Lambdavirus

VIRION

Non-enveloped, head-tail structure. The head is about 60 nm in diameter and consists of 72 capsomers (T=7, laevo).

GENOME

Linear, dsDNA genome of about 48 kb, containing about 70 genes.

GENE EXPRESSION

REPLICATION

CYTOPLASMIC

  1. Adsorption: The phage attaches to target cell adhesion receptors through its tail fibers.
  2. The baseplate of the virion attaches to the entry receptor.
  3. Ejection of the viral DNA into host cell cytoplasm by long flexible tail ejection system.
  4. Transcription and translation of early genes.
  5. Replication of genomic DNA by theta replication.
  6. Replication of genomic DNA by rolling circle.
  7. Transcription and translation of late genes.
  8. Assembly of empty procapsids and viral genome packaging.
  9. Mature virions are released from the cell by lysis.