ORF290

1 entry

Putative uncharacterized protein ORF64

1 entry

Uncharacterized protein in rusA 5'region (ORF151)

1 entry

Putative nuclease ybcO (EC 3.1.-.-)

1 entry

Uncharacterized 13.5 kDa protein in GP7-GP8 intergenic region

1 entry

Uncharacterized protein in rusA 3'region (ORF45)

1 entry

Uncharacterized 3.7 kDa protein in rusA 5'region (ORF33)

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Lambdavirus (taxid:186765)

VIRION

GENOME

GENE EXPRESSION

ENZYMES

REPLICATION

Host

Ecology and disease

Matching UniProtKB/Swiss-Prot entries

Lipoprotein bor

Major capsid protein (Gene product 7) (Gene product E) (gpE) (Major head protein)

Tail completion protein Z (Gene product Z) (GpZ) (Minor tail protein Z) (Tail terminator protein)

Capsid decoration protein (Auxiliary protein D) (Gene product D) (gpD) (Major capsid protein D)

DNA polymerase (EC 2.7.7.7) (EC 3.1.11.-)

Diphtheria toxin (DT) (NAD(+)--diphthamide ADP-ribosyltransferase) (EC 2.4.2.36)

Diphtheria toxin homolog CRM228

Protein ea10

Protein ea22

Protein ea31

Protein ea47

Protein ea59

Protein ea8.5

SAR-endolysin (EC 3.2.1.17) (Endolysin) (Lysis protein) (Lysozyme) (Muramidase)

Exonuclease (EC 3.1.11.3)

DNA-packaging protein FI

Tail fiber protein (stf) (Gene product 27) (gp27)

Head-tail connector protein FII (Head-tail joining protein) (Minor capsid protein FII)

Tail assembly protein G (Gene product G) (gpG) (Minor tail protein G) (Tail assembly chaperone) (TAC)

Host-nuclease inhibitor protein gam

Tail assembly protein GT (Gene product 15) (gp15) (Gene product GT) (gpGT) (Minor tail protein GT)

Head completion protein (HCP) (Head-tail joining protein W) (gpW)

Antiholin

Orphan methyltransferase M.Rho11sI (M.Rho11sI) (EC 2.1.1.37) (Bsu P11s) (Cytosine-specific methyltransferase Rho11sI) (Modification methylase Rho11sI)

Protein ninB

Protein ninD

Protein ninE

Protein ninF

Protein ninG

Protein ninH

Outer membrane porin protein LC

Portal protein B (GpB) (Minor capsid protein B)

Serine/threonine-protein phosphatase (EC 3.1.3.16)

Restriction inhibitor protein ral (Antirestriction protein)

Regulatory protein cro

Antitermination protein N (Regulatory protein N) (PN)

Antitermination protein Q

Protein rexA

Protein rexB

Repressor protein cI

Regulatory protein CII

Protease inhibitor III

Crossover junction endodeoxyribonuclease rusA (EC 3.1.21.10) (Holliday junction nuclease rusA) (Holliday junction resolvase)

Capsid assembly protease C (EC 3.4.21.-) (Gene product C) (GPC) (Minor capsid protein C)

Superinfection exclusion protein B

Spanin, inner membrane subunit (i-spanin) (Lysis protein Rz)

Spanin, outer lipoprotein subunit (o-spanin) (Lysis protein Rz1) (Outer membrane lipoprotein Rz1)

Shiga-like toxin 1 subunit A (SLT-1 A subunit) (SLT-1a) (SLT-Ia) (EC 3.2.2.22) (Verocytotoxin 1 subunit A) (Verotoxin 1 subunit A) (rRNA N-glycosidase 1)

Shiga-like toxin 1 subunit B (SLT-1 B subunit) (SLT-1b) (SLT-Ib) (Verocytotoxin 1 subunit B) (Verotoxin 1 subunit B)

Terminase, large subunit (DNA-packaging protein A) (Large terminase protein) (gpA)

Terminase small subunit (EC 3.6.4.-) (DNA-packaging protein Nu1) (Gene product Nu1) (gpNu1)

Tail fiber assembly protein

Tail tip assembly protein I

Tip attachment protein J (Central tail fiber) (Host specificity protein J)

Tail tip assembly protein K (Probable endopeptidase) (EC 3.4.-.-) (Tail assembly protein K)

Tail tip protein L

Tail tip protein M

Tape measure protein (TMP) (Gene product H) (gpH) (Minor tail protein H)

Tail tube terminator protein (TrP) (Gene product U) (gpU) (Minor tail protein U) (Tail sheath-stabilizing protein) (Tail-to-head joining protein) (THJP)

Tail tube protein (TTP) (Gene product V) (gpV) (Major tail protein V)

Recombination protein bet

Head-tail preconnector protein GP5 (EC 3.4.21.-) (Putative peptidase GP5)

Integrase (EC 2.7.7.-) (EC 3.1.-.-)

Protein kil

Outer membrane protein lom (ORF 206A)

Protein ren

Replication protein O

Helicase loader (Lambda P helicase loader) (Replication protein P)

Excisionase

Head completion protein gp3 (Gene product 3) (gp3) (Head-stabilizing protein) (Head-tail joining protein)

Uncharacterized nin region protein ORF290